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1. 发明授权

US07182735B2 Elongated intracorporal medical device 有权
标题翻译：细长的体内医疗器械
公开(公告)号：US07182735B2
公开(公告)日：2007-02-27
申请号：US10376068
申请日：2003-02-26
申请人： Brice L. Shireman , Brian R. Reynolds , Dave B. Johnson , Alan D. Eskuri , Virgil F. Voeller , Jeffrey A. Miller
发明人： Brice L. Shireman , Brian R. Reynolds , Dave B. Johnson , Alan D. Eskuri , Virgil F. Voeller , Jeffrey A. Miller
IPC分类号： A61B5/00 , A61M25/00
CPC分类号： A61M25/09 , A61M2025/09083
摘要： Alternative designs, materials and manufacturing methods for guidewires. Some embodiments pertain to a composite guidewire having proximal and distal section, and a connector adapted and configured for permanently joining the proximal section to the distal section. In some embodiments, at least one of the sections is made of a linear-elastic nickel-titanium alloy. Several alternative guidewire tip constructions and/or designs including methods and techniques of construction are also disclosed.
摘要翻译：导线的替代设计，材料和制造方法。一些实施例涉及具有近端和远端部分的复合导丝，以及适于和构造用于将近端部分永久地连接到远端部分的连接器。在一些实施例中，至少一个部分由线性弹性镍钛合金制成。还公开了几种替代的导丝尖端结构和/或包括结构的方法和技术的设计。

2. 发明授权

US08222566B2 Elongated intracorporal medical device 有权
标题翻译：细长的体内医疗器械
公开(公告)号：US08222566B2
公开(公告)日：2012-07-17
申请号：US11058393
申请日：2005-02-15
申请人： Brice L. Shireman , Brian R. Reynolds , Dave B. Johnson , Alan D. Eskuri , Virgil F. Voeller , Jeffrey A. Miller
发明人： Brice L. Shireman , Brian R. Reynolds , Dave B. Johnson , Alan D. Eskuri , Virgil F. Voeller , Jeffrey A. Miller
IPC分类号： B23K26/00
CPC分类号： A61M25/09 , A61M2025/09083
摘要： Alternative designs, materials and manufacturing methods for guidewires. Some embodiments pertain to a composite guidewire having proximal and distal section, and a connector adapted and configured for permanently joining the proximal section to the distal section. In some embodiments, at least one of the sections is made of a linear-elastic nickel-titanium alloy. Several alternative guidewire tip constructions and/or designs including methods and techniques of construction are also disclosed.
摘要翻译：导线的替代设计，材料和制造方法。一些实施例涉及具有近端和远端部分的复合导丝，以及适于和构造用于将近端部分永久地连接到远端部分的连接器。在一些实施例中，至少一个部分由线性弹性镍钛合金制成。还公开了几种替代的导丝尖端结构和/或包括结构的方法和技术的设计。

3. 发明授权

US07316656B2 Elongated intracorporal medical device 有权
标题翻译：细长的体内医疗器械
公开(公告)号：US07316656B2
公开(公告)日：2008-01-08
申请号：US10732328
申请日：2003-12-10
申请人： Brice L. Shireman , Brian R. Reynolds , Dave B. Johnson , Alan D. Eskuri , Virgil F. Voeller , Jeffrey A. Miller
发明人： Brice L. Shireman , Brian R. Reynolds , Dave B. Johnson , Alan D. Eskuri , Virgil F. Voeller , Jeffrey A. Miller
IPC分类号： A61B5/00 , A61M25/00
CPC分类号： A61M25/09 , A61M2025/09083
摘要： Alternative designs, materials and manufacturing methods for guidewires. Some embodiments pertain to a composite guidewire having proximal and distal section, and a connector adapted and configured for permanently joining the proximal section to the distal section. In some embodiments, at least one of the sections is made of a linear-elastic nickel-titanium alloy. Several alternative guidewire tip constructions and/or designs including methods and techniques of construction are also disclosed.
摘要翻译：导线的替代设计，材料和制造方法。一些实施例涉及具有近端和远端部分的复合导丝，以及适于和构造用于将近端部分永久地连接到远端部分的连接器。在一些实施例中，至少一个部分由线性弹性镍钛合金制成。还公开了几种替代的导丝尖端结构和/或包括结构的方法和技术的设计。

4. 发明申请

US20080110191A1 Heat and mass exchanger 有权
标题翻译：热交换器
公开(公告)号：US20080110191A1
公开(公告)日：2008-05-15
申请号：US11818711
申请日：2007-06-14
申请人： Andrew Lowenstein , Marc J. Sibilia , Jeffrey A. Miller , Thomas Tonon
发明人： Andrew Lowenstein , Marc J. Sibilia , Jeffrey A. Miller , Thomas Tonon
IPC分类号： F25D23/00 , F25B39/04 , F28F1/12 , F28D5/02
CPC分类号： F24F3/1417 , F28D1/05333 , F28D1/05383 , F28D3/02 , F28D21/0015 , F28F1/32 , F28F13/187 , F28F2240/00
摘要： A mass and heat exchanger includes at least one first substrate with a surface for supporting a continuous flow of a liquid thereon that either absorbs, desorbs, evaporates or condenses one or more gaseous species from or to a surrounding gas; and at least one second substrate operatively associated with the first substrate. The second substrate includes a surface for supporting the continuous flow of the liquid thereon and is adapted to carry a heat exchange fluid therethrough, wherein heat transfer occurs between the liquid and the heat exchange fluid.
摘要翻译：质量和热交换器包括至少一个具有用于支撑其上的液体的连续流动的表面的第一基底，其吸收，解吸，蒸发或冷凝来自或周围气体的一种或多种气态物质; 以及至少一个第二基板，其可操作地与所述第一基板相关联。第二基板包括用于在其上支撑液体的连续流动的表面，并且适于承载通过其中的热交换流体，其中在液体和热交换流体之间发生热传递。

5. 发明授权

US5374524A Solution sandwich hybridization, capture and detection of amplified nucleic acids 失效
标题翻译：溶液夹心杂交，扩增核酸的捕获和检测
公开(公告)号：US5374524A
公开(公告)日：1994-12-20
申请号：US53842
申请日：1993-04-27
申请人： Jeffrey A. Miller
发明人： Jeffrey A. Miller
IPC分类号： C12Q1/68 , C12Q1/70 , C12P19/34
CPC分类号： C12Q1/6834 , Y10S435/81
摘要： A nucleic acid probe assay which combines nucleic acid amplification with solution hybridization using capture and reporter probes followed by or simultaneously with immobilization on a solid support is provided. An assay sensitivity equal to 5 copies of HIV I DNA was achieved.
摘要翻译：提供了一种核酸探针测定法，其使用捕获和报道探针将核酸扩增与溶液杂交结合在一起，同时固定在固体支持物上。获得等于5拷贝的HIV I DNA的测定灵敏度。

6. 外观设计

USD305985S Shipping carton with inventory display 失效
公开(公告)号：USD305985S
公开(公告)日：1990-02-13
申请号：US124769
申请日：1987-11-24
申请人： Jeffrey A. Miller
设计人： Jeffrey A. Miller

7. 发明授权

US07914979B2 Stable and filterable enveloped virus formulations 有权
标题翻译：稳定和可过滤的包膜病毒制剂
公开(公告)号：US07914979B2
公开(公告)日：2011-03-29
申请号：US11718348
申请日：2005-11-04
申请人： Tzer-Fen Chen , Jouhn-Wern Jang , Jeffrey A. Miller
发明人： Tzer-Fen Chen , Jouhn-Wern Jang , Jeffrey A. Miller
IPC分类号： C12Q1/70
CPC分类号： A61K9/0019 , A61K47/26 , C12N7/00 , C12N2760/18151
摘要： Envelope viruses (e.g. Newcastle disease virus (NDV)) are formulated for storage at moderately cold temperatures (e.g. −20° C.). The formulation is an aqueous solution containing the enveloped virus at a concentration of from 106 PFU/mL to 1012 PFU/mL; and a non-reducing saccharide (e.g. sucrose). When the non-reducing saccharide is a disaccharide it is present in the solution at a concentration of from 5% (w/v) to 50% (w/v), and when it is a monosaccharide it is present in the solution at a concentration of from 2.5% (w/v) to 25% (w/v). The solution has an osmotic pressure of about 250 mOs or higher, and has a pH of from 5 to 10.
摘要翻译：包膜病毒（例如新城疫病毒（NDV））被配制用于在适度的低温（例如-20℃）下储存。该制剂是含有浓度为106PFU / mL至1012PFU / mL的包膜病毒的水溶液; 和非还原性糖（例如蔗糖）。当非还原性糖是二糖时，以5％（w / v）至50％（w / v）的浓度存在于溶液中，当其为单糖时，其存在于溶液中浓度为2.5％（w / v）至25％（w / v）。溶液的渗透压为约250mOs以上，pH为5〜10。

8. 发明申请

US20090180994A1 ONCOLYTIC VIRUS THERAPY 失效
标题翻译： ONCOLYTIC VIRUS治疗
公开(公告)号：US20090180994A1
公开(公告)日：2009-07-16
申请号：US12412035
申请日：2009-03-26
申请人： William S. Groene , Jeffrey A. Miller , Stephen N. Mueller
发明人： William S. Groene , Jeffrey A. Miller , Stephen N. Mueller
IPC分类号： A61K35/76 , A61P35/00
CPC分类号： A61K35/768 , A61K35/15 , A61K35/19 , C12N2760/18132 , A61K2300/00
摘要： A method of treating a human subject with cancer is disclosed. A pharmaceutical composition is administered to the subject, the pharmaceutical composition comprising human leukocytes and a replication-competent oncolytic virus in suspension in a physiologically acceptable solution. Alternatively the pharmaceutical composition comprises human leukocytes or platelets infected with an oncolytic virus.
摘要翻译：公开了一种用癌症治疗人类受试者的方法。向受试者施用药物组合物，所述药物组合物包含人白细胞和可复制的溶瘤病毒悬浮于生理学上可接受的溶液中。或者，药物组合物包含用溶瘤病毒感染的人白细胞或血小板。

9. 发明授权

US07410716B2 Electrolyte sheet with protruding features having undercut angles and method of separating such sheet from its carrier 失效
标题翻译：具有底切角的突出特征的电解质片和将其从载体分离的方法
公开(公告)号：US07410716B2
公开(公告)日：2008-08-12
申请号：US10699750
申请日：2003-11-03
申请人： Sean M. Garner , Lanrik Kester , Jeffrey A. Miller
发明人： Sean M. Garner , Lanrik Kester , Jeffrey A. Miller
IPC分类号： H01M8/12 , H01M2/00
CPC分类号： C04B35/486 , C04B35/62218 , C04B35/6264 , C04B35/632 , C04B35/634 , C04B35/6342 , C04B2235/3225 , C04B2235/602 , C04B2235/6025 , C04B2235/77 , C04B2235/945 , H01M4/9033 , H01M8/1016 , H01M8/1253 , Y02E60/525 , Y02P70/56 , Y10T428/24479 , Y10T428/2457
摘要： According to one embodiment of the present invention an electrolyte sheet includes a body of varied thickness, the electrolyte sheet having a textured surface with multiple protruding features. The protruding features form an undercut angle with respect to the normal of the electrolyte sheet, the undercut angle being more than 0 degrees and less than 15 degrees.
摘要翻译：根据本发明的一个实施例，电解质片包括不同厚度的本体，电解质片具有具有多个凸出特征的纹理表面。突出特征相对于电解质片的法线形成底切角，底切角大于0度且小于15度。

10. 发明授权

US07148774B1 Contact assembly 失效
标题翻译：接触组件
公开(公告)号：US07148774B1
公开(公告)日：2006-12-12
申请号：US11178839
申请日：2005-07-11
申请人： John J. Shea , Jeffrey A. Miller
发明人： John J. Shea , Jeffrey A. Miller
IPC分类号： H01H83/00
CPC分类号： H01H1/22 , H01H11/06 , H01H73/04
摘要： A circuit breaker contact assembly includes a line conductor having a folded back fixed contact end, a fixed contact mounted on the contact end, and a movable contact arm having an inner edge and first and second ends. A movable contact is mounted on the first end. The movable contact arm is pivotable about the second end between a closed position in which the inner edge extends adjacent the contact end with the movable contact in contact with the fixed contact to form a reverse current loop, and an open position in which the movable contact is pivoted away from the fixed contact. The contact arm includes a first inner longitudinal member extending along the inner edge and a second outer longitudinal member. The first inner longitudinal member has a higher electrical conductivity than the second outer longitudinal member, which has a higher shear strength and a lower specific density.
摘要翻译：断路器触头组件包括具有折回的固定接触端的线路导体，安装在接触端上的固定触点以及具有内边缘和第一端和第二端的可动触头臂。可移动触点安装在第一端。所述可动接触臂可围绕所述第二端枢转，所述闭合位置中，所述内边缘与所述接触端相邻延伸，所述可动触头与所述固定触头相接触，以形成反向电流回路;以及打开位置，枢转远离固定触点。接触臂包括沿着内边缘延伸的第一内部纵向构件和第二外部纵向构件。第一内部纵向构件具有比第二外部纵向构件更高的导电性，其具有较高的剪切强度和较低的比重。

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