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1. 发明授权

US08802388B2 Detergent compositions containing Bacillus agaradhaerens mannanase and methods of use thereof 有权
标题翻译：含有琼脂糖琼脂糖甘露聚糖酶的洗涤剂组合物及其使用方法
公开(公告)号：US08802388B2
公开(公告)日：2014-08-12
申请号：US14114709
申请日：2012-04-27
申请人： Brian E. Jones , Marc Kolkman , Zhen Qian , Brian Sogaard Laursen , Karsten M. Kragh , Sina Pricelius , Zheyong Yu , Lilia Maria Babe , Melodie Estabrook
发明人： Brian E. Jones , Marc Kolkman , Zhen Qian , Brian Sogaard Laursen , Karsten M. Kragh , Sina Pricelius , Zheyong Yu , Lilia Maria Babe , Melodie Estabrook
IPC分类号： C12Q1/34 , C12N9/24 , C07K1/00
CPC分类号： C12N9/2494 , A23K10/14 , A23K20/189 , A23K50/10 , A23K50/30 , A23K50/60 , A23K50/75 , A23K50/80 , C07K14/435 , C11D3/38636 , C12C5/004 , C12N9/2491 , C12Y302/01078 , Y02A40/818
摘要： The present compositions and methods relate to an endo-β-mannanase cloned from Bacillus agaradhaerens, polynucleotides encoding the endo-β-mannanase, and methods of use thereof. Formulations containing the endo-β-mannanase are highly suitable for use as detergents.
摘要翻译：本发明的组合物和方法涉及从琼脂琼脂糖芽孢杆菌克隆的内切 - 甘露聚糖酶，编码内切 - 甘露聚糖酶的多核苷酸及其使用方法。含有内含物 - 甘露聚糖酶的制剂非常适合用作洗涤剂。

2. 发明申请

US20140135252A1 DETERGENT COMPOSITIONS CONTAINING GEOBACILLUS TEPIDAMANS MANNANASE AND METHODS OF USE THEREOF 审中-公开
标题翻译：含有GEOBACILLUS TEPIDAMANS MANNANASE的洗涤剂组合物及其使用方法
公开(公告)号：US20140135252A1
公开(公告)日：2014-05-15
申请号：US14114711
申请日：2012-04-27
申请人： Brian E. Jones , Marc Kolkman , Zhen Qian , Brian Sogaard Laursen , Karsten M. Kragh , Sina Pricelius , Zheyong Yu , Lilia Maria Babe , Melodie Estabrook , Ling Hua
发明人： Brian E. Jones , Marc Kolkman , Zhen Qian , Brian Sogaard Laursen , Karsten M. Kragh , Sina Pricelius , Zheyong Yu , Lilia Maria Babe , Melodie Estabrook , Ling Hua
IPC分类号： C11D3/386 , C12N9/24
CPC分类号： C11D3/38636 , A23K10/14 , A23K20/189 , C12C5/004 , C12N9/2402 , C12N9/2494 , C12Y302/01078
摘要： The present compositions and methods relate to an endo-B-mannanase cloned from Geobacillus tepidamans, polynucleotides encoding the endo-B-mannanase, and methods of use thereof. Formulations containing the endo-β-mannanase are highly suitable for use as detergents.
摘要翻译：本发明的组合物和方法涉及从地热芽孢杆菌Tepidamans克隆的内切-B-甘露聚糖酶，编码内切-B-甘露聚糖酶的多核苷酸及其使用方法。含有内含物 - 甘露聚糖酶的制剂非常适合用作洗涤剂。

3. 发明申请

US20140073548A1 DETERGENT COMPOSITIONS CONTAINING BACILLUS SP. MANNANASE AND METHODS OF USE THEREOF 审中-公开
标题翻译：含有BACILLUS SP的洗涤剂组合物曼尼诺酶及其使用方法
公开(公告)号：US20140073548A1
公开(公告)日：2014-03-13
申请号：US14114720
申请日：2012-04-27
申请人： Brian E. Jones , Marc Kolkman , Zhen Qian , Brian Sogaard Laursen , Karsten M. Kragh , Sina Pricelius , Zheyong Yu , Lilia Maria Babe , Melodie Estabrook , Ling Hua
发明人： Brian E. Jones , Marc Kolkman , Zhen Qian , Brian Sogaard Laursen , Karsten M. Kragh , Sina Pricelius , Zheyong Yu , Lilia Maria Babe , Melodie Estabrook , Ling Hua
IPC分类号： C11D3/386 , C12N9/24
CPC分类号： C11D3/38636 , C12C5/004 , C12N9/2405 , C12N9/2491 , C12N9/2494 , C12Y302/01078
摘要： The present compositions and methods relate to an endo-B-mannanase cloned from a Bacillus sp., polynucleotides encoding the endo-B-mannanase, and methods of use thereof. Formulations containing the endo-β-mannanase are highly suitable for use as detergents.
摘要翻译：本发明的组合物和方法涉及从Bacillus sp。，编码内切-B-甘露聚糖酶的多核苷酸克隆的内切-B-甘露聚糖酶及其使用方法。含有β-内酰基β-甘露聚糖酶的制剂非常适合用作洗涤剂。

4. 发明申请

US20140073030A1 DETERGENT COMPOSITIONS CONTAINING BACILLUS AGARADHAERENS MANNANASE AND METHODS OF USE THEREOF 有权
标题翻译：含有BACILUS AGARADHAERENS MANNANASE的洗涤剂组合物及其使用方法
公开(公告)号：US20140073030A1
公开(公告)日：2014-03-13
申请号：US14114709
申请日：2012-04-27
申请人： Brian E. Jones , Marc Kolkman , Zhen Qian , Brian Sogaard Laursen , Karsten M. Kragh , Sina Pricelius , Zheyong Yu , Lilian Maria Babe , Melodie Estabrook
发明人： Brian E. Jones , Marc Kolkman , Zhen Qian , Brian Sogaard Laursen , Karsten M. Kragh , Sina Pricelius , Zheyong Yu , Lilian Maria Babe , Melodie Estabrook
IPC分类号： C11D3/386 , C12N9/24
CPC分类号： C12N9/2494 , A23K10/14 , A23K20/189 , A23K50/10 , A23K50/30 , A23K50/60 , A23K50/75 , A23K50/80 , C07K14/435 , C11D3/38636 , C12C5/004 , C12N9/2491 , C12Y302/01078 , Y02A40/818
摘要： The present compositions and methods relate to an endo-β-mannanase cloned from Bacillus agaradhaerens, polynucleotides encoding the endo-β-mannanase, and methods of use thereof. Formulations containing the endo-β-mannanase are highly suitable for use as detergents.
摘要翻译：本发明的组合物和方法涉及从琼脂琼脂琼脂（Bacillus agaradhaerens）克隆的内切β-甘露聚糖酶，编码内切β-甘露聚糖酶的多核苷酸及其使用方法。含有β-内酰基β-甘露聚糖酶的制剂非常适合用作洗涤剂。

5. 发明授权

US07871637B2 Dry hemostatic compositions and methods for their preparation 有权
标题翻译：干燥止血组合物及其制备方法
公开(公告)号：US07871637B2
公开(公告)日：2011-01-18
申请号：US11859312
申请日：2007-09-21
申请人： Zhen Qian , A. Edward Osawa , Cary J. Reich , Donald G. Wallace , Narinder S. Shargill , Felix Vega
发明人： Zhen Qian , A. Edward Osawa , Cary J. Reich , Donald G. Wallace , Narinder S. Shargill , Felix Vega
IPC分类号： A61F13/00 , A61F2/00
CPC分类号： A61L24/0031 , A61L24/043 , A61L24/104 , A61L2400/04 , C08L89/00
摘要： Dry cross-linked gelatin compositions are prepared that rapidly re-hydrate to produce gelatin hydrogels suitable as hemostatic sealants. Gelatin is cross-linked in the presence of certain re-hydration aids, such as polyethylene glycol, polyvinylprovidone, and dextran, in order to produce a dry cross-linked gelatin powder. The use of the re-hydration aids has been found to substantially increase the re-hydration rate in the presence of an aqueous re-hydration medium, typically thrombin-containing saline.
摘要翻译：制备干燥的交联明胶组合物，其快速再水化以产生适合作为止血密封剂的明胶水凝胶。在某些再水化助剂如聚乙二醇，聚乙烯基丙基吡咯烷酮和葡聚糖存在下，明胶是交联的，以产生干燥的交联明胶粉末。已经发现使用再水合助剂在含水的再水合介质（通常为含有凝血酶的盐水）的存在下显着增加再水合速率。

6. 发明申请

US20080003619A1 NOVEL PROTEINS WITH ENHANCED FUNCTIONALITY AND METHODS OF MAKING NOVEL PROTEINS USING CIRCULAR PERMUTATION 有权
标题翻译：具有增强功能的新蛋白质和使用圆形透明制备新蛋白质的方法
公开(公告)号：US20080003619A1
公开(公告)日：2008-01-03
申请号：US11776281
申请日：2007-07-11
申请人： Stefan Lutz , Zhen Qian
发明人： Stefan Lutz , Zhen Qian
IPC分类号： G01N33/573 , C07H21/04 , C07K14/00 , C12N9/00 , C12N9/14
CPC分类号： C12P21/00 , C12N9/20
摘要： The present disclosure is relates to novel proteins and peptides having novel and/or enhanced functions and/or behaviors with respect to a native protein or peptide, and methods of making the novel proteins and peptides using techniques of circular permutation and protein engineering.
摘要翻译：本公开涉及具有关于天然蛋白质或肽的新颖和/或增强的功能和/或行为的新型蛋白质和肽以及使用循环置换和蛋白质工程技术制备新型蛋白质和肽的方法。

7. 发明授权

US08092820B2 Dry hemostatic compositions and methods for their preparation 有权
标题翻译：干燥止血组合物及其制备方法
公开(公告)号：US08092820B2
公开(公告)日：2012-01-10
申请号：US12468316
申请日：2009-05-19
申请人： Zhen Qian , A. Edward Osawa , Cary J. Reich
发明人： Zhen Qian , A. Edward Osawa , Cary J. Reich
IPC分类号： A61F13/00 , A61F2/00 , A61K9/14 , A61K9/50
CPC分类号： A61K38/4833 , A61L24/0031 , A61L24/104 , A61L2400/04
摘要： Dry cross-linked gelatin compositions are prepared that rapidly re-hydrate to produce gelatin hydrogels suitable as hemostatic sealants. Gelatin is cross-linked in the presence of certain re-hydration aids, such as polyethylene glycol, polyvinylprovidone, and dextran, in order to produce a dry cross-linked gelatin powder. The use of the re-hydration aids has been found to substantially increase the re-hydration rate in the presence of an aqueous re-hydration medium, typically thrombin-containing saline.
摘要翻译：制备干燥的交联明胶组合物，其快速再水化以产生适合作为止血密封剂的明胶水凝胶。在某些再水化助剂如聚乙二醇，聚乙烯基丙基吡咯烷酮和葡聚糖存在下，明胶是交联的，以产生干燥的交联明胶粉末。已经发现使用再水合助剂在含水的再水合介质（通常为含有凝血酶的盐水）的存在下显着增加再水合速率。

8. 发明申请

US20080286376A1 DRY HEMOSTATIC COMPOSITIONS AND METHODS FOR THEIR PREPARATION 有权
公开(公告)号：US20080286376A1
公开(公告)日：2008-11-20
申请号：US12176945
申请日：2008-07-21
申请人： Zhen Qian , A. Edward Osawa , Cary J. Reich
发明人： Zhen Qian , A. Edward Osawa , Cary J. Reich
IPC分类号： A61K9/14 , A61K38/16 , A61P7/04
CPC分类号： A61K38/4833 , A61L24/0031 , A61L24/104 , A61L2400/04
摘要： Dry cross-linked gelatin compositions are prepared that rapidly re-hydrate to produce gelatin hydrogels suitable as hemostatic sealants. Gelatin is cross-linked in the presence of certain re-hydration aids, such as polyethylene glycol, polyvinylprovidone, and dextran, in order to produce a dry cross-linked gelatin powder. The use of the re-hydration aids has been found to substantially increase the re-hydration rate in the presence of an aqueous re-hydration medium, typically thrombin-containing saline.

9. 发明申请

US20080187202A1 3D Segmentation of the Colon in MR Colonography 有权
标题翻译： MR结肠镜中结肠的3D分割
公开(公告)号：US20080187202A1
公开(公告)日：2008-08-07
申请号：US12026002
申请日：2008-02-05
申请人： Zhen Qian , Matthias Wolf , Luca Bogoni
发明人： Zhen Qian , Matthias Wolf , Luca Bogoni
IPC分类号： A61B5/00
CPC分类号： G06T7/0012 , G06T7/12 , G06T7/149 , G06T2207/10088 , G06T2207/20101 , G06T2207/20116 , G06T2207/20168 , G06T2207/30032 , Y10S128/922
摘要： A method for segmenting a tubular structure includes providing a three-dimensional image containing the tubular structure, providing at least one seed point within the tubular structure, fitting an initial cylinder into the tubular structure at the seed point, adding cylinder segments to the initial cylinder in forward and backward directions within the three-dimensional image of the tubular structure by tracking the cylinder model over the tubular structure, modeling each cylinder segment using parameters to account for a three-dimensional orientation, a radius, a length and a curvature, describing an intensity image of the tubular structure using a second model to represent an edge and intensity distribution of the tubular structure, fitting the parameters as the cylinder segment is added to the intensity image, and outputting cylinder segments as a segmentation of the tube.
摘要翻译：用于分割管状结构的方法包括提供包含管状结构的三维图像，在管状结构内提供至少一个种子点，将初始圆柱体在种子点处装配到管状结构中，将圆柱体段添加到初始圆柱体在管状结构的三维图像内沿向前和向后的方向，通过在管状结构上跟踪圆柱模型，使用参数建模每个气缸段以考虑三维取向，半径，长度和曲率，描述使用第二模型来表示管状结构的边缘和强度分布的管状结构的强度图像，将作为气缸段的参数拟合到强度图像中，并且作为管的分割输出气缸段。

10. 发明申请

US20070248685A1 DRY HEMOSTATIC COMPOSITIONS AND METHODS FOR THEIR PREPARATION 有权
标题翻译：干燥剂组合物及其制备方法
公开(公告)号：US20070248685A1
公开(公告)日：2007-10-25
申请号：US11766516
申请日：2007-06-21
申请人： Zhen Qian , A. Osawa , Cary Reich
发明人： Zhen Qian , A. Osawa , Cary Reich
IPC分类号： A61K9/14 , A61P7/04
CPC分类号： A61K38/4833 , A61L24/0031 , A61L24/104 , A61L2400/04
摘要： Dry cross-linked gelatin compositions are prepared that rapidly re-hydrate to produce gelatin hydrogels suitable as hemostatic sealants. Gelatin is cross-linked in the presence of certain re-hydration aids, such as polyethylene glycol, polyvinylprovidone, and dextran, in order to produce a dry cross-linked gelatin powder. The use of the re-hydration aids has been found to substantially increase the re-hydration rate in the presence of an aqueous re-hydration medium, typically thrombin-containing saline.
摘要翻译：制备干燥的交联明胶组合物，其快速再水化以产生适合作为止血密封剂的明胶水凝胶。在某些再水化助剂如聚乙二醇，聚乙烯基丙基吡咯烷酮和葡聚糖存在下，明胶是交联的，以产生干燥的交联明胶粉末。已经发现使用再水合助剂在含水的再水合介质（通常为含有凝血酶的盐水）的存在下显着增加再水合速率。

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