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    • 4. 发明申请
    • Method for Producing Molecularly Imprinted Polymers for the Recognition of Target Molecules
    • 生产用于识别目标分子的分子印迹聚合物的方法
    • US20080038832A1
    • 2008-02-14
    • US11665239
    • 2005-10-12
    • Borje SellergrenAndrew Hall
    • Borje SellergrenAndrew Hall
    • G01N33/00C08G73/00
    • C08F212/32B01J20/26B01J20/268B01J20/285C08F2/44C08F212/14C08F212/36C08F220/28C08F222/1006G01N33/0057Y10T436/17
    • The present invention relates to a method of preparing a molecularly imprinted polymer (MIP), which are used for the recognition of target molecules comprising: co-polymerising at least one functional monomer and at least one cross-linking monomer in the presence of at least one template, wherein oxyanions are used as template and the steric and/or electronic structure of the template is at least partly analogous to the target molecule. The target molecules may be nitro-containing compounds, such as nitroaromatic compounds, or lactones. MIPs selective for explosive nitro-aromatic substances may be produced without handling these hazardous compounds. The invention further relates to a method of determining if a sample contains nitro-containing compounds, such as nitroaromatic compounds, or lactones, MIPs selective for nitro-containing compounds and/or lactones, especially nitro-aromatic compounds and a kit, comprising a molecularly imprinted polymer selective for nitro-aromatic compounds and/or lactones. The invention also relates to use of isosteric and/or isoelectronic oxyanions for the production of MIPs for recognition of nitro-containing compounds, especially nitroaromatic compounds, and lactones.
    • 本发明涉及制备分子印迹聚合物(MIP)的方法,其用于识别靶分子,包括:在至少存在下共聚至少一种官能单体和至少一种交联单体 一个模板,其中使用氧阴离子作为模板,并且模板的空间和/或电子结构至少部分类似于靶分子。 靶分子可以是含硝基化合物,例如硝基芳族化合物或内酯。 可以在不处理这些有害化合物的情况下生产对爆炸性硝基芳族物质有选择性的MIP。 本发明还涉及一种确定样品是否含有含硝基化合物如硝基芳族化合物或内酯的方法,对含硝基化合物和/或内酯,特别是硝基芳族化合物和试剂盒有选择性的MIP,包括分子式 对硝基芳族化合物和/或内酯具有选择性的印迹聚合物。 本发明还涉及等熵和/或等电子含氧阴离子用于生产用于识别含硝基化合物,特别是硝基芳族化合物和内酯的MIP。