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1. 发明授权

US4831192A Methods of preparing 4-heteropentacyclic-4-(N-phenyl)amido) piperidine derivatives and intermediate compounds 失效
标题翻译：制备4-异戊环-4-（N-苯基）酰氨基）哌啶衍生物和中间体化合物的方法
公开(公告)号：US4831192A
公开(公告)日：1989-05-16
申请号：US139896
申请日：1987-12-31
申请人： Bor-Sheng Lin , Joseph W. Scheblein
发明人： Bor-Sheng Lin , Joseph W. Scheblein
IPC分类号： C07D211/66 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/4468 , A61P23/00 , A61P25/04 , C07D401/00 , C07D401/04 , C07D401/14 , C07D409/14 , C07D413/00 , C07D413/04 , C07D413/14 , C07D417/00 , C07D417/04 , C07D417/14
CPC分类号： C07D401/04 , C07D401/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： Compounds are disclosed of the formula ##STR1## Where R.sup.1 is an unsubstituted or substituted heterocyclic ring system; R.sup.2 is an unsubstituted or substituted phenyl; R.sup.3 is a lower alkyl or lower alkoxy, and L is selected from a wide variety of groups.
摘要翻译：公开了下式的化合物：其中R 1是未取代或取代的杂环系统; R2是未取代或取代的苯基; R3是低级烷基或低级烷氧基，L选自多种基团。

2. 发明授权

US5145967A Method for preparing 4-alkoxyalkyl-4-phenylaminopiperdines and derivatives thereof 失效
标题翻译： 4-烷氧基烷基-4-苯基氨基哌啶及其衍生物的制备方法
公开(公告)号：US5145967A
公开(公告)日：1992-09-08
申请号：US608427
申请日：1990-11-02
申请人： Bor-Sheng Lin , H. Kenneth Spencer , Joseph W. Scheblein
发明人： Bor-Sheng Lin , H. Kenneth Spencer , Joseph W. Scheblein
IPC分类号： C07D211/58
CPC分类号： C07D211/58
摘要： The present invention is directed to a method for preparing a 4-alkoxyalkyl-4-phenylaminopiperidine compound which comprises the steps of (a) reacting an N-substituted-4-piperidone compound with an aniline compound to form a Schiff base compound, (b) reacting the Schiff base compound with an anionic reagent having an anion stabilizing group to form an amine compound, and (c) reducing the amine compound in step (b) with a reducing agent to displace the anion stabilizing group.The anionic reagent in step (b) above has the general formula:X--CYM--Zwherein X is an anion stabilizing group, Y is hydrogen or lower-alkyl, Z is lower-alkoxy or phenylmethoxy, M is an alkali or alkaline earth metal, and C is a carbon atom.
摘要翻译：本发明涉及一种制备4-烷氧基烷基-4-苯基氨基哌啶化合物的方法，该方法包括以下步骤：（a）使N-取代-4-哌啶酮化合物与苯胺化合物反应形成希夫碱化合物，（b ）使希夫碱化合物与具有阴离子稳定基团的阴离子试剂反应以形成胺化合物，和（c）用还原剂还原步骤（b）中的胺化合物以置换阴离子稳定基团。上述步骤（b）中的阴离子试剂具有以下通式：X-CYM-Z其中X为阴离子稳定基团，Y为氢或低级烷基，Z为低级烷氧基或苯基甲氧基，M为碱金属或碱土金属金属，C为碳原子。

3. 发明授权

US5470862A Substituted pyrazolyl compounds and methods employing such compounds 失效
标题翻译：取代的吡唑基化合物和使用这些化合物的方法
公开(公告)号：US5470862A
公开(公告)日：1995-11-28
申请号：US384294
申请日：1995-02-03
申请人： Bor-Sheng Lin , Joseph W. Scheblein , Jerome R. Bagley
发明人： Bor-Sheng Lin , Joseph W. Scheblein , Jerome R. Bagley
IPC分类号： C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , A61K31/41 , A61K31/44 , C07D213/06
CPC分类号： C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： This invention pertains to novel substituted pyrazolyl compounds useful as intravenous anesthetics represented by the Formula: ##STR1## including geometric and optically active isomeric forms, and the pharmaceutically acceptable acid addition salts thereof, wherein:one of Y and Z is nitrogen, and the other is CH;R.sub.1 is hydrogen or lower-alkyl;R.sub.2 and R.sub.3 are selected from the group consisting of hydrogen, --CHO, lower-alkylcarbonyl, lower-alkoxy carbonyl, lower-alkylaminocarbonyl, lower-alkyl, lower-alkenyl, lower-alkoxy-lower-alkenyl, lower-alkylcarbonyloxymethyl, substituted and unsubstituted heterocyclic rings, and substituted or unsubstituted aryl groups, wherein the symbol * represents a carbon atom which may be asymmetric and at least one of R.sub.2 and R.sub.3 is other than hydrogen.
摘要翻译：本发明涉及用作由下式表示的静脉内麻醉剂的新型取代的吡唑基化合物：包括几何和旋光异构体形式及其药学上可接受的酸加成盐，其中：Y和Z之一是氮，另一个是CH; R1是氢或低级烷基; R2和R3选自氢，-CHO，低级烷基羰基，低级烷氧基羰基，低级烷基氨基羰基，低级烷基，低级烯基，低级烷氧基 - 低级 - 烯基，低级烷基羰氧基甲基，取代和未取代的杂环和取代或未取代的芳基，其中符号*表示可以是不对称的且至少一个R 2和R 3不是氢的碳原子。

4. 发明授权

US08580154B2 Quaternary ammonium salts as a conversion coating or coating enhancement 有权
标题翻译：季铵盐作为转化涂层或涂层增强
公开(公告)号：US08580154B2
公开(公告)日：2013-11-12
申请号：US13726495
申请日：2012-12-24
申请人： Thomas C. Bedard , Thomas David Burleigh , Larry K. Hall , Joseph Kimler , Joseph W. Scheblein , Michael Y. Chiang
发明人： Thomas C. Bedard , Thomas David Burleigh , Larry K. Hall , Joseph Kimler , Joseph W. Scheblein , Michael Y. Chiang
IPC分类号： C09K15/16 , C09K15/20 , C09K15/30 , C23F11/14 , C09K3/00 , C23C8/40 , C23C22/00 , B05D3/10 , B05D7/14
CPC分类号： C09D5/084 , C09D5/086 , C23C22/08 , C23C22/50 , C23C22/68 , C23F11/141 , C23F11/143
摘要： Disclosed are quaternary ammonium salts containing non-halogen anions such as carbonates, bicarbonates, phosphates, glycolates and mixtures thereof as conversion coatings or additives imparting anti-corrosive properties to paints. The invention relates to a method for inhibiting the corrosion of metal surfaces by applying a composition containing one or more quaternary ammonium carbonate or bicarbonate. The disclosure is also directed to anti-corrosive coatings for metal substrates containing these compounds and to metal substrates having these anticorrosive coatings.
摘要翻译：公开了含有非卤素阴离子如碳酸盐，碳酸氢盐，磷酸盐，乙醇酸盐及其混合物的季铵盐，作为赋予油漆防腐性能的转化涂料或添加剂。本发明涉及通过应用含有一种或多种碳酸季铵或碳酸氢铵的组合物来抑制金属表面腐蚀的方法。本公开还涉及含有这些化合物的金属基材和具有这些防腐涂层的金属基材的防腐涂料。

5. 发明申请

US20130126047A1 QUATERNARY AMMONIUM SALTS AS A CONVERSION COATING OR COATING ENHANCEMENT 有权
标题翻译：季铵盐作为转化涂料或涂层增强剂
公开(公告)号：US20130126047A1
公开(公告)日：2013-05-23
申请号：US13726495
申请日：2012-12-24
申请人： Thomas C. Bedard , Thomas David Burleigh , Larry K. Hall , Joseph Kimler , Joseph W. Scheblein , Michael Y. Chiang
发明人： Thomas C. Bedard , Thomas David Burleigh , Larry K. Hall , Joseph Kimler , Joseph W. Scheblein , Michael Y. Chiang
IPC分类号： C09D5/08
CPC分类号： C09D5/084 , C09D5/086 , C23C22/08 , C23C22/50 , C23C22/68 , C23F11/141 , C23F11/143
摘要： Disclosed are quaternary ammonium salts containing non-halogen anions such as carbonates, bicarbonates, phosphates, glycolates and mixtures thereof as conversion coatings or additives imparting anti-corrosive properties to paints. The invention relates to a method for inhibiting the corrosion of metal surfaces by applying a composition containing one or more quaternary ammonium carbonate or bicarbonate. The disclosure is also directed to anti-corrosive coatings for metal substrates containing these compounds and to metal substrates having these anticorrosive coatings.
摘要翻译：公开了含有非卤素阴离子如碳酸盐，碳酸氢盐，磷酸盐，乙醇酸盐及其混合物的季铵盐，作为赋予油漆防腐性能的转化涂料或添加剂。本发明涉及通过应用含有一种或多种碳酸季铵或碳酸氢铵的组合物来抑制金属表面腐蚀的方法。本公开还涉及含有这些化合物的金属基材和具有这些防腐涂层的金属基材的防腐涂料。

6. 发明授权

US08337640B2 Quaternary ammonium salts as a conversion coating or coating enhancement 有权
标题翻译：季铵盐作为转化涂层或涂层增强
公开(公告)号：US08337640B2
公开(公告)日：2012-12-25
申请号：US12952690
申请日：2010-11-23
申请人： Thomas C. Bedard , Thomas David Burleigh , Larry K. Hall , Joseph Kimler , Joseph W. Scheblein , Michael Y. Chiang
发明人： Thomas C. Bedard , Thomas David Burleigh , Larry K. Hall , Joseph Kimler , Joseph W. Scheblein , Michael Y. Chiang
IPC分类号： C23C8/40 , C23C22/00 , B05D3/10 , B05D7/14 , C23F11/14
CPC分类号： C09D5/084 , C09D5/086 , C23C22/08 , C23C22/50 , C23C22/68 , C23F11/141 , C23F11/143
摘要： Disclosed are quaternary ammonium salts containing non-halogen anions such as carbonates, bicarbonates, phosphates, glycolates and mixtures thereof as conversion coatings or additives imparting anti-corrosive properties to paints. The invention relates to a method for inhibiting the corrosion of metal surfaces by applying a composition containing one or more quaternary ammonium carbonate or bicarbonate. The disclosure is also directed to anti-corrosive coatings for metal substrates containing these compounds and to metal substrates having these anticorrosive coatings.
摘要翻译：公开了含有非卤素阴离子如碳酸盐，碳酸氢盐，磷酸盐，乙醇酸盐及其混合物的季铵盐，作为赋予油漆防腐性能的转化涂料或添加剂。本发明涉及通过应用含有一种或多种碳酸季铵或碳酸氢铵的组合物来抑制金属表面腐蚀的方法。本公开还涉及含有这些化合物的金属基材和具有这些防腐涂层的金属基材的防腐涂料。

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