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1. 发明申请

US20050096460A1 Beta-amyloid peptide-binding proteins and polynucleotides encoding the same 失效
公开(公告)号：US20050096460A1
公开(公告)日：2005-05-05
申请号：US10892379
申请日：2004-07-16
申请人： Bradley Ozenberger , Jonathan Bard , Eileen Kajkowski , Jack Jacobsen , Stephen Walker , Heidi Sofia , David Howland
发明人： Bradley Ozenberger , Jonathan Bard , Eileen Kajkowski , Jack Jacobsen , Stephen Walker , Heidi Sofia , David Howland
IPC分类号： A01K67/027 , A61K31/7105 , A61K31/711 , A61K38/00 , A61K39/395 , A61K48/00 , A61P25/28 , A61P43/00 , C07K14/47 , C07K14/705 , C07K16/28 , C07K19/00 , C12N15/09 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , C12N5/06
CPC分类号： C07K14/47 , A01K67/0275 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A61K38/00 , C07K14/4711 , C07K2319/00
摘要： Novel proteins which bind human β-amyloid peptide, polynucleotides which encode these proteins, and methods for producing these proteins are provided. Diagnostic, therapeutic, and screening methods employing the polynucleotides and polypeptides of the present invention are also provided. Transgenic animals and knockout animals are also provided.

2. 发明申请

US20060248605A1 Beta-amyloid peptide-binding proteins and polynucleotides encoding the same 审中-公开
公开(公告)号：US20060248605A1
公开(公告)日：2006-11-02
申请号：US11485074
申请日：2006-07-12
申请人： Bradley Ozenberger , Jonathan Bard , Eileen Kajkowski , Jack Jacobsen , Stephen Walker , Heidi Sofia , David Howland
发明人： Bradley Ozenberger , Jonathan Bard , Eileen Kajkowski , Jack Jacobsen , Stephen Walker , Heidi Sofia , David Howland
IPC分类号： A01K67/00 , C07H21/04 , C12P21/06 , C12N9/64
CPC分类号： C07K14/47 , A01K67/0275 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A61K38/00 , C07K14/4711 , C07K2319/00
摘要： Novel proteins which bind human β-amyloid peptide, polynucleotides which encode these proteins, and methods for producing these proteins are provided. Diagnostic, therapeutic, and screening methods employing the polynucleotides and polypeptides of the present invention are also provided. Transgenic animals and knockout animals are also provided.

3. 发明申请

US20050282999A9 Beta-amyloid peptide-binding proteins and polynucleotides encoding the same 失效
标题翻译： β-淀粉样蛋白肽结合蛋白和编码其的多核苷酸
公开(公告)号：US20050282999A9
公开(公告)日：2005-12-22
申请号：US10892379
申请日：2004-07-16
申请人： Bradley Ozenberger , Jonathan Bard , Eileen Kajkowski , Jack Jacobsen , Stephen Walker , Heidi Sofia , David Howland
发明人： Bradley Ozenberger , Jonathan Bard , Eileen Kajkowski , Jack Jacobsen , Stephen Walker , Heidi Sofia , David Howland
IPC分类号： A01K67/027 , A61K31/7105 , A61K31/711 , A61K38/00 , A61K39/395 , A61K48/00 , A61P25/28 , A61P43/00 , C07K14/47 , C07K14/705 , C07K16/28 , C07K19/00 , C12N15/09 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , C12N5/06
CPC分类号： C07K14/47 , A01K67/0275 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A61K38/00 , C07K14/4711 , C07K2319/00
摘要： Novel proteins which bind human β-amyloid peptide, polynucleotides which encode these proteins, and methods for producing these proteins are provided. Diagnostic, therapeutic, and screening methods employing the polynucleotides and polypeptides of the present invention are also provided. Transgenic animals and knockout animals are also provided.
摘要翻译：提供了结合人β-淀粉样肽的新型蛋白质，编码这些蛋白质的多核苷酸，以及制备这些蛋白质的方法。还提供了使用本发明的多核苷酸和多肽的诊断，治疗和筛选方法。还提供转基因动物和敲除动物。

4. 发明授权

US11019686B2 Flexible heating device 有权
公开(公告)号：US11019686B2
公开(公告)日：2021-05-25
申请号：US15664678
申请日：2017-07-31
申请人： Jason Herbstman , Stephen Walker
发明人： Jason Herbstman , Stephen Walker
IPC分类号： H05B1/02 , H05B3/34 , A61H19/00
摘要： A flexible heating device includes a pouch defined in-part by a flexible heating textile that defines a cavity. The size of the cavity defined by the pouch is adjustable to snugly receive objects, e.g., sex toys, of different sizes. In embodiments, the pouch supports closing structure to facilitate adjustment of the size of the cavity to accommodate different size objects. In embodiments, the flexible heating textile includes an adapter that receives power from a power source such as a battery or wall plug to heat the flexible heating textile.

5. 发明授权

US07285082B1 Airtight box with manufacturing method and apparatus 失效
标题翻译：具有制造方法和装置的气密盒
公开(公告)号：US07285082B1
公开(公告)日：2007-10-23
申请号：US10220270
申请日：2000-03-08
申请人： Stephen Walker
发明人： Stephen Walker
IPC分类号： B31B1/24
CPC分类号： B65D5/742 , B31B50/84
摘要： A method, apparatus for practicing the method, and article manufactured by the method in which a block is cut out with side wall and end wall panels, the end wall panels attached to the side wall panels via end wall fold lines. The box includes a pour opening. Recesses are provided in at least one of the end wall panels for exposing adhesive for attaching the flexible material strip to the corresponding end wall panel.
摘要翻译：一种用于实施该方法的方法，以及通过方法制造的制品，其中通过侧壁和端壁板切割块，所述端壁板通过端壁折叠线附接到侧壁板。箱子包括一个倒入口。在至少一个端壁板上提供凹口，用于暴露用于将柔性材料条附接到相应的端壁板上的粘合剂。

6. 发明申请

US20060117221A1 Method, apparatus, computer program and computer program product for adjusting the frequency at which data is backed up 失效
公开(公告)号：US20060117221A1
公开(公告)日：2006-06-01
申请号：US11255204
申请日：2005-10-20
申请人： David Fisher , Stephen Hobson , Paul Hopewell , Paul Kettley , Robert Millar , Pete Siddall , Stephen Walker
发明人： David Fisher , Stephen Hobson , Paul Hopewell , Paul Kettley , Robert Millar , Pete Siddall , Stephen Walker
IPC分类号： G06F11/00
CPC分类号： G06F11/1461 , G06F11/1458 , G06F11/1471 , Y10S707/99953
摘要： Disclosed is a method, apparatus, computer program and computer program product for adjusting the frequency at which data is backed up. This involves receiving a target recovery time. A current estimated recovery time is then determined and the current and target times are compared. If it is determined that the current estimated recovery time has reached a predetermined threshold relative to the received target recovery time a new backup should be initiated.

7. 发明申请

US20050148552A1 Methods of treating eczema 审中-公开
标题翻译：治疗湿疹的方法
公开(公告)号：US20050148552A1
公开(公告)日：2005-07-07
申请号：US10982979
申请日：2004-11-05
申请人： Maria Ryan , Yu Liu , Lorne Golub , Hsi-Ming Lee , Sanford Simon , Stephen Walker
发明人： Maria Ryan , Yu Liu , Lorne Golub , Hsi-Ming Lee , Sanford Simon , Stephen Walker
IPC分类号： A61K20060101 , A61K31/65
CPC分类号： A61K31/65
摘要： A method of treating eczema in a human or other mammal in need thereof comprising administering systemically to said human or other mammal a tetracycline compound in an amount that is effective to treat eczema, but has substantially no antibacterial activity.
摘要翻译：一种在有需要的人或其他哺乳动物中治疗湿疹的方法，包括向所述人或其他哺乳动物全身施用有效治疗湿疹但基本上没有抗菌活性的四环素化合物。

8. 发明授权

US10155180B2 Contacting systems and methods and uses thereof 有权
公开(公告)号：US10155180B2
公开(公告)日：2018-12-18
申请号：US13266772
申请日：2010-04-28
申请人： Donald Koenig , Wesley Jung , Santosh Y. Limaye , Stuart Robertson , Stephen Walker
发明人： Donald Koenig , Wesley Jung , Santosh Y. Limaye , Stuart Robertson , Stephen Walker
IPC分类号： B01D19/00 , B01D53/00 , B01F3/04 , C10G21/00 , C10G29/20
摘要： In accordance with the present invention, there are provided systems and methods for contacting two or more fluids, useful, for example for purifying or infusing a fluid (by allowing efficient and/or uniform addition of components to or removal of components from the fluid). The components may be undesirable components to be removed from a fluid, or a desired component or components to be added to the fluid, for example, each of which is referred to herein as “component”. In this regard, the disclosed embodiments provide for the purification or infusion of a fluid by passing a liquid and a fluid through a contacting zone which facilitates intimate mixing of the liquid and the fluid. A differential of partial pressure, activity, fugacity or concentration of the components between the liquid and the fluid facilitates the transfer of the components between the liquid and the fluid in the intimately mixed liquid and fluid.

9. 发明授权

US08425396B2 Physiologic pulsatile pump 有权
标题翻译：生理脉动泵
公开(公告)号：US08425396B2
公开(公告)日：2013-04-23
申请号：US12806918
申请日：2010-08-23
申请人： Tani Tatum , Stephen Walker , Bob Wilson
发明人： Tani Tatum , Stephen Walker , Bob Wilson
IPC分类号： A61H31/00
CPC分类号： A61M1/3666 , A01N1/0247 , A61M1/1006 , A61M1/1012 , A61M1/1037 , A61M1/106 , A61M1/107 , A61M1/3667 , A61M2205/505 , A61M2240/00
摘要： A pulsatile blood circulating pump system for use in cardiopulmonary bypass, ventricular assist (LVAD, RVAD, BiVAD), ECMO, organ preservation, fetal cardiac bypass, cancer treatment, and areas of circulation research, which is controlled to produce blood flow that approximates physiological blood flow. The pump system includes a pulsating mechanism having a housing defining a chamber with a compressible-expandable bladder sealably mounted. A hydraulic actuator having a pressure imparting member that acts upon pressure transmissive fluid contained within the actuator chamber to generate a pulsatile pressure on the transmissive fluid, which results in pulsatile pressure being exerted on bladder to controllably vary the volume thereof. Additionally, the system includes a compact, motor that is associated with the hydraulic actuator for moving the pressure imparting member within the fluid chamber and further includes a fully programmable motion controller that controls the motor. The system includes a programmable touch-screen component to control the motion controller.
摘要翻译：用于体外循环，心室辅助（LVAD，RVAD，BiVAD），ECMO，器官保存，胎儿心脏旁路，癌症治疗和循环研究领域的脉动血液循环泵系统，其被控制以产生接近生理学的血流血流量。泵系统包括脉动机构，其具有限定腔室的壳体，其具有可密封地安装的可压缩可膨胀气囊。一种液压致动器，其具有施加在致动器室内的压力传递流体上的压力施加构件，以在透射流体上产生脉动压力，这导致脉动压力施加在气囊上以可控地改变其体积。另外，该系统包括紧凑的马达，其与液压致动器相关联，用于在压力腔内移动压力施加构件，并且还包括控制马达的完全可编程的运动控制器。该系统包括可编程触摸屏部件来控制运动控制器。

10. 发明申请

US20070088970A1 Recovery from failures within data processing systems 有权
标题翻译：从数据处理系统中的故障恢复
公开(公告)号：US20070088970A1
公开(公告)日：2007-04-19
申请号：US10553018
申请日：2003-10-22
申请人： Robert Buxton , David Fishers , Jose Garza , Stephen Hobson , Paul Hopewall , Paul Kettley , Robert Millar , Peter Siddall , Stephen Walker
发明人： Robert Buxton , David Fishers , Jose Garza , Stephen Hobson , Paul Hopewall , Paul Kettley , Robert Millar , Peter Siddall , Stephen Walker
IPC分类号： G06F11/00
CPC分类号： G06F11/1469 , G06F11/1471
摘要： Provided are methods, data processing systems, recovery components and computer programs for recovering from storage failures affecting data repositories. At least a part of the recovery processing is performed while the data repositories are able to receive new data and to allow retrieval of such new data. Although new data items may be received into the repository and retrieved therefrom during recovery processing, updates to the data repository which were performed before the failure and which are then restored to the repository by the recovery processing are restored within a recovery unit of work and are inaccessible to processes other than the recovery process until successful completion of the recovery unit of work. The recovery processing ensures that the recovered repository is consistent with the state of the repository at the time of the failure, but is available for addition and retrieval of new data items before completion of the recovery processing.
摘要翻译：提供了从影响数据存储库的存储故障中恢复的方法，数据处理系统，恢复组件和计算机程序。在数据存储库能够接收新数据并允许检索这些新数据的同时执行恢复处理的至少一部分。虽然在恢复处理期间可以将新的数据项目接收到存储库并从中恢复，但是在故障之前执行的数据存储库的更新以及由恢复处理恢复到存储库的数据库在恢复工作单元内被恢复，并且是恢复过程以外的进程无法访问，直到成功完成恢复单元的工作。恢复处理确保恢复的存储库与故障时存储库的状态一致，但是在完成恢复处理之前可以添加和检索新的数据项。

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