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1. 发明授权

US06496715B1 System and method for non-invasive determination of optimal orientation of an implantable sensing device 有权
标题翻译：用于非侵入性确定可植入感测装置的最佳取向的系统和方法
公开(公告)号：US06496715B1
公开(公告)日：2002-12-17
申请号：US09718689
申请日：2000-11-22
申请人： Brian B. Lee , Michael R. Kane , Eric J. Panken , James D. Reinke
发明人： Brian B. Lee , Michael R. Kane , Eric J. Panken , James D. Reinke
IPC分类号： A61B504
CPC分类号： A61N1/375
摘要： A system and method for determining the optimal positioning of an implantable system for sensing physiologic signals within a body. According to a one embodiment of the system, electrodes are positioned on an external surface of a body, and an ECG monitoring device is used to measure cardiac signals between various pairs of the electrodes. One or more of the electrodes may be re-positioned until an electrode pair position and orientation is located that provides a maximum signal reading. This position and orientation may then be used as the position and orientation in which to implant a corresponding device.
摘要翻译：一种用于确定用于感测身体内的生理信号的可植入系统的最佳定位的系统和方法。根据系统的一个实施例，电极定位在身体的外表面上，并且使用ECG监测装置来测量各对电极之间的心脏信号。一个或多个电极可以被重新定位，直到位于提供最大信号读数的电极对位置和取向。然后可以将该位置和取向用作植入相应装置的位置和取向。

2. 发明授权

US06505067B1 System and method for deriving a virtual ECG or EGM signal 有权
标题翻译：用于导出虚拟ECG或EGM信号的系统和方法
公开(公告)号：US06505067B1
公开(公告)日：2003-01-07
申请号：US09721275
申请日：2000-11-22
申请人： Brian B. Lee , Eric J. Panken , James D. Reinke
发明人： Brian B. Lee , Eric J. Panken , James D. Reinke
IPC分类号： A61B50402
CPC分类号： A61B5/04011 , A61B5/0402 , G06F19/00
摘要： A system and method for obtaining a virtual physiologic voltage signal between a first predetermined point in a second selected point in the body is disclosed. At least three electrodes are used to measure two voltage signals S1 and S2 in a body. In one embodiment, the signal S1 is measured between a first electrode and a common electrode, and the signal S2 is measured between a second electrode and the common electrode. A selected point within the body may be chosen to define a pair of virtual electrodes existing between this selected point and the common electrode. An approximation of the voltage signal S as could be measured between electrodes positioned at these virtual electrode locations may be derived as a function of S1, S2, and &thgr;, wherein &thgr; is the angle between the directional vector U1 for the signal S1 and the directional vector U for the signal S. According to the inventive system and method, the signal value for S is also dependent on the distances between the electrode pairs, on the angle &bgr; between directional vectors U1 and U2, and on the distance between the virtual electrodes. The current invention may be utilized with electrodes that are positioned either externally on the surface of, or implanted within, a body. According to one aspect of the invention, a user may employ a user interface to select the values of &thgr;, &bgr;, and the electrode spacings. Alternatively, ones of these parameters may be predetermined by the system. In another embodiment, the system could derive the signal S over a predetermined range of values for the angle &thgr;. The system may then select the angle of &thgr; resulting in the derived signal S that exhibits a desired waveform morphology.
摘要翻译：公开了一种用于在身体的第二选定点中的第一预定点之间获得虚拟生理电压信号的系统和方法。使用至少三个电极来测量身体中的两个电压信号S1和S2。在一个实施例中，在第一电极和公共电极之间测量信号S1，并且在第二电极和公共电极之间测量信号S2。可以选择体内的选定点以限定存在于该选定点和公共电极之间的一对虚拟电极。可以在位于这些虚拟电极位置的电极之间测量的电压信号S的近似作为S1，S2和θ的函数导出，其中θ是信号S1的方向矢量U1与方向信号S的矢量U根据本发明的系统和方法，S的信号值也取决于在方向矢量U1和U2之间的角度β上的电极对之间的距离，以及虚拟电极之间的距离。本发明可以与位于体外表面或植入体内的电极一起使用。根据本发明的一个方面，用户可以使用用户界面来选择θ，β和电极间距的值。或者，这些参数中的一个可以由系统预先确定。在另一个实施例中，系统可以在角度θ的预定值范围内导出信号S. 然后，系统可以选择θ的角度，导致出现所需波形形态的导出信号S.

3. 发明授权

US06522915B1 Surround shroud connector and electrode housings for a subcutaneous electrode array and leadless ECGS 有权
标题翻译：环绕护罩连接器和电极外壳，用于皮下电极阵列和无引线ECGS
公开(公告)号：US06522915B1
公开(公告)日：2003-02-18
申请号：US09697438
申请日：2000-10-26
申请人： Thomas I. Ceballos , John E. Nicholson , Eric J. Panken , James D. Reinke , James Strom , Kevin K. Tidemand
发明人： Thomas I. Ceballos , John E. Nicholson , Eric J. Panken , James D. Reinke , James Strom , Kevin K. Tidemand
IPC分类号： A61B5042
CPC分类号： A61B5/6852 , A61B5/0422 , A61B5/7203 , A61B5/7207 , A61B5/7217 , A61B2562/0209 , A61B2562/043 , A61B2562/164 , A61N1/375
摘要： The invention discloses a subcutaneous electrode array or SEA for use in medical devices. The arrangement provides an enhanced capability for detecting and gathering electrical cardiac signals via the array of relatively closely spaced subcutaneous electrodes. Further, switching circuits, signal processors and memory to process electric cardiac signals are implemented to enable a leadless orientation-insensitive SEA scheme for receiving the electrical signal from the heart. The SEA is distributed over the perimeter of the implanted medical device and includes a non-conductive surround shroud of biocompatible material. The surround shroud is placed around the periphery of the case of the implanted medical device. Various configurations of recesses, each of which contain individual electrodes, are implemented to provide an enhanced signal to noise ratio for improved signal quality.
摘要翻译：本发明公开了一种用于医疗器械的皮下电极阵列或SEA。该装置提供了通过相对紧密间隔的皮下电极阵列检测和收集电心电信号的增强功能。此外，实现开关电路，信号处理器和用于处理电心脏信号的存储器，以实现用于从心脏接收电信号的无引导取向不敏感的SEA方案。 SEA分布在植入的医疗装置的周边上，并且包括生物相容性材料的非导电环绕护罩。环绕护罩放置在植入医疗装置的壳体的周围。实现各种构造的凹槽，其中每个包含单独的电极，以提供增强的信噪比，以改善信号质量。

4. 发明授权

US07634310B2 Method and apparatus for atrial fibrillation detection based on ventricular cycle lengths 有权
标题翻译：基于心室周期长度的心房颤动检测方法和装置
公开(公告)号：US07634310B2
公开(公告)日：2009-12-15
申请号：US11554275
申请日：2006-10-30
申请人： Brian B. Lee , Eric J. Panken
发明人： Brian B. Lee , Eric J. Panken
IPC分类号： A61B5/024
CPC分类号： A61B5/046 , A61B5/02405 , A61N1/3621 , A61N1/3925 , A61N1/395
摘要： A method and apparatus for detecting atrial arrhythmias include acquiring a cardiac signal comprising R-waves. Differences between pairs of consecutive R-R intervals occurring during a first time interval are computed from the cardiac signal. An atrial arrhythmia is detected subsequent to the first time interval in response to the computed differences. Storage of the cardiac signal is triggered in response to the atrial arrhythmia detection.
摘要翻译：用于检测心房心律失常的方法和装置包括获取包括R波的心脏信号。从心脏信号计算在第一时间间隔期间发生的连续R-R间隔对之间的差异。响应于所计算的差异，在第一时间间隔之后检测心房心律失常。响应于心房心律失常检测触发心脏信号的存储。

5. 发明申请

US20080081958A1 Implantable medical device with sensor self-test feature 审中-公开
标题翻译：具有传感器自检功能的植入式医疗设备
公开(公告)号：US20080081958A1
公开(公告)日：2008-04-03
申请号：US11789438
申请日：2007-04-24
申请人： Timothy J. Denison , Brian B. Lee , Keith A. Miesel , Eric J. Panken
发明人： Timothy J. Denison , Brian B. Lee , Keith A. Miesel , Eric J. Panken
IPC分类号： A61B5/00
CPC分类号： A61N1/3706 , A61B2560/0276 , A61N1/36535 , A61N1/36542 , A61N1/3702
摘要： An implantable medical device (IMD) applies a sensor self-test when a sensing device generates a sensor signal indicating an event, or when the sensor is used to validate an event detected by another device. The event may be based on a sensed condition that triggers an operational adjustment, such as a therapy or diagnostic adjustment within the IMD. A sensor self-test verifies that an implantable sensing device is functional, and can be performed with or without activating the sensor. Activating the sensor may involve, application of an electrical input signal that causes the sensor to generate an output signal. Alternatively, the sensor self-test may be performed without activating the sensor by analyzing the continuity of a signal path between the sensor and sensor interface circuitry. In either case, a sensor self-test verifies proper operation so that operational adjustments can be made with greater confidence.
摘要翻译：当感测装置产生指示事件的传感器信号时，或者当传感器用于验证另一个设备检测到的事件时，可植入医疗设备（IMD）应用传感器自检。事件可以基于触发操作调整的感测条件，例如IMD内的治疗或诊断调整。传感器自检可以验证可植入的感测装置是否起作用，并且可以在启动或不启动传感器的情况下执行。激活传感器可能涉及施加导致传感器产生输出信号的电输入信号。或者，可以通过分析传感器和传感器接口电路之间的信号路径的连续性而不激活传感器来执行传感器自检。在任一种情况下，传感器自检将验证正确的操作，以便可以更有信心地进行操作调整。

6. 发明申请

US20110166464A1 TELEMETRY-SYNCHRONIZED PHYSIOLOGICAL MONITORING AND THERAPY DELIVERY SYSTEMS 审中-公开
标题翻译：电话同步生理监测和治疗传递系统
公开(公告)号：US20110166464A1
公开(公告)日：2011-07-07
申请号：US13048951
申请日：2011-03-16
申请人： Brian B. Lee , Eric J. Panken , Can Cinbis , Gerard J. Hill , John J. Grevious
发明人： Brian B. Lee , Eric J. Panken , Can Cinbis , Gerard J. Hill , John J. Grevious
IPC分类号： A61B5/0402 , A61B5/0476 , A61N1/36
CPC分类号： A61N1/37288 , A61N1/3611 , A61N1/36135 , A61N1/36585 , Y10S128/903
摘要： A physiological monitoring or therapy delivery system includes autonomous, wirelessly linked, implantable devices located at different areas to sense physiologic signals and deliver therapy. At least one of the implantable devices can trigger synchronized action (e.g. data capture or therapy delivery) by other implantable devices via a telemetry link.
摘要翻译：生理监测或治疗递送系统包括位于不同区域的自主的，无线连接的可植入装置，以感测生理信号并递送治疗。可植入装置中的至少一个可以经由遥测链路触发其它可植入装置的同步动作（例如数据捕获或治疗传递）。

7. 发明授权

US07912537B2 Telemetry-synchronized physiological monitoring and therapy delivery systems 有权
标题翻译：遥测同步生理监测和治疗传播系统
公开(公告)号：US07912537B2
公开(公告)日：2011-03-22
申请号：US11380435
申请日：2006-04-27
申请人： Brian B. Lee , Eric J. Panken , Can Cinbis , Gerard J. Hill , John J. Grevious
发明人： Brian B. Lee , Eric J. Panken , Can Cinbis , Gerard J. Hill , John J. Grevious
IPC分类号： A61N1/06
CPC分类号： A61N1/37288 , A61N1/3611 , A61N1/36135 , A61N1/36585 , Y10S128/903
摘要： A physiological monitoring or therapy delivery system includes autonomous, wirelessly linked, implantable devices located at different areas to sense physiologic signals and deliver therapy. At least one of the implantable devices can trigger synchronized action (e.g. data capture or therapy delivery) by other implantable devices via a telemetry link.
摘要翻译：生理监测或治疗递送系统包括位于不同区域的自主的，无线连接的可植入装置，以感测生理信号并递送治疗。可植入装置中的至少一个可以经由遥测链路触发其它可植入装置的同步动作（例如数据捕获或治疗传递）。

8. 发明申请

US20080188764A1 METHOD AND APPARATUS FOR ATRIAL FIBRILLATION DETECTION BASED ON VENTRICULAR CYCLE LENGTHS 有权
标题翻译：基于静脉循环长度的ATRIAL FIBRILLATION检测方法与装置
公开(公告)号：US20080188764A1
公开(公告)日：2008-08-07
申请号：US11554275
申请日：2006-10-30
申请人： Brian B. Lee , Eric J. Panken
发明人： Brian B. Lee , Eric J. Panken
IPC分类号： A61B5/04
CPC分类号： A61B5/046 , A61B5/02405 , A61N1/3621 , A61N1/3925 , A61N1/395
摘要： A method and apparatus for detecting atrial arrhythmias include acquiring a cardiac signal comprising R-waves. Differences between pairs of consecutive R-R intervals occurring during a first time interval are computed from the cardiac signal. An atrial arrhythmia is detected subsequent to the first time interval in response to the computed differences. Storage of the cardiac signal is triggered in response to the atrial arrhythmia detection.
摘要翻译：用于检测心房心律失常的方法和装置包括获取包括R波的心脏信号。从心脏信号计算在第一时间间隔期间发生的连续R-R间隔对之间的差异。响应于所计算的差异，在第一时间间隔之后检测心房心律失常。响应于心房心律失常检测触发心脏信号的存储。

9. 发明授权

US10369353B2 Seizure disorder evaluation based on intracranial pressure and patient motion 有权
公开(公告)号：US10369353B2
公开(公告)日：2019-08-06
申请号：US12359037
申请日：2009-01-23
申请人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken , Timothy J. Denison , Keith A. Miesel , Michele H. Herzog
发明人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken , Timothy J. Denison , Keith A. Miesel , Michele H. Herzog
IPC分类号： A61B5/03 , A61N1/05 , A61B5/00 , A61N1/36
摘要： Intracranial pressure of a patient may be monitored in order to evaluate a seizure disorder. In some examples, trends in the intracranial pressure over time may be monitored, e.g., to detect changes to the patient's condition. In addition, in some examples, a seizure metric may be generated for a detected seizure based on sensed intracranial pressures. The seizure metric may indicate, for example, an average, median, or highest relative intracranial pressure value observed during a seizure, a percent change from a baseline value during the seizure, or the time for the intracranial pressure to return to a baseline state after the occurrence of a seizure. In addition to or instead of intracranial pressure, patient motion or posture may be monitored in order to assess the patient's seizure disorder. For example, a seizure type or severity may be determined based on patient motion sensed during a seizure.

10. 发明授权

US09776008B2 Posture state responsive therapy delivery using dwell times 有权
公开(公告)号：US09776008B2
公开(公告)日：2017-10-03
申请号：US12433017
申请日：2009-04-30
申请人： Dennis M. Skelton , Jon P. Davis , Eric J. Panken
发明人： Dennis M. Skelton , Jon P. Davis , Eric J. Panken
IPC分类号： A61N1/00 , A61N1/365 , A61B5/11 , A61B5/00
CPC分类号： A61N1/36542 , A61B5/1116 , A61B5/1118 , A61B5/686 , A61B5/7264 , A61B2562/0219 , A61N1/36535 , G06F19/00
摘要： Techniques related to classifying a posture state of a living body are disclosed. One aspect relates to sensing at least one signal indicative of a posture state of a living body. Posture state detection logic classifies the living body as being in a posture state based on the at least one signal, wherein this classification may take into account at least one of posture and activity state of the living body. The posture state detection logic further determines whether the living body is classified in the posture state for at least a predetermined period of time. Response logic is described that initiates a response as a result of the body being classified in the posture state only after the living body has maintained the classified posture state for at least the predetermined period of time. This response may involve a change in therapy, such as neurostimulation therapy, that is delivered to the living body.

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