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1. 发明授权

US5053032A Method of signalling a patient during buccal agent delivery 失效
标题翻译：信号交换中患者信号的方法
公开(公告)号：US5053032A
公开(公告)日：1991-10-01
申请号：US633590
申请日：1990-12-21
申请人： Brian L. Barclay , Jerry D. Childers , Jeri Wright , Virgil A. Place , Patrick S. L. Wong
发明人： Brian L. Barclay , Jerry D. Childers , Jeri Wright , Virgil A. Place , Patrick S. L. Wong
IPC分类号： A61K20060101 , A61K9/00 , A61K9/22
CPC分类号： A61K9/0004
摘要： An osmotic device for delivering a beneficial drug, such as an anti-fungal, into the mouth of a human patient is disclosed. The device has a size and shape adapting it to be comfortably retained in the mouth for extended periods of time. The device comprises a wall surrounding a compartment housing a layer of an agent that is insoluble to very soluble in aqueous biological fluids, e.g., saliva, and a layer of a fluid swellable, hydrophilic polymer. A passageway in the wall connects the agent with the exterior of the device. The wall is permeable to the passage of aqueous biological fluid but substantially impermeable to the passage of the hydrophilic polymer. In one embodiment the beneficial agent has a different color than the hydrophilic polymer. The wall is sufficiently translucent to permit the patient to see the amount of drug/beneficial agent remaining to be delivered. Marking lines may be provided on the wall indicating the amount of drug/agent which has been delivered and/or the amount remaining to be delivered.

2. 发明授权

US5021053A Oral osmotic device with hydrogel driving member 失效
标题翻译：具有水凝胶驱动构件的口腔渗透装置
公开(公告)号：US5021053A
公开(公告)日：1991-06-04
申请号：US380229
申请日：1989-07-14
申请人： Brian L. Barclay , Jerry D. Childers , Jeri Wright , Virgil A. Place , Patrick S. L. Wong
发明人： Brian L. Barclay , Jerry D. Childers , Jeri Wright , Virgil A. Place , Patrick S. L. Wong
IPC分类号： A61K20060101 , A61K9/00 , A61K9/22
CPC分类号： A61K9/0004
摘要： An osmotic device for delivering a beneficial drug, such as an anti-fungal, into the mouth of a human patient is disclosed. The device has a size and shape adapting it to be comfortably retained in the mouth for extended periods of time. The device comprises a wall surrounding a compartment housing a layer of an agent that is insoluble to very soluble in aqueous biological fluid, e.g., saliva, and a layer of a fluid swellable, hydrophilic polymer. A passageway in the wall connects the agent with the exterior of the device. The wall is permeable to the passage of aqueous biological fluid but substantially impermeable to the passage of the hydrophilic polymer. In one embodiment the beneficial agent has a different color than the hydrophilic polymer. The wall is sufficiently translucent to permit the patient to see the amount of drug/beneficial agent remaining to be delivered. Marking lines may be provided on the wall indicating the amount of drug/agent which has been delivered and/or the amount remaining to be delivered.
摘要翻译：公开了用于将有益药物（例如抗真菌）递送到人类患者的口腔中的渗透装置。该装置的尺寸和形状适应于舒适地保持在口中长时间。该装置包括一个围绕隔室的壁，该隔室容纳不溶于非常可溶于水生物流体例如唾液的一层试剂，以及一层流体可溶胀的亲水性聚合物。墙壁上的一个通道可将药剂与装置的外部连接起来。该壁对于水性生物流体的通道是可渗透的，但是对亲水性聚合物的通过基本上是不可渗透的。在一个实施方案中，有益剂具有与亲水性聚合物不同的颜色。该壁足够半透明以允许患者看到剩余的待传递的药物/有益剂的量。可以在墙上提供标记线，指示已经递送的药物/药剂的量和/或剩余的待传送量。

3. 发明授权

US5869096A Oral osmotic device with hydrogel driving member 失效
标题翻译：具有水凝胶驱动构件的口腔渗透装置
公开(公告)号：US5869096A
公开(公告)日：1999-02-09
申请号：US353568
申请日：1994-12-09
申请人： Brian L. Barclay , Jerry D. Childers , Jeri Wright , Virgil A. Place , Patrick S. L. Wong
发明人： Brian L. Barclay , Jerry D. Childers , Jeri Wright , Virgil A. Place , Patrick S. L. Wong
IPC分类号： A61K9/00 , A61K9/52 , A61K9/24
CPC分类号： A61K9/0004
摘要： An osmotic device (10) for delivering a beneficial drug, such as an anti-fungal, into the mouth of a human patient is disclosed. The device (10) has a size and shape adapting it to be comfortably retained in the mouth for extended periods of time. The device (10) comprises a wall (12) surrounding a compartment (13) housing a layer of an agent (14) that is insoluble to very soluble in aqueous biological fluids, e.g., saliva, and a layer (16) of a fluid swellable, hydrophilic polymer. A passageway (17) in the wall (12) connects the agent (14) with the exterior of the device (10). The wall (12) is permeable to the passage of aqueous biological fluid but substantially impermeable to the passage of the hydrophilic polymer (16). In one embodiment the beneficial agent (14) has a different color than the hydrophilic polymer (16). The wall (12) is sufficiently translucent to permit the patient to see the amount of drug/beneficial agent (14) remaining to be delivered. Marking lines (19) may be provided on the wall (12) indicating the amount of drug/agent (14) which has been delivered and/or the amount remaining to be delivered.
摘要翻译：公开了一种用于将有益药物（例如抗真菌）递送到人类患者的口中的渗透装置（10）。装置（10）具有适应其舒适地保持在口中长时间的尺寸和形状。装置（10）包括围绕隔室（13）的壁（12），该隔室（13）容纳不溶于非常可溶于水生物流体（例如唾液）的试剂（14）层，以及流体层可溶胀的亲水性聚合物。壁（12）中的通道（17）将试剂（14）与装置（10）的外部连接。所述壁（12）对于水性生物流体的通道是可渗透的，但是对于亲水性聚合物（16）的通过基本上是不透水的。在一个实施方案中，有益剂（14）具有与亲水性聚合物（16）不同的颜色。壁（12）是足够半透明的，以允许患者看到待传送的药物/有益剂（14）的量。标记线（19）可以设置在壁（12）上，指示已经被输送的药物/试剂（14）的量和/或剩余的待传送量。

4. 发明授权

US5776493A Oral osmotic device for delivery of nystatin with hydrogel driving member 失效
标题翻译：口服渗透装置用于用水凝胶驱动构件递送制霉菌素
公开(公告)号：US5776493A
公开(公告)日：1998-07-07
申请号：US171875
申请日：1993-12-22
申请人： Brian L. Barclay , Jerry D. Childers , Jeri Wright , Virgil A. Place , Patrick S.-L. Wong
发明人： Brian L. Barclay , Jerry D. Childers , Jeri Wright , Virgil A. Place , Patrick S.-L. Wong
IPC分类号： A61K9/00 , A61K9/52 , A61K9/24
CPC分类号： A61K9/0004
摘要： An osmotic device (10) for delivering a beneficial drug, such as an anti-fungal, into the mouth of a human patient is disclosed. The device (10) has a size and shape adapting it to be comfortably retained in the mouth for extended periods of time. The device (10) comprises a wall (12) surrounding a compartment (13) housing a layer of an agent (14) that is insoluble to very soluble in aqueous biological fluids, e.g., saliva, and a layer (16) of a fluid swellable, hydrophilic polymer. A passageway (17) in the wall (12) connects the agent (14) with the exterior of the device (10). The wall (12) is permeable to the passage of aqueous biological fluid but substantially impermeable to the passage of the hydrophilic polymer (16). In one embodiment the beneficial agent (14) has a different color than the hydrophilic polymer (16). The wall (12) is sufficiently translucent to permit the patient to see the amount of drug/beneficial agent (14) remaining to be delivered. Marking lines (19) may be provided on the wall (12) indicating the amount of drug/agent (14) which has been delivered and/or the amount remaining to be delivered.
摘要翻译：公开了一种用于将有益药物（例如抗真菌）递送到人类患者的口中的渗透装置（10）。装置（10）具有适应其舒适地保持在口中长时间的尺寸和形状。装置（10）包括围绕隔室（13）的壁（12），该隔室（13）容纳不溶于非常可溶于水生物流体（例如唾液）的试剂（14）层，以及流体层可溶胀的亲水性聚合物。壁（12）中的通道（17）将试剂（14）与装置（10）的外部连接。所述壁（12）对于水性生物流体的通道是可渗透的，但是对于亲水性聚合物（16）的通过基本上是不透水的。在一个实施方案中，有益剂（14）具有与亲水性聚合物（16）不同的颜色。壁（12）是足够半透明的，以允许患者看到待传送的药物/有益剂（14）的量。标记线（19）可以设置在壁（12）上，指示已经被输送的药物/试剂（14）的量和/或剩余的待传送量。

5. 发明申请

US20050238709A1 Methods and devices for providing prolonged drug therapy 审中-公开
公开(公告)号：US20050238709A1
公开(公告)日：2005-10-27
申请号：US10639914
申请日：2003-08-12
申请人： Andrew Lam , Padmaja Shivanand , Atul Ayer , Zahedeh Hatamkhany , Suneel Gupta , Diane Guinta , Carol Christopher , Samuel Saks , Lawrence Hamel , Jeri Wright , Richard Weyers
发明人： Andrew Lam , Padmaja Shivanand , Atul Ayer , Zahedeh Hatamkhany , Suneel Gupta , Diane Guinta , Carol Christopher , Samuel Saks , Lawrence Hamel , Jeri Wright , Richard Weyers
IPC分类号： A61K9/00 , A61K9/20 , A61K9/24 , A61K9/50 , A61K9/70 , A61K31/00 , A61K31/137 , A61K31/421 , A61K31/4422 , A61K31/4458 , A61K31/445
CPC分类号： A61K9/2086 , A61K9/0002 , A61K9/0004 , A61K9/2072 , A61K9/209 , A61K9/5084 , A61K9/70 , A61K31/00 , A61K31/137 , A61K31/421 , A61K31/4422 , A61K31/4458
摘要： Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are provided. The dosage forms may additionally comprise an immediate-release dose of drug.

6. 发明申请

US20050025832A1 Methods and devices for providing prolonged drug therapy 有权
公开(公告)号：US20050025832A1
公开(公告)日：2005-02-03
申请号：US10639355
申请日：2003-08-12
申请人： Andrew Lam , Padmaja Shivanand , Atul Ayer , Zahedeh Hatamkhany , Suneel Gupta , Diane Guinta , Carol Christopher , Samuel Saks , Lawrence Hamel , Jeri Wright , Richard Weyers
发明人： Andrew Lam , Padmaja Shivanand , Atul Ayer , Zahedeh Hatamkhany , Suneel Gupta , Diane Guinta , Carol Christopher , Samuel Saks , Lawrence Hamel , Jeri Wright , Richard Weyers
IPC分类号： A61K9/00 , A61K9/20 , A61K9/24 , A61K9/50 , A61K9/70 , A61K31/00 , A61K31/137 , A61K31/421 , A61K31/4422 , A61K31/4458
CPC分类号： A61K9/2086 , A61K9/0002 , A61K9/0004 , A61K9/2072 , A61K9/209 , A61K9/5084 , A61K9/70 , A61K31/00 , A61K31/137 , A61K31/421 , A61K31/4422 , A61K31/4458
摘要： Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are provided. The dosage forms may additionally comprise an immediate-release dose of drug.

7. 发明申请

US20050025831A1 Methods and devices for providing prolonged drug therapy 审中-公开
公开(公告)号：US20050025831A1
公开(公告)日：2005-02-03
申请号：US10638977
申请日：2003-08-12
申请人： Andrew Lam , Padmaja Shivanand , Atul Ayer , Zahedeh Hatamkhany , Suneel Gupta , Diane Guinta , Carol Christopher , Samuel Saks , Lawrence Hamel , Jeri Wright , Richard Weyers
发明人： Andrew Lam , Padmaja Shivanand , Atul Ayer , Zahedeh Hatamkhany , Suneel Gupta , Diane Guinta , Carol Christopher , Samuel Saks , Lawrence Hamel , Jeri Wright , Richard Weyers
IPC分类号： A61K9/00 , A61K9/20 , A61K9/24 , A61K9/50 , A61K9/70 , A61K31/00 , A61K31/137 , A61K31/421 , A61K31/4422 , A61K31/4458
CPC分类号： A61K9/2086 , A61K9/0002 , A61K9/0004 , A61K9/2072 , A61K9/209 , A61K9/5084 , A61K9/70 , A61K31/00 , A61K31/137 , A61K31/421 , A61K31/4422 , A61K31/4458
摘要： Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are provided. The dosage forms may additionally comprise an immediate-release dose of drug.

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