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1. 发明授权

US08338088B2 Methods related to cell surface glycosylation 有权
标题翻译：与细胞表面糖基化有关的方法
公开(公告)号：US08338088B2
公开(公告)日：2012-12-25
申请号：US12595902
申请日：2008-04-15
申请人： Brian Edward Collins , Carlos J. Bosques , Xiangping Zhu , Dorota A. Bulik , Lakshmanan Thiruneelakantapillai , Ian Christopher Parsons , Zachary Shriver , Rajeev Chillakuru , Ganesh Venkataraman
发明人： Brian Edward Collins , Carlos J. Bosques , Xiangping Zhu , Dorota A. Bulik , Lakshmanan Thiruneelakantapillai , Ian Christopher Parsons , Zachary Shriver , Rajeev Chillakuru , Ganesh Venkataraman
IPC分类号： C12Q1/00
CPC分类号： G01N33/5308 , G01N2400/00
摘要： The present disclosure provides methods for assessing the glycosylation of a target glycoprotein produced by a cell through analysis of cell-surface glycans on the cell. The present disclosure therefore teaches that glycosylation of cell surface proteins can serve as a proxy for glycosylation of other proteins.
摘要翻译：本公开提供了通过分析细胞上的细胞表面聚糖来评估由细胞产生的目标糖蛋白的糖基化的方法。因此，本发明公开了细胞表面蛋白的糖基化可以作为其他蛋白质糖基化的代用物。

2. 发明申请

US20100196940A1 METHODS RELATED TO CELL SURFACE GLYCOSYLATION 有权
标题翻译：与细胞表面糖化相关的方法
公开(公告)号：US20100196940A1
公开(公告)日：2010-08-05
申请号：US12595902
申请日：2008-04-15
申请人： Brian Edward Collins , Carlos J. Bosques , Xiangping Zhu , Dorota A. Bulik , Lakshmanan Thiruneelakantapillai , Ian Christopher Parsons , Zachary Shriver , Rajeev Chillakuru , Ganesh Venkataraman
发明人： Brian Edward Collins , Carlos J. Bosques , Xiangping Zhu , Dorota A. Bulik , Lakshmanan Thiruneelakantapillai , Ian Christopher Parsons , Zachary Shriver , Rajeev Chillakuru , Ganesh Venkataraman
IPC分类号： C12Q1/02 , C12Q1/37
CPC分类号： G01N33/5308 , G01N2400/00
摘要： The present disclosure provides methods for assessing the glycosylation of a target glycoprotein produced by a cell through analysis of cell-surface glycans on the cell. The present disclosure therefore teaches that glycosylation of cell surface proteins can serve as a proxy for glycosylation of other proteins.
摘要翻译：本公开提供了通过分析细胞上的细胞表面聚糖来评估由细胞产生的目标糖蛋白的糖基化的方法。因此，本发明公开了细胞表面蛋白的糖基化可以作为其他蛋白质糖基化的代用物。

3. 发明申请

US20100113294A1 DEFINED GLYCOPROTEIN PRODUCTS AND RELATED METHODS 审中-公开
标题翻译：定义的GLYCOPROTEIN产品及相关方法
公开(公告)号：US20100113294A1
公开(公告)日：2010-05-06
申请号：US12596171
申请日：2008-04-15
申请人： Ganesh Venkataraman , Brian Edward Collins , Carlos J. Bosques , Lakshmanan Thiruneelakantapillai , Dorota A. Bulik , Ian Christopher Parsons , Zachary Shriver , Rajeev Chillakuru
发明人： Ganesh Venkataraman , Brian Edward Collins , Carlos J. Bosques , Lakshmanan Thiruneelakantapillai , Dorota A. Bulik , Ian Christopher Parsons , Zachary Shriver , Rajeev Chillakuru
IPC分类号： C40B30/02 , C40B40/10
CPC分类号： C12P21/005 , G16B50/00
摘要： The invention provides methods, databases and systems for making glycoprotein products having defined properties.
摘要翻译：本发明提供了制备具有确定特性的糖蛋白产物的方法，数据库和系统。

4. 发明授权

US08470603B2 Methods of evaluating diethylamide in glatiramer acetate 有权
标题翻译：醋酸格拉默的二乙胺评估方法
公开(公告)号：US08470603B2
公开(公告)日：2013-06-25
申请号：US12298591
申请日：2007-04-30
申请人： Zachary Shriver , Ganesh Venkataraman , Jonathan Lansing , Corinne Bauer , Xiangping Zhu
发明人： Zachary Shriver , Ganesh Venkataraman , Jonathan Lansing , Corinne Bauer , Xiangping Zhu
IPC分类号： G01N24/08 , A61K38/00
CPC分类号： G01N33/9493 , A61K38/02 , G01N33/15 , G01N33/68 , G01N33/6806 , G01N33/6821 , G01N33/6848 , Y10T436/24 , Y10T436/25125
摘要： The presently disclosed subject matter provides methods for evaluating and characterizing peptides, peptide mixtures, and polypeptide mixtures. More particularly, the presently disclosed subject matter provides methods for evaluating or characterizing complex peptide or polypeptide mixtures comprising glutamic acid, alanine, tyrosine, and lysine, e.g., Copolymer-1 or glatiramer acetate, including, but not limited to, methods of identifying, isolating, quantifying, and purifying amino acids, peptides, polypeptides, and combinations thereof having a diethylamide group instead of a carboxyl group present on the C-terminus. The presently disclosed methods can be used to determine the mole percent of polypeptides having a diethylamide group at a C-terminus thereof and can be used to evaluate one or more properties of a sample of one polypeptide mixture as compared to one or more properties of a different sample of a polypeptide mixture.
摘要翻译：目前公开的主题提供了用于评估和表征肽，肽混合物和多肽混合物的方法。更具体地，本发明公开的主题提供了用于评估或表征包含谷氨酸，丙氨酸，酪氨酸和赖氨酸的复合肽或多肽混合物的方法，例如共聚物-1或乙酸格拉默，包括但不限于鉴定，分离，定量和纯化具有二乙基酰胺基团而不是C末端存在的羧基的氨基酸，肽，多肽及其组合。目前公开的方法可以用于确定在C末端具有二乙酰胺基团的多肽的摩尔百分比，并且可以用于评估一种多肽混合物的样品的一种或多种性质，与一种或多种性质的不同样品的多肽混合物。

5. 发明授权

US09103821B2 Methods related to modified glycans 有权
标题翻译：与改性聚糖相关的方法
公开(公告)号：US09103821B2
公开(公告)日：2015-08-11
申请号：US13140553
申请日：2009-12-18
申请人： Carlos J. Bosques , Jennifer Lynn Murphy , Sibel Nur Gunay , Zachary Shriver , Cuihua Liu
发明人： Carlos J. Bosques , Jennifer Lynn Murphy , Sibel Nur Gunay , Zachary Shriver , Cuihua Liu
IPC分类号： G01N33/50 , G01N33/52 , C12Q1/34 , G01N33/53
CPC分类号： G01N33/5308 , C12Q1/34 , G01N33/50 , G01N33/52 , G01N2400/38
摘要： Among other things, the present disclosure provides methods for enriching, identifying, and/or quantifying unusually modified glycans (e.g., phosphorylated glycans, sulfated glycans, and/or multi-acetylated glycans). In many embodiments, methods comprise providing a glycan preparation from which sialic acids have been released; subjecting the sialidase-treated glycan preparation to a separation technique that separates glycans based on charge-to-mass ratio; and quantifying the charged products using at least one quantification standard.
摘要翻译：除其他之外，本公开提供了用于富集，鉴定和/或定量异常修饰的聚糖（例如磷酸化聚糖，硫酸化聚糖和/或多乙酰化聚糖）的方法。在许多实施方案中，方法包括提供已经从其释放唾液酸的聚糖制剂; 将经唾液酸酶处理的聚糖制剂进行基于电荷与质量比的分离聚糖的分离技术; 并使用至少一个定量标准量化带电产物。

6. 发明申请

US20110306075A1 METHODS RELATED TO MODIFIED GLYCANS 有权
标题翻译：与修饰的甘蓝相关的方法
公开(公告)号：US20110306075A1
公开(公告)日：2011-12-15
申请号：US13140553
申请日：2009-12-18
申请人： Carlos J. Bosques , Jennifer Lynn Murphy , Sibel Nur Gunay , Zachary Shriver
发明人： Carlos J. Bosques , Jennifer Lynn Murphy , Sibel Nur Gunay , Zachary Shriver
IPC分类号： C12Q1/34
CPC分类号： G01N33/5308 , C12Q1/34 , G01N33/50 , G01N33/52 , G01N2400/38
摘要： Among other things, the present disclosure provides methods for enriching, identifying, and/or quantifying unusually modified glycans (e.g., phosphorylated glycans, sulfated glycans, and/or multi-acetylated glycans). In many embodiments, methods comprise providing a glycan preparation from which sialic acids have been released; subjecting the sialidase-treated glycan preparation to a separation technique that separates glycans based on charge-to-mass ratio; and quantifying the charged products using at least one quantification standard.
摘要翻译：除其他之外，本公开提供了用于富集，鉴定和/或定量异常修饰的聚糖（例如磷酸化聚糖，硫酸化聚糖和/或多乙酰化聚糖）的方法。在许多实施方案中，方法包括提供已经释放唾液酸的聚糖制剂; 将经唾液酸酶处理的聚糖制剂进行基于电荷与质量比的分离聚糖的分离技术; 并使用至少一个定量标准量化带电产物。

7. 发明授权

US08512969B2 Methods for analyzing a heparin sample 有权
标题翻译：分析肝素样品的方法
公开(公告)号：US08512969B2
公开(公告)日：2013-08-20
申请号：US13465639
申请日：2012-05-07
申请人： Ram Sasisekharan , Ganesh Venkataraman , Zachary Shriver , Dongfang Liu , Mallikarjun Sundaram , Yiwei Qi
发明人： Ram Sasisekharan , Ganesh Venkataraman , Zachary Shriver , Dongfang Liu , Mallikarjun Sundaram , Yiwei Qi
IPC分类号： A61K31/727
CPC分类号： G01N33/66 , A61K31/727 , C08B37/0075 , C12P19/26 , G01N33/86 , G01N2400/10 , G01N2400/40 , Y10T436/143333
摘要： The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
摘要翻译：本发明涉及用于表征和使用多糖的方法和产品。描述了低分子量肝素产品和使用方法。还描述了表征包括糖胺聚糖如肝素的多糖制剂的纯度和活性的方法。

8. 发明申请

US20100129868A1 DELTA 4,5 GLYCURONIDASE COMPOSITIONS AND METHODS RELATED THERETO 有权
标题翻译： DELTA 4,5 GLYCURONIDASE组合物及其相关方法
公开(公告)号：US20100129868A1
公开(公告)日：2010-05-27
申请号：US12616764
申请日：2009-11-11
申请人： James R. Myette , Zachary Shriver , Ganesh Venkataraman , Ram Sasisekharan , Maitland W. McLean
发明人： James R. Myette , Zachary Shriver , Ganesh Venkataraman , Ram Sasisekharan , Maitland W. McLean
IPC分类号： C12P21/06
CPC分类号： C12Y302/01056 , A61K38/00 , C07H21/04 , C12N9/2402 , C12Q1/34 , C12Y302/01166 , Y02A50/481
摘要： The invention relates to Δ4,5 glycuronidase, related compositions, and methods of use thereof.
摘要翻译：本发明涉及＆amp; 4,5g糖醛酸糖苷酶，相关组合物及其使用方法。

9. 发明授权

US07429474B2 2-O sulfatase compositions and methods of analyzing therewith 有权
标题翻译： 2-O硫酸酯酶组合物及其分析方法
公开(公告)号：US07429474B2
公开(公告)日：2008-09-30
申请号：US11433228
申请日：2006-05-11
申请人： Ram Sasisekharan , James R. Myette , Zachary Shriver , Ganesh Venkataraman
发明人： Ram Sasisekharan , James R. Myette , Zachary Shriver , Ganesh Venkataraman
IPC分类号： C12N9/16
CPC分类号： C12N9/16 , A61K38/00 , C12P19/04 , G01N33/5041 , G01N2400/40
摘要： The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode these molecules. The invention also provides methods of using 2-O sulfatase for a variety of purposes, including degrading and analyzing glycosaminoglycans (GAGs) present in a sample. For instance, 2-O sulfatase may be used for determining the purity, identity, composition and sequence of glycosaminoglycans present in a sample. The invention also relates to methods of inhibiting angiogenesis and cellular proliferation as well as methods for treating cancer, neurodegenerative disease, atherosclerosis and microbial infection using 2-O sulfatase and/or GAG fragments produced by degradation with 2-O sulfatase.
摘要翻译：本发明涉及2-O硫酸酯酶及其用途。特别地，本发明涉及编码这些分子的重组产生的2-O硫酸酯酶，功能变体和核酸分子。本发明还提供了用于各种目的的2-O硫酸酯酶的方法，包括降解和分析样品中存在的糖胺聚糖（GAG）。例如，2-O硫酸酯酶可用于测定样品中存在的糖胺聚糖的纯度，同一性，组成和顺序。本发明还涉及抑制血管生成和细胞增殖的方法以及使用2-O硫酸酯酶降解产生的2- O硫酸酯酶和/或GAG片段来治疗癌症，神经变性疾病，动脉粥样硬化和微生物感染的方法。

10. 发明授权

US07412332B1 Method for analyzing polysaccharides 有权
标题翻译：多糖分析方法
公开(公告)号：US07412332B1
公开(公告)日：2008-08-12
申请号：US09557997
申请日：2000-04-24
申请人： Ganesh Venkataraman , Zachary Shriver , Rahul Raman , Ram Sasisekharan , Nishla Keiser
发明人： Ganesh Venkataraman , Zachary Shriver , Rahul Raman , Ram Sasisekharan , Nishla Keiser
IPC分类号： G06F19/00
CPC分类号： G06F19/703 , C07K1/00 , G06F19/28 , Y10S707/99936 , Y10S707/99943
摘要： A data structure, tangibly embodied in a computer-readable medium, representing a polymer of chemical units is disclosed. The data structure includes an identifier including a plurality of fields for storing values corresponding to properties of the polymer. The polymer may, for example, be a polysaccharide and the chemical units may be saccharides. Also disclosed is a computer-implemented method for determining whether properties of a query sequence of chemical units match properties of a polymer of chemical units. The query sequence is represented by a first data structure, and the polymer is represented by a second data structure, each are tangibly embodied in a computer-readable medium, including an identifier including a plurality of bit fields for storing values corresponding to properties of the query sequence and polymer, respectively. The invention also involves a notational system referred to as Property Encoded Nomenclature.
摘要翻译：公开了一种有形地体现在表示化学单元的聚合物的计算机可读介质中的数据结构。数据结构包括标识符，其包括用于存储与聚合物的性质对应的值的多个场。聚合物可以是例如多糖，化学单元可以是糖。还公开了一种用于确定化学单元的查询序列的属性是否与化学单元的聚合物的性质匹配的计算机实现的方法。查询序列由第一数据结构表示，并且聚合物由第二数据结构表示，每个数据结构都有形地体现在计算机可读介质中，包括包括多个位字段的标识符，用于存储对应于查询序列和聚合物。本发明还涉及称为属性编码术语的符号系统。

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