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1. 发明授权

US11445915B2 Compact briefcase OCT system for point-of-care imaging 有权
公开(公告)号：US11445915B2
公开(公告)日：2022-09-20
申请号：US16520037
申请日：2019-07-23
申请人： The Board of Trustees of the University of Illinois
发明人： Stephen A. Boppart , Roshan I. Dsouza , Darold R. Spillman, Jr. , Paritosh Pande , Guillermo L. Monroy
IPC分类号： A61B5/00 , A61B1/227 , G01B9/02 , G01N21/47 , G01B9/02091
摘要： A detector for characterizing at least one of a middle ear fluid and a middle ear biofilm includes a handheld probe outputting near-infrared and visible light, an OCT system to obtain A-scans at a plurality of positions on a tympanic membrane, and a camera to obtain surface sub-images at the plurality of positions. A-scans and surface sub-images are synchronized and the surface sub-images are mosaicked to generate a surface image of the tympanic membrane. Cross-sectional scan images or a thickness map are generated from the synchronized A-scans and segmented to extract a plurality of specified features. The specified features are then classified to characterize at least one of the middle ear fluid and the middle ear biofilm. The detector, including handheld probe with camera, OCT system, and a laptop computer, is sized to fit into a handheld, portable, compact, foam-padded briefcase weighing less than 10 kg.

2. 发明申请

US20160040978A1 Smart Phone Attachment for 3-D Optical Coherence Tomography Imaging 有权
标题翻译：智能手机附件3-D光学相干断层成像
公开(公告)号：US20160040978A1
公开(公告)日：2016-02-11
申请号：US14819551
申请日：2015-08-06
申请人： The Board of Trustees of the University of Illinois
发明人： Stephen A. Boppart , Ryan L. Shelton , Nathan Shemonski
IPC分类号： G01B9/02
CPC分类号： G01B9/02091
摘要： Methods and apparatus for tomographic imaging of a sample. Low-coherence light is split into a sample path and a reference path. A steering optic recombines light in the reference path with light scattered by a sample onto a camera having an areal focal plane array of detector elements such that light in the reference path and light scattered by the sample are characterized by respectively offset propagation vectors at incidence upon the camera. A processor derives depth information from light scattered by the sample on the basis of interference fringes between light in the reference path and light scattered by the sample. The apparatus tracks lateral motion and may be hand-held or attached to a mobile device such as a smartphone, thus enabling 3-D imaging with the mobile device.
摘要翻译：样品断层成像的方法和装置。低相干光分为采样路径和参考路径。转向光学器件将参考路径中的光与由样本散射的光重新组合到具有检测器元件的面焦平面阵列的相机上，使得参考路径中的光和由样本散射的光分别通过偏移传播向量相机。处理器根据基准路径中的光与样本散射的光之间的干涉条纹，从样本散射的光中导出深度信息。该装置跟踪横向运动，并且可以是手持式的或附接到诸如智能手机的移动装置，因此能够利用移动装置进行3-D成像。

3. 发明申请

US20160007840A1 Handheld Device for Identification of Microbiological Constituents in the Middle Ear 审中-公开
标题翻译：用于识别中耳微生物成分的手持装置
公开(公告)号：US20160007840A1
公开(公告)日：2016-01-14
申请号：US14722344
申请日：2015-05-27
申请人： The Board of Trustees of the University of Illinois
发明人： Stephen A. Boppart , Ryan L. Shelton
IPC分类号： A61B1/07 , A61B1/055 , A61B1/227
CPC分类号： A61B5/0075 , A61B5/0086 , A61B5/6817
摘要： Methods and apparatus for identifying microbiological constituents in the middle ear. A spectrometer receives Raman-scattered light from the region of the tympanic membrane and resolves spectral features of the Raman-scattered light. A processor receives the interferometry signal and the Raman signal, and generates a Raman spectrum of the tympanic membrane and material adjacent thereto. In some embodiments of the invention, low-coherence light and substantially monochromatic excitation light are directed onto a tympanic membrane of the ear of a person via an otoscopic tip that abuts the ear canal. An interferometer combines scattered low-coherence light from the ear tissue with a reference signal to generate an interferometric signal.
摘要翻译：识别中耳微生物成分的方法和装置。光谱仪从鼓膜区域接收拉曼散射光，并解析拉曼散射光的光谱特征。处理器接收干涉测量信号和拉曼信号，并产生鼓膜和与其相邻的材料的拉曼光谱。在本发明的一些实施例中，低相干光和基本上单色的激发光通过邻接耳道的耳镜头引导到人的耳朵的鼓膜上。干涉仪将来自耳朵组织的散射的低相干光与参考信号组合以产生干涉信号。

4. 发明授权

US11083375B2 Handheld device for identification of microbiological constituents in the middle ear 有权
公开(公告)号：US11083375B2
公开(公告)日：2021-08-10
申请号：US16012201
申请日：2018-06-19
申请人： The Board of Trustees of the University of Illinois
发明人： Stephen A. Boppart , Ryan L. Shelton
IPC分类号： A61B5/00
摘要： Methods and apparatus for identifying microbiological constituents in the middle ear. A spectrometer receives Raman-scattered light from the region of the tympanic membrane and resolves spectral features of the Raman-scattered light. A processor receives the interferometry signal and the Raman signal, and generates a Raman spectrum of the tympanic membrane and material adjacent thereto. In some embodiments of the invention, low-coherence light and substantially monochromatic excitation light are directed onto a tympanic membrane of the ear of a person via an otoscopic tip that abuts the ear canal. An interferometer combines scattered low-coherence light from the ear tissue with a reference signal to generate an interferometric signal.

5. 发明申请

US20160028204A1 Bright Few-Cycle Fiber Source using Resonant Dispersive Wave Emission in an Optical Fiber 有权
标题翻译：光纤中使用谐振分散波发射的明亮的少量循环光纤源
公开(公告)号：US20160028204A1
公开(公告)日：2016-01-28
申请号：US14445245
申请日：2014-07-29
申请人： Board of Trustees of the University of Illinois
发明人： Haohua Tu , Stephen A. Boppart
IPC分类号： H01S3/067 , H01S3/16 , H01S3/11 , G02B6/02 , H01S3/00
CPC分类号： H01S3/06725 , G02B6/02214 , H01S3/0057 , H01S3/06712 , H01S3/06741 , H01S3/06754 , H01S3/1112 , H01S3/1608 , H01S2301/085
摘要： Methods and apparatus for generating ultrashort optical pulses. Pulses of an infrared source are launched into an optical fiber characterized by a zero-dispersion wavelength (ZDW), where the wavelength of the infrared source exceeds the ZDW of the optical fiber by at least 100 nm. A resonant dispersion wave (RDW) is generated in the optical fiber that has a central wavelength blue-shifted by more than 500 nm relative to the pump wavelength, and, in some cases, by more than 700 nm. The optical fiber has a core of a diameter exceeding the central wavelength of the RDW by at least a factor of five. In a preferred embodiment, the infrared source includes a master-oscillator-power-amplifier, embodied entirely in optical fiber, and may include an Erbium:fiber oscillator, in particular.
摘要翻译：用于产生超短光脉冲的方法和装置。将红外源的脉冲发射到特征为零色散波长（ZDW）的光纤中，其中红外源的波长超过光纤的ZDW至少100nm。在相对于泵浦波长蓝色偏移大于500nm的中心波长的光纤中产生谐振色散波（RDW），并且在一些情况下，产生大于700nm的共振色散波（RDW）。光纤具有直径超过RDW的中心波长的核心至少五倍。在一个优选实施例中，红外源包括一个完全体现在光纤中的主振荡器功率放大器，并且可以包括铒光纤振荡器。

6. 发明申请

US20140333925A1 Optical Parametric Amplification of Weak Signals for Imaging Biological Tissue 有权
标题翻译：弱信号的光学参数放大成像生物组织
公开(公告)号：US20140333925A1
公开(公告)日：2014-11-13
申请号：US14157840
申请日：2014-01-17
申请人： The Board of Trustees of the University of Illinois
发明人： Stephen A. Boppart , Youbo Zhao
IPC分类号： G01N21/47 , G01N21/64 , G01N21/65
CPC分类号： G01N21/47 , G01N21/6486 , G01N21/65 , G02F1/3534 , G02F1/39 , G02F2001/3528 , G02F2001/392
摘要： Methods and apparatus for obtaining an image of light scattering biological tissue. A series of pulses of substantially monochromatic light of a first wavelength is generated and split into two parts, of which one part illuminates a scattering biological tissue at an intensity too low to damage the tissue, while a second part is upconverted to generate a pump beam. Sample light from the biological tissue, which may be scattered (or transmitted) light, or fluorescence, or Raman scattering, etc., is collected and directed from the scattering biological tissue, along with the pump beam, into a non-linear optical element, in a single pass or multiple passes. Parametrically amplified sample light emerging from the non-linear optical element is detected and analyzed or displayed.
摘要翻译：获得光散射生物组织图像的方法和装置。产生一系列具有第一波长的基本单色光的脉冲，并将其分为两部分，其中一部分以强度太低而不能损伤组织的方式照射散射生物组织，而第二部分被上变频以产生泵浦光束。来自可能被散射（或透射）光或荧光或拉曼散射等的来自生物组织的样品光以及泵浦光束从散射生物组织被收集并引导到非线性光学元件，单程或多次。从非线性光学元件出射的参数放大样本光被检测和分析或显示。

7. 发明申请

US20220228987A1 Clipping-Assisted Dual-Fluorophore Sensing 有权
公开(公告)号：US20220228987A1
公开(公告)日：2022-07-21
申请号：US17621922
申请日：2020-05-05
申请人： The Board of Trustees of the University of Illinois
发明人： Stephen A. Boppart , Haohua Tu , Sixian You
IPC分类号： G01N21/64
摘要： A method is provided for characterizing a biological sample having a plurality of fluorophores, including a red fluorophore and a blue fluorophore, comprises exciting the red fluorophore via absorption of a photon order of n by a single wavelength band of light that has longer wavelengths than a typical wavelength band of light known to excite the red fluorophore would have. The method further comprises exciting the blue fluorophore substantially via absorption of a photon order of n+1 by the single wavelength band of light. The method also comprises simultaneously detecting light emitted by the red fluorophore and the blue fluorophore. The method further comprises creating an image or a temporal series for sensing from the light detected in the plurality of orthogonal colors.

8. 发明授权

US09506858B2 Optical parametric amplification of weak signals for imaging biological tissue 有权
标题翻译：用于成像生物组织的弱信号的光学参数放大
公开(公告)号：US09506858B2
公开(公告)日：2016-11-29
申请号：US14157840
申请日：2014-01-17
申请人： The Board of Trustees of the University of Illinois
发明人： Stephen A. Boppart , Youbo Zhao
IPC分类号： G01J3/44 , G01N21/47 , G01N21/64 , G01N21/65 , G02F1/39 , G02F1/35
CPC分类号： G01N21/47 , G01N21/6486 , G01N21/65 , G02F1/3534 , G02F1/39 , G02F2001/3528 , G02F2001/392
摘要： Methods and apparatus for obtaining an image of light scattering biological tissue. A series of pulses of substantially monochromatic light of a first wavelength is generated and split into two parts, of which one part illuminates a scattering biological tissue at an intensity too low to damage the tissue, while a second part is upconverted to generate a pump beam. Sample light from the biological tissue, which may be scattered (or transmitted) light, or fluorescence, or Raman scattering, etc., is collected and directed from the scattering biological tissue, along with the pump beam, into a non-linear optical element, in a single pass or multiple passes. Parametrically amplified sample light emerging from the non-linear optical element is detected and analyzed or displayed.
摘要翻译：获得光散射生物组织图像的方法和装置。产生一系列具有第一波长的基本单色光的脉冲，并将其分成两部分，其中一部分以强度太低而不能损伤组织的方式照射散射生物组织，而第二部分被上变频以产生泵浦光束。来自可能被散射（或透射）光或荧光或拉曼散射等的来自生物组织的样品光以及泵浦光束从散射生物组织被收集并引导到非线性光学元件，单程或多次。从非线性光学元件出射的参数放大样本光被检测和分析或显示。

9. 发明授权

US09300107B2 Bright few-cycle fiber source using resonant dispersive wave emission in an optical fiber 有权
标题翻译：光纤中使用谐振色散波的明亮的几周期光纤源
公开(公告)号：US09300107B2
公开(公告)日：2016-03-29
申请号：US14445245
申请日：2014-07-29
申请人： Board of Trustees of the University of Illinois
发明人： Haohua Tu , Stephen A. Boppart
IPC分类号： G02B6/26 , H01S3/067 , G02B6/02 , H01S3/00 , H01S3/11 , H01S3/16
CPC分类号： H01S3/06725 , G02B6/02214 , H01S3/0057 , H01S3/06712 , H01S3/06741 , H01S3/06754 , H01S3/1112 , H01S3/1608 , H01S2301/085
摘要： Methods and apparatus for generating ultrashort optical pulses. Pulses of an infrared source are launched into an optical fiber characterized by a zero-dispersion wavelength (ZDW), where the wavelength of the infrared source exceeds the ZDW of the optical fiber by at least 100 nm. A resonant dispersion wave (RDW) is generated in the optical fiber that has a central wavelength blue-shifted by more than 500 nm relative to the pump wavelength, and, in some cases, by more than 700 nm. The optical fiber has a core of a diameter exceeding the central wavelength of the RDW by at least a factor of five. In a preferred embodiment, the infrared source includes a master-oscillator-power-amplifier, embodied entirely in optical fiber, and may include an Erbium:fiber oscillator, in particular.
摘要翻译：用于产生超短光脉冲的方法和装置。将红外源的脉冲发射到特征为零色散波长（ZDW）的光纤中，其中红外源的波长超过光纤的ZDW至少100nm。在相对于泵浦波长蓝色偏移大于500nm的中心波长的光纤中产生谐振色散波（RDW），并且在一些情况下，产生大于700nm的共振色散波（RDW）。光纤具有直径超过RDW的中心波长的核心至少五倍。在一个优选实施例中，红外源包括一个完全体现在光纤中的主振荡器功率放大器，并且可以包括铒光纤振荡器。

10. 发明申请

US20150297084A1 Low-Coherence Interferometry and Optical Coherence Tomography for Image-Guided Surgical Treatment of Solid Tumors 审中-公开
标题翻译：低相干干涉测量和光学相干断层扫描用于实体肿瘤的图像引导手术治疗
公开(公告)号：US20150297084A1
公开(公告)日：2015-10-22
申请号：US14593013
申请日：2015-01-09
申请人： The Board of Trustees of the University of Illinois
发明人： Stephen A. Boppart , Freddy T. Nguyen , Adam M. Zysk
IPC分类号： A61B5/00
CPC分类号： A61B5/0066 , A61B5/0073 , A61B5/415 , A61B5/418 , A61B5/6852 , A61B5/6853 , A61B5/7257 , A61B2562/0238
摘要： A system for providing intraoperative feedback to a user during the course of surgery. A core imaging unit provides low-coherence optical radiation coupled to a sampling device and generates optical coherence tomography (OCT) data based on combining scattered light received from the sampling device together with a reference signal. The sampling device is adapted to receive the low-coherence optical radiation from the core imaging unit and to illuminate the tissue, and to collect light scattered by the tissue and to return said light to the core imaging unit. A core software unit receives the OCT data from the core imaging unit provides real-time feedback, such as an image, to the user.
摘要翻译：一种用于在手术过程中向使用者提供术中反馈的系统。核心成像单元提供耦合到采样装置的低相干光辐射，并且基于将从采样装置接收的散射光与参考信号组合而产生光学相干断层摄影（OCT）数据。采样装置适于接收来自核心成像单元的低相干光辐射并照亮组织，并收集由组织散射的光并将所述光返回到核心成像单元。核心软件单元从核心成像单元接收OCT数据，向用户提供诸如图像的实时反馈。

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