专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06573238B2 Method for producing sustained-release formulations 失效
标题翻译：缓释制剂的制备方法
公开(公告)号：US06573238B2
公开(公告)日：2003-06-03
申请号：US09187780
申请日：1998-11-06
申请人： Bret Shirley , Maninder Hora , Derek O'Hagan , Manmohan Singh
发明人： Bret Shirley , Maninder Hora , Derek O'Hagan , Manmohan Singh
IPC分类号： A61K3800
CPC分类号： A61K9/0019 , A61K9/0024 , A61K9/1647 , A61K9/1694 , A61K38/30 , A61K47/183
摘要： Methods for preparing biodegradable microparticles are provided. Also provided are microparticles prepared by the method which include IGF-1 entrapped therein. The microparticles allow for controlled release of IGF-1 and other polypeptides over prolonged periods of time.
摘要翻译：提供了制备可生物降解的微粒的方法。还提供了通过包含IGF-1的方法制备的微粒。微粒允许在长时间内控制释放IGF-1和其他多肽。

2. 发明授权

US07846479B2 Microparticle compositions and methods for the manufacture thereof 有权
标题翻译：微粒组合物及其制造方法
公开(公告)号：US07846479B2
公开(公告)日：2010-12-07
申请号：US10775964
申请日：2004-02-10
申请人： Jia-Hwa Fang , Manmohan Singh , Derek O'Hagan , Maninder Hora
发明人： Jia-Hwa Fang , Manmohan Singh , Derek O'Hagan , Maninder Hora
IPC分类号： A61K9/14
CPC分类号： A61K9/1676 , A61K9/1647
摘要： Microparticles with adsorbed complexes of macromolecule and detergent, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surfaces of the microparticles have adsorbed thereon a complex of biologically active macromolecules, such as nucleic acids, polypeptides, antigens, and adjuvants, and a detergent. Preferred polymers are poly(D,L-lactide-co-glycolides), more preferably those having a lactide/glycolide molar ratio ranging from 40:60 to 60:40 and having a molecular weight ranging from 30,000 Daltons to 70,000 Daltons. Preferred macromolecules are bacterial and viral antigens (such as HIV antigens, meningitis B antigens, streptococcus B antigens, and Influenza A hemagglutinin antigens) as well as polynucleotides that encode for such antigens.
摘要翻译：公开了具有大分子和洗涤剂的吸附复合物的微粒，制备这种微粒的方法及其用途。微粒包含聚（α-羟基酸），多羟基丁酸，聚己内酯，聚原酸酯，聚酐等聚合物，并使用阳离子，阴离子或非离子型洗涤剂形成。微粒表面上吸附有生物活性大分子如核酸，多肽，抗原和佐剂以及洗涤剂的复合物。优选的聚合物是聚（D，L-丙交酯 - 共 - 乙交酯），更优选丙交酯/乙交酯摩尔比范围为40:60至60:40且分子量范围为30,000道尔顿至70,000道尔顿的聚合物。优选的大分子是细菌和病毒抗原（例如HIV抗原，脑膜炎B抗原，B链球菌抗原和甲型流感血凝素抗原）以及编码这些抗原的多核苷酸。

3. 发明授权

US10286056B2 Adjuvant nanoemulsions with crystallisation inhibitors 有权
公开(公告)号：US10286056B2
公开(公告)日：2019-05-14
申请号：US13982042
申请日：2012-01-27
申请人： Luis Brito , Manmohan Singh , Derek O'Hagan
发明人： Luis Brito , Manmohan Singh , Derek O'Hagan
IPC分类号： A61K39/39 , A61K39/095 , A61K9/107 , A61K31/00 , A61K31/4745 , A61K9/00 , A61K31/4375 , A61K47/26 , A61K47/32 , A61K47/44
摘要： High loading of lipophilic pharmacological agents (in particular, lipophilic immunopotentiators) in oil-in-water emulsions can result in crystallisation of the lipophilic agent. To overcome this problem the invention uses an oil-in-water emulsion in combination with a crystallisation inhibitor, and this combination provides emulsions which can be loaded with high levels of lipophilic pharmacological agents.

4. 发明授权

US09636410B2 Cationic oil-in-water emulsions 有权
公开(公告)号：US09636410B2
公开(公告)日：2017-05-02
申请号：US14130886
申请日：2012-07-06
申请人： Luis Brito , Michelle Chan , Andrew Geall , Derek O'Hagan , Manmohan Singh
发明人： Luis Brito , Michelle Chan , Andrew Geall , Derek O'Hagan , Manmohan Singh
IPC分类号： A61K47/48 , A61K9/107 , A61K47/06 , A61K47/24 , A61K39/12 , A61K39/39 , A61K39/00
CPC分类号： A61K39/39 , A61K9/1075 , A61K39/12 , A61K39/155 , A61K39/245 , A61K47/02 , A61K47/06 , A61K47/12 , A61K47/22 , A61K47/24 , A61K47/26 , A61K47/34 , A61K2039/5256 , A61K2039/53 , A61K2039/55555 , A61K2039/55566 , A61K2039/575 , C12N7/00 , C12N2710/16134 , C12N2710/16171 , C12N2710/16734 , C12N2710/16771 , C12N2760/18534 , C12N2760/18571 , C12N2770/36134 , C12N2770/36143 , C12N2840/203 , Y02A50/386 , Y02A50/388 , Y02A50/412
摘要： This invention generally relates to cationic oil-in-water emulsions that contain high concentrations of cationic lipids and have a defined oil:lipid ratio. The cationic lipid can interact with the negatively charged molecule thereby anchoring the molecule to the emulsion particles. The cationic emulsions described herein are useful for delivering negatively charged molecules, such as nucleic acid molecules to cells, and for formulating nucleic acid-based vaccines.

5. 发明授权

US09192661B2 Delivery of self-replicating RNA using biodegradable polymer particles 有权
标题翻译：使用可生物降解的聚合物颗粒递送自我复制的RNA
公开(公告)号：US09192661B2
公开(公告)日：2015-11-24
申请号：US13808245
申请日：2011-06-07
申请人： Siddhartha Jain , Derek O'Hagan , Manmohan Singh
发明人： Siddhartha Jain , Derek O'Hagan , Manmohan Singh
IPC分类号： A61K39/385 , A61K9/16 , A61K9/51 , A61K39/155 , C12N15/86 , C12N15/88 , A61K39/12 , A61K39/00
CPC分类号： A61K39/385 , A61K9/1617 , A61K9/1647 , A61K9/5123 , A61K9/5153 , A61K39/12 , A61K39/155 , A61K2039/5256 , A61K2039/53 , A61K2039/55555 , A61K2039/622 , A61P31/14 , C12N15/86 , C12N15/88 , C12N2760/18534 , C12N2770/36143
摘要： Particle compositions comprising adsorbed RNA replicons as well as methods of making and using the same are described.
摘要翻译：描述包含吸附的RNA复制子的颗粒组合物以及其制备和使用方法。

6. 发明申请

US20130195898A1 MICROEMULSIONS WITH ADSORBED MACROMOLECULES AND MICROPARTICLES 有权
公开(公告)号：US20130195898A1
公开(公告)日：2013-08-01
申请号：US13621174
申请日：2012-09-15
申请人： Derek O'Hagan , Gary S. Ott , John Donnelly , Jina Kazzaz , Mildred Ugozzoli , Manmohan Singh , John Barackman
发明人： Derek O'Hagan , Gary S. Ott , John Donnelly , Jina Kazzaz , Mildred Ugozzoli , Manmohan Singh , John Barackman
IPC分类号： A61K39/39
CPC分类号： A61K39/39 , A61K9/1075 , A61K9/167 , A61K39/0208 , A61K39/21 , A61K39/245 , A61K39/29 , Y02A50/411 , Y02A50/471
摘要： Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided. Methods of stimulating an immune response, methods of immunizing a host animal against a viral, bacterial, or parasitic infection, and methods of increasing a Th1 immune response in a host animal by administering to the animal an immunogenic composition of the microparticles, and/or microemulsions of the invention, are also provided.

7. 发明授权

US08431160B2 Microparticles containing biodegradable polymer and cationic polysaccharide for use in immunogenic compositions 有权
公开(公告)号：US08431160B2
公开(公告)日：2013-04-30
申请号：US11710250
申请日：2007-02-24
申请人： Derek O'Hagan , Manmohan Singh , Janet Wendorf , Jina Kazzaz , Padma Malyala
发明人： Derek O'Hagan , Manmohan Singh , Janet Wendorf , Jina Kazzaz , Padma Malyala
IPC分类号： A61K9/14 , A61K39/00 , A61K39/39 , A61K39/12 , A61K39/02 , A61K39/002 , A61K39/21 , A61K39/29 , A61K39/145 , A61K39/10 , A61K39/05 , A61K39/08 , A61P37/04
CPC分类号： A61K9/1652 , A61K39/095 , A61K39/385 , A61K39/39 , A61K2039/55555 , A61K2039/55561 , A61K2039/6093
摘要： Immunogenic compositions are described herein which comprise microparticles that further comprise a biodegradable polymer. The microparticle compositions also comprise a cationic polysaccharide and an immunological species selected from an antigen, an immunological adjuvant and a combination thereof. Also described are methods of making such compositions and methods of administering such compositions. Methods of modulating the release rate of immunological species from microparticles are also described. These methods comprise varying the ratio of the cationic polysaccharide relative to the biodegradable polymer within the microparticles.

8. 发明授权

US07731967B2 Compositions for inducing immune responses 有权
标题翻译：用于诱导免疫反应的组合物
公开(公告)号：US07731967B2
公开(公告)日：2010-06-08
申请号：US10837117
申请日：2004-04-29
申请人： Derek O'Hagan , Manmohan Singh
发明人： Derek O'Hagan , Manmohan Singh
IPC分类号： A61K39/00
CPC分类号： A61K39/39 , A61K2039/55511 , A61K2039/55555
摘要： The invention provides, inter alia, immunogenic compositions comprising a first antigen, at least two adjuvants, wherein a first adjuvant comprises a polymer derived from poly(lactides) and/or poly(lactide-co-glycolides), and wherein a second adjuvant comprises an imidazoquinoline, wherein said first antigen is encapsulated within, adsorbed or conjugated to, co-lyophilized or mixed with said first adjuvant, and a pharmaceutically acceptable excipient, wherein said composition elicits a cellular immune response when administered to a vertebrate subject. The invention also provides methods of producing immunogenic compositions, methods for producing a cytotoxic-T lymphocyte (CTL) response in a vertebrate subject, and methods of immunization.
摘要翻译：本发明尤其提供包含第一抗原，至少两种佐剂的免疫原性组合物，其中第一佐剂包含衍生自聚（丙交酯）和/或聚（丙交酯 - 共 - 乙交酯）的聚合物，并且其中第二佐剂包含咪唑并喹啉，其中所述第一抗原包被在所述第一佐剂中并被共冻干或混合，吸附或缀合，以及药学上可接受的赋形剂，其中所述组合物在施用于脊椎动物受试者时引起细胞免疫应答。本发明还提供产生免疫原性组合物的方法，在脊椎动物受试者中产生细胞毒性T淋巴细胞（CTL）应答的方法和免疫方法。

9. 发明授权

US07604802B2 Method of obtaining cellular immune responses from proteins 失效
标题翻译：从蛋白质获得细胞免疫应答的方法
公开(公告)号：US07604802B2
公开(公告)日：2009-10-20
申请号：US10340034
申请日：2003-01-08
申请人： Derek O'Hagan , Manmohan Singh
发明人： Derek O'Hagan , Manmohan Singh
IPC分类号： A61K39/00
CPC分类号： A61K39/245 , A61K39/00 , A61K39/12 , A61K2039/54 , A61K2039/545 , A61K2039/55555 , A61K2039/57 , A61K2039/6081 , A61K2039/6093 , C12N2710/16634 , Y10S977/802 , Y10S977/918
摘要： A method for producing a cellular immune response in a vertebrate subject comprising administering to the vertebrate subject a vaccine composition comprising a protein particle antigen and a pharmaceutically acceptable excipient is disclosed.
摘要翻译：公开了一种在脊椎动物对象中产生细胞免疫应答的方法，包括对脊椎动物给药包含蛋白质颗粒抗原和药学上可接受的赋形剂的疫苗组合物。

10. 发明授权

US06861410B1 Immunological adjuvant compositions 有权
公开(公告)号：US06861410B1
公开(公告)日：2005-03-01
申请号：US10103673
申请日：2002-03-21
申请人： Gary S. Ott , Derek O'Hagan , Manmohan Singh
发明人： Gary S. Ott , Derek O'Hagan , Manmohan Singh
IPC分类号： A61K9/00 , A61K9/107 , A61K47/26 , C07H15/24 , A01N45/00
CPC分类号： A61K9/0019 , A61K9/107 , A61K47/26 , C07H15/24
摘要： The present invention is directed to novel adjuvant compositions, which target the cellular and/or humoral arms of immunity. According to an embodiment of the invention, an oil-in-water adjuvant composition is provided that comprises: (a) water; (b) a metabolizable oil comprising at least one branched or unbranched long-chain hydrocarbon moiety; (c) a steroid; and (d) a saponin.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式