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1. 发明申请

US20100317913A1 IMPLANTABLE AUDITORY STIMULATION SYSTEM AND METHOD WITH OFFSET IMPLANTED MICROPHONES 有权
标题翻译：可移植的审计刺激系统和方法与偏移植入式微波
公开(公告)号：US20100317913A1
公开(公告)日：2010-12-16
申请号：US12790404
申请日：2010-05-28
申请人： Brian M. Conn , José H. Bedoya
发明人： Brian M. Conn , José H. Bedoya
IPC分类号： H04R25/00
CPC分类号： H04R25/606 , A61F2/18 , A61F2002/183 , A61N1/36032 , A61N1/36036 , H04R25/353 , H04R25/405 , H04R25/407 , H04R2225/67 , H04R2430/03 , H04R2430/20
摘要： An improved implantable auditory stimulation system includes two or more implanted microphones for transcutaneous detection of acoustic signals. Each of the implanted microphones provides an output signal. The microphone output signals may be combinatively utilized by an implanted processor to generate a signal for driving an implanted auditory stimulation device. The implanted microphones may be located at offset subcutaneous locations and/or may be provided with different design sensitivities, wherein combinative processing of the microphone output signals may yield an improved drive signal. In one embodiment, the microphone signal may be processed for beamforming and/or directionality purposes.
摘要翻译：改进的植入式听觉刺激系统包括用于经皮肤检测声信号的两个或多个植入麦克风。每个植入麦克风提供输出信号。麦克风输出信号可以被植入的处理器组合利用，以产生用于驱动植入的听觉刺激装置的信号。植入的麦克风可以位于偏移的皮下位置处和/或可以被提供有不同的设计灵敏度，其中麦克风输出信号的组合处理可产生改进的驱动信号。在一个实施例中，麦克风信号可以被处理用于波束成形和/或方向性目的。

2. 发明授权

US08771166B2 Implantable auditory stimulation system and method with offset implanted microphones 有权
标题翻译：植入式听觉刺激系统和偏移植入麦克风的方法
公开(公告)号：US08771166B2
公开(公告)日：2014-07-08
申请号：US12790404
申请日：2010-05-28
申请人： Brian M. Conn , José H. Bedoya
发明人： Brian M. Conn , José H. Bedoya
IPC分类号： H04R25/00
CPC分类号： H04R25/606 , A61F2/18 , A61F2002/183 , A61N1/36032 , A61N1/36036 , H04R25/353 , H04R25/405 , H04R25/407 , H04R2225/67 , H04R2430/03 , H04R2430/20
摘要： An improved implantable auditory stimulation system includes two or more implanted microphones for transcutaneous detection of acoustic signals. Each of the implanted microphones provides an output signal. The microphone output signals may be combinatively utilized by an implanted processor to generate a signal for driving an implanted auditory stimulation device. The implanted microphones may be located at offset subcutaneous locations and/or may be provided with different design sensitivities, wherein combinative processing of the microphone output signals may yield an improved drive signal. In one embodiment, the microphone signal may be processed for beamforming and/or directionality purposes.
摘要翻译：改进的植入式听觉刺激系统包括用于经皮肤检测声信号的两个或多个植入麦克风。每个植入麦克风提供输出信号。麦克风输出信号可以被植入的处理器组合利用，以产生用于驱动植入的听觉刺激装置的信号。植入的麦克风可以位于偏移的皮下位置处和/或可以被提供有不同的设计灵敏度，其中麦克风输出信号的组合处理可产生改进的驱动信号。在一个实施例中，麦克风信号可以被处理用于波束成形和/或方向性目的。

3. 发明授权

US6019788A Vascular shunt graft and junction for same 失效
标题翻译：血管分流移植物和接头相同
公开(公告)号：US6019788A
公开(公告)日：2000-02-01
申请号：US964119
申请日：1997-11-04
申请人： Leslie C. Butters , Charles E. Biggerstaff , Brian M. Conn , Ramona Hicks , Anita Switzer
发明人： Leslie C. Butters , Charles E. Biggerstaff , Brian M. Conn , Ramona Hicks , Anita Switzer
IPC分类号： A61B17/064 , A61B17/11 , A61B17/115 , A61F2/06
CPC分类号： A61M1/3655 , A61B17/064 , A61B17/11 , A61B17/1152 , A61F2/064 , A61B2017/1107 , A61B2017/1135 , A61B2017/1139
摘要： An improved implantable medical device and junction between a blood conduit and a blood vessel are disclosed. The device of the present invention provides a connection to a blood vessel that is resistant to occlusion. Resistance to occlusion is achieved by providing an implantable medical junction with: improved and consistent anastomotic geometry and hemodynamics to minimize turbulence and inappropriate shear stresses on the native blood vessels; intraluminal configuration that does not require penetration through to the luminal surface of the blood vessel or the device for anchoring; protection of the native blood vessel from the forces of blood flow in the impact zone and beyond the impact zone; and isolation of injured and traumatized tissues from the lumen of the blood vessel and the device. A cuff is also provided at the junction to reduce blood leakage from the native blood vessel, and to provide additional device anchoring.
摘要翻译：公开了一种改进的可植入医疗装置以及血管和血管之间的连接处。本发明的装置提供了对阻塞的血管的连接。通过提供可植入的医用接头来实现阻塞阻塞：具有改进和一致的吻合几何形状和血流动力学，以最小化天然血管上的紊流和不适当的剪切应力; 管腔内构造，其不需要穿透到血管的腔表面或用于锚定的装置; 保护本地血管免受冲击区域内和超出冲击区域的血液流动力; 以及从血管和装置的内腔分离损伤和创伤的组织。在连接处还提供袖带以减少来自天然血管的血液渗漏，并提供额外的装置锚定。

4. 发明申请

US20100318167A1 NEUROSTIMULATION ELECTRODE ARRAY AND METHOD OF MANUFACTURE 审中-公开
标题翻译：神经网络电极阵列及其制造方法
公开(公告)号：US20100318167A1
公开(公告)日：2010-12-16
申请号：US12762540
申请日：2010-04-19
申请人： Brian M. Conn , James R. Easter , Farid Moumane , Michel Bruhwiler , Ira Spool , Melissa Rosen
发明人： Brian M. Conn , James R. Easter , Farid Moumane , Michel Bruhwiler , Ira Spool , Melissa Rosen
IPC分类号： A61N1/05
CPC分类号： A61N1/0541 , A61N1/0529 , Y10T29/49208
摘要： An implantable neurostimulation electrode array may include a flexible, electrically non-conductive carrier, and a plurality of electrodes supportably interconnected to and spaced along a length of a carrier. In various embodiments, different ones of at least some of the plurality of electrodes may comprise corresponding contact surfaces having different areas. The different surface areas may be achieved by defining a different area per unit length of the carrier and/or by defining a different total length (e.g. as measured along a length of the carrier). In some embodiments, insulator portions having different corresponding lengths may be disposed between different adjacent ones of the electrodes. The insulated portions may be integrally defined with the carrier. Electrical connection lines may be embedded within the carrier. In a manufacturing method, a plurality of electrodes may be supportably interconnected to a first side of a sacrificial substrate and a carrier may be interconnected to the electrodes. In turn, at least a portion of the substrate may be removed from the electrodes to yield at least a partially completed electrode array. The substrate may be configured into a predetermined configuration wherein the carrier material may be formed within an internal volume thereof to define at least a portion of the configuration of the carrier of the electrode array.
摘要翻译：可植入神经刺激电极阵列可以包括柔性的非导电载体，以及多个电极，其可被支撑地互连到载体的长度上并沿其间隔开。在各种实施例中，多个电极中的至少一些电极中的不同的电极可以包括具有不同区域的对应的接触表面。可以通过限定载体的每单位长度的不同面积和/或通过限定不同的总长度（例如沿着载体的长度测量）来实现不同的表面积。在一些实施例中，具有不同对应长度的绝缘体部分可以设置在不同的相邻电极之间。绝缘部分可以与载体一体地限定。电连接线可以嵌入在载体内。在制造方法中，多个电极可以可支撑地互连到牺牲衬底的第一侧，并且载体可以互连到电极。反过来，衬底的至少一部分可以从电极去除以产生至少部分完成的电极阵列。衬底可以被配置成预定的构造，其中载体材料可以形成在其内部体积内以限定电极阵列的载体的构造的至少一部分。

5. 发明申请

US20090240099A1 BI-MODAL COCHLEA STIMULATION 审中-公开
标题翻译：双模式COCHLEA刺激
公开(公告)号：US20090240099A1
公开(公告)日：2009-09-24
申请号：US12395307
申请日：2009-02-27
申请人： Brian M. Conn
发明人： Brian M. Conn
IPC分类号： H04R25/00 , A61F11/04 , A61N1/36
CPC分类号： A61N1/0541 , A61N1/36036 , H04R25/606
摘要： An improved implantable hearing instrument and associated method utilize a transducer to mechanically stimulate a patient's cochlea (e.g. via the round window or oval window) in response to a first electrical drive signal, and a supply electrode to electrically stimulate the patient's cochlea in response to a second drive signal. The first and second drive signals may be provided to affect mechanical stimulation across a first predetermined frequency range and electrical stimulation across a second predetermined frequency range, respectively, wherein the predetermined frequency ranges are at least partially non-overlapping. In one embodiment an electromechanical transducer, having the supply member supportably interconnect thereto, may be selectively positioned via a mounting member fixedly interconnected to a patient's skull. The supply electrode may define a distal tip that is supportably interconnected to a vibratory member of the electromechanical transducer. In another embodiment, an implantable transducer may be employed that includes an external housing and an active transducer element located within an internal chamber of the external housing for receiving the first electrical signal. Further, the supply electrode may be one of electrically connected to and defined by at least an electrically-conductive portion of the external housing of the transducer.
摘要翻译：改进的可植入式听力仪器和相关方法利用换能器来响应于第一电驱动信号机械地刺激患者的耳蜗（例如通过圆窗或椭圆窗），以及供应电极以响应于电刺激患者的耳蜗第二驱动信号。可以提供第一和第二驱动信号以分别影响穿过第一预定频率范围的机械刺激和跨越第二预定频率范围的电刺激，其中预定频率范围至少部分地不重叠。在一个实施例中，具有与其可支撑地互连的供应构件的机电换能器可以经由固定地互连到患者头骨的安装构件来选择性地定位。供电电极可以限定可靠地互连到机电换能器的振动构件的远侧末端。在另一个实施例中，可以采用可植入的换能器，其包括位于外部壳体的内部腔室内的外部壳体和主动换能器元件，用于接收第一电信号。此外，供电电极可以是与换能器的外壳的至少导电部分电连接并限定的电极。

6. 发明授权

US09044588B2 Reference electrode apparatus and method for neurostimulation implants 有权
标题翻译：用于神经刺激植入物的参比电极装置和方法
公开(公告)号：US09044588B2
公开(公告)日：2015-06-02
申请号：US12759545
申请日：2010-04-13
申请人： Brian M. Conn
发明人： Brian M. Conn
IPC分类号： A61N1/00 , A61N1/05
CPC分类号： A61N1/0541 , A61N1/0558
摘要： An implantable apparatus and method are provided for use in conjunction with an implantable neurostimulation signal generator that provides an electrical stimulation signal to an active electrode. In auditory stimulation applications, the apparatus includes at least one anchor member having a distal end portion for directly contacting a patient's cranial bone and an electrically conductive portion extending from the distal end portion to a contact location proximal to the distal end portion. An electrical connection line may be electrically interconnected at a first end to the contact location of the anchor member and electrically interconnected at a second end to an implantable auditory neurostimulation signal generator to define a reference electrode. A bracket member may be mounted to a patient's cranial bone utilizing the anchor member, wherein an electrically conductive pathway extends from a first contact location to a second contact location of the bracket member. The first contact location may selectively contact the contact location of the anchor member and the second location of the bracket member may be adapted for electrical interconnection to the electrical connection line.
摘要翻译：提供可植入装置和方法，其与可植入的神经刺激信号发生器结合使用，其向活性电极提供电刺激信号。在听觉刺激应用中，该装置包括至少一个锚固构件，其具有用于直接接触患者颅骨的远端部分和从远端部分延伸到靠近远端部分的接触位置的导电部分。电连接线可以在第一端处电连接到锚固构件的接触位置，并且在第二端处电连接到可植入听觉神经刺激信号发生器以限定参考电极。托架构件可以利用锚定构件安装到患者的颅骨，其中导电路径从支架构件的第一接触位置延伸到第二接触位置。第一接触位置可以选择性地接触锚定构件的接触位置，并且支架构件的第二位置可以适于与电连接线的电互连。

7. 发明申请

US20130079844A1 Implantable Neurostimulation Electrode Interface 审中-公开
标题翻译：植入式神经刺激电极接口
公开(公告)号：US20130079844A1
公开(公告)日：2013-03-28
申请号：US13622096
申请日：2012-09-18
申请人： Brian M. Conn , Denis Dupeyron
发明人： Brian M. Conn , Denis Dupeyron
IPC分类号： A61N1/36 , A61N1/372
CPC分类号： A61N1/36125 , A61N1/0529 , A61N1/0541 , A61N1/36036 , A61N1/3605 , A61N1/37217 , A61N1/37229
摘要： An implantable neurostimulation electrode interface and related system arrangements and methods are provided. The implantable interface may include at least a first stimulation signal channel for receiving a first electrode stimulation signal and a plurality of electrode signal channels electrically interconnected or interconnectable to a plurality of electrodes for neurostimulation. The interface may further include a router electrically interconnected to the first stimulation signal channel and to the plurality of electrode signal channels. The router is controllable to directly route the first electrode stimulation signal to different first successive sets of one or more of the plurality of electrode signal channels. The router may be adapted for routing the first electrode stimulation signal as an electrical current signal, without modification of the signal. Stimulation signal generation componentry and power source componentry may be located remotely from the implantable interface. Such componentry may be selectively interconnectable to and disconnectable from the implantable interface.
摘要翻译：提供了可植入神经刺激电极界面和相关的系统布置和方法。可植入界面可以包括用于接收第一电极刺激信号的至少第一刺激信号通道和电互连或互连到多个用于神经刺激的电极的多个电极信号通道。接口还可以包括与第一刺激信号通道电连接的多个电极信号通道的路由器。路由器是可控制的，以将第一电极刺激信号直接路由到多个电极信号通道中的一个或多个的不同的第一连续组。路由器可以适于将第一电极刺激信号作为电流信号进行路由，而不改变信号。刺激信号生成组件和电源组件可以远离植入式界面定位。这种组件可以选择性地互连到可植入界面并且可与可植入界面断开连接。

8. 发明申请

US20100268313A1 REFERENCE ELECTRODE APPARATUS AND METHOD FOR NEUROSTIMULATION IMPLANTS 有权
标题翻译：参考电极装置和神经移植植入物的方法
公开(公告)号：US20100268313A1
公开(公告)日：2010-10-21
申请号：US12759545
申请日：2010-04-13
申请人： Brian M. Conn
发明人： Brian M. Conn
IPC分类号： A61N1/05
CPC分类号： A61N1/0541 , A61N1/0558
摘要： An implantable apparatus and method are provided for use in conjunction with an implantable neurostimulation signal generator that provides an electrical stimulation signal to an active electrode. In auditory stimulation applications, the apparatus includes at least one anchor member having a distal end portion for directly contacting a patient's cranial bone and an electrically conductive portion extending from the distal end portion to a contact location proximal to the distal end portion. An electrical connection line may be electrically interconnected at a first end to the contact location of the anchor member and electrically interconnected at a second end to an implantable auditory neurostimulation signal generator to define a reference electrode. A bracket member may be mounted to a patient's cranial bone utilizing the anchor member, wherein an electrically conductive pathway extends from a first contact location to a second contact location of the bracket member. The first contact location may selectively contact the contact location of the anchor member and the second location of the bracket member may be adapted for electrical interconnection to the electrical connection line.
摘要翻译：提供可植入装置和方法，其与可植入的神经刺激信号发生器结合使用，其向活性电极提供电刺激信号。在听觉刺激应用中，该装置包括至少一个锚固构件，其具有用于直接接触患者颅骨的远端部分和从远端部分延伸到靠近远端部分的接触位置的导电部分。电连接线可以在第一端处电连接到锚定构件的接触位置，并且在第二端处电连接到可植入听觉神经刺激信号发生器以限定参考电极。托架构件可以利用锚定构件安装到患者的颅骨，其中导电路径从支架构件的第一接触位置延伸到第二接触位置。第一接触位置可以选择性地接触锚定构件的接触位置，并且支架构件的第二位置可以适于与电连接线的电互连。

9. 发明申请

US20100042119A1 SYSTEMS AND METHODS FOR SECURING SUBCUTANEOUS IMPLANTED DEVICES 审中-公开
标题翻译：用于保护嵌入式装置的系统和方法
公开(公告)号：US20100042119A1
公开(公告)日：2010-02-18
申请号：US12538760
申请日：2009-08-10
申请人： William J. Simms , Scott Allan Miller, III , Nicholas Pergola , Brian M. Conn , James R. Easter
发明人： William J. Simms , Scott Allan Miller, III , Nicholas Pergola , Brian M. Conn , James R. Easter
IPC分类号： A61B17/00
CPC分类号： H04R25/606 , H04R2225/67
摘要： A system for reducing subcutaneous migration of an implantable device or housing relative to surrounding soft tissue. For instance, the implantable housing may support a microphone diaphragm. The system includes at least one securement member having at least one aperture extending therethrough that may selectively receive one of a soft tissue securement device (e.g., soft tissue suture) and soft tissue growth therethrough. The securement member is at least one of interconnected to and disposable over at least a portion of the housing and at least one of extends away from and is selectively extendable away from a periphery of the housing. In one arrangement, at least one mesh member may be optionally included with the system that may allow for tissue growth to enhance securement of the implanted device relative to the soft tissue.
摘要翻译：一种用于减少可植入装置或壳体相对于周围软组织的皮下移动的系统。例如，可植入壳体可以支撑麦克风隔膜。该系统包括至少一个固定构件，其具有延伸穿过其中的至少一个孔，其可选择性地接收软组织固定装置（例如，软组织缝合线）中的一个以及通过其中的软组织生长。固定构件是至少一个互连到壳体的至少一部分上并且一次性的壳体中的至少一个，并且至少一个延伸远离壳体并且可选择地从外壳的周边延伸。在一种布置中，至少一个网状构件可以任选地包括在系统中，其可以允许组织生长以增强植入的装置相对于软组织的固定。

10. 发明申请

US20090287277A1 IMPLANTABLE NEUROSTIMULATION ELECTRODE INTERFACE 审中-公开
标题翻译：可植入神经网络电极接口
公开(公告)号：US20090287277A1
公开(公告)日：2009-11-19
申请号：US12211664
申请日：2008-09-16
申请人： Brian M. Conn , Denis Dupeyron
发明人： Brian M. Conn , Denis Dupeyron
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36125 , A61N1/0529 , A61N1/0541 , A61N1/36036 , A61N1/3605 , A61N1/37217 , A61N1/37229
摘要： An implantable neurostimulation electrode interface and related system arrangements and methods are provided. The implantable interface may include at least a first stimulation signal channel for receiving a first electrode stimulation signal and a plurality of electrode signal channels electrically interconnected or interconnectable to a plurality of electrodes for neurostimulation. The interface may further include a router electrically interconnected to the first stimulation signal channel and to the plurality of electrode signal channels. The router is controllable to directly route the first electrode stimulation signal to different first successive sets of one or more of the plurality of electrode signal channels. The router may be adapted for routing the first electrode stimulation signal as an electrical current signal, without modification of the signal. Stimulation signal generation componentry and power source componentry may be located remotely from the implantable interface. Such componentry may be selectively interconnectable to and disconnectable from the implantable interface.
摘要翻译：提供了可植入神经刺激电极界面和相关的系统布置和方法。可植入界面可以包括用于接收第一电极刺激信号的至少第一刺激信号通道和电互连或互连到多个用于神经刺激的电极的多个电极信号通道。接口还可以包括与第一刺激信号通道电连接的多个电极信号通道的路由器。路由器是可控制的，以将第一电极刺激信号直接路由到多个电极信号通道中的一个或多个的不同的第一连续组。路由器可以适于将第一电极刺激信号作为电流信号进行路由，而不改变信号。刺激信号生成组件和电源组件可以远离植入式界面定位。这种组件可以选择性地互连到可植入界面并且可与可植入界面断开连接。

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