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1. 发明申请

US20140134677A1 METHOD FOR REDUCING VISCOSITY IN SACCHARIFICATION PROCESS 审中-公开
标题翻译：降低渗透过程粘度的方法
公开(公告)号：US20140134677A1
公开(公告)日：2014-05-15
申请号：US14004877
申请日：2012-03-16
申请人： Colin Mitchinson , Mian Li , Bradley R. Kelemen , Suzanne E. Lantz , Keith D. Wing , William D. Hitz
发明人： Colin Mitchinson , Mian Li , Bradley R. Kelemen , Suzanne E. Lantz , Keith D. Wing , William D. Hitz
IPC分类号： C12P19/02 , C12P19/14
CPC分类号： C12N9/2437 , C12P19/02 , C12P19/14 , C12Y302/01004
摘要： The present invention relates to compositions that can be used in hydrolyzing biomass such as compositions comprising a polypeptide having glycosyl hydrolase family 61/endoglucanase activity, methods for hydrolyzing biomass material, and methods for reducing viscosity of biomass mixture using a composition comprising a polypeptide having glycosyl hydrolase family 61/endoglucanase activity.
摘要翻译：本发明涉及可用于水解生物质的组合物，例如包含具有糖基水解酶家族61 /内切葡聚糖酶活性的多肽的组合物，用于水解生物质材料的方法，以及使用包含具有糖基的多肽的组合物降低生物质混合物的粘度的方法水解酶家族61 /内切葡聚糖酶活性。

2. 发明申请

US20080152638A1 STORAGE-STABLE GLUCOSE OXIDASE 失效
标题翻译：储存稳定的葡萄糖氧化酶
公开(公告)号：US20080152638A1
公开(公告)日：2008-06-26
申请号：US11959342
申请日：2007-12-18
申请人： Bradley R. Kelemen , Suzanne E. Lantz
发明人： Bradley R. Kelemen , Suzanne E. Lantz
IPC分类号： A61K38/44 , C12N9/96 , A61Q99/00
CPC分类号： C12Y101/03004 , A61K8/66 , A61Q19/00 , C12N9/0006 , C12N9/96
摘要： The present invention provides methods and compositions comprising at least one glucose oxidase enzyme, wherein the glucose oxidase has improved storage stability. In some preferred embodiments, the glucose oxidase enzyme is stable after exposure to elevated temperatures. In some alternative preferred embodiments, the glucose oxidase has improved storage stability in liquid formulations. In some particularly preferred embodiments, the present invention provides methods and compositions comprising glucose oxidase(s) obtained from Aspergillus sp. In some more particularly preferred embodiments, the glucose oxidase is obtained from A. niger. The present invention finds use in applications involving cleaning, including personal care applications.
摘要翻译：本发明提供包含至少一种葡萄糖氧化酶的方法和组合物，其中葡萄糖氧化酶具有改善的储存稳定性。在一些优选的实施方案中，葡萄糖氧化酶在暴露于升高的温度之后是稳定的。在一些替代的优选实施方案中，葡萄糖氧化酶在液体制剂中具有改善的储存稳定性。在一些特别优选的实施方案中，本发明提供了包含从曲霉属（Aspergillus sp。）获得的葡萄糖氧化酶的方法和组合物。在一些更特别优选的实施方案中，葡萄糖氧化酶得自黑曲霉。本发明用于涉及清洁的应用，包括个人护理应用。

3. 发明授权

US07892536B2 Storage-stable glucose oxidase 失效
标题翻译：储存稳定的葡萄糖氧化酶
公开(公告)号：US07892536B2
公开(公告)日：2011-02-22
申请号：US11959342
申请日：2007-12-18
申请人： Bradley R. Kelemen , Suzanne E. Lantz
发明人： Bradley R. Kelemen , Suzanne E. Lantz
IPC分类号： C12N9/96 , A61K38/44
CPC分类号： C12Y101/03004 , A61K8/66 , A61Q19/00 , C12N9/0006 , C12N9/96
摘要： The present invention provides methods and compositions comprising at least one glucose oxidase enzyme, wherein the glucose oxidase has improved storage stability. In some preferred embodiments, the glucose oxidase enzyme is stable after exposure to elevated temperatures. In some alternative preferred embodiments, the glucose oxidase has improved storage stability in liquid formulations. In some particularly preferred embodiments, the present invention provides methods and compositions comprising glucose oxidase(s) obtained from Aspergillus sp. In some more particularly preferred embodiments, the glucose oxidase is obtained from A. niger. The present invention finds use in applications involving cleaning, including personal care applications.
摘要翻译：本发明提供包含至少一种葡萄糖氧化酶的方法和组合物，其中葡萄糖氧化酶具有改善的储存稳定性。在一些优选的实施方案中，葡萄糖氧化酶在暴露于升高的温度之后是稳定的。在一些替代的优选实施方案中，葡萄糖氧化酶在液体制剂中具有改善的储存稳定性。在一些特别优选的实施方案中，本发明提供了包含从曲霉属（Aspergillus sp。）获得的葡萄糖氧化酶的方法和组合物。在一些更特别优选的实施方案中，葡萄糖氧化酶得自黑曲霉。本发明用于涉及清洁的应用，包括个人护理应用。

4. 发明授权

US07745066B2 Method for preparing solid materials comprising immobilized proteorhodopsin 有权
标题翻译：包含固定化蛋白质视紫红质的固体材料的制备方法
公开(公告)号：US07745066B2
公开(公告)日：2010-06-29
申请号：US12113789
申请日：2008-05-01
申请人： Rasmus B. Jensen , Bradley R. Kelemen , Joseph C. McAuliffe , Wyatt Charles Smith
发明人： Rasmus B. Jensen , Bradley R. Kelemen , Joseph C. McAuliffe , Wyatt Charles Smith
IPC分类号： F21L4/04
CPC分类号： G11B7/245 , B42D25/378 , B42D2035/24 , C07H21/04 , C07K14/195 , C07K14/705 , C09D11/037 , G11B7/246 , G11B7/2531 , G11B7/2532 , G11B7/2533 , G11B7/2539 , Y10S430/146
摘要： The present invention relates to materials comprising hydrophilic polymers and immobilized proteorhodopsin and the use of such materials as an optical information carrier. The material comprises one or more hydrophilic polymers that are capable to form a homogeneous phase with proteorhodopsin prior to solidification to a solid form. The hydrophilic polymer, for example, is silica sol-gel, gelatin, polyvinylalcohol, agarose, agar, methyl cellulose, polyvinyl acetate, polyvinyl pyrrolidone, polyethylene glycol, or a mixture thereof. The solid material having immobilized proteorhodopsin is deposited on a substrate selected from the group consisting of glass, paper, metal, fabric material, plastic material, and used as an optical data storage material or a fraud-proof carrier. The present invention further provides a security ink comprising proteorhodopsin and one or more hydrophilic polymers.
摘要翻译：本发明涉及包含亲水性聚合物和固定的蛋白质视紫红质的材料以及这种材料作为光学信息载体的用途。该材料包含一种或多种能够在固化成固体形式之前与蛋白质视紫红质形成均相的亲水性聚合物。亲水性聚合物例如是硅溶胶 - 凝胶，明胶，聚乙烯醇，琼脂糖，琼脂，甲基纤维素，聚乙酸乙烯酯，聚乙烯吡咯烷酮，聚乙二醇或它们的混合物。具有固定化蛋白质视紫红质的固体材料沉积在选自玻璃，纸，金属，织物材料，塑料材料的基材上，并用作光学数据存储材料或防欺负载体。本发明还提供了包含蛋白视紫红质和一种或多种亲水性聚合物的安全油墨。

5. 发明申请

US20080292828A1 Composition Comprising Various Proteorhodopsins and/or Bacteriorhodopsins and Use Thereof 有权
标题翻译：包含各种蛋白质视紫红质和/或细菌视紫红质及其用途的组合物
公开(公告)号：US20080292828A1
公开(公告)日：2008-11-27
申请号：US11569862
申请日：2005-06-09
申请人： Richard R. Bott , Rasmus B. Jensen , Bradley R. Kelemen , Donald E. Ward, II , Gregory M. Whited
发明人： Richard R. Bott , Rasmus B. Jensen , Bradley R. Kelemen , Donald E. Ward, II , Gregory M. Whited
IPC分类号： C08L89/00 , C07K14/195 , B32B27/00
CPC分类号： G11C7/00 , C07K14/215 , C09D11/037 , C09D11/50 , G11B7/242 , Y10S430/146 , Y10T428/249921 , Y10T428/31623 , Y10T428/31685 , Y10T428/31725 , Y10T428/31783
摘要： The present invention provides a solid material comprising an immobilized mixture of two or more proteorhodopsins, two or more bacteriorhodopsins, or one or more bacteriorhodopsin and one or more proteorhodopsins. The proteorhodopsins are selected from the group consisting of all-trans-retinal-containing proteorhodopsins and retinal analog-containing proteorhodopsins; all of which have absorption spectra that do not overlap. The bacteriorhodopsins are selected from the group consisting of all-trans-retinal-containing bacteriorhodopsins and retinal analog-containing bacteriorhodopsins; all of which have absorption spectra that do not overlap. The present invention also provides an optical information carrier, such as an optical data storage material and a fraud-proof optical data carrier, comprising the above-described solid material and a substrate selected from the group consisting of glass, paper, metal, fabric material, and plastic material, wherein said solid material is deposited on said substrate. The present invention further provides security ink comprising one or more hydrophilic polymers and a mixture of various photochromic materials.
摘要翻译：本发明提供了一种固体材料，其包含两种或多种蛋白质视紫红质，两种或更多种细菌视紫红质，或一种或多种细菌视紫红质和一种或多种蛋白质视紫质的固定化混合物。蛋白质视紫红质选自全反式视黄醛的蛋白质视黄素和含视网膜类似物的蛋白质视紫红质; 所有这些都具有不重叠的吸收光谱。细菌视紫红质选自全反式视网膜含细菌视紫红质和视网膜类似物的细菌视紫红质; 所有这些都具有不重叠的吸收光谱。本发明还提供一种光学信息载体，例如光学数据存储材料和防欺诈光学数据载体，其包括上述固体材料和选自玻璃，纸，金属，织物材料的基材和塑料材料，其中所述固体材料沉积在所述基底上。本发明还提供了包含一种或多种亲水聚合物和各种光致变色材料的混合物的安全油墨。

6. 发明授权

US08372953B2 Composition comprising various proteorhodopsins and/or bacteriorhodopsins and use thereof 失效
标题翻译：包含各种蛋白质视紫红质和/或细菌视紫红质的组合物及其用途
公开(公告)号：US08372953B2
公开(公告)日：2013-02-12
申请号：US13181387
申请日：2011-07-12
申请人： Richard R. Bott , Rasmus B. Jensen , Bradley R. Kelemen , Donald E. Ward, II , Gregory M. Whited
发明人： Richard R. Bott , Rasmus B. Jensen , Bradley R. Kelemen , Donald E. Ward, II , Gregory M. Whited
IPC分类号： C07K17/00 , G03C1/00
CPC分类号： G11C7/00 , C07K14/215 , C09D11/037 , C09D11/50 , G11B7/242 , Y10S430/146 , Y10T428/249921 , Y10T428/31623 , Y10T428/31685 , Y10T428/31725 , Y10T428/31783
摘要： The present invention provides a solid material comprising an immobilized mixture of two or more proteorhodopsins, two or more bacteriorhodopsins, or one or more bacteriorhodopsin and one or more proteorhodopsins. The proteorhodopsins are selected from the group consisting of all-trans-retinal-containing proteorhodopsins and retinal analog-containing proteorhodopsins; all of which have absorption spectra that do not overlap. The bacteriorhodopsins are selected from the group consisting of all-trans-retinal-containing bacteriorhodopsins and retinal analog-containing bacteriorhodopsins; all of which have absorption spectra that do not overlap. The present invention also provides an optical information carrier, such as an optical data storage material and a fraud-proof optical data carrier, comprising the above-described solid material and a substrate selected from the group consisting of glass, paper, metal, fabric material, and plastic material, wherein said solid material is deposited on said substrate. The present invention further provides security ink comprising one or more hydrophilic polymers and a mixture of various photochromic materials.
摘要翻译：本发明提供了一种固体材料，其包含两种或多种蛋白质视紫红质，两种或更多种细菌视紫红质，或一种或多种细菌视紫红质和一种或多种蛋白质视紫质的固定化混合物。蛋白质视紫红质选自全反式视黄醛的蛋白质视黄素和含视网膜类似物的蛋白质视紫红质; 所有这些都具有不重叠的吸收光谱。细菌视紫红质选自全反式视网膜含细菌视紫红质和视网膜类似物的细菌视紫红质; 所有这些都具有不重叠的吸收光谱。本发明还提供一种光学信息载体，例如光学数据存储材料和防欺诈光学数据载体，其包括上述固体材料和选自玻璃，纸，金属，织物材料的基材和塑料材料，其中所述固体材料沉积在所述基底上。本发明还提供了包含一种或多种亲水聚合物和各种光致变色材料的混合物的安全油墨。

7. 发明授权

US07638073B2 Photochromic material comprising a proteorhodopsin apoprotein and a retinal analog 失效
标题翻译：包含蛋白质视紫红质脱辅基蛋白和视网膜类似物的光致变色材料
公开(公告)号：US07638073B2
公开(公告)日：2009-12-29
申请号：US11569864
申请日：2005-06-09
申请人： Rasmus B. Jensen , Bradley R. Kelemen , Donald E. Ward, II , Alfred E. Asato
发明人： Rasmus B. Jensen , Bradley R. Kelemen , Donald E. Ward, II , Alfred E. Asato
IPC分类号： C07C231/00 , C12Q1/68
CPC分类号： C07C403/14 , A61K31/07 , A61K31/19 , A61K31/20 , A61K31/215 , A61K31/275 , A61K38/1709 , C07C47/225 , C07C47/24 , C07C47/548 , C07C2601/16 , C07C2602/30 , G02B5/23 , A61K2300/00
摘要： The present invention relates to a photochromic material comprising a proteorhodopsin apoprotein and a retinal analog. In one embodiment, the retinal analog is an azulenic retinoid compound. In another embodiment, the retinal analog is a compound that is structurally similarly to all-trans-retinal. The proteorhodopsin apoprotein and the retinal analog form a photochromic material having different spectral properties from those of a corresponding photochromic material formed by the same proteorhodopsin apoprotein and all-trans-retinal. In one embodiment of the application, the retinal analog-containing proteorhodopsin has an absorbance spectrum that does not overlap significantly with that of all-trans-retinal-containing proteorhodopsin. In another embodiment of the application, the retinal analog-containing proteorhodopsin yields a red-shifted visual chromophore compared with the all-trans-retinal-containing proteorhodopsin chromophore. The photochromic material of the present invention is useful as an optical data storage carrier, a fraud-proof optical data carrier, security ink, and in other optical applications.
摘要翻译：本发明涉及包含蛋白质视紫红质脱辅蛋白和视网膜类似物的光致变色材料。在一个实施方案中，视黄醛类似物是靛蓝色素类化合物。在另一个实施方案中，视黄醛类似物是在结构上类似于全反式视黄醛的化合物。蛋白质视紫红质脱辅基蛋白和视网膜类似物形成与由相同的蛋白质视紫红质脱蛋白和全反式视网膜形成的相应的光致变色材料具有不同光谱性质的光致变色材料。在本申请的一个实施方案中，含视网膜类似物的蛋白质视紫红质具有与全反式视黄醛的蛋白质视紫红质相似的吸收光谱。在本申请的另一个实施方案中，与含全反式视网膜的蛋白质视紫红质发色团相比，含视网膜类似物的蛋白质视紫红质产生红移视觉发色团。本发明的光致变色材料可用作光学数据存储载体，防欺诈光学数据载体，安全墨水以及其它光学应用。

8. 发明申请

US20080290328A1 Photochromic Material Comprising a Proteorhodopsin Apoprotein and a Retinal Analog 失效
标题翻译：包含蛋白质视紫红质蛋白和视网膜模拟物的光致变色材料
公开(公告)号：US20080290328A1
公开(公告)日：2008-11-27
申请号：US11569864
申请日：2005-06-09
申请人： Rasmus B. Jensen , Bradley R. Kelemen , Donald E. Ward, II , Alfred E. Asato
发明人： Rasmus B. Jensen , Bradley R. Kelemen , Donald E. Ward, II , Alfred E. Asato
IPC分类号： G02B5/23
CPC分类号： C07C403/14 , A61K31/07 , A61K31/19 , A61K31/20 , A61K31/215 , A61K31/275 , A61K38/1709 , C07C47/225 , C07C47/24 , C07C47/548 , C07C2601/16 , C07C2602/30 , G02B5/23 , A61K2300/00
摘要： The present invention relates to a photochromic material comprising a proteorhodopsin apoprotein and a retinal analog. In one embodiment, the retinal analog is an azulenic retinoid compound. In another embodiment, the retinal analog is a compound that is structurally similarly to all-trans-retinal. The proteorhodopsin apoprotein and the retinal analog form a photochromic material having different spectral properties from those of a corresponding photochromic material formed by the same proteorhodopsin apoprotein and all-trans-retinal. In one embodiment of the application, the retinal analog-containing proteorhodopsin has an absorbance spectrum that does not overlap significantly with that of all-trans-retinal-containing proteorhodopsin. In another embodiment of the application, the retinal analog-containing proteorhodopsin yields a red-shifted visual chromophore compared with the all-trans-retinal-containing proteorhodopsin chromophore. The photochromic material of the present invention is useful as an optical data storage carrier, a fraud-proof optical data carrier, security ink, and in other optical applications.
摘要翻译：本发明涉及包含蛋白质视紫红质脱辅蛋白和视网膜类似物的光致变色材料。在一个实施方案中，视黄醛类似物是靛类视黄醇化合物。在另一个实施方案中，视黄醛类似物是在结构上类似于全反式视黄醛的化合物。蛋白质视紫红质脱辅基蛋白和视网膜类似物形成与由相同的蛋白质视紫红质脱蛋白和全反式视网膜形成的相应的光致变色材料具有不同光谱性质的光致变色材料。在本申请的一个实施方案中，含视网膜类似物的蛋白质视紫红质具有与全反式视黄醛的蛋白质视紫红质相似的吸收光谱。在本申请的另一个实施方案中，与含全反式视网膜的蛋白质视紫红质发色团相比，含视网膜类似物的蛋白质视紫红质产生红移视觉发色团。本发明的光致变色材料可用作光学数据存储载体，防欺诈光学数据载体，安全墨水以及其它光学应用。

9. 发明授权

US09701969B2 Filamentous fungal host strains and DNA constructs, and methods of use thereof 有权
公开(公告)号：US09701969B2
公开(公告)日：2017-07-11
申请号：US13701479
申请日：2011-06-03
申请人： Benjamin S. Bower , Thijs Kaper , Bradley R. Kelemen
发明人： Benjamin S. Bower , Thijs Kaper , Bradley R. Kelemen
IPC分类号： C12N15/80 , C12P21/02 , C12N9/42
CPC分类号： C12N15/80 , C12N9/2437 , C12P21/02 , C12Y302/01091 , Y02P20/52
摘要： The present disclosure relates to filamentous fungal host strains and recombinant DNA constructs for creation and use thereof. The filamentous fungal host strains are particularly useful for efficiently screening DNA libraries encoding recombinant proteins.

10. 发明申请

US20130149742A1 FILAMENTOUS FUNGAL HOST STRAINS AND DNA CONSTRUCTS, AND METHODS OF USE THEREOF 有权
标题翻译：真菌真菌宿主菌和DNA构建体及其使用方法
公开(公告)号：US20130149742A1
公开(公告)日：2013-06-13
申请号：US13701479
申请日：2011-06-03
申请人： Benjamin S. Bower , Thijs Kaper , Bradley R. Kelemen
发明人： Benjamin S. Bower , Thijs Kaper , Bradley R. Kelemen
IPC分类号： C12N15/80
CPC分类号： C12N15/80 , C12N9/2437 , C12P21/02 , C12Y302/01091 , Y02P20/52
摘要： The present disclosure relates to filamentous fungal host strains and recombinant DNA constructs for creation and use thereof. The filamentous fungal host strains are particularly useful for achieving reliable expression of recombinant enzymes and variants.
摘要翻译：本公开涉及丝状真菌宿主菌株和用于其产生和使用的重组DNA构建体。丝状真菌宿主菌株对于实现重组酶和变体的可靠表达特别有用。

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