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1. 发明申请

US20040073155A1 Methods and devices for maintaining patency of surgically created channels in tissue 审中-公开
标题翻译：用于在组织中维持外科手术通道的通畅的方法和装置
公开(公告)号：US20040073155A1
公开(公告)日：2004-04-15
申请号：US10458085
申请日：2003-06-09
申请人： Broncus Technologies, Inc.
发明人： Michael D. Laufer , Cary Cole , Bryan Loomas , Gary Kaplan , Cary J. Reich , Ed Roschak , Trudy Estridge
IPC分类号： A61F002/04 , A61B019/00
CPC分类号： A61F2/91 , A61B5/489 , A61B8/06 , A61B8/12 , A61B17/064 , A61B17/0644 , A61B17/068 , A61B17/08 , A61B17/11 , A61B17/12022 , A61B17/12104 , A61B17/22 , A61B18/1477 , A61B18/1485 , A61B18/1492 , A61B18/1815 , A61B90/36 , A61B2017/00106 , A61B2017/00252 , A61B2017/0046 , A61B2017/00477 , A61B2017/00575 , A61B2017/00601 , A61B2017/1135 , A61B2017/1139 , A61B2017/22051 , A61B2017/22067 , A61B2017/22077 , A61B2018/00005 , A61B2018/00029 , A61B2018/00214 , A61B2018/00273 , A61B2018/00285 , A61B2018/00541 , A61B2018/00738 , A61B2018/1417 , A61B2018/1425 , A61B2018/1437 , A61B2018/1472 , A61B2018/1475 , A61B2090/08021 , A61B2090/3782 , A61B2090/395 , A61B2218/002 , A61F2/02 , A61F2/07 , A61F2/20 , A61F2/2412 , A61F2/2418 , A61F2/90 , A61F2/92 , A61F2002/043 , A61F2002/061 , A61F2002/068 , A61F2002/8483 , A61F2220/0008 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/0008 , A61F2230/0019 , A61F2230/005 , A61F2230/0078 , A61N2007/0078
摘要： Devices and methods are directed to altering gaseous flow within a lung to improve the expiration cycle of, for instance, an individual having chronic obstructive pulmonary disease. More particularly, methods and devices are disclosed that inhibit closure of channels surgically created through an airway wall such that air is able to pass directly out of the lung tissue to facilitate both the exchange of oxygen ultimately into the blood and/or to decompress hyper-inflated lungs. Devices, instruments, medicine, bioactive agents, or combinations thereof serve to maintain the patency of the surgically created channels. In one embodiment of the present invention, a conduit includes a bioactive coating that inhibits tissue overgrowth when the conduit is deployed in a surgically created channel. Still other methods and devices are described that serve to maintain surgically created channels.
摘要翻译：装置和方法旨在改变肺内的气流以改善例如具有慢性阻塞性肺疾病的个体的呼气循环。更具体地，公开了抑制通过气道壁手术产生的通道的闭合，使得空气能够直接从肺组织传出，以促进氧气最终进入血液和/或解压缩超氧化物质，充气肺装置，仪器，药物，生物活性剂或其组合用于维持手术产生的通道的通畅。在本发明的一个实施方案中，导管包括生物活性涂层，其在导管部署在手术创建的通道中时抑制组织过度生长。描述了用于维持手术创建的通道的其它方法和装置。

2. 发明申请

US20040031494A1 Methods of treating asthma 有权
标题翻译：治疗哮喘的方法
公开(公告)号：US20040031494A1
公开(公告)日：2004-02-19
申请号：US10640967
申请日：2003-08-13
申请人： Broncus Technologies, Inc.
发明人： Christopher James Danek , Michael Biggs , Bryan Loomas , Michael D. Laufer , Gary Kaplan , Kelly Shriner
IPC分类号： A61B019/00
CPC分类号： A61B18/12 , A61B17/22004 , A61B18/00 , A61B18/08 , A61B18/14 , A61B18/1485 , A61B18/1492 , A61B2017/00115 , A61B2017/00292 , A61B2017/003 , A61B2017/22062 , A61B2018/00083 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00541 , A61B2018/00654 , A61B2018/00666 , A61B2018/00678 , A61B2018/00761 , A61B2018/00791 , A61B2018/00797 , A61B2018/00803 , A61B2018/044 , A61B2018/046 , A61B2018/1807 , A61B2090/3614 , A61M25/0043 , A61M29/00 , A61M2025/0096 , A61M2210/1039 , A61N5/0601
摘要： This relates to treating an asthmatic lung and more particularly, relates to advancing a treatment device into the lung and treating the lung with the device. This also includes additional steps of treating the airway wall, applying energy or heat to the airway wall in an asthmatic lung.
摘要翻译：这涉及治疗哮喘肺，更具体地涉及将治疗装置推进到肺中并用装置治疗肺。这还包括治疗气道壁，向哮喘肺中的气道壁施加能量或热量的附加步骤。

3. 发明申请

US20040211434A1 Extrapleural airway device and method 有权
标题翻译：胸外气道装置及方法
公开(公告)号：US20040211434A1
公开(公告)日：2004-10-28
申请号：US10615491
申请日：2003-07-07
申请人： Broncus Technologies, Inc.
发明人： Bryan Loomas , Gary Kaplan
IPC分类号： A61B019/00 , A61B018/18
CPC分类号： A61F2/04 , A61F2002/046
摘要： This is directed to improving the gaseous exchange in a lung of an individual and particularly, this is directed to improving the gaseous exchange in individuals having chronic obstructive pulmonary disease. It generally includes fluidly connecting the lung to an extrapleural airway such as the trachea. In one variation, a conduit is deployed to place the lung and the trachea in fluid communication which allows trapped oxygen-reduced air to pass directly out of the lung and into the trachea. Removing nonfunctional air from the lung tends to improve the gaseous exchange of oxygen into the blood and decompress hyper-inflated lungs. Sealant and biocompatible adhesives may be provided on the exterior of the conduit to prevent side flow, leaks and to otherwise prevent air from entering spaces not intended to receive air such as the pleura space.
摘要翻译：这旨在改善个体肺中的气体交换，特别是涉及改善具有慢性阻塞性肺疾病的个体中的气体交换。它通常包括将肺流体连接到胸膜前气道如气管。在一个变型中，部署导管以将肺和气管置于流体连通中，其允许被捕获的减氧空气直接通过肺部并进入气管。从肺部去除非功能性空气有助于改善氧气进入血液的气体交换并减压超膨胀的肺。可以在导管的外部设置密封剂和生物相容性粘合剂，以防止侧流，泄漏并防止空气进入不想接收诸如胸膜空间的空气的空间。

4. 发明申请

US20020111620A1 Devices and methods for maintaining collateral channels in tissue 失效
标题翻译：用于维持组织中的旁路通道的装置和方法
公开(公告)号：US20020111620A1
公开(公告)日：2002-08-15
申请号：US09947144
申请日：2001-09-04
申请人： Broncus Technologies, Inc.
发明人： Joel D. Cooper , James M. Davenport , Bryan Loomas , Don Tanaka , Gary Kaplan
IPC分类号： A61B018/18
CPC分类号： A61F2/90 , A61B5/489 , A61B8/06 , A61B8/12 , A61B8/445 , A61B17/064 , A61B17/11 , A61B17/320068 , A61B18/1477 , A61B18/1485 , A61B18/1492 , A61B90/36 , A61B2017/00106 , A61B2017/00252 , A61B2017/00575 , A61B2017/00809 , A61B2017/22067 , A61B2018/00214 , A61B2018/00541 , A61B2018/00601 , A61B2018/00738 , A61B2018/00982 , A61B2018/1417 , A61B2018/1425 , A61B2018/1472 , A61B2090/395 , A61B2218/002 , A61F2/07 , A61F2/2412 , A61F2/91 , A61F2/92 , A61F2002/043 , A61F2002/061 , A61F2002/072 , A61F2002/8483 , A61F2220/0008 , A61F2220/0016 , A61F2230/005 , A61F2230/0058 , A61F2230/0067 , A61F2230/0076 , A61F2230/0078
摘要： The devices and methods of placement of such devices disclosed herein are directed to altering gaseous flow within a lung to improve the expiration cycle of, for instance, an individual having Chronic Obstructive Pulmonary Disease. More particularly, these devices produce and maintain collateral openings or channels through the airway wall so that oxygen depleted/carbon dioxide rich air is able to pass directly out of the lung tissue to facilitate both the exchange of oxygen ultimately into the blood and/or to decompress hyper-inflated lungs. The medical kits disclosed herein are also directed to produce and maintain collateral openings through airway walls.
摘要翻译：本文公开的这种装置的放置装置和方法旨在改变肺内的气流以改善例如具有慢性阻塞性肺疾病的个体的呼气循环。更具体地说，这些装置通过气道壁产生和保持侧支开口或通道，使得贫氧/富含二氧化碳的空气能够直接从肺组织中流出，以促进氧气最终进入血液和/或减压超膨胀肺。本文公开的医疗用具还涉及通过气道壁产生和维持侧支开口。

5. 发明申请

US20040220556A1 Devices and methods for maintaining collateral channels in tissue 审中-公开
标题翻译：用于维持组织中的旁路通道的装置和方法
公开(公告)号：US20040220556A1
公开(公告)日：2004-11-04
申请号：US10862933
申请日：2004-06-08
申请人： Broncus Technologies, Inc.
发明人： Joel D. Cooper , James M. Davenport , Bryan Loomas , Don Tanaka , Gary Kaplan
IPC分类号： A61B017/00
CPC分类号： A61F2/90 , A61B5/489 , A61B8/06 , A61B8/12 , A61B8/445 , A61B17/064 , A61B17/11 , A61B18/1477 , A61B18/1485 , A61B18/1492 , A61B90/36 , A61B2017/00106 , A61B2017/00252 , A61B2017/00575 , A61B2017/00809 , A61B2017/22067 , A61B2018/00214 , A61B2018/00541 , A61B2018/00601 , A61B2018/00738 , A61B2018/00982 , A61B2018/1417 , A61B2018/1425 , A61B2018/1472 , A61B2090/395 , A61B2218/002 , A61F2/07 , A61F2/2412 , A61F2/91 , A61F2/92 , A61F2002/043 , A61F2002/061 , A61F2002/072 , A61F2002/8483 , A61F2220/0008 , A61F2220/0016 , A61F2230/005 , A61F2230/0058 , A61F2230/0067 , A61F2230/0076 , A61F2230/0078
摘要： The devices and methods of placement of such devices disclosed herein are directed to altering gaseous flow within a lung to improve the expiration cycle of, for instance, an individual having Chronic Obstructive Pulmonary Disease. More particularly, these devices produce and maintain collateral openings or channels through the airway wall so that oxygen depleted/carbon dioxide rich air is able to pass directly out of the lung tissue to facilitate both the exchange of oxygen ultimately into the blood and/or to decompress hyper-inflated lungs. The medical kits disclosed herein are also directed to produce and maintain collateral openings through airway walls.
摘要翻译：本文公开的这种装置的放置装置和方法旨在改变肺内的气流以改善例如具有慢性阻塞性肺疾病的个体的呼气循环。更具体地说，这些装置通过气道壁产生和保持侧支开口或通道，使得贫氧/富含二氧化碳的空气能够直接从肺组织中流出，以促进氧气最终进入血液和/或减压超膨胀肺。本文公开的医疗用具还涉及通过气道壁产生和维持侧支开口。

6. 发明申请

US20040073201A1 Methods for treating chronic obstructive pulmonary disease 审中-公开
标题翻译：治疗慢性阻塞性肺疾病的方法
公开(公告)号：US20040073201A1
公开(公告)日：2004-04-15
申请号：US10633902
申请日：2003-08-04
申请人： Broncus Technologies, Inc.
发明人： Joel D. Cooper , Bryan Loomas , Don Tanaka , Michael D. Laufer , David Thompson , James M. Davenport , Gary Kaplan , Dave Haugaard , Glendon E. French
IPC分类号： A61B018/18
CPC分类号： A61B17/064 , A61B5/489 , A61B8/06 , A61B8/12 , A61B8/445 , A61B17/0644 , A61B17/08 , A61B17/11 , A61B17/22 , A61B18/1445 , A61B18/1477 , A61B18/1492 , A61B18/1815 , A61B90/36 , A61B2017/00106 , A61B2017/00252 , A61B2017/00575 , A61B2017/00809 , A61B2017/1135 , A61B2017/1139 , A61B2017/22067 , A61B2017/22077 , A61B2017/3425 , A61B2017/3484 , A61B2018/00005 , A61B2018/00029 , A61B2018/00214 , A61B2018/00273 , A61B2018/00285 , A61B2018/00541 , A61B2018/1425 , A61B2018/1437 , A61B2018/1475 , A61B2018/1497 , A61B2090/08021 , A61B2090/3782 , A61B2090/395 , A61F2/02 , A61F2/07 , A61F2/20 , A61F2/2412 , A61F2/2418 , A61F2/856 , A61F2/90 , A61F2/91 , A61F2/92 , A61F2002/043 , A61F2002/8483 , A61F2220/005 , A61F2220/0066 , A61F2220/0075 , A61F2230/0058 , A61F2230/0076 , A61F2230/0078 , A61F2230/0091 , A61N2007/0078
摘要： The methods and devices disclosed altering gaseous flow within a lung to improve the expiration cycle of individuals having Chronic Obstructive Pulmonary Disease.
摘要翻译：所公开的方法和装置改变肺内的气流以改善具有慢性阻塞性肺疾病的个体的呼气循环。

7. 发明申请

US20030233099A1 Modification of airways by application of energy 有权
标题翻译：通过应用能源改变航空公司
公开(公告)号：US20030233099A1
公开(公告)日：2003-12-18
申请号：US10414253
申请日：2003-04-14
申请人： Broncus Technologies, Inc.
发明人： Christopher James Danaek , Michael Biggs , Keith M. Burger , Bryan Loomas , Thomas Keast , Dave Haugaard
IPC分类号： A61F002/00 , A61F002/32 , A61F002/34 , A61F002/36 , A61F002/38 , A61B017/58 , A61B017/60 , A61B017/24 , A61B017/26
CPC分类号： A61B18/1492 , A61B18/08 , A61B18/1477 , A61B2017/00084 , A61B2017/00123 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00541 , A61B2018/00791 , A61B2018/00982 , A61B2018/046 , A61B2018/1467 , A61B2018/1475 , A61B2018/1497 , A61B2090/3614 , A61N1/06 , A61N1/403 , A61N5/00
摘要： This relates to methods and devices for treating reversible chronic obstructive pulmonary disease, and more particularly, relates to a device for exchanging energy with airway tissue such as that found in the airway of human lungs. The exchange of energy with this airway tissue in the airways reduces the ability of the air ways to constrict and/or reduces the resistance within the airway to the flow of air through the airway. This also relates to a method for decreasing responsiveness or decreasing resistance to airflow of airways involves the transfer of energy to or from the airway walls to prevent or reduce airway constriction and other symptoms of lung diseases. The treatment reduces the ability of the airway to contract during an acute narrowing of the airways, reduces mucus plugging of the airways, and/or increases the airway diameter. The methods according to the present invention provide a longer duration and/or more effective treatment for lung diseases than currently used drug treatments, and obviate patient compliance issues. This also includes additional steps that reduce the ability of the lung to produce at least one of the symptoms of reversible obstructive pulmonary disease and to reduce the resistance to the flow of air through a lung.
摘要翻译：这涉及用于治疗可逆性慢性阻塞性肺疾病的方法和装置，更具体地涉及用于与例如人肺气道中发现的气道组织交换能量的装置。与气道中的这种气道组织的能量交换降低了气道收缩和/或降低气道内通过气道的空气流动的阻力的能力。这也涉及一种降低呼吸道反应性或降低气道阻力的方法，涉及将气体转移到气道壁或从气道壁传递，以防止或减少气道收缩和其他肺部疾病症状。该治疗降低了在气道急性变窄期间气道收缩的能力，减少气道的粘液堵塞和/或增加气道直径。根据本发明的方法提供比目前使用的药物治疗更长的持续时间和/或更有效的肺部疾病治疗，并且消除患者依从性问题。这还包括额外的步骤，其降低肺产生可逆性阻塞性肺疾病的至少一种症状的能力并降低对通过肺的空气流动的抵抗力。

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