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1. 发明授权

US08128682B2 Medical device with tensionably attached remodelable material 有权
标题翻译：具有可张力连接的可重塑材料的医疗装置
公开(公告)号：US08128682B2
公开(公告)日：2012-03-06
申请号：US12777947
申请日：2010-05-11
申请人： Brian C. Case , Jacob A. Flagle , Ram H. Paul, Jr. , Sean D. Chambers
发明人： Brian C. Case , Jacob A. Flagle , Ram H. Paul, Jr. , Sean D. Chambers
IPC分类号： A61F2/82
CPC分类号： A61F2/2418 , A61F2/07 , A61F2/2475 , A61F2/86 , A61F2/90 , A61F2002/075 , A61F2210/0004 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/0071 , A61F2250/0018 , A61F2250/0031 , A61F2250/0071
摘要： Medical devices for implantation in a body vessel, and methods of using and making the same, are provided. A medical device includes a support frame having struts and a weakened frame portion, and a remodelable material tensionably attached to the support frame. The weakened frame portion has a first configuration in which the support frame has a first outward radial force and a second configuration in which the support frame has a second, lesser outward radial force. The remodelable material restricts expansion of the frame from a radially compressed configuration to a radially expanded configuration when the weakened frame portion is in the first configuration. The remodelable material can form one or more valve leaflets adapted to regulate fluid flow in a body vessel, such as a vein.
摘要翻译：提供了用于植入体内的医疗装置及其使用和制造方法。医疗装置包括具有支柱和弱化框架部分的支撑框架和可张紧地附接到支撑框架的可重塑材料。弱化的框架部分具有第一构造，其中支撑框架具有第一向外径向力和第二构造，其中支撑框架具有第二较小的向外径向力。当变弱的框架部分处于第一构型时，可重塑材料将框架从径向压缩构型扩展到径向扩张构型。可重塑材料可以形成适于调节诸如静脉的体内血管中的流体流动的一个或多个瓣膜小叶。

2. 发明申请

US20100280586A1 MEDICAL DEVICE WITH TENSIONABLY ATTACHED REMODELABLE MATERIAL 有权
标题翻译：具有可张紧连接的可重复材料的医疗装置
公开(公告)号：US20100280586A1
公开(公告)日：2010-11-04
申请号：US12777947
申请日：2010-05-11
申请人： Brian C. Case , Jacob A. Flagle , Ram H. Paul, JR. , Sean D. Chambers
发明人： Brian C. Case , Jacob A. Flagle , Ram H. Paul, JR. , Sean D. Chambers
IPC分类号： A61F2/82
CPC分类号： A61F2/2418 , A61F2/07 , A61F2/2475 , A61F2/86 , A61F2/90 , A61F2002/075 , A61F2210/0004 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/0071 , A61F2250/0018 , A61F2250/0031 , A61F2250/0071
摘要： Medical devices for implantation in a body vessel, and methods of using and making the same, are provided. A medical device includes a support frame having struts and a weakened frame portion, and a remodelable material tensionably attached to the support frame. The weakened frame portion has a first configuration in which the support frame has a first outward radial force and a second configuration in which the support frame has a second, lesser outward radial force. The remodellable material restricts expansion of the frame from a radially compressed configuration to a radially expanded configuration when the weakened frame portion is in the first configuration. The remodelable material can form one or more valve leaflets adapted to regulate fluid flow in a body vessel, such as a vein.
摘要翻译：提供了用于植入体内的医疗装置及其使用和制造方法。医疗装置包括具有支柱和弱化框架部分的支撑框架和可张紧地附接到支撑框架的可重塑材料。弱化的框架部分具有第一构造，其中支撑框架具有第一向外径向力和第二构造，其中支撑框架具有第二较小的向外径向力。当减弱的框架部分处于第一构造时，可重构材料限制框架从径向压缩构型到径向膨胀构型的膨胀。可重塑材料可以形成适于调节诸如静脉的体内血管中的流体流动的一个或多个瓣膜小叶。

3. 发明授权

US08382822B2 Implantable vascular device 有权
标题翻译：植入式血管装置
公开(公告)号：US08382822B2
公开(公告)日：2013-02-26
申请号：US12574870
申请日：2009-10-07
申请人： Dusan Pavcnik , Brian C. Case , Jacob A. Flagle , Michael Garrison , Andrew K. Hoffa , Raymond B. Leonard, II , Thomas A. Osborne , Ram H. Paul, Jr. , Darin G. Schaeffer , Richard B Sisken
发明人： Dusan Pavcnik , Brian C. Case , Jacob A. Flagle , Michael Garrison , Andrew K. Hoffa , Raymond B. Leonard, II , Thomas A. Osborne , Ram H. Paul, Jr. , Darin G. Schaeffer , Richard B Sisken
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2002/825 , A61F2002/8483 , A61F2220/0016 , A61F2230/0008 , A61F2230/001 , A61F2230/0017 , A61F2230/0021 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0095
摘要： A valve prosthesis, such as an artificial venous valve, having a support frame and leaf structure comprising one or more leaflets in which the outer edge of each leaflet engages the inner circumference of the bodily passageway along a serpentine path urged against the passageway by an expandable frame, while the inner edges move in response to fluid to restrict retrograde flow. Optionally, one or more elements can extend from the support frame/leaf structure to provide centering support and/or protection from the leaflet adhering to the vessel wall. In one embodiment, the centering support structure comprises a second or third expandable frames attached to and extending from the proximal and/or distal ends of main valve structure and support frame. In another embodiment, one or more support elements extend outward from the valve support frame to engage the vessel wall to provide greater longitudinal stability.
摘要翻译：一种阀门假体，例如人造静脉瓣，其具有支撑框架和叶片结构，其包括一个或多个小叶，每个小叶的外边缘沿着沿着通过可扩张的第二通道推动抵靠通道的蛇形路径接合身体通道的内周框架，而内边缘响应流体移动以限制逆行流。任选地，一个或多个元件可以从支撑框架/叶结构延伸，以提供定位支撑和/或防止附着在血管壁上的小叶的保护。在一个实施例中，定心支撑结构包括附接到主阀结构和支撑框架的近端和/或远端的第二或第三可膨胀框架。在另一个实施例中，一个或多个支撑元件从阀支撑框架向外延伸以接合血管壁以提供更大的纵向稳定性。

4. 发明授权

US08398663B2 Valvulotome device and method 有权
标题翻译：瓣膜切除装置及方法
公开(公告)号：US08398663B2
公开(公告)日：2013-03-19
申请号：US12781300
申请日：2010-05-17
申请人： Ram H. Paul, Jr. , Brian C. Case , Jacob A. Flagle
发明人： Ram H. Paul, Jr. , Brian C. Case , Jacob A. Flagle
IPC分类号： A61B17/22
CPC分类号： A61B17/3207 , A61B17/320725 , A61B2017/22097
摘要： Valvulotome devices and methods are provided. Valvulotome devices include one or more valvulotome arms that have a u-shaped curved body with opposing arms and a base portion that extends between the arms. The valvulotome arm defines a notch open at one end on one of the arms and extending into the base portion of the u-shaped curved body. The notch defines an angled surface that provides a cutting edge. Methods of making valvulotome devices are also described.
摘要翻译：提供瓣膜切除装置和方法。瓣膜切开装置包括一个或多个瓣膜切开臂，其具有带相对臂的u形弯曲体和在臂之间延伸的基部。瓣膜切开臂限定了在一个臂上的一端处开口并且延伸到U形弯曲体的基部中的凹口。切口限定了提供切削刃的成角度的表面。还描述了制造瓣膜切开术装置的方法。

5. 发明授权

US07717930B2 Valvulotome with a cutting edge 有权
标题翻译：瓣切开术带有切削刃
公开(公告)号：US07717930B2
公开(公告)日：2010-05-18
申请号：US11070130
申请日：2005-02-28
申请人： Ram H. Paul, Jr. , Brian C. Case , Jacob A. Flagle
发明人： Ram H. Paul, Jr. , Brian C. Case , Jacob A. Flagle
IPC分类号： A61B17/22
CPC分类号： A61B17/3207 , A61B17/320725 , A61B2017/22097
摘要： Valvulotome devices comprising a cutting edge are provided. Some valvulotome devices incisably engage a venous valve leaflet within a body vessel while at least a portion of the cutting edge is oriented substantially parallel to the longitudinal axis of the valvulotome device. Valvulotome devices are preferably configured to slidably engage a venous valve leaflet upon translation of the valvulotome device along the longitudinal axis of a body vessel. A valvulotome device can further comprise one or more valvulotome arms of variable lengths and dimensions. In some embodiments, the valvulotome device can be self expanding. Embodiments of the invention also provide delivery systems comprising a valvulotome device. The present invention also provides for methods of using a valvulotome device. Kits comprising a valvulotome device are also provided.
摘要翻译：提供包括切削刃的瓣膜切开装置。一些瓣膜切开装置可切割地与身体血管内的静脉瓣膜接合，同时切割边缘的至少一部分基本上平行于瓣膜切开装置的纵向轴线定向。瓣膜切开装置优选地构造成在沿着身体血管的纵向轴线平移瓣膜切开装置时可滑动地接合静脉瓣膜瓣。瓣膜切开装置还可以包括一个或多个可变长度和尺寸的瓣膜切开臂。在一些实施例中，瓣膜切开装置可以是自膨胀的。本发明的实施例还提供包括瓣膜切开装置的输送系统。本发明还提供了使用瓣膜切开装置的方法。还提供了包括瓣膜切开装置的套件。

6. 发明授权

US08540760B2 Tubular devices having reversible components for deployment of endoluminal occluders and related methods and systems 有权
标题翻译：具有用于部署腔内封堵器的可逆组件的管状装置及相关方法和系统
公开(公告)号：US08540760B2
公开(公告)日：2013-09-24
申请号：US12164520
申请日：2008-06-30
申请人： Ram H. Paul, Jr. , Jacob A. Flagle , Brian C. Case
发明人： Ram H. Paul, Jr. , Jacob A. Flagle , Brian C. Case
IPC分类号： A61F2/84
CPC分类号： A61B17/0057 , A61B17/12022 , A61B17/12136 , A61B17/12181 , A61B17/1219 , A61B17/3468 , A61B2017/1205
摘要： Described are devices, methods, and systems useful for deploying one or more occlusive prostheses within the vasculature of a patient. Illustrative devices can include a deployment tube or sheath that contains an occlusive prosthesis, wherein a segment of the sheath is reversible by a user so as to deploy the prosthesis from the sheath lumen within a bodily lumen of a patient.
摘要翻译：描述了用于在患者的脉管系统内部署一个或多个闭塞假体的装置，方法和系统。示例性装置可以包括包含闭塞假体的展开管或护套，其中护套的一部分可由使用者逆转，以便将该假体从皮肤内腔部署到患者体内。

7. 发明申请

US20090018637A1 TUBULAR DEVICES HAVING REVERSIBLE COMPONENTS FOR DEPLOYMENT OF ENDOLUMINAL OCCLUDERS AND RELATED METHODS AND SYSTEMS 有权
标题翻译：具有用于分泌内分泌系统的可逆组分的管状装置及相关方法和系统
公开(公告)号：US20090018637A1
公开(公告)日：2009-01-15
申请号：US12164520
申请日：2008-06-30
申请人： Ram H. Paul, JR. , Jacob A. Flagle , Brian C. Case
发明人： Ram H. Paul, JR. , Jacob A. Flagle , Brian C. Case
IPC分类号： A61F2/06
CPC分类号： A61B17/0057 , A61B17/12022 , A61B17/12136 , A61B17/12181 , A61B17/1219 , A61B17/3468 , A61B2017/1205
摘要： Described are devices, methods, and systems useful for deploying one or more occlusive prostheses within the vasculature of a patient. Illustrative devices can include a deployment tube or sheath that contains an occlusive prosthesis, wherein a segment of the sheath is reversible by a user so as to deploy the prosthesis from the sheath lumen within a bodily lumen of a patient.
摘要翻译：描述了用于在患者的脉管系统内部署一个或多个闭塞假体的装置，方法和系统。示例性装置可以包括包含闭塞假体的展开管或护套，其中护套的一部分可由使用者逆转，以便将该假体从皮肤内腔部署到患者体内。

8. 发明授权

US07604661B2 Implantable vascular device 有权
标题翻译：植入式血管装置
公开(公告)号：US07604661B2
公开(公告)日：2009-10-20
申请号：US11931182
申请日：2007-10-31
申请人： Dusan Pavcnik , Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Ram H. Paul, Jr. , Andrew K. Hoffa , Raymond B. Leonard, II , Darin G. Schaeffer , Richard B. Sisken
发明人： Dusan Pavcnik , Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Ram H. Paul, Jr. , Andrew K. Hoffa , Raymond B. Leonard, II , Darin G. Schaeffer , Richard B. Sisken
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/24 , A61F2/01 , A61F2/2418 , A61F2/2475 , A61F2002/018 , A61F2002/8483 , A61F2230/0008 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0069 , A61F2230/0095
摘要： An valve prosthesis, such as an artificial venous valve, having a support frame and leaf structure comprising one or more leaflets in which the outer edge of each leaflet engages the inner circumference of the bodily passageway along a serpentine path urged against the passageway by an expandable frame, while the inner edges move in response to fluid to restrict retrograde flow. Optionally, one or more elements can extend from the support frame/leaf structure to provide centering support and/or protection from the leaflet adhering to the vessel wall. In one embodiment, the centering support structure comprises a second or third expandable frames attached to and extending from the proximal and/or distal ends of main valve structure and support frame. In another embodiment, one or more support elements extend outward from the valve support frame to engage the vessel wall to provide greater longitudinal stability.
摘要翻译：一种阀门假体，例如人造静脉瓣，其具有支撑框架和叶结构，其包括一个或多个小叶，其中每个小叶的外边缘沿着沿着通过可扩展框架，而内边缘响应流体移动以限制逆行流。任选地，一个或多个元件可以从支撑框架/叶结构延伸，以提供定位支撑和/或防止附着在血管壁上的小叶的保护。在一个实施例中，定心支撑结构包括附接到主阀结构和支撑框架的近端和/或远端的第二或第三可膨胀框架。在另一个实施例中，一个或多个支撑元件从阀支撑框架向外延伸以接合血管壁以提供更大的纵向稳定性。

9. 发明授权

US09421096B2 Artificial valve prosthesis with improved flow dynamics 有权
标题翻译：具有改善流动动力学的人造瓣膜假体
公开(公告)号：US09421096B2
公开(公告)日：2016-08-23
申请号：US13550229
申请日：2012-07-16
申请人： Brian C. Case , Michael L. Garrison , Andrew Hoffa , Darin G. Schaeffer , Jacob A. Flagle
发明人： Brian C. Case , Michael L. Garrison , Andrew Hoffa , Darin G. Schaeffer , Jacob A. Flagle
IPC分类号： A61F2/24 , A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2002/068 , A61F2220/0008 , A61F2220/0016 , A61F2230/0054 , A61F2230/0076 , A61F2230/0078 , A61F2230/008 , A61F2250/0037 , A61F2250/0039
摘要： An expandable venous valve having a support structure that is configured to enlarge the area adjacent to the valve structure such that the flow patterns of retrograde flow are modified in a way that facilitates the flushing of the pockets at the base of the valve area to prevent stagnation of bodily fluid, which in the venous system, can lead to thrombus formation. The enlarged pocket areas can be created by forming an artificial sinus adjacent the valve structure in an unsupported section of vessel wall between two support frame sections or the support frame can comprise an expanded-diameter intermediate or proximal section that forms an artificial sinus adjacent the valve structure.
摘要翻译：一种可膨胀静脉瓣，其具有支撑结构，所述支撑结构被构造成扩大与所述瓣膜结构相邻的区域，使得逆行流的流动模式以便于在所述瓣膜区域的底部冲洗所述凹穴以防止停滞的方式被修改的体液，其在静脉系统中可导致血栓形成。可以通过在两个支撑框架部分之间的容器壁的无支撑部分中形成邻近阀结构的人造窦来形成扩大的口袋区域，或者支撑框架可以包括形成邻近瓣膜的人造窦的扩张直径的中间或近端部分结构体。

10. 发明授权

US08157857B2 Intralumenally-implantable frames 有权
标题翻译：腔内可植入框架
公开(公告)号：US08157857B2
公开(公告)日：2012-04-17
申请号：US12605585
申请日：2009-10-26
申请人： Brian C. Case , Jacob A. Flagle , Michael L. Garrison
发明人： Brian C. Case , Jacob A. Flagle , Michael L. Garrison
IPC分类号： A61F2/82
CPC分类号： A61F2/86 , A61F2/06 , A61F2/2418 , A61F2/2475 , A61F2/91 , A61F2/915 , A61F2002/068 , A61F2002/91508 , A61F2002/91516 , A61F2002/91533 , A61F2002/91575 , A61F2220/0016 , A61F2220/0058 , A61F2230/0054 , A61F2250/0037 , A61F2250/0039
摘要： Implantable frames for use in body passages are provided herein. The implantable frames can include a plurality of hoop members joined by a plurality of longitudinal connecting members to form a tubular frame defining a cylindrical lumen. The plurality of longitudinal connecting members may include first and second longitudinal connecting members joining a first hoop member to a second hoop member such that the first and second longitudinal connecting members extend across an entire space separating the first and second hoop members.
摘要翻译：本文提供了用于身体通道的植入框架。可植入框架可以包括由多个纵向连接构件连接以形成限定圆柱形管腔的管状框架的多个环形构件。多个纵向连接构件可以包括将第一箍构件连接到第二箍构件的第一和第二纵向连接构件，使得第一和第二纵向连接构件跨越分隔第一和第二箍构件的整个空间延伸。

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