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    • 6. 发明授权
    • Methods for producing chiral aldehydes
    • 生产手性醛的方法
    • US06399834B1
    • 2002-06-04
    • US09831925
    • 2001-05-15
    • Walter LeitnerSabine KainzDaniel KochGiancarlo Francio
    • Walter LeitnerSabine KainzDaniel KochGiancarlo Francio
    • C07C4550
    • C07C45/505Y02P20/544
    • The present invention relates to methods for producing chiral aldehydes by the enantioselective hydroformylation of prochiral substrates with the aid of a catalyst consisting of a transition metal and a chiral ligand, characterized in that said chiral ligand is a compound of general formula 1 wherein the rings R7-R10 drawn with dotted lines are optional and one or more of rings R1-R6 or R7-R10 are substituted with one or more independently selected substituents of general formula —(CH2)x(CF2)yF(x=0-5; y=1-12) or their branched isomers. In particular, the invention relates to the conducting of the mentioned methods in compressed (liquid or supercritical) carbon dioxide as the reaction medium.
    • 本发明涉及通过由过渡金属和手性配体组成的催化剂辅助前手性底物的对映选择性加氢甲酰化来制备手性醛的方法,其特征在于所述手性配体是通式1的化合物,其中R 7〜 用虚线绘制的R10是任选的,并且一个或多个R 1 -R 6或R 7 -R 10的环被一个或多个独立选择的通式 - (CH 2)x(CF 2)y F(x = 0-5; y = 1-12)或其支链异构体。 特别地,本发明涉及在作为反应介质的压缩(液体或超临界)二氧化碳中进行所述方法。