会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 3. 发明授权
    • Supercritical fluid sterilization method
    • 超临界流体灭菌方法
    • US6149864A
    • 2000-11-21
    • US104775
    • 1998-06-25
    • Angela K. DillowRobert S. LangerNeil FosterJeffrey S. Hrkach
    • Angela K. DillowRobert S. LangerNeil FosterJeffrey S. Hrkach
    • A61L2/18A61L2/00
    • A61L2/18A61L2/16
    • A method is provided for sterilizing materials, particularly polymers, for drug delivery and implantation, wherein the material is treated with supercritical fluid carbon dioxide at pressures in the range of 2000 to 3000 psi (140 to 210 bar) and temperatures preferably between 30 and 45.degree. C. for periods between 20 minutes and six hours, more preferably between 0.5 and 2 hours. Agitation, pressure cycling, and the presence of water were found to enhance the sterilization method, which promotes diffusion of the supercritical fluid carbon dioxide into the cells of the microorganism to thereby alter the pH within the cells, killing them. The magnitude and frequency of the pressure cycling, as well as the process time and temperature, may vary according to the type and form of the material to be sterilized and the type of organisms to be killed.
    • 提供了一种用于消毒材料,特别是用于药物递送和植入的聚合物的方法,其中用超临界流体二氧化碳在2000-3000psi(140-210巴)范围内的压力下处理材料,温度优选在30和45之间 时间为20分钟至6小时,更优选为0.5小时至2小时。 发现搅拌,压力循环和水的存在增强灭菌方法,促进超临界流体二氧化碳向微生物细胞的扩散,从而改变细胞内的pH,从而杀死它们。 压力循环的大小和频率以及工艺时间和温度可以根据要灭菌的材料的类型和形式以及要杀死的生物体的类型而变化。