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1. 发明申请

US20110189102A1 COATED QUANTUM DOTS AND METHODS OF MAKING AND USING THEREOF 审中-公开
标题翻译：涂层量子及其制备方法和使用方法
公开(公告)号：US20110189102A1
公开(公告)日：2011-08-04
申请号：US12864763
申请日：2009-02-05
申请人： Brad A. Kairdolf , Shuming Nie
发明人： Brad A. Kairdolf , Shuming Nie
IPC分类号： H01L33/06 , A61B5/00 , H01L33/52 , B82Y99/00 , B82Y40/00 , B82Y20/00
CPC分类号： G01N21/6486 , B82Y30/00
摘要： The present disclosure provides embodiments of a new class of hydroxylated quantum dots. The quantum dots have a hydroxylated coat disposed thereon, and which serves to minimize non-specific cellular binding and to maintain the small size of quantum dot probes. Embodiments of the coated quantum dots of the disclosure are just slightly larger than the diameter of uncoated quantum dots, and are bright with high quantum yields. They are also very stable under both basic and acidic conditions. Embodiments of the hydroxylated quantum dots result in significant reductions in non-specific binding relative to that of carboxylated dots, and to protein and PEG-coated dots. Embodiments of the disclosure are advantageous in a range of biological applications where non-specific binding is a major problem, such as in multiplexed biomarker staining in cells and tissues, detection of biomarkers in body fluid samples (blood, urine, etc.), as well as live cell imaging.
摘要翻译：本公开提供了一类新型羟基化量子点的实施方案。量子点具有设置在其上的羟基化涂层，其用于最小化非特异性细胞结合并维持量子点探针的小尺寸。本公开的涂覆的量子点的实施例略大于未涂覆的量子点的直径，并且具有高量子产率的明亮。它们在碱性和酸性条件下也非常稳定。羟基化量子点的实施方案导致非特异性结合相对于羧化点，以及蛋白质和PEG-包被点的显着降低。本公开的实施方案在生物应用范围内是有利的，其中非特异性结合是主要问题，例如细胞和组织中多重生物标志物染色，体液样品（血液，尿液等）中生物标志物的检测，如以及活细胞成像。

2. 发明申请

US20110260111A1 QUANTUM DOTS, METHODS OF MAKING QUANTUM DOTS, AND METHODS OF USING QUANTUM DOTS 有权
标题翻译：量子函数，量子方法和量子方法
公开(公告)号：US20110260111A1
公开(公告)日：2011-10-27
申请号：US13060513
申请日：2009-09-03
申请人： Shuming Nie , Andrew M. Smith , Brad A. Kairdolf
发明人： Shuming Nie , Andrew M. Smith , Brad A. Kairdolf
IPC分类号： C09K11/02 , C09K11/88 , B82Y30/00
CPC分类号： B82Y10/00 , C01B19/007 , C01P2002/84 , C01P2004/04 , C01P2004/80 , C09K11/025 , C09K11/883 , H01L21/0256 , H01L21/02562 , H01L21/02568 , H01L21/02601
摘要： Embodiments of the present disclosure provide: methods of making a quantum dot, quantum dots, and the like.
摘要翻译：本公开的实施例提供：制造量子点，量子点等的方法。

3. 发明授权

US09073751B2 Quantum dots, methods of making quantum dots, and methods of using quantum dots 有权
标题翻译：量子点，制造量子点的方法和使用量子点的方法
公开(公告)号：US09073751B2
公开(公告)日：2015-07-07
申请号：US13060513
申请日：2009-09-03
申请人： Shuming Nie , Andrew M. Smith , Brad A. Kairdolf
发明人： Shuming Nie , Andrew M. Smith , Brad A. Kairdolf
IPC分类号： B82Y10/00 , C09K11/02 , C01B19/00 , H01L21/02
CPC分类号： B82Y10/00 , C01B19/007 , C01P2002/84 , C01P2004/04 , C01P2004/80 , C09K11/025 , C09K11/883 , H01L21/0256 , H01L21/02562 , H01L21/02568 , H01L21/02601
摘要： Embodiments of the present disclosure provide: methods of making a quantum dot, quantum dots, and the like.
摘要翻译：本公开的实施例提供：制造量子点，量子点等的方法。

4. 发明申请

US20140329716A1 DEVICES HAVING A CALIBRATION CONTROL REGION, SYSTEMS AND METHODS FOR IMMUNOHISTOCHEMICAL ANALYSES 审中-公开
标题翻译：具有校准控制区域的设备，用于免疫组织化学分析的系统和方法
公开(公告)号：US20140329716A1
公开(公告)日：2014-11-06
申请号：US14241475
申请日：2012-08-28
申请人： Brad A. Kairdolf , Shuming Nie
发明人： Brad A. Kairdolf , Shuming Nie
IPC分类号： G01N33/574
CPC分类号： G01N33/57407 , G01N33/574
摘要： The disclosure relates to devices, systems and methods that address the variability in immunohistochemistry (IHC) tests that can lead to inaccurate diagnosis or misdiagnosis while maintaining important structural information within the specimen. The devices may include a control region having a control unit including a plurality of substantially homogenous samples and a biological sample region.
摘要翻译：本公开涉及解决免疫组织化学（IHC）测试的变异性的装置，系统和方法，其可导致不准确的诊断或误诊，同时保持样品内的重要结构信息。所述装置可以包括具有包括多个基本上均匀的样品和生物样品区域的控制单元的控制区域。

5. 发明申请

US20130337471A1 CELL IDENTIFICATION WITH NANOPARTICLES, COMPOSITIONS AND METHODS RELATED THERETO 审中-公开
标题翻译：细胞识别与纳米颗粒，组合物和方法相关
公开(公告)号：US20130337471A1
公开(公告)日：2013-12-19
申请号：US13517895
申请日：2012-06-14
申请人： Shuming Nie , Jian Liu , Brad A. Kairdolf
发明人： Shuming Nie , Jian Liu , Brad A. Kairdolf
IPC分类号： G01N21/76
CPC分类号： G01N33/587 , G01N33/57426
摘要： The present disclosure provides a method for identifying rare or low-abundant biological entities such as Hodgkin's and Reed-Sternberg cells, circulating tumor cells in peripheral blood, circulating fetal cells, stem cells, somatic cells, HIV-infected T cells, bacteria or viruses in water, adenoviruses, enteroviruses, hepatitis A and E, dengue, Swine Flu, bovine diarrhea, and protozpa/helminthes. The method uses a suite of nanoparticle-conjugated agents to mark biological targets of interest for subsequent fluorescence imaging. In certain embodiments, the nanoparticle-conjugated agents are fluorescent semiconductor nanocrystals conjugated with antibodies with affinity for CD15, CD30, CD45, and Pax5. In certain embodiments, a method is developed to differentiate Hodgkin's and Reed-Sternberg (HRS) cells from amongst surrounding immune cells such as T and B lymphocytes with greater specificity and precision than traditional immunohistochemistry (IHC) for the diagnosis of Hodgkin's lymphoma.
摘要翻译：本公开提供了一种用于鉴定罕见或低丰度生物实体的方法，例如霍奇金和里德 - 斯特伯格细胞，外周血循环肿瘤细胞，循环胎儿细胞，干细胞，体细胞，HIV感染的T细胞，细菌或病毒在水，腺病毒，肠道病毒，甲型和E型，登革热，猪流感，牛腹泻和原虫/癣。该方法使用一套纳米颗粒偶联剂来标记感兴趣的生物靶标用于随后的荧光成像。在某些实施方案中，纳米颗粒偶联剂是与抗CD15，CD30，CD45和Pax5具有亲和力的荧光半导体纳米晶体。在某些实施方案中，开发了一种方法，以将Hodgkin's和Reed-Sternberg（HRS）细胞与周围免疫细胞如T和B淋巴细胞区分开来，具有比传统的免疫组化（IHC）更高的特异性和精确度，用于诊断霍奇金淋巴瘤。

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