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1. 发明授权

US08022013B2 Method of forming and using solid-phase support 有权
标题翻译：形成和使用固相载体的方法
公开(公告)号：US08022013B2
公开(公告)日：2011-09-20
申请号：US10651568
申请日：2003-08-29
申请人： Brett Ellman , Michal Lebl , Aaron Jones , Steve Fambro , David Heiner
发明人： Brett Ellman , Michal Lebl , Aaron Jones , Steve Fambro , David Heiner
IPC分类号： C40B50/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00315 , B01J2219/00355 , B01J2219/00421 , B01J2219/00463 , B01J2219/0049 , B01J2219/005 , B01J2219/00509 , B01J2219/00527 , B01J2219/0059 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00675 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/5085 , B01L2200/12 , B01L2300/069 , B01L2300/0851 , C40B40/06 , C40B40/10 , C40B40/14 , C40B50/14 , C40B60/14 , Y10T156/10 , Y10T156/109 , Y10T436/25
摘要： A method of forming a solid-phase support, the method including the steps of providing a substrate having a reaction vessel, dispensing a particle in the reaction vessel, and permanently bonding the particle in the substrate within the reaction vessel. The particle may include a microbead. The particle may include controlled pore glass. A method of synthesis is also disclosed that includes including the steps of providing a solid-phase support including a particle embedded to the substrate adjacent a surface of substrate, the particle being functionalized to covalently attach an intermediate compound of a synthetic reaction, dispensing a liquid including a reagent to the solid-phase support to effect the synthetic reaction, and removing the liquid from the solid-phase support by centrifugation, whereby the intermediate compound remains attached to the substrate by the particle.
摘要翻译：一种形成固相载体的方法，所述方法包括以下步骤：提供具有反应容器的基材，在反应容器中分配颗粒，并将颗粒永久粘合在反应容器内的基材中。颗粒可以包括微珠。颗粒可以包括受控孔隙玻璃。还公开了一种合成方法，其包括以下步骤：提供固相载体，该固相载体包括邻近基底表面嵌入到基底中的颗粒，所述颗粒被官能化以共价连接合成反应的中间体化合物，分配液体包括用于进行合成反应的固相载体的试剂，以及通过离心从固相载体中除去液体，由此中间体化合物通过颗粒保持附着于基材。

2. 发明授权

US08912130B2 Methods of forming and using a solid-phase support 有权
标题翻译：形成和使用固相载体的方法
公开(公告)号：US08912130B2
公开(公告)日：2014-12-16
申请号：US13235269
申请日：2011-09-16
申请人： Brett Ellman , Michal Lebl , Aaron Jones , Steve Fambro , David Heiner
发明人： Brett Ellman , Michal Lebl , Aaron Jones , Steve Fambro , David Heiner
IPC分类号： C40B50/18 , B82Y30/00 , B01J19/00 , B01L3/00 , C40B40/06 , C40B40/10 , C40B40/14 , C40B50/14 , C40B60/14
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00315 , B01J2219/00355 , B01J2219/00421 , B01J2219/00463 , B01J2219/0049 , B01J2219/005 , B01J2219/00509 , B01J2219/00527 , B01J2219/0059 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00675 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/5085 , B01L2200/12 , B01L2300/069 , B01L2300/0851 , C40B40/06 , C40B40/10 , C40B40/14 , C40B50/14 , C40B60/14 , Y10T156/10 , Y10T156/109 , Y10T436/25
摘要： Disclosed herein are methods of method of making a substrate for performing a chemical synthesis reaction.
摘要翻译：本文公开了制备用于进行化学合成反应的基材的方法的方法。

3. 发明申请

US20120012250A1 METHODS OF FORMING AND USING A SOLID-PHASE SUPPORT 有权
标题翻译：形成和使用固相支持的方法
公开(公告)号：US20120012250A1
公开(公告)日：2012-01-19
申请号：US13235269
申请日：2011-09-16
申请人： Brett Ellman , Michal Lebl , Aaron Jones , Steve Fambro , David Heiner
发明人： Brett Ellman , Michal Lebl , Aaron Jones , Steve Fambro , David Heiner
IPC分类号： B32B38/08 , B05D7/22
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00315 , B01J2219/00355 , B01J2219/00421 , B01J2219/00463 , B01J2219/0049 , B01J2219/005 , B01J2219/00509 , B01J2219/00527 , B01J2219/0059 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00675 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/5085 , B01L2200/12 , B01L2300/069 , B01L2300/0851 , C40B40/06 , C40B40/10 , C40B40/14 , C40B50/14 , C40B60/14 , Y10T156/10 , Y10T156/109 , Y10T436/25
摘要： Disclosed herein are methods of method of making a substrate for performing a chemical synthesis reaction.
摘要翻译：本文公开了制备用于进行化学合成反应的基材的方法的方法。

4. 发明申请

US20050048667A1 Method of forming and using solid-phase support 有权
标题翻译：形成和使用固相载体的方法
公开(公告)号：US20050048667A1
公开(公告)日：2005-03-03
申请号：US10651568
申请日：2003-08-29
申请人： Brett Ellman , Michal Lebl , Aaron Jones , Steve Fambro , David Heiner
发明人： Brett Ellman , Michal Lebl , Aaron Jones , Steve Fambro , David Heiner
IPC分类号： B01J19/00 , B01L3/00 , C40B40/06 , C40B40/10 , C40B40/14 , C40B50/14 , C40B60/14 , G01N1/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00315 , B01J2219/00355 , B01J2219/00421 , B01J2219/00463 , B01J2219/0049 , B01J2219/005 , B01J2219/00509 , B01J2219/00527 , B01J2219/0059 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00675 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/5085 , B01L2200/12 , B01L2300/069 , B01L2300/0851 , C40B40/06 , C40B40/10 , C40B40/14 , C40B50/14 , C40B60/14 , Y10T156/10 , Y10T156/109 , Y10T436/25
摘要： A method of forming a solid-phase support, the method including the steps of providing a substrate having a reaction vessel, dispensing a particle in the reaction vessel, and permanently bonding the particle in the substrate within the reaction vessel. The particle may include a microbead. The particle may include controlled pore glass. A method of synthesis is also disclosed that includes including the steps of providing a solid-phase support including a particle embedded to the substrate adjacent a surface of substrate, the particle being functionalized to covalently attach an intermediate compound of a synthetic reaction, dispensing a liquid including a reagent to the solid-phase support to effect the synthetic reaction, and removing the liquid from the solid-phase support by centrifugation, whereby the intermediate compound remains attached to the substrate by the particle.
摘要翻译：一种形成固相载体的方法，所述方法包括以下步骤：提供具有反应容器的基材，在反应容器中分配颗粒，并将颗粒永久粘合在反应容器内的基材中。颗粒可以包括微珠。颗粒可以包括受控孔隙玻璃。还公开了一种合成方法，其包括以下步骤：提供固相载体，该固相载体包括邻近基底表面嵌入到基底中的颗粒，所述颗粒被官能化以共价连接合成反应的中间体化合物，分配液体包括用于进行合成反应的固相载体的试剂，以及通过离心从固相载体中除去液体，由此中间体化合物通过颗粒保持附着于基材。

5. 发明申请

US20070117178A1 Continuous polymer synthesizer 审中-公开
公开(公告)号：US20070117178A1
公开(公告)日：2007-05-24
申请号：US11521574
申请日：2006-09-13
申请人： David Heiner , Aaron Jones , Steven Fambro , Mark Nibbe , Steven Burgett , Brett Ellman , Michal Lebl
发明人： David Heiner , Aaron Jones , Steven Fambro , Mark Nibbe , Steven Burgett , Brett Ellman , Michal Lebl
IPC分类号： C12M3/00 , C12P21/06 , C12P19/34
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00283 , B01J2219/00315 , B01J2219/00326 , B01J2219/0036 , B01J2219/00423 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00612 , B01J2219/00659 , B01J2219/00675 , B01J2219/00693 , B01J2219/00722 , B01J2219/00725 , C40B60/14 , Y10T436/115831 , Y10T436/12
摘要： Described is a system and method for synthesizing polymeric molecules such as oligonucleotides and polypeptides. The system is capable of continuously synthesizing molecules by providing an array of reaction sites and an array of stations for carrying out synthetic manipulations. The reaction sites in the former array can be placed in a fixed order and at fixed intervals relative to each other. Similarly, the stations can be placed in a fixed order and at fixed intervals relative to each other. The two arrays can be moved relative to each other such that the stations carry out desired steps of a reaction scheme at each reaction site. The relative locations of the stations and the schedule for the relative movement can correlate with the order and duration of reaction steps in the reaction scheme such that once a reaction site has completed a cycle of interacting with the full array of stations then the reaction scheme is complete.

6. 发明申请

US20070110638A1 Continuous polymer synthesizer 有权
标题翻译：连续聚合物合成仪
公开(公告)号：US20070110638A1
公开(公告)日：2007-05-17
申请号：US11521573
申请日：2006-09-13
申请人： David Heiner , Aaron Jones , Steven Fambro , Mark Nibbe , Steve Burgett , Brett Ellman , Michal Lebl
发明人： David Heiner , Aaron Jones , Steven Fambro , Mark Nibbe , Steve Burgett , Brett Ellman , Michal Lebl
IPC分类号： B01J19/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00283 , B01J2219/00315 , B01J2219/00326 , B01J2219/0036 , B01J2219/00423 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00612 , B01J2219/00659 , B01J2219/00675 , B01J2219/00693 , B01J2219/00722 , B01J2219/00725 , C40B60/14 , Y10T436/115831 , Y10T436/12
摘要： Described is a system and method for synthesizing polymeric molecules such as oligonucleotides and polypeptides. The system is capable of continuously synthesizing molecules by providing an array of reaction sites and an array of stations for carrying out synthetic manipulations. The reaction sites in the former array can be placed in a fixed order and at fixed intervals relative to each other. Similarly, the stations can be placed in a fixed order and at fixed intervals relative to each other. The two arrays can be moved relative to each other such that the stations carry out desired steps of a reaction scheme at each reaction site. The relative locations of the stations and the schedule for the relative movement can correlate with the order and duration of reaction steps in the reaction scheme such that once a reaction site has completed a cycle of interacting with the full array of stations then the reaction scheme is complete.
摘要翻译：描述了用于合成聚合物分子如寡核苷酸和多肽的系统和方法。该系统能够通过提供反应位点阵列和用于进行合成操作的站阵列来连续合成分子。前一阵列中的反应位点可以相对于彼此以固定的顺序和固定的间隔放置。类似地，站可以以固定的顺序相对于彼此以固定的间隔放置。两个阵列可以相对于彼此移动，使得站在每个反应位置进行反应方案的期望步骤。站的相对位置和相对运动的时间表可以与反应方案中的反应步骤的顺序和持续时间相关联，使得一旦反应位点完成了与整个站阵列相互作用的循环，则反应方案为完成。

7. 发明授权

US08597594B2 Apparatus for fragmenting nucleic acids 有权
标题翻译：破碎核酸的装置
公开(公告)号：US08597594B2
公开(公告)日：2013-12-03
申请号：US13551704
申请日：2012-07-18
申请人： Jonathan Posner , Kamil Salloum , Michal Lebl , Mark Reed , Dale Buermann , Matthew Hage , Bryan Crane , David Heiner , Robert Kain , Michael Schroeder
发明人： Jonathan Posner , Kamil Salloum , Michal Lebl , Mark Reed , Dale Buermann , Matthew Hage , Bryan Crane , David Heiner , Robert Kain , Michael Schroeder
IPC分类号： B01L3/00
CPC分类号： F04B37/10 , F04B19/00 , Y10T436/2575
摘要： An apparatus for fragmenting nucleic acid. The apparatus includes a sample reservoir that comprises a fluid having nucleic acids. The apparatus can also include a shear wall that is positioned within the sample reservoir. The shear wall includes a porous core medium that has pores that are sized to permit nucleic acids to flow therethrough. The apparatus also includes first and second chambers that are separated by the shear wall. The first and second chambers are in fluid communication with each other through the porous core medium of the shear wall. Also, the apparatus may include first and second electrodes that are located within the first and second chambers, respectively. The first and second electrodes are configured to generate an electric field that induces a flow of the sample fluid. The nucleic acids move through the shear wall thereby fragmenting the nucleic acids.
摘要翻译：核酸分裂装置。该装置包括包含具有核酸的流体的样品储存器。该装置还可以包括位于样品容器内的剪切壁。剪切壁包括多孔芯介质，其具有尺寸允许核酸流过其中的孔。该装置还包括被剪力墙隔开的第一和第二室。第一和第二腔室通过剪切壁的多孔纤维介质彼此流体连通。此外，该装置可以包括分别位于第一和第二室内的第一和第二电极。第一和第二电极被配置成产生诱发样品流体流动的电场。核酸通过剪切壁移动，从而使核酸分裂。

8. 发明申请

US20100187115A1 ELECTROOSMOTIC PUMP WITH IMPROVED GAS MANAGEMENT 有权
标题翻译：具有改进气体管理的电动泵
公开(公告)号：US20100187115A1
公开(公告)日：2010-07-29
申请号：US12626353
申请日：2009-11-25
申请人： Jonathan Posner , Kamil Salloum , Michal Lebl , Mark Reed , Dale Buermann , Matthew Hage , Bryan Crane , David Heiner , Robert Kain
发明人： Jonathan Posner , Kamil Salloum , Michal Lebl , Mark Reed , Dale Buermann , Matthew Hage , Bryan Crane , David Heiner , Robert Kain
IPC分类号： B01D57/02 , F04B19/00 , B01D61/46 , B81B7/02 , C12Q1/68 , B01J19/00 , G01N27/447
CPC分类号： F04B37/10 , F04B19/00 , Y10T436/2575
摘要： An electroosmotic (EO) pump is provided that includes a housing having a pump cavity, a porous core medium and electrodes. The porous core medium is positioned within the pump cavity to form an exterior reservoir that extends at least partially about an exterior surface of the porous core medium. The porous core medium has an open inner chamber provided therein. The inner chamber represents an interior reservoir. The electrodes are positioned in the inner chamber and are positioned proximate the exterior surface. The electrodes induce flow of a fluid through the porous core medium between the interior and exterior reservoirs, wherein a gas is generated when the electrodes induce flow of the fluid. The housing has a fluid inlet to convey the fluid to one of the interior reservoir and the exterior reservoir. The housing has a fluid outlet to discharge the fluid from another of the interior reservoir and the exterior reservoir. The housing has a gas removal device to remove the gas from the pump cavity.
摘要翻译：提供一种电渗（EO）泵，其包括具有泵腔的壳体，多孔芯介质和电极。多孔芯介质定位在泵腔内以形成至少部分地围绕多孔芯介质的外表面延伸的外部储存器。多孔芯介质具有设置在其中的开放内室。内室表示内部储存器。电极定位在内室中并且位于外表面附近。电极通过多孔芯介质在内部和外部储存器之间引导流体流动，其中当电极引起流体流动时产生气体。壳体具有用于将流体输送到内部储存器和外部储存器中的一个的流体入口。壳体具有流体出口，以从另一个内部储存器和外部储存器排出流体。壳体具有用于从泵腔去除气体的气体去除装置。

9. 发明申请

US20120292190A1 APPARATUS FOR FRAGMENTING NUCLEIC ACIDS 有权
标题翻译：装备核酸的装置
公开(公告)号：US20120292190A1
公开(公告)日：2012-11-22
申请号：US13551704
申请日：2012-07-18
申请人： Jonathan Posner , Kamil Salloum , Michal Lebl , Mark Reed , Dale Buermann , Matthew Hage , Bryan Crane , David Heiner , Robert Kain
发明人： Jonathan Posner , Kamil Salloum , Michal Lebl , Mark Reed , Dale Buermann , Matthew Hage , Bryan Crane , David Heiner , Robert Kain
IPC分类号： C25B7/00
CPC分类号： F04B37/10 , F04B19/00 , Y10T436/2575
摘要： An apparatus for fragmenting nucleic acid. The apparatus includes a sample reservoir that comprises a fluid having nucleic acids. The apparatus can also include a shear wall that is positioned within the sample reservoir. The shear wall includes a porous core medium that has pores that are sized to permit nucleic acids to flow therethrough. The apparatus also includes first and second chambers that are separated by the shear wall. The first and second chambers are in fluid communication with each other through the porous core medium of the shear wall. Also, the apparatus may include first and second electrodes that are located within the first and second chambers, respectively. The first and second electrodes are configured to generate an electric field that induces a flow of the sample fluid. The nucleic acids move through the shear wall thereby fragmenting the nucleic acids.
摘要翻译：核酸分裂装置。该装置包括包含具有核酸的流体的样品储存器。该装置还可以包括位于样品容器内的剪切壁。剪切壁包括多孔芯介质，其具有尺寸允许核酸流过其中的孔。该装置还包括被剪力墙隔开的第一和第二室。第一和第二腔室通过剪切壁的多孔纤维介质彼此流体连通。此外，该装置可以包括分别位于第一和第二室内的第一和第二电极。第一和第二电极被配置成产生诱发样品流体流动的电场。核酸通过剪切壁移动，从而使核酸分裂。

10. 发明授权

US08252250B2 Electroosmotic pump with improved gas management 有权
标题翻译：电渗泵具有改进的气体管理
公开(公告)号：US08252250B2
公开(公告)日：2012-08-28
申请号：US12626353
申请日：2009-11-25
申请人： Jonathan Posner , Kamil Salloum , Michal Lebl , Mark Reed , Dale Buermann , Matthew Hage , Bryan Crane , David Heiner , Robert Kain
发明人： Jonathan Posner , Kamil Salloum , Michal Lebl , Mark Reed , Dale Buermann , Matthew Hage , Bryan Crane , David Heiner , Robert Kain
IPC分类号： B01L3/00
CPC分类号： F04B37/10 , F04B19/00 , Y10T436/2575
摘要： An electroosmotic (EO) pump is provided that includes a housing having a pump cavity, a porous core medium and electrodes. The porous core medium is positioned within the pump cavity to form an exterior reservoir that extends at least partially about an exterior surface of the porous core medium. The porous core medium has an open inner chamber provided therein. The inner chamber represents an interior reservoir. The electrodes are positioned in the inner chamber and are positioned proximate the exterior surface. The electrodes induce flow of a fluid through the porous core medium between the interior and exterior reservoirs, wherein a gas is generated when the electrodes induce flow of the fluid. The housing has a fluid inlet to convey the fluid to one of the interior reservoir and the exterior reservoir. The housing has a fluid outlet to discharge the fluid from another of the interior reservoir and the exterior reservoir. The housing has a gas removal device to remove the gas from the pump cavity.
摘要翻译：提供一种电渗（EO）泵，其包括具有泵腔的壳体，多孔芯介质和电极。多孔芯介质定位在泵腔内以形成至少部分地围绕多孔芯介质的外表面延伸的外部储存器。多孔芯介质具有设置在其中的开放内室。内室表示内部储存器。电极定位在内室中并且位于外表面附近。电极通过多孔芯介质在内部和外部储存器之间引导流体流动，其中当电极引起流体流动时产生气体。壳体具有用于将流体输送到内部储存器和外部储存器中的一个的流体入口。壳体具有流体出口，以从另一个内部储存器和外部储存器排出流体。壳体具有用于从泵腔去除气体的气体去除装置。

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