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    • 2. 发明授权
    • Transmembrane access systems and methods
    • 跨膜进入系统和方法
    • US08029470B2
    • 2011-10-04
    • US10956899
    • 2004-09-30
    • James S. WhitingNeal L. EiglerJohn L. WardleWerner HafelfingerBrian Mann
    • James S. WhitingNeal L. EiglerJohn L. WardleWerner HafelfingerBrian Mann
    • A61M5/178
    • A61M25/0662A61M25/0041A61M2025/0681
    • Systems and methods for penetrating a tissue membrane to gain access to a target site are disclosed. In some examples, systems and methods for accessing the left atrium from the right atrium of a patient's heart are carried out by puncturing the intra-atrial septal wall. One embodiment provides a system for transseptal cardiac access that includes a stabilizer sheath having a side port, a shaped guiding catheter configured to exit the side port and a tissue penetration member disposed within and extendable from the distal end of the guide catheter. The tissue penetration member may be configured to penetrate tissue upon rotation and may be coupled to a distal portion of a torqueable shaft. In some embodiments, the stabilizer sheath and shaped guiding catheter may be moved relative to the patient's body structure and relative to each other so that a desired approach angle may be obtained for the tissue penetration member with respect to the target tissue.
    • 公开了渗透组织膜以获得进入目标部位的系统和方法。 在一些实例中,通过穿刺房间隔壁来进行从患者心脏的右心房进入左心房的系统和方法。 一个实施例提供了一种用于经心脏进入的系统,其包括具有侧端口的稳定器护套,被配置为离开侧端口的成形引导导管和设置在引导导管的远端内并且可从引导导管的远端延伸的组织穿透构件。 组织穿透构件可以构造成在旋转时穿透组织并且可以联接到可扭转轴的远侧部分。 在一些实施例中,稳定器护套和成形引导导管可以相对于患者的身体结构相对于彼此移动,使得组织穿透构件相对于目标组织可以获得期望的接近角。
    • 5. 发明授权
    • Patient signaling method for treating cardiovascular disease
    • 用于治疗心血管疾病的患者信号传导方法
    • US07590449B2
    • 2009-09-15
    • US11289126
    • 2005-11-29
    • Brian MannJames S. WhitingNeal L. Eigler
    • Brian MannJames S. WhitingNeal L. Eigler
    • A61B5/02A61N1/365
    • A61B5/0215A61B5/4839A61B5/6882A61B2560/0209A61N1/3627A61N1/36564G06F19/00
    • A method of treating cardiovascular disease in a medical patient is provided. The method includes the steps of generating a sensor signal indicative of a fluid pressure within the left atrium of the patient's heart, and delivering an electrical stimulus to a location in the heart. The electrical stimulus is delivered based at least in part on the sensor signal. The method also includes the steps of generating a processor output indicative of a treatment to a signaling device. The processor output is based at least in part on the sensor signal. At least two treatment signals are provided to the medical patient. The treatment signals are distinguishable from one another by the patient, and are indicative of a therapeutic treatment. The treatment signals are based at least in part on the processor output.
    • 提供了一种在医疗患者中治疗心血管疾病的方法。 该方法包括以下步骤:产生指示患者心脏的左心房内的流体压力的传感器信号,以及将电刺激递送到心脏中的位置。 至少部分地基于传感器信号传送电刺激。 该方法还包括以下步骤:产生指示对信号装置的处理的处理器输出。 处理器输出至少部分地基于传感器信号。 向医疗病人提供至少两个治疗信号。 治疗信号可由患者彼此区分,并且指示治疗性治疗。 治疗信号至少部分地基于处理器输出。