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1. 发明申请

US20070036794A1 Agonist anti-trk-C monoclonal antibodies 有权
标题翻译：激动剂抗-trk-C单克隆抗体
公开(公告)号：US20070036794A1
公开(公告)日：2007-02-15
申请号：US11581865
申请日：2006-10-16
申请人： Brigitte Devaux , Jo-Anne Hongo , Leonard Presta , David Shelton
发明人： Brigitte Devaux , Jo-Anne Hongo , Leonard Presta , David Shelton
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C07K16/40 , C12N5/06
CPC分类号： C07K16/32 , A61K2039/505 , C07K16/2863 , C07K2317/21 , C07K2317/34
摘要： The invention concerns agonist anti-trkC monoclonal antibodies which mimic certain biological activities of NT-3, the native ligand of trkC. The invention further concerns the use of such antibodies in the prevention and/or treatment of cellular degeneration, including nerve cell damage associated with acute nervous cell system injury and chronic neurodegenerative diseases, including peripheral neuropathy.
摘要翻译：本发明涉及模拟NT-3（trkC的天然配体）的某些生物学活性的激动剂抗-trkC单克隆抗体。本发明还涉及这种抗体在预防和/或治疗细胞变性中的用途，包括与急性神经细胞系统损伤和慢性神经变性疾病（包括周围神经病变）相关的神经细胞损伤。

2. 发明申请

US20110236880A1 Potentiated Biocidal Compositions and Methods of Use 审中-公开
标题翻译：增强的杀菌组合物和使用方法
公开(公告)号：US20110236880A1
公开(公告)日：2011-09-29
申请号：US13034929
申请日：2011-02-25
申请人： Molly Ryan Callahan , David Shelton
发明人： Molly Ryan Callahan , David Shelton
IPC分类号： C12Q1/70 , C12Q1/18
CPC分类号： A01N37/44 , A01N25/02 , A01N25/30 , A01N33/12 , A01N37/04
摘要： The present technology relates to biocidal compositions and methods that contain and utilize at least one biocidal agent and at least one potentiator system wherein the resultant combination has an enhanced biocidal efficacy. The present technology also discloses a rapid screening assay for determining biocidal compositions with enhanced efficacy, e.g., a microbial contact kill time of 5 minutes or less. Further, the present technology provides a method of determining biocidally effective concentrations of biocidal compositions comprising at least one biocidal agent and at least one potentiator system.
摘要翻译：本技术涉及含有和利用至少一种杀生物剂和至少一种增效剂系统的杀生物组合物和方法，其中所得组合具有增强的杀生物效力。本技术还公开了用于测定具有增强功效的杀生物组合物的快速筛选测定法，例如5分钟或更短时间的微生物接触杀灭时间。此外，本技术提供了确定杀生物组合物的杀生物有效浓度的方法，所述杀生物组合物包含至少一种杀生物剂和至少一种增效剂系统。

3. 发明申请

US20050227342A1 Secreted and transmembrane polypeptides and nucleic acids encoding the same 审中-公开
公开(公告)号：US20050227342A1
公开(公告)日：2005-10-13
申请号：US10165036
申请日：2001-10-19
申请人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
发明人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
IPC分类号： C07K14/705 , G01N33/53 , C07H21/04 , C12N5/06 , C12N9/00 , C12P21/02
CPC分类号： C07K14/705
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

4. 发明申请

US20050037458A1 Secreted and transmembrane polypeptides and nucleic acids encoding the same 审中-公开
公开(公告)号：US20050037458A1
公开(公告)日：2005-02-17
申请号：US10805667
申请日：2004-07-23
申请人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
发明人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
IPC分类号： C07H21/04 , C07K14/47 , C12N9/00
CPC分类号： C07K14/47 , G01N33/6872
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

5. 发明申请

US20100118377A1 DYNAMIC REFLECTARRAY TECHNOLOGY FOR ELECTRO-OPTICAL SENSORS 有权
标题翻译：电光传感器动态反射技术
公开(公告)号：US20100118377A1
公开(公告)日：2010-05-13
申请号：US12549938
申请日：2009-08-28
申请人： Thomas E. HABERFELDE , Edit L. Braunstein , Glenn Boreman , James Ginn , David Shelton , Gene D. Tener , Andrew H. Hawkins
发明人： Thomas E. HABERFELDE , Edit L. Braunstein , Glenn Boreman , James Ginn , David Shelton , Gene D. Tener , Andrew H. Hawkins
IPC分类号： G02F1/015
CPC分类号： G02F1/015
摘要： An array of two or more tunable electro-optical reflecting elements where the phase response of one or more elements may be adjusted by a variety of approaches including, but not limited to: a liquid crystal superstrate, schottky contact(s), ultra-violet radiation pulses, and illumination of photoconductive substrates. Methods and apparatus for direct and/or adaptive control of phase response via the above approaches are also discussed.
摘要翻译：两个或更多个可调电光反射元件的阵列，其中一个或多个元件的相位响应可以通过多种方法来调节，包括但不限于：液晶覆盖层，肖特基接触，紫外线辐射脉冲和光电导基板的照明。还讨论了通过上述方法直接和/或自适应地控制相位响应的方法和装置。

6. 发明申请

US20060078964A1 Secreted and transmembrane polypeptides and nucleic acids encoding the same 审中-公开
公开(公告)号：US20060078964A1
公开(公告)日：2006-04-13
申请号：US10216161
申请日：2002-08-09
申请人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
发明人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
IPC分类号： C07H21/04 , C12P21/06 , C12N9/00 , C07K16/18 , C07K14/47
CPC分类号： C07K14/705
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

7. 发明申请

US20050088908A1 Apparatus for Cooling Concrete While in Mixing Chamber 审中-公开
标题翻译：混合室冷却混凝土的装置
公开(公告)号：US20050088908A1
公开(公告)日：2005-04-28
申请号：US10905423
申请日：2005-01-03
申请人： David Shelton
发明人： David Shelton
IPC分类号： B01F15/06 , B28C5/46
CPC分类号： B28C5/468 , B01F15/063
摘要： A apparatus for cooling concrete while inside the concrete mixing chamber with a space related outer covering consisting of sections of mild steel welded around an existing portable mixing tank, a chamber access door located in the upper most rear of the mixing chamber for insertion of ice or CO2 pellets, a locking mechanism for securing the chamber door, a check valve located adjacent to the chamber access door for release of CO2 gases, a ball valve located at a 180 degree angle and on the opposite end of the mixing chamber from the access door for drainage of melted ice and a preferred embodiment includes the covering is made of galvanized iron, as well as stainless steel.
摘要翻译：一种用于在混凝土混合室内冷却混凝土的装置，其具有空间相关的外覆盖物，其由围绕现有的便携式混合罐焊接的低碳钢部分组成，位于混合室最上部后部的用于插入冰的室门二氧化碳颗粒，用于固定室门的锁定机构，邻近室入口门排放二氧化碳气体的止回阀，位于180度角的球阀，以及位于混合室相对端的入口门为了排出熔融的冰，优选实施例包括覆盖物由镀锌铁以及不锈钢制成。

8. 发明授权

US09676871B2 Engineered polypeptide conjugates and methods for making thereof using transglutaminase 有权
公开(公告)号：US09676871B2
公开(公告)日：2017-06-13
申请号：US13883535
申请日：2011-11-03
申请人： Pavel Strop , Magdalena Grazyna Dorywalska , Arvind Rajpal , David Shelton , Shu-Hui Liu , Jaume Pons , Russell Dushin
发明人： Pavel Strop , Magdalena Grazyna Dorywalska , Arvind Rajpal , David Shelton , Shu-Hui Liu , Jaume Pons , Russell Dushin
IPC分类号： A61K47/48 , C07K16/28 , C07K16/30 , C07K16/46 , A61K38/06 , A61K38/08 , C07K17/02
CPC分类号： C07K17/02 , A61K47/48369 , A61K47/48384 , A61K47/48569 , A61K47/48715 , A61K47/68 , A61K47/6803 , A61K47/6851 , A61K47/6889 , C07K16/30 , C07K2317/31 , C07K2317/73
摘要： The present invention provides engineered polypeptide conjugates (e.g., antibody-drug-conjugates, toxin-(biocompatible polymer) conjugates, antibody-(biocompatible polymer) conjugates, and bispecific antibodies) comprising acyl donor glutamine-containing tags and amine donor agents. In one aspect, the invention provides an engineered Fc-containing polypeptide conjugate comprising the formula (Fc-containing polypeptide)-T-A, wherein T is an acyl donor glutamine-containing tag engineered at a specific site or comprises an endogenous glutamine made reactive by the Fc-containing polypeptide engineering, wherein A is an amine donor agent, and wherein the amine donor agent is site-specifically conjugated to the acyl donor glutamine-containing tag or the endogenous glutamine. The invention also provides methods of making engineered polypeptide conjugates using transglutaminase.

9. 发明申请

US20070262199A1 Shelton wing in ground effect 审中-公开
标题翻译：谢尔顿翼地面效应
公开(公告)号：US20070262199A1
公开(公告)日：2007-11-15
申请号：US11432170
申请日：2006-05-11
申请人： David Shelton
发明人： David Shelton
IPC分类号： B64C39/12
CPC分类号： B60V1/08
摘要： Wing in ground effect vehicles operate near the surface to acquire benefits in aerodynamic performance. However, a lack of sufficient stability has been a frequent limitation for such vehicles. The disclosed invention is a wing in ground effect vehicle that comprises a plurality of mechanical devices to acquire stability in roll and height with respect to the surface. Each device comprises a pivotally mounted aerodynamic lifting surface, surface contacting element, and interconnecting structure. The disclosed arrangement of these components actively determines the angle of attack of the aerodynamic lifting surfaces and produces vehicle stability in roll and height with respect to the surface.
摘要翻译：地面效应车翼在地面附近运行，以获得空气动力性能的好处。然而，缺乏足够的稳定性是这种车辆的频繁限制。所公开的发明是地面效应车辆的机翼，其包括多个机械装置以获得相对于表面的滚动和高度的稳定性。每个装置包括枢转安装的空气动力提升表面，表面接触元件和互连结构。所公开的这些部件的布置主动地确定空气动力提升表面的迎角，并且相对于表面产生辊和高度的车辆稳定性。

10. 发明申请

US20070014786A1 Methods for treating taxol-induced gut disorder 审中-公开
标题翻译：治疗紫杉醇诱发肠道疾病的方法
公开(公告)号：US20070014786A1
公开(公告)日：2007-01-18
申请号：US10549441
申请日：2004-03-22
申请人： David Shelton
发明人： David Shelton
IPC分类号： A61K39/395
CPC分类号： C07K16/2863 , A61K2039/505 , C07K2317/70
摘要： This invention relates to the field of taxol-induced gut disorder. More specifically, the invention relates to methods of treating taxol-induced gut disorder comprising administration of agonist anti-trkC antibody for the treatment, prevention, and/or amelioration of a symptom of taxol-induced gut disorder.
摘要翻译：本发明涉及紫杉醇诱导的肠道疾病的领域。更具体地，本发明涉及治疗紫杉醇诱导的肠障碍的方法，包括施用激动剂抗-trkC抗体用于治疗，预防和/或改善紫杉醇诱导的肠道病症症状。

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