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2. 发明申请

US20030082228A1 Anti-angiogenic therapy using liposome-encapsulated chemotherapeutic agents 审中-公开
标题翻译：使用脂质体包封的化学治疗剂进行抗血管生成治疗
公开(公告)号：US20030082228A1
公开(公告)日：2003-05-01
申请号：US10143545
申请日：2002-05-09
申请人： Inex Pharmaceuticals Corporation
发明人： Clay Flowers , David Saltman , Patrick M.S. Tam , Clive T.R. Burge , Troy O. Hasrasym
IPC分类号： A61K009/127 , A61K031/4745
CPC分类号： A61K9/127 , A61K9/1271 , A61K9/1272
摘要： The present invention provides methods and compositions for the treatment and prevention of any of a large number of diseases and conditions with an angiogenic component, e.g., cancer. The present invention is based upon the discovery that liposome-encapsulated chemotherapeutic agents, such as alkaloids (e.g., vinca alkaloids such as vincristine), are surprisingly effective at treating such diseases or conditions when administered at a higher frequency than those used with conventional administration strategies. Such methods can be used to treat diseases such as cancer even when the cancer comprises cells that are resistant to the chemotherapeutic alkaloid. The liposome encapsulation of the chemotherapeutic agents, e.g., alkaloids, imparts dramatic improvements in the stability, biodistribution, and delivery of the agents, thereby allowing more efficacious and convenient administration to a patient with any of the herein-described diseases or conditions.
摘要翻译：本发明提供用于治疗和预防具有血管生成成分例如癌症的大量疾病和病症中的任何一种的方法和组合物。本发明基于以下发现：当以比常规施用策略使用的那些更高的频率施用时，脂质体包封的化学治疗剂，例如生物碱（例如长春花碱长春花生物碱）在治疗这些疾病或病症方面令人惊奇地有效。即使当癌症包含对化学治疗性生物碱具有抗性的细胞时，也可以使用这样的方法来治疗诸如癌症的疾病。化学治疗剂（例如生物碱）的脂质体包封赋予了药剂的稳定性，生物分布和递送的显着改善，从而允许对具有任何本文描述的疾病或病症的患者更有效和方便的给药。

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