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1. 发明授权

US5827729A Diffusion gradient bioreactor and extracorporeal liver device using a three-dimensional liver tissue 失效
标题翻译：扩散梯度生物反应器和体外肝脏装置使用三维肝组织
公开(公告)号：US5827729A
公开(公告)日：1998-10-27
申请号：US636591
申请日：1996-04-23
申请人： Brian A. Naughton , Craig R. Halberstadt , Benson Sibanda
发明人： Brian A. Naughton , Craig R. Halberstadt , Benson Sibanda
IPC分类号： C12M1/00 , A01N1/02 , A61F2/02 , A61M1/34 , A61M1/36 , C12M1/16 , C12M3/06 , C12N5/00 , C12N5/071 , B01D63/00
CPC分类号： C12M29/04 , A61F2/022 , A61M1/3489 , C12M21/08 , C12M25/14 , C12M35/04 , C12M35/08 , C12M41/32 , C12N5/0671 , C12N2500/02 , C12N2500/32
摘要： A tissue engineering bioreactor is disclosed for growing three-dimensional tissue. Cells are seeded onto a mesh and provided with two media flows, each contacting a different side of the cells. The media flows contain different concentrations of nutrients, allowing nutrients to be delivered to the cells by diffusion gradient. The bioreactor can be used to grow liver tissue, and designed as an extracorporeal liver assist device in which blood or plasma is exposed to the three-dimensional liver tissue. The blood or plasma from a patient directed to flow against the liver tissue. The liver tissue is further exposed on its opposite side to media providing nutrients and gases. The device provides porous boundaries between the blood or plasma, tissue, and media, allowing nutrient and protein delivery by diffusion gradient to dialyze a patient's blood.
摘要翻译：公开了用于生长三维组织的组织工程生物反应器。将细胞接种到网状物上，并提供两个培养基流，每个接触细胞的不同侧。培养基流中含有不同浓度的营养物质，允许通过扩散梯度将营养物质递送到细胞。生物反应器可用于生长肝组织，并被设计为体外肝辅助装置，其中血液或血浆暴露于三维肝组织。来自患者的血液或血浆导向流向肝组织。肝脏组织进一步暴露在与提供营养和气体的介质的相对侧。该装置在血液或血浆，组织和培养基之间提供多孔边界，允许营养和蛋白质通过扩散梯度递送以透析患者的血液。

2. 发明授权

US06218182B1 Method for culturing three-dimensional tissue in diffusion gradient bioreactor and use thereof 失效
标题翻译：在扩散梯度生物反应器中培养三维组织的方法及其用途
公开(公告)号：US06218182B1
公开(公告)日：2001-04-17
申请号：US09470317
申请日：1999-12-21
申请人： Brian A. Naughton , Craig R. Halberstadt , Benson Sibanda
发明人： Brian A. Naughton , Craig R. Halberstadt , Benson Sibanda
IPC分类号： A01N102
CPC分类号： C12M29/04 , A61F2/022 , A61M1/3489 , C12M21/08 , C12M25/14 , C12M35/04 , C12M35/08 , C12M41/32 , C12N5/0671 , C12N2500/02 , C12N2500/32
摘要： A tissue engineering bioreactor is disclosed for growing three-dimensional tissue. Cells are seeded onto a mesh and provided with two media flows, each contacting a different side of the cells. The media flows contain different concentrations of nutrients, allowing nutrients to be delivered to the cells by diffusion gradient. The bioreactor can be used to grow liver tissue, and designed as an extracorporeal liver assist device in which blood or plasma is exposed to the three-dimensional liver tissue. The blood or plasma from a patient directed to flow against the liver tissue. The liver tissue is further exposed on its opposite side to media providing nutrients and gases. The device provides porous boundaries between the blood or plasma, tissue, and media; allowing nutrient and protein delivery by diffusion gradient to dialyze a patient's blood.
摘要翻译：公开了用于生长三维组织的组织工程生物反应器。将细胞接种到网状物上，并提供两个培养基流，每个接触细胞的不同侧。培养基流中含有不同浓度的营养物质，允许通过扩散梯度将营养物质递送到细胞。生物反应器可用于生长肝组织，并被设计为体外肝辅助装置，其中血液或血浆暴露于三维肝组织。来自患者的血液或血浆导向流向肝组织。肝脏组织进一步暴露在与提供营养和气体的介质的相对侧。该装置在血液或血浆，组织和培养基之间提供多孔边界; 允许营养和蛋白质通过扩散梯度递送以透析患者的血液。

3. 发明授权

US6008049A Diffusion gradient bioreactor and extracorporeal liver device 失效
标题翻译：扩散梯度生物反应器和体外肝脏装置
公开(公告)号：US6008049A
公开(公告)日：1999-12-28
申请号：US136503
申请日：1998-08-19
申请人： Brian A. Naughton , Craig R. Halberstadt , Benson Sibanda
发明人： Brian A. Naughton , Craig R. Halberstadt , Benson Sibanda
IPC分类号： C12M1/00 , A01N1/02 , A61F2/02 , A61M1/34 , A61M1/36 , C12M1/16 , C12M3/06 , C12N5/00 , C12N5/071 , C12M3/00
CPC分类号： C12M29/04 , A61F2/022 , A61M1/3489 , C12M21/08 , C12M25/14 , C12M35/04 , C12M35/08 , C12M41/32 , C12N5/0671 , C12N2500/02 , C12N2500/32
摘要： A tissue engineering bioreactor is disclosed for growing three-dimensional tissue. Cells are seeded onto a mesh and provided with two media flows, each contacting a different side of the cells. The media flows contain different concentrations of nutrients, allowing nutrients to be delivered to the cells by diffusion gradient. The bioreactor can be used to grow liver tissue, and designed as an extracorporeal liver assist device in which blood or plasma is exposed to the three-dimensional liver tissue. The blood or plasma from a patient directed to flow against the liver tissue. The liver tissue is further exposed on its opposite side to media providing nutrients and gases. The device provides porous boundaries between the blood or plasma, tissue, and media, allowing nutrient and protein delivery by diffusion gradient to dialyze a patient's blood.
摘要翻译：公开了用于生长三维组织的组织工程生物反应器。将细胞接种到网状物上，并提供两个培养基流，每个接触细胞的不同侧。培养基流中含有不同浓度的营养物质，允许通过扩散梯度将营养物质递送到细胞。生物反应器可用于生长肝组织，并被设计为体外肝辅助装置，其中血液或血浆暴露于三维肝组织。来自患者的血液或血浆导向流向肝组织。肝脏组织进一步暴露在与提供营养和气体的介质的相对侧。该装置在血液或血浆，组织和培养基之间提供多孔边界，允许营养和蛋白质通过扩散梯度递送以透析患者的血液。

5. 发明申请

US20130330364A1 THERAPEUTIC FORMULATIONS 有权
标题翻译：治疗配方
公开(公告)号：US20130330364A1
公开(公告)日：2013-12-12
申请号：US13883433
申请日：2011-11-10
申请人： Joydeep Basu , Richard Payne , Neil F. Robbins , Oluwatoyin A. Knight , Deepak Jain , Craig R. Halberstadt , Monica A. Serban
发明人： Joydeep Basu , Richard Payne , Neil F. Robbins , Oluwatoyin A. Knight , Deepak Jain , Craig R. Halberstadt , Monica A. Serban
IPC分类号： A61K35/22 , A61K45/06
CPC分类号： A61K35/22 , A61K45/06 , A61L27/222 , A61L27/54 , A61L2400/06 , A61L2430/26
摘要： The present invention concerns therapeutic formulations containing active agents, such bioactive cell populations, and methods of making and using the same.
摘要翻译：本发明涉及含有活性剂，这种生物活性细胞群体的治疗制剂及其制备和使用方法。

7. 发明授权

US5081035A Bioreactor system 失效
标题翻译：生物反应器系统
公开(公告)号：US5081035A
公开(公告)日：1992-01-14
申请号：US654418
申请日：1991-02-11
申请人： Craig R. Halberstadt , A. Rees Midgley
发明人： Craig R. Halberstadt , A. Rees Midgley
IPC分类号： C12M3/06
CPC分类号： C12M29/10 , C12M23/24 , C12M29/12 , C12M35/04 , C12M35/08 , C12M41/00 , C12M41/32
摘要： A system for continuous perfusion culturing of anchorage-dependent and anchorage-independent mammalian cell lines, inter alia, wherein in vivo capillary bed conditions are simulated by providing a bioreactor having a growth chamber wherein the cells are grown between a multitubular array comprising at least three functionally separate, inert non-degradable and structurally strong tubes or sets of tubes. A constant nutrient gradient is maintained along the entire length of the tubes by perfusing medium through the tubes at a flow rate which is sufficient to expose all areas of the chamber to fresh medium by convective forces rather than diffusion. Oxygen transfer and removal of toxic wastes is improved by the invention herein. In a preferred embodiment, porous inert expanded Teflon tubes are employed having an inner diameter of approximately between 1 and 2 millimeters.
摘要翻译：一种用于连续灌注培养锚定依赖和不依赖锚定的哺乳动物细胞系的系统，其中特别地，其中通过提供具有生长室的生物反应器来模拟体内毛细管床条件，其中所述细胞在包含至少三个功能分离，惰性不可降解和结构强的管或套管。通过使培养基通过管子以足够的流量使培养基通过对流力而不是扩散将培养室的所有区域暴露于新鲜培养基的流速，保持恒定的养分梯度。本发明改善了有毒废物的氧气转移和去除。在一个优选的实施方式中，使用内径大约在1和2毫米之间的多孔惰性膨胀的特氟隆管。

8. 发明授权

US09724367B2 Injectable formulations for organ augmentation 有权
公开(公告)号：US09724367B2
公开(公告)日：2017-08-08
申请号：US13883433
申请日：2011-11-10
申请人： Joydeep Basu , Richard Payne , Neil F. Robbins , Oluwatoyin A. Knight , Deepak Jain , Craig R. Halberstadt , Monica A. Serban
发明人： Joydeep Basu , Richard Payne , Neil F. Robbins , Oluwatoyin A. Knight , Deepak Jain , Craig R. Halberstadt , Monica A. Serban
IPC分类号： A61F13/00 , A61K9/14 , A61K31/74 , A61K38/00 , A61K38/16 , A61K47/00 , A61K35/22 , A61L27/22 , A61L27/54 , A61K45/06
CPC分类号： A61K35/22 , A61K45/06 , A61L27/222 , A61L27/54 , A61L2400/06 , A61L2430/26
摘要： The present invention concerns phase changing injectable formulations for organ augmentation containing active agents, such as bioactive cell populations, and methods of making and using the same.

9. 发明申请

US20150030657A1 SMOOTH MUSCLE CELL CONSTRUCTS 审中-公开
标题翻译： SMOOTH肌肉细胞结构
公开(公告)号：US20150030657A1
公开(公告)日：2015-01-29
申请号：US13696051
申请日：2011-05-03
申请人： John W. Ludlow , Manuel J. Jayo , Joydeep Basu , Timothy A. Bertram , Christopher W. Genheimer , Kelly I. Guthrie , Roger M. Ilagan , Deepak Jain , Oluwatoyin A. Knight , Richard Payne , Sarah F. Quinlan , H. Scott Rapoport , Namrata D. Sangha , Jacob E. Shokes , Teresa B. Burnette , Sarah A. Boyd , Craig R. Halberstadt , Dominic M. Justewicz , Elias A. Rivera , Wendy Sharp , Neil F. Robbins
发明人： John W. Ludlow , Manuel J. Jayo , Joydeep Basu , Timothy A. Bertram , Christopher W. Genheimer , Kelly I. Guthrie , Roger M. Ilagan , Deepak Jain , Oluwatoyin A. Knight , Richard Payne , Sarah F. Quinlan , H. Scott Rapoport , Namrata D. Sangha , Jacob E. Shokes , Teresa B. Burnette , Sarah A. Boyd , Craig R. Halberstadt , Dominic M. Justewicz , Elias A. Rivera , Wendy Sharp , Neil F. Robbins
IPC分类号： A61K35/34
CPC分类号： A61K35/34 , A61F2/042 , A61L27/3826 , A61L2430/22
摘要： The present invention relates to the regeneration, reconstruction, augmentation or replacement of luminal organs or tissue structures in a subject in need using scaffolds seeded with autologous or non-autologous cell populations that are or are not derived from the corresponding organ or tissue structure that is the subject of the regeneration, reconstruction, augmentation or replacement.
摘要翻译：本发明涉及在有需要的受试者中使用自体或非自体细胞群体接种的支架的再生，重建，增加或替代，所述自体或非自体细胞群是衍生自相应器官或组织结构的或不衍生自相应器官或组织结构的支架重建，重建，增加或更换的主题。

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