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1. 发明申请

US20130109735A1 SALACINOL AND PONKORANOL HOMOLOGUES, DERIVATIVES THEREOF, AND METHODS OF SYNTHESIZING SAME 审中-公开
标题翻译：沙胺醇和非那雄酮类似物，其衍生物及其合成方法
公开(公告)号：US20130109735A1
公开(公告)日：2013-05-02
申请号：US13513142
申请日：2010-12-01
申请人： Brian Mario Pinto , Sankar Mohan , Ravindranath Nasi , Jayakanthan Kumarasamy , Razieh Eskarandi
发明人： Brian Mario Pinto , Sankar Mohan , Ravindranath Nasi , Jayakanthan Kumarasamy , Razieh Eskarandi
IPC分类号： C07D333/46 , C07D207/12 , C07D493/04 , C07D345/00
CPC分类号： C07D333/46 , C07D207/12 , C07D345/00 , C07D493/04 , C07H5/10 , C07H15/18
摘要： Salacinol and ponkoranol homologues, derivatives thereof and methods of synthesizing and using said homologies and derivatives. The derivatives include stereoisomers, de-O-sulfonated compounds and congeners of the naturally occurring homologues. Some of the derivatives exhibit enhanced glucosidase inhibitory bioactivity in comparison to the naturally occurring compounds which have been isolated from Salacia reticulata.
摘要翻译： salacinol和ponkoranol同源物，其衍生物和合成和使用所述同源物和衍生物的方法。衍生物包括立体异构体，脱-O-磺化化合物和天然存在的同系物的同源物。与从Salacia reticulata分离的天然存在的化合物相比，一些衍生物表现出增强的葡糖苷酶抑制生物活性。

2. 发明申请

US20110268822A1 METHODS FOR SYNTHESIZING KOTALANOL AND STEREOISOMERS AND ANALOGUES THEREOF, AND NOVEL COMPOUNDS PRODUCED THEREBY 审中-公开
标题翻译：合成木兰醇和立体异构体及其类似物的方法和生产的新型化合物
公开(公告)号：US20110268822A1
公开(公告)日：2011-11-03
申请号：US12934898
申请日：2009-03-25
申请人： Brian Mario Pinto , Jayakanthan Kumarasamy , Ravindranath Nasi , Sankar Mohan
发明人： Brian Mario Pinto , Jayakanthan Kumarasamy , Ravindranath Nasi , Sankar Mohan
IPC分类号： A61K36/00 , A61K31/40 , A61K31/381 , G01N27/447 , C07D207/00 , C07D333/46 , A61P1/00 , A61P3/10 , A61K31/33 , C07D345/00
CPC分类号： C07D207/12 , C07D319/06 , C07D327/10 , C07D333/46 , C07D345/00 , C07D407/04 , C07D407/06 , C07D411/04 , C07D493/04 , C07D497/04
摘要： Compounds having the general formula (I): wherein X is S, Se or NH, and stereoisomers thereof, and de-O-sulfonated analogues of all of the foregoing, but excluding naturally occurring kotalanol and de-O-sulfonated kotalanol, and methods for synthesizing same. The compounds are useful as glycosidase inhibitors, and may be used in the treatment of diabetes. The synthetic compounds may also be used as standards in the calibration or grading of natural or herbal remedies produced from natural sources of glycosidase inhibitors such as kotalanol.
摘要翻译：具有通式（I）的化合物：其中X是S，Se或NH及其立体异构体，以及所有上述的脱-O-磺化类似物，但不包括天然存在的kotalanol和de-O-磺化的kotalanol，以及方法用于合成。该化合物可用作糖苷酶抑制剂，可用于治疗糖尿病。合成的化合物也可以用作由天然来源的糖苷酶抑制剂如kotalanol产生的天然或草药的校准或分级的标准品。

3. 发明申请

US20070244184A1 GLYCOSIDASE INHIBITORS AND METHODS OF SYNTHESIZING SAME 审中-公开
标题翻译：糖苷酶抑制剂及其合成方法
公开(公告)号：US20070244184A1
公开(公告)日：2007-10-18
申请号：US11621466
申请日：2007-01-09
申请人： Brian Pinto , Nag Kumar , Ramakrishna Bhat , Hui Liu , Ravindranath Nasi , Wang Chen , Sankar Mohan
发明人： Brian Pinto , Nag Kumar , Ramakrishna Bhat , Hui Liu , Ravindranath Nasi , Wang Chen , Sankar Mohan
IPC分类号： A61K31/381 , A61K31/33 , A61K31/4015 , A61P3/10 , C07D207/12 , C07D333/32 , C07D345/00
CPC分类号： C07D333/32 , C07D207/12 , C07D345/00
摘要： The compounds of the present invention relate to chain-extended and chain-modified analogues of salacinol, including embodiments where the sulfate moiety has been substituted with a carboxylate or phosphate moiety. In other embodiments the sulfate moiety has been shifted by one carbon atom in the zwitterionic structure. In another embodiment the polyhydroxylated side chain may be replaced with a lipophilic alkyl chain and a suitable counterion. The invention also encompasses methods for synthesizing the salacinol analogues and using the analogues for enzyme inhibition applications.
摘要翻译：本发明的化合物涉及salacinol的延伸链和链修饰的类似物，包括其中硫酸盐部分已被羧酸酯或磷酸酯部分取代的实施方案。在其它实施方案中，硫酸酯部分已经在两性离子结构中移位了一个碳原子。在另一个实施方案中，多羟基化侧链可以用亲脂性烷基链和合适的抗衡离子代替。本发明还包括用于合成salacinol类似物并使用该类似物进行酶抑制应用的方法。

4. 发明申请

US20120010254A1 COMPOUNDS AND METHODS FOR TREATMENT OF INFLUENZA 审中-公开
标题翻译：化合物和治疗流感的方法
公开(公告)号：US20120010254A1
公开(公告)日：2012-01-12
申请号：US13142750
申请日：2009-12-30
申请人： Brian Mario Pinto , Sankar Mohan
发明人： Brian Mario Pinto , Sankar Mohan
IPC分类号： A61K31/4192 , C12Q1/70 , A61K31/196 , A61P31/16 , C07D249/04 , C07C61/22
CPC分类号： C07C335/34 , C07C233/52 , C07C247/14 , C07C275/26 , C07C279/16 , C07C2601/16 , C07D249/04
摘要： The present invention provides in part a compound of Formula (I) or a pharmaceutically-acceptable salt or stereoisomer thereof: where R1 is selected from the group consisting of a substituted triazole group, a guanidine group, a urea group, a thiourea group, an amidine group, and N3; and R2 is selected from the group consisting of H, Me, Et and an amino acid, and methods and uses thereof.
摘要翻译：本发明部分提供式（I）化合物或其药学上可接受的盐或立体异构体：其中R 1选自取代的三唑基，胍基，脲基，硫脲基，脒基和N 3; 并且R 2选自H，Me，Et和氨基酸，及其方法和用途。

5. 发明申请

US20070056826A1 Power transfer devices with on-demand lubrication systems 失效
标题翻译：带按需润滑系统的动力传递装置
公开(公告)号：US20070056826A1
公开(公告)日：2007-03-15
申请号：US11634476
申请日：2006-12-06
申请人： Timothy Burns , Sankar Mohan
发明人： Timothy Burns , Sankar Mohan
IPC分类号： F16D13/72
CPC分类号： F16D25/123
摘要： A vehicle includes an engine that generates drive torque and a power transfer device that selectively transfers the drive torque to a driveline. The power transfer device includes an input shaft, an output shaft and a torque biasing system. The torque biasing system has a clutch pack and an actuator that regulates engagement of the clutch pack. An on-demand lubrication system supplies a lubricating fluid flow through the clutch pack based on a control signal generated by a control system. A passively actuated positive displacement pump supplies the lubricating fluid flow through the clutch pack based on a speed differential between the input shaft and the output shaft.
摘要翻译：车辆包括产生驱动扭矩的发动机和选择性地将驱动扭矩传递到传动系的动力传递装置。动力输送装置包括输入轴，输出轴和转矩偏置系统。扭矩偏压系统具有离合器组件和调节离合器组件接合的致动器。按需润滑系统基于由控制系统产生的控制信号，提供通过离合器组件的润滑流体流。被动地驱动的容积式泵基于输入轴和输出轴之间的速度差来提供通过离合器组件的润滑流体流。

6. 发明申请

US20050023102A1 Low power hydraulic clutch actuation systems 失效
标题翻译：低功率液压离合器致动系统
公开(公告)号：US20050023102A1
公开(公告)日：2005-02-03
申请号：US10872159
申请日：2004-06-18
申请人： James Brissenden , Sankar Mohan , Eric Bansbach , Timothy Burns , Steven O'Hara
发明人： James Brissenden , Sankar Mohan , Eric Bansbach , Timothy Burns , Steven O'Hara
IPC分类号： F16D48/02 , F16D25/00
CPC分类号： F16D25/14 , B60K17/3467 , B60K17/35 , B60K23/0808 , B60K2023/043 , B60K2023/0825 , B60K2023/0833 , B60K2023/0866 , F16D25/123 , F16D48/02 , F16D48/04 , F16D48/066 , F16D2048/0203 , F16D2048/0209 , F16D2500/10425 , F16D2500/10431 , F16D2500/70406 , F16D2500/7044 , F16D2500/7061 , F16D2500/70631
摘要： A torque transfer mechanism for controlling the magnitude of a clutch engagement force exerted on a clutch pack that is operably disposed between a first rotary member and a second rotary member includes a hydraulic clutch actuation system. The hydraulic clutch actuation system includes an electric motor drivingly coupled to a pump. The pump supplies pressurized fluid to an accumulator. The pressurized fluid within the accumulator is selectively supplied to a piston to provide a clutch engagement force.
摘要翻译：用于控制施加在可操作地设置在第一旋转构件和第二旋转构件之间的离合器组件上的离合器接合力的大小的扭矩传递机构包括液压离合器致动系统。液压离合器致动系统包括驱动地联接到泵的电动马达。泵将加压流体供应到蓄能器。蓄能器内的加压流体选择性地供应到活塞以提供离合器接合力。

7. 发明申请

US20060131122A1 On-demand cooling control for power transfer system 失效
标题翻译：电力传输系统的按需冷却控制
公开(公告)号：US20060131122A1
公开(公告)日：2006-06-22
申请号：US11020002
申请日：2004-12-21
申请人： Timothy Burns , Sankar Mohan
发明人： Timothy Burns , Sankar Mohan
IPC分类号： F16D13/72
CPC分类号： F16D25/123
摘要： A vehicle includes an engine that generates drive torque and a power transfer device that selectively transfers the drive torque to a driveline. The power transfer device includes an input shaft, an output shaft and a torque biasing system. The torque biasing system has a clutch pack and an actuator that regulates engagement of the clutch pack. An on-demand lubrication system supplies a lubricating fluid flow through the clutch pack based on a control signal generated by a control system. A passively actuated positive displacement pump supplies the lubricating fluid flow through the clutch pack based on a speed differential between the input shaft and the output shaft.
摘要翻译：车辆包括产生驱动扭矩的发动机和选择性地将驱动扭矩传递到传动系的动力传递装置。动力输送装置包括输入轴，输出轴和转矩偏置系统。扭矩偏压系统具有离合器组件和调节离合器组件接合的致动器。按需润滑系统基于由控制系统产生的控制信号，提供通过离合器组件的润滑流体流。被动地驱动的容积式泵基于输入轴和输出轴之间的速度差来提供通过离合器组件的润滑流体流。

8. 发明申请

US20060079369A1 Torque vectoring axle assembly 失效
标题翻译：扭矩矢量轴总成
公开(公告)号：US20060079369A1
公开(公告)日：2006-04-13
申请号：US11226993
申请日：2005-09-15
申请人： Sankar Mohan , Anupam Sharma , Thomas Bowen
发明人： Sankar Mohan , Anupam Sharma , Thomas Bowen
IPC分类号： F16H48/06
CPC分类号： F16H48/30 , B60K17/16 , B60K17/3462 , B60K23/0808 , B60W10/14 , B60W40/11 , B60W40/112 , B60W40/114 , F16H48/10 , F16H48/11 , F16H48/22 , F16H48/295 , F16H48/34 , F16H2048/106 , F16H2048/204 , F16H2048/343 , F16H2048/346
摘要： A drive axle assembly includes first and second axleshafts connected to a pair of wheels and a drive mechanism operable to selectively couple a driven input shaft to one or both of the axleshafts. The drive mechanism includes a differential, a speed changing unit operably disposed between the differential assembly and the first and second axleshafts, first and second mode clutches and a brake unit. The first mode clutch is operable to increase the rotary speed of the first axleshaft which, in turn, causes a corresponding decrease in the rotary speed of the second axleshaft. The second mode clutch is operable to increase the rotary speed of the second axleshaft so as to cause a decrease in the rotary speed of the first axleshaft. The brake unit is operable to engage the speed changing unit. A control system controls actuation of both mode clutches.
摘要翻译：驱动轴组件包括连接到一对车轮的第一和第二轴轴和可操作以选择性地将从动输入轴联接到轴轴中的一个或两个的驱动机构。驱动机构包括差速器，变速单元，可操作地设置在差速器组件与第一和第二轴轴之间，第一和第二模式离合器以及制动单元。第一模式离合器可操作以增加第一轴轴的转速，这反过来又导致第二轴轴的转速的相应降低。第二模式离合器可操作以增加第二轴轴的转速，从而导致第一轴轴的转速降低。制动单元可操作以接合变速单元。一个控制系统控制两个模式离合器的启动。

9. 发明申请

US20060231368A1 Hydraulic clutch actuation system 失效
公开(公告)号：US20060231368A1
公开(公告)日：2006-10-19
申请号：US11450927
申请日：2006-06-09
申请人： James Brissenden , Timothy Burns , Sankar Mohan , Eric Bansbach , Steven O'Hara
发明人： James Brissenden , Timothy Burns , Sankar Mohan , Eric Bansbach , Steven O'Hara
IPC分类号： F16D25/0638
CPC分类号： F16D25/14 , B60K17/344 , B60K17/3467 , B60K23/04 , B60K23/0808 , B60K2023/043 , B60K2023/0825 , B60K2023/0833 , B60K2023/0866 , B60Y2400/424 , F16D48/02 , F16D48/04 , F16D2048/0203 , F16D2048/0209
摘要： A torque transfer mechanism for controlling the magnitude of a clutch engagement force exerted on a clutch pack that is operably disposed between a first rotary member and a second rotary member includes a hydraulic clutch actuation system. The hydraulic clutch actuation system includes a primary fluid circuit coupled to a secondary fluid circuit by a pressure intensifier. The pressure intensifier provides magnified pressure to a piston for actuating the clutch pack.

10. 发明申请

US20060173603A1 Slip loss reduction control system for improving driveline efficiency 审中-公开
标题翻译：减速控制系统，提高传动系效率
公开(公告)号：US20060173603A1
公开(公告)日：2006-08-03
申请号：US11301084
申请日：2005-12-12
申请人： Sankar Mohan , Eric Bansbach , Anupam Sharma
发明人： Sankar Mohan , Eric Bansbach , Anupam Sharma
IPC分类号： G06F17/00
CPC分类号： B60T8/172 , B60K28/16 , B60T8/1755 , B60T8/17616 , B60T2210/12 , B60T2240/06 , B60W2520/26 , B60W2530/20 , B60W2720/30
摘要： A method is provided for reducing slip loss experienced by the tires of a vehicle. The method includes: determining a longitudinal force associated with each tire; determining an optimal slip coefficient for each tire based in part on the corresponding longitudinal force for the tire; and determining a torque to be applied to each tire based in part on the optimal slip coefficient, thereby reducing the slip loss experienced by the tires of the vehicle. This method is typically employed in the absence of other control algorithms used by a vehicle's traction control system.
摘要翻译：提供一种用于减少车辆轮胎经历的滑动损失的方法。该方法包括：确定与每个轮胎相关联的纵向力; 部分地基于相应的轮胎纵向力确定每个轮胎的最佳滑移系数; 并且部分地基于最佳滑移系数确定要施加到每个轮胎的扭矩，从而减少车辆的轮胎经历的滑移损失。通常在没有车辆牵引力控制系统使用的其他控制算法的情况下使用该方法。

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