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1. 发明授权

US08362281B2 Intermediates for hydroxylated contrast enhancement agents 有权
标题翻译：羟基化对比增强剂的中间体
公开(公告)号：US08362281B2
公开(公告)日：2013-01-29
申请号：US12751286
申请日：2010-03-31
申请人： Brian James Grimmond , Michael James Rishel , Rong Zhang
发明人： Brian James Grimmond , Michael James Rishel , Rong Zhang
IPC分类号： C07D319/08 , C07F9/40
CPC分类号： C07F9/091 , C07F9/4006 , C07F9/65522 , Y02P20/55
摘要： In one aspect, the present invention provides a protected ligand precursor having structure XX wherein R8 is independently at each occurrence a protected hydroxy group, a protected C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, and b is 0-4; R9-R11 are independently at each occurrence hydrogen, a protected C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, with the proviso that at least one of R8-R11 is a protected hydroxy group or a protected C1-C3 hydroxyalkyl group; and R12 and R13 are independently at each occurrence a protecting group is selected from the group consisting of C1-C30 aliphatic radicals, C3-C30 cycloaliphatic radicals, and C2-C30 aromatic radicals.
摘要翻译：一方面，本发明提供具有结构XX的保护配体前体，其中R8在每次出现时独立地为保护的羟基，受保护的C1-C3羟烷基或C1-C3烷基，b为0-4; R 9 -R 11在每次出现时独立地为氢，被保护的C 1 -C 3羟基烷基或C 1 -C 3烷基，条件是R 8 -R 11中的至少一个为保护的羟基或被保护的C 1 -C 3羟烷基 ; 并且R 12和R 13在每次出现时独立地为保护基团，选自C 1 -C 30脂族基，C 3 -C 30环脂族基和C 2 -C 30芳族基。

2. 发明申请

US20110245512A1 HYDROXYLATED CONTRAST ENHANCEMENT AGENTS 有权
标题翻译：羟基对比增强剂
公开(公告)号：US20110245512A1
公开(公告)日：2011-10-06
申请号：US12956629
申请日：2010-11-30
申请人： Brian James Grimmond , Michael James Rishel , Rong Zhang , Jeannette Christine DePuy
发明人： Brian James Grimmond , Michael James Rishel , Rong Zhang , Jeannette Christine DePuy
IPC分类号： C07F7/18 , C07F9/40 , C07F9/6596 , C07F9/6561 , C07F9/38
CPC分类号： A61K49/103 , C07F9/3808 , C07F9/4075 , C07F9/6552 , C07F9/65522 , C07F9/6596
摘要： In one aspect, the present invention provides a contrast enhancement agent comprising an iron chelate having structure I and salts thereof wherein R1 is independently at each occurrence a hydroxy group, a C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, and b is 0-4; R2-R7 are independently at each occurrence hydrogen, a C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, with the proviso that at least one of R1-R7 is a hydroxy group or a C1-C3 hydroxyalkyl group; and wherein Q is one or more charge balancing counterions. Also provided are a metal chelating ligand having structure IX and medical formulations comprising the contrast enhancement agent I.
摘要翻译：一方面，本发明提供一种对比度增强剂，其包含具有结构I的铁螯合物及其盐，其中R1在每次出现时独立地为羟基，C1-C3羟烷基或C1-C3烷基，b 是0-4; R2-R7各自独立地为氢，C1-C3羟基烷基或C1-C3烷基，条件是R1-R7中的至少一个为羟基或C1-C3羟烷基; 并且其中Q是一个或多个电荷平衡抗衡离子。还提供了具有结构IX的金属螯合配体和包含对比度增强剂I的医药制剂。

3. 发明授权

US08722020B2 Hydroxylated contrast enhancement agents 有权
标题翻译：羟基化对比增强剂
公开(公告)号：US08722020B2
公开(公告)日：2014-05-13
申请号：US12956629
申请日：2010-11-30
申请人： Brian James Grimmond , Michael James Rishel , Rong Zhang , Jeannette Christine DePuy
发明人： Brian James Grimmond , Michael James Rishel , Rong Zhang , Jeannette Christine DePuy
IPC分类号： A61B5/055 , C07F9/48 , C07D319/08
CPC分类号： A61K49/103 , C07F9/3808 , C07F9/4075 , C07F9/6552 , C07F9/65522 , C07F9/6596
摘要： In one aspect, the present invention provides a contrast enhancement agent comprising an iron chelate having structure I and salts thereof wherein R1 is independently at each occurrence a hydroxy group, a C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, and b is 0-4; R2-R7 are independently at each occurrence hydrogen, a C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, with the proviso that at least one of R1-R7 is a hydroxy group or a C1-C3 hydroxyalkyl group; and wherein Q is one or more charge balancing counterions. Also provided are a metal chelating ligand having structure IX and medical formulations comprising the contrast enhancement agent I.
摘要翻译：一方面，本发明提供一种对比度增强剂，其包含具有结构I的铁螯合物及其盐，其中R1在每次出现时独立地为羟基，C1-C3羟烷基或C1-C3烷基，b 是0-4; R2-R7各自独立地为氢，C1-C3羟基烷基或C1-C3烷基，条件是R1-R7中的至少一个为羟基或C1-C3羟烷基; 并且其中Q是一个或多个电荷平衡抗衡离子。还提供了具有结构IX的金属螯合配体和包含对比度增强剂I的医药制剂。

4. 发明申请

US20110243858A1 HYDROXYLATED CONTRAST ENHANCEMENT AGENTS AND IMAGING METHOD 有权
标题翻译：羟基对比增强剂和成像方法
公开(公告)号：US20110243858A1
公开(公告)日：2011-10-06
申请号：US13077746
申请日：2011-03-31
申请人： Brian James Grimmond , Michael James Rishel , Rong Zhang , Jeannette Christine Roberts
发明人： Brian James Grimmond , Michael James Rishel , Rong Zhang , Jeannette Christine Roberts
IPC分类号： A61K49/10 , A61K49/00 , A61P43/00
CPC分类号： A61K49/103
摘要： A method of diagnostic imaging is disclosed comprising administering a medical formulation to a subject, the formulation comprising a contrast enhancement agent having structure I and salts thereof wherein R1 is independently at each occurrence a hydroxy group, a C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, and b is 0-4; R2-R7 are independently at each occurrence hydrogen, a C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, with the proviso that at least one of R1-R7 is a hydroxy group or a C1-C3 hydroxyalkyl group; and wherein Q is one or more charge balancing counterions; and one or more pharmaceutically acceptable carriers and excipients. The subject is subjected to a diagnostic imaging technique such as magnetic resonance imaging. The technique may be used in a variety of diagnostic imaging regimes, such as imaging of circulatory systems, genitourinary systems, hepatobiliary systems, central nervous systems, tumors, and abscesses among others.
摘要翻译：公开了一种诊断成像方法，其包括向受试者施用药物制剂，所述制剂包含具有结构I的对比增强剂及其盐，其中R1在每次出现时独立地为羟基，C1-C3羟烷基或C1 -C 3烷基，b为0-4; R2-R7各自独立地为氢，C1-C3羟基烷基或C1-C3烷基，条件是R1-R7中的至少一个为羟基或C1-C3羟烷基; 并且其中Q是一个或多个电荷平衡抗衡离子; 和一种或多种药学上可接受的载体和赋形剂。对受试者进行诸如磁共振成像的诊断成像技术。该技术可用于各种诊断成像方案，例如循环系统的成像，泌尿生殖系统，肝胆系统，中枢神经系统，肿瘤和脓肿等。

5. 发明授权

US08765977B2 Hydroxylated contrast enhancement agents and imaging method 有权
标题翻译：羟基化对比增强剂和成像方法
公开(公告)号：US08765977B2
公开(公告)日：2014-07-01
申请号：US13077746
申请日：2011-03-31
申请人： Brian James Grimmond , Michael James Rishel , Rong Zhang , Jeannette Christine Roberts
发明人： Brian James Grimmond , Michael James Rishel , Rong Zhang , Jeannette Christine Roberts
IPC分类号： C07D319/08 , C07D309/30
CPC分类号： A61K49/103
摘要： A method of diagnostic imaging is disclosed comprising administering a medical formulation to a subject, the formulation comprising a contrast enhancement agent having structure I and salts thereof wherein R1 is independently at each occurrence a hydroxy group, a C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, and b is 0-4; R2-R7 are independently at each occurrence hydrogen, a C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, with the proviso that at least one of R1-R7 is a hydroxy group or a C1-C3 hydroxyalkyl group; and wherein Q is one or more charge balancing counterions; and one or more pharmaceutically acceptable carriers and excipients. The subject is subjected to a diagnostic imaging technique such as magnetic resonance imaging. The technique may be used in a variety of diagnostic imaging regimes, such as imaging of circulatory systems, genitourinary systems, hepatobiliary systems, central nervous systems, tumors, and abscesses among others.
摘要翻译：公开了一种诊断成像方法，其包括向受试者施用药物制剂，所述制剂包含具有结构I的对比增强剂及其盐，其中R1在每次出现时独立地为羟基，C1-C3羟烷基或C1 -C 3烷基，b为0-4; R2-R7各自独立地为氢，C1-C3羟基烷基或C1-C3烷基，条件是R1-R7中的至少一个为羟基或C1-C3羟烷基; 并且其中Q是一个或多个电荷平衡抗衡离子; 和一种或多种药学上可接受的载体和赋形剂。对受试者进行诸如磁共振成像的诊断成像技术。该技术可用于各种诊断成像方案，例如循环系统的成像，泌尿生殖系统，肝胆系统，中枢神经系统，肿瘤和脓肿等。

6. 发明申请

US20110245511A1 Intermediates for Hydroxylated Contrast Enhancement Agents 有权
标题翻译：羟基对比增强剂中间体
公开(公告)号：US20110245511A1
公开(公告)日：2011-10-06
申请号：US12751286
申请日：2010-03-31
申请人： Brian James Grimmond , Michael James Rishel , Rong Zhang
发明人： Brian James Grimmond , Michael James Rishel , Rong Zhang
IPC分类号： C07F9/40 , C07F7/10 , C07F9/38 , C07F7/18
CPC分类号： C07F9/091 , C07F9/4006 , C07F9/65522 , Y02P20/55
摘要： In one aspect, the present invention provides a protected ligand precursor having structure XX wherein R8 is independently at each occurrence a protected hydroxy group, a protected C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, and b is 0-4; R9-R11 are independently at each occurrence hydrogen, a protected C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, with the proviso that at least one of R8-R11 is a protected hydroxy group or a protected C1-C3 hydroxyalkyl group; and R12 and R13 are independently at each occurrence a protecting group is selected from the group consisting of C1-C30 aliphatic radicals, C3-C30 cycloaliphatic radicals, and C2-C30 aromatic radicals.
摘要翻译：一方面，本发明提供具有结构XX的保护配体前体，其中R8在每次出现时独立地为保护的羟基，受保护的C1-C3羟烷基或C1-C3烷基，b为0-4; R 9 -R 11在每次出现时独立地为氢，被保护的C 1 -C 3羟基烷基或C 1 -C 3烷基，条件是R 8 -R 11中的至少一个为被保护的羟基或被保护的C 1 -C 3羟烷基 ; 并且R 12和R 13在每次出现时独立地为保护基团，选自C 1 -C 30脂族基，C 3 -C 30环脂族基和C 2 -C 30芳族基。

7. 外观设计

USD952560S1 Waterproof battery box 有权
公开(公告)号：USD952560S1
公开(公告)日：2022-05-24
申请号：US29759923
申请日：2020-11-25
申请人： Rong Zhang
设计人： Rong Zhang

8. 发明申请

US20180152478A1 SYSTEMS AND METHODS FOR GENERATION AND SELECTION OF ACCESS RULES 审中-公开
公开(公告)号：US20180152478A1
公开(公告)日：2018-05-31
申请号：US15365389
申请日：2016-11-30
申请人： Haochuan Zhou , Hung-Tzaw Hu , Rong Zhang , Benjamin Scott Boding
发明人： Haochuan Zhou , Hung-Tzaw Hu , Rong Zhang , Benjamin Scott Boding
IPC分类号： H04L29/06
CPC分类号： H04L63/20 , H04L63/0263 , H04L63/10
摘要： A resource security system may generate access rules for use in determining whether to grant or deny a request for access to a resource. In order to generate the access rules, the resource security system may select certain access request parameters and determine conditions associated with those parameters. The resource security system may generate mutually exclusive segments associated with a condition of each of the parameters. The resource security system may generate independent access rules based on the segments. The resource security system may then evaluate the performance of each of the access rules based on validity information corresponding to previously received access requests that satisfy the conditions of a particular access rule.

9. 发明授权

US09612059B2 Systems and methods of thermal transfer and/or storage 有权
公开(公告)号：US09612059B2
公开(公告)日：2017-04-04
申请号：US12885411
申请日：2010-09-17
申请人： XiaoDong Xiang , Rong Zhang
发明人： XiaoDong Xiang , Rong Zhang
IPC分类号： F28D15/00 , F28D15/02 , C09K5/06 , C09K5/10 , C09K5/12 , F01K3/00 , F24H7/04 , F28D20/00 , F28D20/02
CPC分类号： F28D15/02 , C09K5/063 , C09K5/10 , C09K5/12 , F01K3/004 , F01K3/008 , F24D2220/10 , F24H7/0433 , F24H2240/127 , F28D20/00 , F28D20/02 , F28D20/023 , F28D20/026 , F28D20/028 , F28D2020/0021 , F28D2020/0047 , F28D2020/006 , F28D2020/0082 , F28F2265/26 , Y02B10/20 , Y02E60/142 , Y02E60/145
摘要： Systems, methods, and computer-implemented embodiments consistent with the inventions herein are directed to storing and/or transferring heat. In one exemplary implementation, there is provided a system for transferring/storing heat comprised of a heat exchange/storage apparatus including a chamber, and a heat input device adapted to heat/provide a vapor into the chamber. Other exemplary implementations may include one or more features consistent with a heat output device through which a working medium/fluid passes, a thermal storage medium located within the chamber, and/or a heat exchange system that delivers a heat exchange medium/fluid to the thermal storage medium.

10. 发明授权

US09431592B2 Submount with cavities and through vias for LED packaging 有权
标题翻译：底座带有空腔和通孔，用于LED封装
公开(公告)号：US09431592B2
公开(公告)日：2016-08-30
申请号：US14122929
申请日：2012-06-01
申请人： Shi-Wei Lee , Rong Zhang
发明人： Shi-Wei Lee , Rong Zhang
IPC分类号： H01L21/00 , H01L33/62 , H01L23/00 , H01L25/075 , H01L33/50
CPC分类号： H01L33/62 , H01L24/16 , H01L25/075 , H01L33/502 , H01L2224/16 , H01L2224/16145 , H01L2224/48091 , H01L2224/48247 , H01L2224/48465 , H01L2924/01029 , H01L2924/10253 , H01L2924/12041 , H01L2933/0033 , H01L2924/00012 , H01L2924/00 , H01L2924/00014
摘要： A wafer having a plurality of light-emitting diode (LED) submounts and a method for fabricating an LED submount are provided. Each of the plurality of LED submounts of the wafer includes: a substrate (201), including through vias (203a); an LED die (208) mounted in a cavity (204) on a first side of the substrate (201) and connected to the through vias (203a); a redistribution layer (205a) attached to a second side of the substrate (201) connected to the LED die (208) through the through vias (203a). The method includes providing a wafer as a substrate (201); providing a cavity (204) in the substrate (201) on a first side of the substrate (201); providing through vias (203a) in the substrate (201), providing a redistribution layer (205a) on the second side of the substrate (201), and mounting an LED (208) in the cavity (204), wherein the LED die (208) is connected to the redistribution layer (205a) through the through vias (203a).
摘要翻译：提供具有多个发光二极管（LED）底座的晶片和制造LED基座的方法。晶片的多个LED基座中的每一个包括：包括通孔（203a）的衬底（201）; 安装在基板（201）的第一侧上的空腔（204）中并连接到通孔（203a）的LED管芯（208）; 通过通孔（203a）连接到连接到LED管芯（208）的衬底（201）的第二侧的再分布层（205a）。该方法包括提供晶片作为衬底（201）; 在衬底（201）的第一侧上在衬底（201）中提供腔（204）; 通过所述衬底（201）中的通孔（203a）提供，在所述衬底（201）的第二侧上提供再分配层（205a），以及将LED（208）安装在所述空腔（204）中，其中所述LED管芯 208）通过通孔（203a）连接到再分配层（205a）。

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