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1. 发明申请

US20080182303A1 Methods for Making Simvastatin and Intermediates 失效
标题翻译：辛伐他汀和中间体的制备方法
公开(公告)号：US20080182303A1
公开(公告)日：2008-07-31
申请号：US10576122
申请日：2004-10-20
申请人： Brian Morgan , Mark Burk , Michael Levin , Zuolin Zhu , Jennifer Chaplin , Karen Kustedjo , Zillin Huang , William Greenberg
发明人： Brian Morgan , Mark Burk , Michael Levin , Zuolin Zhu , Jennifer Chaplin , Karen Kustedjo , Zillin Huang , William Greenberg
IPC分类号： C12P17/06 , C12P17/02 , C12P7/18
CPC分类号： C12P17/06 , C07D309/30
摘要： The invention provides synthetic chemical and chemoenzymatic methods of producing simvastatin and various intermediates. In one aspect, enzymes such as hydrolases, e.g., esterases, are used in the methods of the invention.
摘要翻译：本发明提供了生产辛伐他汀和各种中间体的合成化学和化学酶学方法。在一个方面，酶如水解酶，例如酯酶，用于本发明的方法中。

2. 发明授权

US07700329B2 Methods for making simvastatin and intermediates 失效
标题翻译：辛伐他汀和中间体的制备方法
公开(公告)号：US07700329B2
公开(公告)日：2010-04-20
申请号：US10576122
申请日：2004-10-20
申请人： Brian Morgan , Mark Burk , Michael Levin , Zuolin Zhu , Jennifer Chaplin , Karen Kustedjo , Zilin Huang , William Greenberg
发明人： Brian Morgan , Mark Burk , Michael Levin , Zuolin Zhu , Jennifer Chaplin , Karen Kustedjo , Zilin Huang , William Greenberg
IPC分类号： C12P17/06 , C12P17/12 , C12P17/18
CPC分类号： C12P17/06 , C07D309/30
摘要： The invention provides synthetic chemical and chemoenzymatic methods of producing simvastatin and various intermediates. In one aspect, enzymes such as hydrolases, e.g., esterases, are used in the methods of the invention.
摘要翻译：本发明提供了生产辛伐他汀和各种中间体的合成化学和化学酶学方法。在一个方面，酶如水解酶，例如酯酶，用于本发明的方法中。

3. 发明申请

US20110059493A1 Methods for Making Simvastatin and Intermediates 审中-公开
标题翻译：辛伐他汀和中间体的制备方法
公开(公告)号：US20110059493A1
公开(公告)日：2011-03-10
申请号：US12763198
申请日：2010-04-19
申请人： Brian Morgan , Mark Burk , Michael Levin , Zuolin Zhu , Jennifer Chaplin , Karen Kustedjo , Zilin Huang , William Greenberg
发明人： Brian Morgan , Mark Burk , Michael Levin , Zuolin Zhu , Jennifer Chaplin , Karen Kustedjo , Zilin Huang , William Greenberg
IPC分类号： C12P17/06 , C12N9/14 , C12P7/42
CPC分类号： C12N9/14 , C12P17/06
摘要： The invention provides synthetic chemical and chemoenzymatic methods of producing simvastatin and various intermediates. In one aspect, enzymes such as hydrolases, e.g., esterases, are used in the methods of the invention.
摘要翻译：本发明提供了生产辛伐他汀和各种中间体的合成化学和化学酶学方法。在一个方面，酶如水解酶，例如酯酶，用于本发明的方法中。

4. 发明申请

US20050153407A1 Chemoenzymatic methods for the synthesis of statins and stain intermediates 失效
标题翻译：用于合成他汀类和染色中间体的化学酶学方法
公开(公告)号：US20050153407A1
公开(公告)日：2005-07-14
申请号：US10472157
申请日：2003-08-19
申请人： William Greenberg , Mark Burk , Alexander Varvak , Kelvin Wong
发明人： William Greenberg , Mark Burk , Alexander Varvak , Kelvin Wong
IPC分类号： A01H1/00 , A01K67/027 , C07H21/04 , C12N9/10 , C12N9/88 , C12N15/82 , C12P20060101 , C12P7/42 , C12P7/62 , C12P13/00 , C12P17/02 , C12P17/06 , C12P17/10 , C12P17/12
CPC分类号： C12P13/004 , C12N9/88 , C12P7/42 , C12P17/02 , C12P17/06 , C12P17/10 , C12P17/12
摘要： The invention provides novel aldolases, nucleic acids encoding them and methods for making and using them, including chemoenzymatic processes for making β,δ-dihydroxyheptanoic acid side chains and compositions comprising these side chains, e.g., [R-(R*,R*)]-2-(4-fluorophenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-(phenylamino)-carbonyl]-1H-pyrrole-1-heptanoic acid (atorvastatin, LIPITOR™), rosuvastatin (CRESTOR™), fluvastatin (LESCOL™), related compounds and their intermediates.
摘要翻译：本发明提供了新的醛缩酶，编码它们的核酸以及制备和使用它们的方法，包括制备β，δ-二羟基庚酸侧链的化学酶法和包含这些侧链的组合物，例如[R-（R *，R *） ] -2-（4-氟苯基）-b，d-二羟基-5-（1-甲基乙基）-3-苯基-4-（苯基氨基） - 羰基] -1H-吡咯-1-庚酸（阿托伐他汀，LIPITOR TM）），罗苏伐他汀（CRESTOR TM），氟伐他汀（LESCOL TM）），相关化合物及其中间体。

5. 外观设计

USD928709S1 Battery terminal 有权
公开(公告)号：USD928709S1
公开(公告)日：2021-08-24
申请号：US29707684
申请日：2019-09-30
申请人： William Greenberg , Danny Finley
设计人： William Greenberg , Danny Finley

6. 发明申请

US20140305693A1 Fuse and Power Distribution Block 审中-公开
标题翻译：保险丝和配电块
公开(公告)号：US20140305693A1
公开(公告)日：2014-10-16
申请号：US14157365
申请日：2014-01-16
申请人： William Greenberg
发明人： William Greenberg
IPC分类号： B60R16/03 , H01R9/24
CPC分类号： H02G3/08 , H01H2085/208 , H01R9/245
摘要： A fuse and power distribution block is provided which includes a polymer base, and multiple conductive base blocks for connection with incoming power lines or outgoing accessory lines. Each conductive base block also provides multiple alternative fuse connections on a first upper horizontal platform, a second lower horizontal platform, and a third intermediate vertical platform interconnecting the first and second platforms. The fuse and power distribution block may, depending on the desired accessory system, include 4 or 6 conductive base blocks. The fuse and power distribution block has an attractive transparent polymer cover and shell.
摘要翻译：提供了一种保险丝和配电块，其包括聚合物基座和用于与输入电力线或输出附件线连接的多个导电基座。每个导电基座块还在第一上水平平台，第二下水平平台和互连第一和第二平台的第三中间垂直平台上提供多个替代保险丝连接。根据所需的附件系统，保险丝和配电块可以包括4或6个导电基座。保险丝和配电块具有吸引人的透明聚合物盖和外壳。

7. 发明申请

US20090124515A1 METHODS AND COMPOSITIONS FOR PREPARATION OF SELECTIVELY PROTECTED CARBOHYDRATES 有权
标题翻译：制备选择性保护的碳水化合物的方法和组合物
公开(公告)号：US20090124515A1
公开(公告)日：2009-05-14
申请号：US12141348
申请日：2008-06-18
申请人： Frances H. Arnold , Chi-Huey Wong , Yuuichi Mitsuda , Michael M. Chen , Clay Bennett , William Greenberg , Jared Crawford Lewis , Sabine Bastian
发明人： Frances H. Arnold , Chi-Huey Wong , Yuuichi Mitsuda , Michael M. Chen , Clay Bennett , William Greenberg , Jared Crawford Lewis , Sabine Bastian
IPC分类号： C40B30/08 , C12P19/00 , C12P19/02 , C12N9/02 , C12N15/11 , C12N15/00 , C12N1/21 , C12Q1/26
CPC分类号： C12Q1/26 , C12N9/0077 , C12P19/00 , C12P19/02 , G01N2333/90245 , G01N2500/04
摘要： The disclosure relates to engineered P450 polypeptides and use of such polypeptides in chemoenzymatic methods to construct selectively protected carbohydrates, which are useful as building blocks for preparation of carbohydrate derivatives and oligosaccharides
摘要翻译：本公开涉及工程化P450多肽，并且在化学酶学方法中使用这种多肽来构建选择性保护的碳水化合物，其可用作制备碳水化合物衍生物和寡糖的构建块

8. 发明申请

US20060259993A1 Amidases, nucleic acids encoding them and methods for making and using them 审中-公开
标题翻译：酰胺酶，编码它们的核酸和制备和使用它们的方法
公开(公告)号：US20060259993A1
公开(公告)日：2006-11-16
申请号：US10502832
申请日：2003-01-28
申请人： Nelson Barton , David Weiner , William Greenberg , Samantha Luu , Kristine Chang , Elizabeth Waters
发明人： Nelson Barton , David Weiner , William Greenberg , Samantha Luu , Kristine Chang , Elizabeth Waters
IPC分类号： A01K67/027 , A01H5/00 , C12N1/21 , C12Q1/68 , C07H21/04 , C07D501/00 , C12N9/80 , C07D501/14 , C12N15/74 , C12N15/82 , C12P35/02
CPC分类号： C07D501/00 , A01K2217/05 , A61K38/00 , C12N9/78 , C12P35/00 , C12P35/02 , C12P41/007 , C12Q1/34
摘要： This invention provides amidases, polynucleotides encoding the amidases, methods of making and using these polynucleotides and polypeptides. In one aspect, the invention provides enzymes having secondary amidase activity, e.g., having activity in the hydrolysis of amides, including enzymes having peptidase, protease and/or hydantoinase activity. In alternative aspects, the enzymes of the invention can be used to used to increase flavor in food (e.g., enzyme ripened cheese), promote bacterial and fungal killing, modify and de-protect fine chemical intermediates, synthesize peptide bonds, carry out chiral resolutions, hydrolyze Cephalosporin C. The enzymes of the invention can be used to generate 7-aminocephalosporanic acid (7-ACA) and semi-synthetic cephalosporin antibiotics, including caphalothin, cephaloridine and cefuroxime. The enzymes of the invention can be used as antimicrobial agents, e.g., as cell wall hydrolytic agents. The invention also provides a fluorescent amidase substrate comprising 7-(ε-D-2-aminoadipoyladipoylamido)-4-methylcoumarin.
摘要翻译：本发明提供酰胺酶，编码酰胺酶的多核苷酸，制备和使用这些多核苷酸和多肽的方法。一方面，本发明提供了具有仲酰胺酶活性的酶，例如在酰胺水解中具有活性，包括具有肽酶，蛋白酶和/或乙内酰脲酶活性的酶。在替代方面，本发明的酶可用于增加食物中的风味（例如酶熟干酪），促进细菌和真菌杀死，改善和去保护精细化学中间体，合成肽键，进行手性拆分，水解头孢菌素C.本发明的酶可用于产生7-氨基头孢烷酸（7-ACA）和半合成头孢菌素抗生素，包括沙司他啶，头孢菌啶和头孢呋辛。本发明的酶可以用作抗微生物剂，例如细胞壁水解剂。本发明还提供了包含7-（ε-D-2-氨基己二酰己二酰氨基）-4-甲基香豆素的荧光酰胺酶底物。

9. 发明授权

US08802401B2 Methods and compositions for preparation of selectively protected carbohydrates 有权
标题翻译：用于制备选择性保护的碳水化合物的方法和组合物
公开(公告)号：US08802401B2
公开(公告)日：2014-08-12
申请号：US12141348
申请日：2008-06-18
申请人： Frances H. Arnold , Chi-Huey Wong , Yuuichi Mitsuda , Michael M. Chen , Clay Bennett , William Greenberg , Jared Crawford Lewis , Sabine Bastian
发明人： Frances H. Arnold , Chi-Huey Wong , Yuuichi Mitsuda , Michael M. Chen , Clay Bennett , William Greenberg , Jared Crawford Lewis , Sabine Bastian
IPC分类号： C12P7/00 , C12P21/06 , C12P21/04 , C12N9/02 , C12N15/00 , C07H21/04
CPC分类号： C12Q1/26 , C12N9/0077 , C12P19/00 , C12P19/02 , G01N2333/90245 , G01N2500/04
摘要： The disclosure relates to engineered P450 polypeptides and use of such polypeptides in chemoenzymatic methods to construct selectively protected carbohydrates, which are useful as building blocks for preparation of carbohydrate derivatives and oligosaccharides
摘要翻译：本公开涉及工程化P450多肽，并且在化学酶学方法中使用这种多肽来构建选择性保护的碳水化合物，其可用作制备碳水化合物衍生物和寡糖的构建块

10. 发明授权

US07414119B2 Aldolases, nucleic acids encoding them and methods for making and using them 失效
标题翻译：醛缩酶，编码它们的核酸和制备和使用它们的方法
公开(公告)号：US07414119B2
公开(公告)日：2008-08-19
申请号：US10472157
申请日：2003-08-19
申请人： William Greenberg , Mark J. Burk , Alexander Varvak , Kelvin Wong
发明人： William Greenberg , Mark J. Burk , Alexander Varvak , Kelvin Wong
IPC分类号： C12N15/60 , C12N15/62 , C12N15/79 , C12N9/88 , C12N17/06
CPC分类号： C12P13/004 , C12N9/88 , C12P7/42 , C12P17/02 , C12P17/06 , C12P17/10 , C12P17/12
摘要： The invention provides novel aldolases, nucleic acids encoding them and methods for making and using them, including chemoenzymatic processes for making β,δ-dihydroxyheptanoic acid side chains and compositions comprising these side chains, e.g., [R-(R*,R*)]-2-(4-fluorophenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-(phenylamino)-carbonyl]-1H-pyrrole-1-heptanoic acid (atorvastatin, LIPITOR™), rosuvastatin (CRESTOR™), fluvastatin (LESCOL™), related compounds and their intermediates.
摘要翻译：本发明提供了新的醛缩酶，编码它们的核酸以及制备和使用它们的方法，包括制备β，δ-二羟基庚酸侧链的化学酶法和包含这些侧链的组合物，例如[R-（R *，R *） ] -2-（4-氟苯基）-b，d-二羟基-5-（1-甲基乙基）-3-苯基-4-（苯基氨基） - 羰基] -1H-吡咯-1-庚酸（阿托伐他汀，LIPITOR TM）），罗苏伐他汀（CRESTOR TM），氟伐他汀（LESCOL TM）），相关化合物及其中间体。

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