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1. 发明授权

US07458987B2 Vascular valves having implanted and target configurations and methods of preparing the same 有权
标题翻译：具有植入和靶构造的血管瓣及其制备方法
公开(公告)号：US07458987B2
公开(公告)日：2008-12-02
申请号：US11260770
申请日：2005-10-27
申请人： Brian C. Case , Jacob A. Flagle , Michael L. Garrison , F. Joseph Obermiller , Dusan Pavcnik
发明人： Brian C. Case , Jacob A. Flagle , Michael L. Garrison , F. Joseph Obermiller , Dusan Pavcnik
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2436 , A61F2/2475 , A61F2210/0004 , A61F2220/0016 , A61F2250/0067
摘要： Described are vascular valve devices for implantation in a patient. The vascular valve devices are designed to compensate for the retraction characteristics of a remodelable material used to form one or more leaflets. Alternatively, or in addition, the devices are designed to reduce retraction of the remodelable leaflet-forming material. Further described are methods for preparing and using these vascular valve devices.
摘要翻译：描述了用于植入患者体内的血管瓣膜装置。血管瓣膜装置被设计成补偿用于形成一个或多个传单的可重塑材料的回缩特性。或者或另外，设备被设计成减少可重塑的小叶形成材料的缩回。进一步描述了制备和使用这些血管瓣膜装置的方法。

2. 发明授权

US08444666B2 Retrievable filter 有权
标题翻译：可检索过滤器
公开(公告)号：US08444666B2
公开(公告)日：2013-05-21
申请号：US10662216
申请日：2003-09-12
申请人： Dusan Pavcnik , Brian C. Case , John A. Kaufman , Michael L. Garrison , Jacob A. Flagle
发明人： Dusan Pavcnik , Brian C. Case , John A. Kaufman , Michael L. Garrison , Jacob A. Flagle
IPC分类号： A61B17/00 , A61F2/06 , A61F2/82
CPC分类号： A61F2/01 , A61F2002/016 , A61F2230/005 , A61F2230/0067
摘要： A filter may have an apical hub and a plurality of divergent legs. A first attachment member may be separate from, but attached to the second end of at least one of the plurality of divergent legs. A second attachment member may be separate from, but attached to a stent. The first and second attachment members may be separate from, but attachable to one another to releasably attach the filter to the stent. One of the first attachment member and the second attachment member may include an attachment wire that is positioned in a lumen of a tubular member or one of the first attachment member and the second attachment member may comprise a cannula. In some implementations, an upward motion applied to the retrieval connection member may disengage at least one attachment wire of the first attachment member from the second attachment member.
摘要翻译：过滤器可以具有顶端毂和多个发散腿。第一附接构件可以与多个发散腿中的至少一个分开，但是附接到多个发散腿中的至少一个的第二端。第二附接构件可以与支架分离但附接到支架。第一和第二附接构件可以彼此分离，但可彼此附接以将过滤器可释放地附接到支架。第一附接构件和第二附接构件中的一个可以包括定位在管状构件的内腔中的附接线，或者第一附接构件和第二附接构件中的一个可以包括套管。在一些实施方式中，施加到取回连接构件的向上运动可以使第一附接构件的至少一个附接线与第二附接构件脱离接触。

3. 发明授权

US07628803B2 Implantable vascular device 有权
公开(公告)号：US07628803B2
公开(公告)日：2009-12-08
申请号：US10642372
申请日：2003-08-15
申请人： Dusan Pavcnik , Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Andrew K. Hoffa , Raymond B. Leonard, II , Darin G. Schaeffer , Richard B. Sisken
发明人： Dusan Pavcnik , Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Andrew K. Hoffa , Raymond B. Leonard, II , Darin G. Schaeffer , Richard B. Sisken
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/24 , A61F2/01 , A61F2/2418 , A61F2/2475 , A61F2002/018 , A61F2002/8483 , A61F2230/0008 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0069 , A61F2230/0095
摘要： An valve prosthesis, such as an artificial venous valve, having a support frame and leaf structure comprising one or more leaflets in which the outer edge of each leaflet engages the inner circumference of the bodily passageway along a serpentine path urged against the passageway by an expandable frame, while the inner edges move in response to fluid to restrict retrograde flow. Optionally, one or more elements can extend from the support frame/leaf structure to provide centering support and/or protection from the leaflet adhering to the vessel wall. In one embodiment, the centering support structure comprises a second or third expandable frames attached to and extending from the proximal and/or distal ends of main valve structure and support frame. In another embodiment, one or more support elements extend outward from the valve support frame to engage the vessel wall to provide greater longitudinal stability.

4. 发明授权

US07604661B2 Implantable vascular device 有权
标题翻译：植入式血管装置
公开(公告)号：US07604661B2
公开(公告)日：2009-10-20
申请号：US11931182
申请日：2007-10-31
申请人： Dusan Pavcnik , Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Ram H. Paul, Jr. , Andrew K. Hoffa , Raymond B. Leonard, II , Darin G. Schaeffer , Richard B. Sisken
发明人： Dusan Pavcnik , Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Ram H. Paul, Jr. , Andrew K. Hoffa , Raymond B. Leonard, II , Darin G. Schaeffer , Richard B. Sisken
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/24 , A61F2/01 , A61F2/2418 , A61F2/2475 , A61F2002/018 , A61F2002/8483 , A61F2230/0008 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0069 , A61F2230/0095
摘要： An valve prosthesis, such as an artificial venous valve, having a support frame and leaf structure comprising one or more leaflets in which the outer edge of each leaflet engages the inner circumference of the bodily passageway along a serpentine path urged against the passageway by an expandable frame, while the inner edges move in response to fluid to restrict retrograde flow. Optionally, one or more elements can extend from the support frame/leaf structure to provide centering support and/or protection from the leaflet adhering to the vessel wall. In one embodiment, the centering support structure comprises a second or third expandable frames attached to and extending from the proximal and/or distal ends of main valve structure and support frame. In another embodiment, one or more support elements extend outward from the valve support frame to engage the vessel wall to provide greater longitudinal stability.
摘要翻译：一种阀门假体，例如人造静脉瓣，其具有支撑框架和叶结构，其包括一个或多个小叶，其中每个小叶的外边缘沿着沿着通过可扩展框架，而内边缘响应流体移动以限制逆行流。任选地，一个或多个元件可以从支撑框架/叶结构延伸，以提供定位支撑和/或防止附着在血管壁上的小叶的保护。在一个实施例中，定心支撑结构包括附接到主阀结构和支撑框架的近端和/或远端的第二或第三可膨胀框架。在另一个实施例中，一个或多个支撑元件从阀支撑框架向外延伸以接合血管壁以提供更大的纵向稳定性。

5. 发明授权

US07909862B2 Delivery systems and methods for deploying expandable intraluminal medical devices 有权
标题翻译：用于部署扩张型管腔内医疗器械的输送系统和方法
公开(公告)号：US07909862B2
公开(公告)日：2011-03-22
申请号：US10804386
申请日：2004-03-19
申请人： Michael L. Garrison , Brian C. Case , Andrew K. Hoffa , Jacob A. Flagle , Dusan Pavcnik
发明人： Michael L. Garrison , Brian C. Case , Andrew K. Hoffa , Jacob A. Flagle , Dusan Pavcnik
IPC分类号： A61F2/06 , A61M29/00
CPC分类号： A61F2/95 , A61F2/013 , A61F2/966 , A61F2002/011 , A61F2002/015 , A61F2230/0006 , A61F2230/005
摘要： Methods and devices for delivering and deploying expandable intraluminal medical devices at a desired point of treatment within a body vessel are provided. A delivery device is provided, inserted into a body vessel, and navigated through the vessel to place an associated expandable intraluminal medical device at a desired point of treatment. Once the desired location is reached, an elongate member on which the expandable intraluminal medical device is disposed is spaced from a wall surface of the body vessel using an expandable wire basket, balloon, or other suitable structure. The expandable intraluminal medical device is deployed from the delivery system, which can ultimately be withdrawn from the body vessel.
摘要翻译：提供了用于在体内容器内的期望治疗点递送和部署可膨胀管腔内医疗装置的方法和装置。提供输送装置，插入体内容器，并通过血管导航，将相关的可扩张的管腔内医疗装置放置在期望的治疗点。一旦达到所需的位置，可扩张的管腔内医疗装置就位于其上的细长构件就可以使用可膨胀的丝网筐，球囊或其它合适的结构与身体容器的壁表面间隔开。可扩展的管腔内医疗装置从输送系统部署，其最终可以从体内容器中取出。

6. 发明授权

US09421096B2 Artificial valve prosthesis with improved flow dynamics 有权
标题翻译：具有改善流动动力学的人造瓣膜假体
公开(公告)号：US09421096B2
公开(公告)日：2016-08-23
申请号：US13550229
申请日：2012-07-16
申请人： Brian C. Case , Michael L. Garrison , Andrew Hoffa , Darin G. Schaeffer , Jacob A. Flagle
发明人： Brian C. Case , Michael L. Garrison , Andrew Hoffa , Darin G. Schaeffer , Jacob A. Flagle
IPC分类号： A61F2/24 , A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2002/068 , A61F2220/0008 , A61F2220/0016 , A61F2230/0054 , A61F2230/0076 , A61F2230/0078 , A61F2230/008 , A61F2250/0037 , A61F2250/0039
摘要： An expandable venous valve having a support structure that is configured to enlarge the area adjacent to the valve structure such that the flow patterns of retrograde flow are modified in a way that facilitates the flushing of the pockets at the base of the valve area to prevent stagnation of bodily fluid, which in the venous system, can lead to thrombus formation. The enlarged pocket areas can be created by forming an artificial sinus adjacent the valve structure in an unsupported section of vessel wall between two support frame sections or the support frame can comprise an expanded-diameter intermediate or proximal section that forms an artificial sinus adjacent the valve structure.
摘要翻译：一种可膨胀静脉瓣，其具有支撑结构，所述支撑结构被构造成扩大与所述瓣膜结构相邻的区域，使得逆行流的流动模式以便于在所述瓣膜区域的底部冲洗所述凹穴以防止停滞的方式被修改的体液，其在静脉系统中可导致血栓形成。可以通过在两个支撑框架部分之间的容器壁的无支撑部分中形成邻近阀结构的人造窦来形成扩大的口袋区域，或者支撑框架可以包括形成邻近瓣膜的人造窦的扩张直径的中间或近端部分结构体。

7. 发明授权

US08157857B2 Intralumenally-implantable frames 有权
标题翻译：腔内可植入框架
公开(公告)号：US08157857B2
公开(公告)日：2012-04-17
申请号：US12605585
申请日：2009-10-26
申请人： Brian C. Case , Jacob A. Flagle , Michael L. Garrison
发明人： Brian C. Case , Jacob A. Flagle , Michael L. Garrison
IPC分类号： A61F2/82
CPC分类号： A61F2/86 , A61F2/06 , A61F2/2418 , A61F2/2475 , A61F2/91 , A61F2/915 , A61F2002/068 , A61F2002/91508 , A61F2002/91516 , A61F2002/91533 , A61F2002/91575 , A61F2220/0016 , A61F2220/0058 , A61F2230/0054 , A61F2250/0037 , A61F2250/0039
摘要： Implantable frames for use in body passages are provided herein. The implantable frames can include a plurality of hoop members joined by a plurality of longitudinal connecting members to form a tubular frame defining a cylindrical lumen. The plurality of longitudinal connecting members may include first and second longitudinal connecting members joining a first hoop member to a second hoop member such that the first and second longitudinal connecting members extend across an entire space separating the first and second hoop members.
摘要翻译：本文提供了用于身体通道的植入框架。可植入框架可以包括由多个纵向连接构件连接以形成限定圆柱形管腔的管状框架的多个环形构件。多个纵向连接构件可以包括将第一箍构件连接到第二箍构件的第一和第二纵向连接构件，使得第一和第二纵向连接构件跨越分隔第一和第二箍构件的整个空间延伸。

8. 发明授权

US07955376B2 Implantable medical device with constrained expansion 有权
标题翻译：植入式医疗器械具有约束扩张
公开(公告)号：US07955376B2
公开(公告)日：2011-06-07
申请号：US11539925
申请日：2006-10-10
申请人： Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Andrew K. Hoffa , Michael L. Garrison
发明人： Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Andrew K. Hoffa , Michael L. Garrison
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0026 , A61F2230/0095
摘要： A medical device comprises a support structure and one or more graft members comprising a valve portion and a constraining portion. The support structure has a first, unexpanded configuration and a second, expanded configuration. The constraining portion is adapted to substantially prevent the support structure from achieving the second, expanded configuration. The valve portion is adapted to permit fluid flow through a body vessel in a first direction and substantially prevent fluid flow through the vessel in a second, opposite direction.
摘要翻译：医疗装置包括支撑结构和包括阀部分和约束部分的一个或多个移植物构件。支撑结构具有第一，未膨胀的构造和第二扩展构型。约束部分适于基本上防止支撑结构实现第二扩张构型。阀部分适于允许流体沿第一方向流过身体容器，并且基本上防止流体沿第二相反方向流过血管。

9. 发明申请

US20100131055A1 ARTIFICIAL VALVE PROSTHESIS WITH IMPROVED FLOW DYNAMICS 审中-公开
标题翻译：人工阀具有改进的流动动力学
公开(公告)号：US20100131055A1
公开(公告)日：2010-05-27
申请号：US12614878
申请日：2009-11-09
申请人： Brian C. Case , Michael L. Garrison , Andrew Hoffa , Darin G. Schaeffer , Jacob A. Flagle
发明人： Brian C. Case , Michael L. Garrison , Andrew Hoffa , Darin G. Schaeffer , Jacob A. Flagle
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2002/068 , A61F2220/0008 , A61F2220/0016 , A61F2230/0054 , A61F2230/0076 , A61F2230/0078 , A61F2230/008 , A61F2250/0037 , A61F2250/0039
摘要： An expandable venous valve having a support structure configured to enlarge the area adjacent the valve structure. The enlarged pocket areas can be created by forming an artificial sinus adjacent the valve structure in an unsupported section of vessel wall between two support frame sections.
摘要翻译：一种具有支撑结构的可膨胀静脉瓣，该支撑结构构造成扩大邻近瓣膜结构的区域。可以通过在两个支撑框架部分之间的容器壁的无支撑部分中形成邻近阀结构的人造窦来产生扩大的口袋区域。

10. 发明授权

US08221492B2 Artificial valve prosthesis with improved flow dynamics 有权
标题翻译：具有改善流动动力学的人造瓣膜假体
公开(公告)号：US08221492B2
公开(公告)日：2012-07-17
申请号：US10554494
申请日：2004-04-21
申请人： Brian C. Case , Michael L. Garrison , Andrew Hoffa , Darin G. Schaeffer , Jacob A. Flagle
发明人： Brian C. Case , Michael L. Garrison , Andrew Hoffa , Darin G. Schaeffer , Jacob A. Flagle
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2002/068 , A61F2220/0008 , A61F2220/0016 , A61F2230/0054 , A61F2230/0076 , A61F2230/0078 , A61F2230/008 , A61F2250/0037 , A61F2250/0039
摘要： An expandable venous valve having a support structure that configured to enlarge the area adjacent to the valve structure such that the flow patterns of retrograde flow are modified in a way that facilitates the flushing of the pockets at the base of the valve area to prevent stagnation of bodily fluid, which in the venous system, can lead to thrombus formation. The enlarged pocket areas can be created by forming an artificial sinus adjacent the valve structure in an unsupported section of vessel wall between two support frame section or the support frame can comprise an expanded-diameter intermediate or proximal section that forms an artificial sinus adjacent the valve structure. In another group of embodiments, the attachment pathway between opposing leaflets and the support frame and/or vessel wall comprises a proximal portion that places the leaflets in extended contact with one another and a distal portion forms a large angle with respect to the adjacent walls such that a large pocket is created at the base of the leaflets. In one embodiment, the attachment pathway extends distally along a pair of substantially parallel longitudinal attachment struts to create an extended leaflet contact area, then angles circumferentially and distally from the former along distal attachment struts to define the bottom edge of the leaflets.
摘要翻译：一种可膨胀静脉瓣，其具有支撑结构，该支撑结构被配置为扩大邻近阀结构的区域，使逆行流的流动模式以便于冲洗瓣膜区域底部的口袋的方式进行改变，以防止滞留在静脉系统中的体液可导致血栓形成。扩大的口袋区域可以通过在两个支撑框架部分之间的容器壁的无支撑部分中形成邻近阀结构的人造窦来形成，或者支撑框架可以包括形成邻近瓣膜的人造窦的扩张直径的中间或近端部分结构体。在另一组实施例中，相对的小叶与支撑框架和/或血管壁之间的附接通路包括将小叶彼此延伸接触的近端部分，并且远侧部分相对于相邻壁形成大角度，在传单的底部创造了一个大口袋。在一个实施例中，附接通道沿着一对基本上平行的纵向连接支柱向远侧延伸，以产生延伸的小叶接触区域，然后沿着远侧连接支柱沿着周向和远端远离成形器，以限定传单的底部边缘。

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