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1. 发明授权

US09682082B2 Combinations of AKT and MEK inhibitor compounds, and methods of use 有权
公开(公告)号：US09682082B2
公开(公告)日：2017-06-20
申请号：US14009320
申请日：2012-03-30
申请人： Brian Lee , Kui Lin , Michelle Nannini , Elizabeth Punnoose , Deepak Sampath
发明人： Brian Lee , Kui Lin , Michelle Nannini , Elizabeth Punnoose , Deepak Sampath
IPC分类号： A61K31/517 , A61K31/165 , A61K31/4402 , A61K45/06 , C07D239/70 , A61K31/166 , A61K31/4523
CPC分类号： A61K31/517 , A61K31/165 , A61K31/166 , A61K31/4402 , A61K31/4523 , A61K45/06 , C07D239/70 , A61K2300/00
摘要： The invention provides combinations comprising a) compound of formula I: (formula I), or a pharmaceutically acceptable salt thereof; and another agent selected from GDC-0973, PD-0325901, or a pharmaceutically acceptable salt thereof. The combinations are particularly useful for treating hyperproliferative disorders, such as cancer.

2. 发明申请

US20140155372A1 COMBINATIONS OF AKT AND MEK INHIBITOR COMPOUNDS, AND METHODS OF USE 有权
标题翻译： AKT和MEK抑制剂化合物的组合及其使用方法
公开(公告)号：US20140155372A1
公开(公告)日：2014-06-05
申请号：US14009320
申请日：2012-03-30
申请人： Brian Lee , Kui Lin , Michelle Nannini , Elizabeth Punnoose , Deepak Sampath
发明人： Brian Lee , Kui Lin , Michelle Nannini , Elizabeth Punnoose , Deepak Sampath
IPC分类号： A61K31/517 , A61K31/166 , A61K31/4523
CPC分类号： A61K31/517 , A61K31/165 , A61K31/166 , A61K31/4402 , A61K31/4523 , A61K45/06 , C07D239/70 , A61K2300/00
摘要： The invention provides combinations comprising a) compound of formula I: (formula I), or a pharmaceutically acceptable salt thereof; and another agent selected from GDC-0973, PD-0325901, or a pharmaceutically acceptable salt thereof. The combinations are particularly useful for treating hyperproliferative disorders, such as cancer.
摘要翻译：本发明提供组合，其包含a）式I化合物：（式I）或其药学上可接受的盐; 和选自GDC-0973，PD-0325901或其药学上可接受的盐的另一种药剂。这些组合对于治疗过度增殖性疾病如癌症特别有用。

3. 发明申请

US20150064171A1 COMBINATIONS OF AKT INHIBITOR COMPOUNDS AND CHEMOTHERAEPTUC AGENTS, AND METHODS OF USE 审中-公开
标题翻译： AKT抑制剂化合物和化学治疗剂的组合及使用方法
公开(公告)号：US20150064171A1
公开(公告)日：2015-03-05
申请号：US14009314
申请日：2012-03-30
申请人： Kui Lin , Michelle Nannini , Elizabeth Punnoose , Deepak Sampath , Jeffrey Wallin , Premal Patel
发明人： Kui Lin , Michelle Nannini , Elizabeth Punnoose , Deepak Sampath , Jeffrey Wallin , Premal Patel
IPC分类号： C07D403/12 , A61K31/517 , A61K31/513 , A61K31/282 , A61K39/395 , A61K31/4745 , A61K31/337 , A61K31/704 , A61K31/4188 , C07D239/70 , A61K31/519
CPC分类号： A61K31/517 , A61K31/138 , A61K31/282 , A61K31/337 , A61K31/4166 , A61K31/4188 , A61K31/436 , A61K31/437 , A61K31/4745 , A61K31/495 , A61K31/496 , A61K31/513 , A61K31/519 , A61K31/555 , A61K31/58 , A61K31/704 , A61K31/7068 , A61K39/3955 , A61K2039/505 , C07D239/70 , C07D403/12 , C07K16/40 , A61K2300/00
摘要： The invention provides combinations comprising a) compound of formula (I) or a pharmaceutically acceptable salt thereof wherein R1, R2, R5, R10, and A have any of the values defined in the specification; and b) one or more agents selected from 5-FU, a platinum agent, leucovorin, irinotecan, docetaxel, doxorubicin, gemcitabine, SN-38, capecitabine, temozolomide, paclitaxel, bevacizumab, pertuzumab, tamoxifen, rapamycin and lapatinib. The combinations are particularly useful for treating hyperproliferative disorders, such as cancer.
摘要翻译：本发明提供组合，其包含a）式（I）化合物或其药学上可接受的盐，其中R 1，R 2，R 5，R 10和A具有说明书中定义的任何值; 和b）选自5-FU，铂药剂，甲酰四氢叶酸，伊立替康，多西他赛，多柔比星，吉西他滨，SN-38，卡培他滨，替莫唑胺，紫杉醇，贝伐珠单抗，依托单抗，他莫昔芬，雷帕霉素和拉帕替尼的一种或多种药剂。这些组合对于治疗过度增殖性疾病如癌症特别有用。

4. 发明申请

US20140031259A1 BIOMARKERS FOR PREDICTING SENSITIVITY TO CANCER TREATMENTS 审中-公开
标题翻译：用于预测癌症治疗敏感性的生物标志物
公开(公告)号：US20140031259A1
公开(公告)日：2014-01-30
申请号：US14009317
申请日：2012-03-30
申请人： Kui Lin , Elizabeth Punnoose , Somasekar Seshagiri
发明人： Kui Lin , Elizabeth Punnoose , Somasekar Seshagiri
IPC分类号： G01N33/574 , C12Q1/68
CPC分类号： A61K31/517 , A61K31/58 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , G01N33/5748
摘要： Methods for predicting sensitivity to cancer treatments by assessing biomarkers and combinations of biomarkers include evaluating the presence of mutations to Akt, wherein the presence of said mutations correlates with the sensitivity of Akt inhibitors.
摘要翻译：通过评估生物标志物和生物标志物的组合预测对癌症治疗的敏感性的方法包括评估Akt的突变的存在，其中所述突变的存在与Akt抑制剂的敏感性相关。

5. 发明授权

US09420055B2 System, apparatus for content delivery for internet traffic and methods thereof 有权
标题翻译：用于互联网流量的内容传送的系统，装置及其方法
公开(公告)号：US09420055B2
公开(公告)日：2016-08-16
申请号：US13105625
申请日：2011-05-11
申请人： Sanqi Li , Tao Qian , Houxiao Han , Hongbo Tian , Kui Lin
发明人： Sanqi Li , Tao Qian , Houxiao Han , Hongbo Tian , Kui Lin
IPC分类号： H04L29/08 , H04L12/14 , H04L29/06 , H04M15/00 , G06F17/30 , H04L29/14 , H04L12/24 , H04L12/26
CPC分类号： H04L65/80 , G06F17/30902 , H04L12/14 , H04L12/1435 , H04L12/1439 , H04L12/1485 , H04L12/1489 , H04L41/5029 , H04L41/5067 , H04L43/10 , H04L63/30 , H04L65/1063 , H04L65/4092 , H04L65/60 , H04L67/143 , H04L67/2842 , H04L67/2847 , H04L67/2885 , H04L67/306 , H04L69/324 , H04L69/325 , H04L69/40 , H04M15/83 , H04M15/84 , H04M15/844 , H04M15/85 , H04M15/852 , H04M15/88 , H04M15/888
摘要： In one embodiment, a method of serving media includes receiving a request to serve a cacheable media content to a user equipment at a second media server deployed in a second layer2 access network. The request is received around when the user equipment is handed-off from a first layer2 node in a first layer2 access network to a second layer2 node in the second layer2 access network and when a streaming session of the cacheable media content to the user equipment from a first media server is terminated. The method further includes determining if the cacheable media content is stored in a cache of the second media server, and serving the cacheable media content from the cache of the second media server to the user equipment if the media content is stored in the cache of the second media server.
摘要翻译：在一个实施例中，服务媒体的方法包括在部署在第二层2接入网络中的第二媒体服务器处接收向可缓存媒体内容服务的请求给用户设备。当用户设备从第一层2接入网络中的第一层2节点切换到第二层2接入网络中的第二层2节点并且当可高速缓存媒体内容的流媒体会话到用户设备从第一个媒体服务器被终止。该方法还包括确定可缓存媒体内容是否存储在第二媒体服务器的高速缓存中，以及如果媒体内容存储在第二媒体服务器的高速缓存中，则将可缓存媒体内容从第二媒体服务器的高速缓存服务给用户设备第二媒体服务器。

6. 发明申请

US20110280153A1 System, Apparatus for Content Delivery for Internet Traffic and Methods Thereof 有权
标题翻译：系统，互联网流量内容传送装置及其方法
公开(公告)号：US20110280153A1
公开(公告)日：2011-11-17
申请号：US13105439
申请日：2011-05-11
申请人： Sanqi Li , Tao Qian , Houxiao Han , Hongbo Tian , Kui Lin
发明人： Sanqi Li , Tao Qian , Houxiao Han , Hongbo Tian , Kui Lin
IPC分类号： H04L12/28
CPC分类号： H04L65/80 , G06F17/30902 , H04L12/14 , H04L12/1435 , H04L12/1439 , H04L12/1485 , H04L12/1489 , H04L41/5029 , H04L41/5067 , H04L43/10 , H04L63/30 , H04L65/1063 , H04L65/4092 , H04L65/60 , H04L67/143 , H04L67/2842 , H04L67/2847 , H04L67/2885 , H04L67/306 , H04L69/324 , H04L69/325 , H04L69/40 , H04M15/83 , H04M15/84 , H04M15/844 , H04M15/85 , H04M15/852 , H04M15/88 , H04M15/888
摘要： In one embodiment, a method of serving media includes receiving a request to serve media content to an user equipment, and receiving caching information regarding the media content. The caching information includes information regarding whether the media content requested by the user equipment is cacheable. A first media server is assigned from a hierarchical set of media servers to serve the user equipment if the media content to be served is cacheable. The hierarchical set of media servers includes a plurality of first type of media servers deployed in a plurality of layer2 (L2) access networks. The user equipment is coupled to the content delivery network through a layer2 access network of the plurality of L2 access networks.
摘要翻译：在一个实施例中，服务媒体的方法包括接收向用户设备提供媒体内容的请求，以及接收关于媒体内容的缓存信息。缓存信息包括关于用户设备请求的媒体内容是否可高速缓存的信息。如果要被服务的媒体内容是可缓存的，则从分层的媒体服务器集合分配第一媒体服务器以服务于用户设备。媒体服务器的分级集包括部署在多个第二层（L2）接入网络中的多个第一类型的媒体服务器。用户设备通过多个L2接入网络的第二层接入网络耦合到内容传送网络。

7. 发明授权

US09288511B2 Methods and apparatus for media navigation 有权
标题翻译：媒体导航的方法和装置
公开(公告)号：US09288511B2
公开(公告)日：2016-03-15
申请号：US13398682
申请日：2012-02-16
申请人： Kui Lin , Hong Heather Yu
发明人： Kui Lin , Hong Heather Yu
IPC分类号： G06F3/00 , G06F15/16 , H04N21/2343 , H04N21/235 , H04N21/25 , H04N21/2665 , H04N21/431 , H04N21/472 , H04N21/4725 , H04N21/4728 , H04N21/6543 , H04N21/6587 , H04N21/81 , H04N21/84 , H04N21/8543 , H04N21/858 , H04N21/258 , H04N21/462 , H04N21/658 , H04N21/845
CPC分类号： H04N21/234327 , H04N21/235 , H04N21/251 , H04N21/25891 , H04N21/2665 , H04N21/4316 , H04N21/4622 , H04N21/47217 , H04N21/4725 , H04N21/4728 , H04N21/6543 , H04N21/6582 , H04N21/6587 , H04N21/8133 , H04N21/84 , H04N21/8455 , H04N21/8456 , H04N21/8543 , H04N21/8583
摘要： In accordance with an embodiment of the present invention, an apparatus for streaming a media includes a server side receiver for receiving a request to stream a media from a media player. The apparatus further includes a content generator, a server side transmitter, and a media stream generator. The content generator is configured to generate content information providing a plurality of presentation options to consume the media. The server side transmitter is configured to send the content information. The server side receiver is further configured to receive a selected presentation option from amongst the plurality of presentation options. The media stream generator is configured to generate a media stream comprising the media based on the selected presentation option.
摘要翻译：根据本发明的实施例，用于流媒体的装置包括服务器侧接收器，用于从媒体播放器接收流媒体的请求。该装置还包括内容生成器，服务器侧发送器和媒体流生成器。内容生成器被配置为生成提供多个呈现选项以消费媒体的内容信息。服务器端发送器被配置为发送内容信息。服务器侧接收器还被配置为从多个呈现选项中接收所选择的呈现选项。媒体流生成器被配置为基于所选择的呈现选项来生成包括媒体的媒体流。

8. 发明申请

US20130024599A1 Method and Apparatus for SSD Storage Access 审中-公开
标题翻译： SSD存储访问的方法和装置
公开(公告)号：US20130024599A1
公开(公告)日：2013-01-24
申请号：US13477924
申请日：2012-05-22
申请人： Yiren Huang , Yong Wang , Kui Lin
发明人： Yiren Huang , Yong Wang , Kui Lin
IPC分类号： G06F12/02
CPC分类号： G06F3/0611 , G06F3/0625 , G06F3/064 , G06F3/0658 , G06F3/0659 , G06F3/0688 , Y02D10/154
摘要： A media management system including an application layer, a system layer, and a solid state drive (SSD) storage layer. The application layer includes a media data analytics application configured to assign a classification code to a data file. The system layer is in communication with the application layer. The system layer includes a file system configured to issue a write command to a SSD controller. The write command includes the classification code of the data file. The SSD storage layer includes the SSD controller and erasable blocks. The SSD controller is configured to write the data file to one of the erasable blocks based on the classification code of the data file in the write command. In an embodiment, the SSD controller is configured to write the data file to one of the erasable blocks storing other data files also having the classification code.
摘要翻译：包括应用层，系统层和固态驱动器（SSD）存储层的媒体管理系统。应用层包括被配置为将分类代码分配给数据文件的媒体数据分析应用。系统层与应用层通信。系统层包括被配置为向SSD控制器发出写命令的文件系统。写命令包括数据文件的分类代码。 SSD存储层包括SSD控制器和可擦除块。 SSD控制器被配置为基于写入命令中的数据文件的分类代码将数据文件写入可擦除块之一。在一个实施例中，SSD控制器被配置为将数据文件写入存储还具有分类代码的其他数据文件的可擦除块之一。

9. 发明申请

US20110191679A1 System and Method for Online Media Preview 审中-公开
标题翻译：在线媒体预览的系统和方法
公开(公告)号：US20110191679A1
公开(公告)日：2011-08-04
申请号：US13018121
申请日：2011-01-31
申请人： Kui Lin , Jiangping Feng , Yu Huang , Hong Heather Yu
发明人： Kui Lin , Jiangping Feng , Yu Huang , Hong Heather Yu
IPC分类号： G06F3/01
CPC分类号： H04N21/8549 , G06F16/70 , H04N21/8153 , H04N21/8456
摘要： An embodiment of a system and method for online media preview extracts a plurality of preview frames from a media file. The preview frames are saved in a layered data structure. In addition, the preview frames may be scaled to a lower resolution so that the preview file formed by the preview frames is reduced in size. After receiving a preview request, a delivery scheduling scheme delivers the preview frames at selected time points to minimize startup delay and playback jitter.
摘要翻译：用于在线媒体预览的系统和方法的实施例从媒体文件中提取多个预览帧。预览帧保存在分层数据结构中。此外，可以将预览帧缩放到较低分辨率，使得由预览帧形成的预览文件的大小减小。在接收到预览请求之后，传送调度方案在选定的时间点传送预览帧以最小化启动延迟和播放抖动。

10. 发明授权

US09628579B2 System, apparatus for content delivery for internet traffic and methods thereof 有权
公开(公告)号：US09628579B2
公开(公告)日：2017-04-18
申请号：US13105705
申请日：2011-05-11
申请人： Sanqi Li , Tao Qian , Houxiao Han , Hongbo Tian , Kui Lin
发明人： Sanqi Li , Tao Qian , Houxiao Han , Hongbo Tian , Kui Lin
IPC分类号： H04L29/08 , H04L12/14 , H04L29/06 , H04M15/00 , H04M15/02 , G06F17/30 , H04L29/14 , H04L12/24 , H04L12/26
CPC分类号： H04L65/80 , G06F17/30902 , H04L12/14 , H04L12/1435 , H04L12/1439 , H04L12/1485 , H04L12/1489 , H04L41/5029 , H04L41/5067 , H04L43/10 , H04L63/30 , H04L65/1063 , H04L65/4092 , H04L65/60 , H04L67/143 , H04L67/2842 , H04L67/2847 , H04L67/2885 , H04L67/306 , H04L69/324 , H04L69/325 , H04L69/40 , H04M15/83 , H04M15/84 , H04M15/844 , H04M15/85 , H04M15/852 , H04M15/88 , H04M15/888
摘要： In one embodiment, a method of serving media includes receiving a delivery log of traffic use after every first time interval for an user equipment. The user equipment is part of a hot billing class of users. The traffic use comprises data usage by the user equipment during communication with a media server in a layer2 access network. A user traffic information computed from the delivery log is transmitted to a billing center. A account status information is received from the billing center. The account status information is received if the user equipment exceeds a user account metric. A session termination information based on the account status information is transmitted.

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