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1. 发明授权

US5693015A Exchangeable integrated-wire balloon catheter 失效
标题翻译：可换式集成丝球囊导管
公开(公告)号：US5693015A
公开(公告)日：1997-12-02
申请号：US469265
申请日：1995-06-06
申请人： Blair Walker , Manouchehr Miraki , William Rice , Kambiz Ghearzadeh , Brett Trauthen , Hye Lee , Greg Welsh , Henry Nita , Shawn O'Leary
发明人： Blair Walker , Manouchehr Miraki , William Rice , Kambiz Ghearzadeh , Brett Trauthen , Hye Lee , Greg Welsh , Henry Nita , Shawn O'Leary
IPC分类号： A61F2/958 , A61L29/04 , A61M25/00 , A61M29/02 , A61M29/00
CPC分类号： A61M25/104 , A61L29/04 , A61M25/09 , A61M25/10 , A61M2025/0047 , A61M2025/09008 , A61M2025/091 , A61M2025/1052 , A61M2025/1063 , A61M2025/1079 , A61M2025/1093 , A61M25/0075 , A61M25/1002
摘要： A balloon catheter includes a flexible small-diameter guide wire provided with an enlarged-diameter distal end portion, and a flexible elongated tubular shaft with at least one dual-function fluid-conducting lumen adapted to both receive the guide wire extending therethrough, and to communicate pressurized inflation fluid to a distal balloon of the catheter. A distal orifice of the catheter communicates with the balloon and is provided with selective valving means for releasably engaging sealingly with the enlarged distal end portion of the guide wire. Apparatus is disclosed for axially moving the guide wire to effect engagement and disengagement of the enlarged distal end portion with the selective valving means of the catheter shaft. A torquer device is also provided by means of which the guide wire may be rotated relative to the catheter shaft for steering of the guide wire along a vascular pathway. A distal end tapered portion of the catheter shaft provides protection for a joint of the guide wire assembly. The tubular shaft of the catheter may extend through the balloon to provide better pushability for the catheter, especially in versions which employ a comparatively limp material for the balloon. Several alternative constructions for the selective valving means of the catheter shaft and for the enlarged distal end portion of the guide wire assembly are presented.
摘要翻译：球囊导管包括设置有扩大直径的远端部分的柔性小直径导丝线和具有至少一个双功能流体导流腔的柔性细长管状轴，其适于两者都容纳延伸穿过其中的导丝，并且将加压的充气流体传递到导管的远端球囊。导管的远端孔与球囊连通并设置有选择性阀门装置，用于可释放地与引导线的扩大的远端部分紧密接合。公开了用于轴向移动导丝以使扩大的远端部分与导管轴的选择性阀装置的接合和分离的装置。还提供了一种绞盘装置，通过该装置，引导线可以相对于导管轴旋转，以沿着血管通路转向导丝。导管轴的远端锥形部分为导丝组件的接头提供保护。导管的管状轴可以延伸穿过气囊以为导管提供更好的推动性，特别是在采用气囊相对较差的材料的形式中。提出了用于导管轴的选择性阀装置和导丝组件的扩大的远端部分的几种替代结构。

2. 发明授权

US5454788A Exchangeable integrated-wire balloon catheter 失效
标题翻译：可换式集成丝球囊导管
公开(公告)号：US5454788A
公开(公告)日：1995-10-03
申请号：US228550
申请日：1994-04-15
申请人： Blair Walker , Manouchehr Miraki , William Rice , Kambiz Ghaerzadeh , Brett Trauthen , Hey Lee , Greg Welsh , Henry Nita , Shawn O'Leary , Mark Dehdashtian , Sheryl W. Higgins , Nora Pham
发明人： Blair Walker , Manouchehr Miraki , William Rice , Kambiz Ghaerzadeh , Brett Trauthen , Hey Lee , Greg Welsh , Henry Nita , Shawn O'Leary , Mark Dehdashtian , Sheryl W. Higgins , Nora Pham
IPC分类号： A61F2/958 , A61L29/04 , A61M25/00 , A61M29/02 , A61M29/00
CPC分类号： A61M25/104 , A61L29/04 , A61M25/09 , A61M25/10 , A61M2025/0047 , A61M2025/09008 , A61M2025/091 , A61M2025/1052 , A61M2025/1063 , A61M2025/1079 , A61M2025/1093 , A61M25/0075 , A61M25/1002
摘要： A balloon catheter includes a flexible small-diameter guide wire provided with an enlarged-diameter distal end portion, and a flexible elongated tubular shaft with at least one dual-function fluid-conducting lumen adapted to both receive the guide wire extending therethrough, and to communicate pressurized inflation fluid to a distal balloon of the catheter. A distal orifice of the catheter communicates with the balloon and is provided with selective valving means for releasably engaging sealingly with the enlarged distal end portion of the guide wire. Apparatus is disclosed for axially moving the guide wire to effect engagement and disengagement of the enlarged distal end portion with the selective valving means of the catheter shaft. A torquer device is also provided by means of which the guide wire may be rotated relative to the catheter shaft for steering of the guide wire along a vascular pathway. A distal end tapered portion of the catheter shaft provides protection for a joint of the guide wire assembly. The tubular shaft of the catheter may extend through the balloon to provide better pushability for the catheter, especially in versions which employ a comparatively limp material for the balloon. Several alternative constructions for the selective valving means of the catheter shaft and for the enlarged distal end portion of the guide wire assembly are presented.
摘要翻译：球囊导管包括设置有扩大直径的远端部分的柔性小直径导丝线和具有至少一个双功能流体导流腔的柔性细长管状轴，其适于两者都容纳延伸穿过其中的导丝，并且将加压的充气流体传递到导管的远端球囊。导管的远端孔与球囊连通并设置有选择性阀门装置，用于可释放地与引导线的扩大的远端部分紧密接合。公开了用于轴向移动导丝以使扩大的远端部分与导管轴的选择性阀装置的接合和分离的装置。还提供了一种绞盘装置，通过该装置，引导线可以相对于导管轴旋转，以沿着血管通路转向导丝。导管轴的远端锥形部分为导丝组件的接头提供保护。导管的管状轴可以延伸穿过气囊以为导管提供更好的推动性，特别是在采用气囊相对较差的材料的形式中。提出了用于导管轴的选择性阀装置和导丝组件的扩大的远端部分的几种替代结构。

3. 发明申请

US20070213690A1 Blood conduit connector 审中-公开
标题翻译：血管连接器
公开(公告)号：US20070213690A1
公开(公告)日：2007-09-13
申请号：US11371208
申请日：2006-03-08
申请人： Nickolas Phillips , Anthony Viole , Michael Scott , Robert Pecor , Shawn O'Leary , Dominic Dinh
发明人： Nickolas Phillips , Anthony Viole , Michael Scott , Robert Pecor , Shawn O'Leary , Dominic Dinh
IPC分类号： A61M39/10 , A61M37/00 , F16L33/00
CPC分类号： A61M1/3653 , A61M1/10 , A61M1/1005 , A61M1/1008 , A61M1/101 , A61M1/1034 , A61M1/1086 , A61M1/12 , A61M1/122 , A61M1/125 , A61M1/3659 , A61M39/12
摘要： A conduit for use with a blood pump can have a flared inner surface at an end of the conduit. In some embodiments, the conduit can include a strain relief member such as overmolded silicone. The strain relief member can maintain the profile of the flared inner surface. A conduit with a flared inner surface can be configured for connection to a blood pump via a connector. For example, the conduit can include an anchor member such as flange configured to engage with various components of a connector to connect the conduit to a fitting on a pump or another structure. In some embodiments, the conduit can be configured to connect to a blood conduit connector including a member such as a compression collet and a fitting such as a coupler. The connector can include a bayonet connection to facilitate rapid connection and disconnection of the conduit from a fitting.
摘要翻译：与血泵一起使用的导管可以在导管的端部具有扩张的内表面。在一些实施例中，导管可以包括应变消除部件，例如包覆成型硅树脂。应变消除构件可以保持扩张内表面的轮廓。具有扩张内表面的管道可以被配置为经由连接器连接到血液泵。例如，管道可以包括锚定构件，例如凸缘，其构造成与连接器的各种部件接合以将导管连接到泵或另一结构上的配件。在一些实施例中，导管可以被配置成连接到包括诸如压缩夹头的部件和诸如耦合器的配件的血液导管连接器。连接器可以包括卡口连接，以便于导管与配件的快速连接和断开。

4. 发明申请

US20060270894A1 Implantable heart assist system and method of applying same 审中-公开
公开(公告)号：US20060270894A1
公开(公告)日：2006-11-30
申请号：US11418490
申请日：2006-05-03
申请人： Anthony Viole , Laksen Sirimanne , Steven Bolling , Shawn O'Leary , Robert Pecor , Ryan Kelly , Wolfgang Werner , Masoud Beizai
发明人： Anthony Viole , Laksen Sirimanne , Steven Bolling , Shawn O'Leary , Robert Pecor , Ryan Kelly , Wolfgang Werner , Masoud Beizai
IPC分类号： A61N1/362
CPC分类号： A61M1/3621 , A61M1/10 , A61M1/1005 , A61M1/1008 , A61M1/101 , A61M1/1034 , A61M1/107 , A61M1/1086 , A61M1/122 , A61M1/125 , A61M1/3655 , A61M25/0026 , A61M25/007
摘要： An extracardiac pumping for supplementing the circulation of blood, including the cardiac output, in a patient without any component thereof being connected to the patient's heart, and methods of using same. One embodiment of the intravascular extracardiac system comprises a pump with inflow and outflow conduits that are sized and configured to be implantable intravascularly through a non-primary vessel, whereby it may positioned where desired within the patient's vasculature. The system comprises a subcardiac pump that may be driven directly or electromagnetically from within or without the patient. The pump is configured to be operated continuously or in a pulsatile fashion, synchronous with the patient's heart, thereby potentially reducing the afterload of the heart. In another embodiment, the system is positioned extracorporeally, with the inflow conduit and outflow conduit applied percutaneously to a non-primary vessel for circulating blood to and from the non-primary vessel or between the non-primary vessel and another blood vessel within the patient's vasculature.

5. 发明申请

US20060270892A1 Implantable heart assist system and method of applying same 失效
公开(公告)号：US20060270892A1
公开(公告)日：2006-11-30
申请号：US11417889
申请日：2006-05-03
申请人： Steven Bolling , Anthony Viole , Shawn O'Leary
发明人： Steven Bolling , Anthony Viole , Shawn O'Leary
IPC分类号： A61N1/362
CPC分类号： A61M1/101 , A61M1/10 , A61M1/1005 , A61M1/1008 , A61M1/1034 , A61M1/107 , A61M1/1086 , A61M1/12 , A61M1/122 , A61M1/125 , A61M1/3621 , A61M1/3653 , A61M1/3655 , A61M1/3659 , A61M25/0026 , A61M25/003 , A61M25/007 , A61M2230/04
摘要： An extracardiac pumping for supplementing the circulation of blood, including the cardiac output, in a patient without any component thereof being connected to the patient's heart, and methods of using same. One embodiment provides a vascular graft that has a first end that is sized and configured to couple to a non-primary blood vessel and a second end that is fluidly coupled to a pump to conduct blood between the pump and the non-primary blood vessel. An outflow conduit is also provided that has a first end sized and configured to be positioned within the same or different blood vessel, whether primary or non-primary, through the vascular graft. The outflow conduit is fluidly coupled to the pump to conduct blood between the pump and the patient. The vascular graft may be connected to the blood vessel subcutaneously to permit application of the extracardiac pumping system in a minimally-invasive procedure.

6. 发明申请

US20050256363A1 Implantable heart assist system and method of applying same 有权
公开(公告)号：US20050256363A1
公开(公告)日：2005-11-17
申请号：US11121352
申请日：2005-05-03
申请人： Steven Bolling , Anthony Viole , Shawn O'Leary
发明人： Steven Bolling , Anthony Viole , Shawn O'Leary
IPC分类号： A61M1/10 , A61M1/12 , A61M1/36 , A61M25/00 , A61M39/10 , A61N1/362
CPC分类号： A61M1/101 , A61M1/10 , A61M1/1005 , A61M1/1008 , A61M1/1034 , A61M1/107 , A61M1/1086 , A61M1/12 , A61M1/122 , A61M1/125 , A61M1/3621 , A61M1/3653 , A61M1/3655 , A61M1/3659 , A61M25/0026 , A61M25/003 , A61M25/007 , A61M2230/04
摘要： An extracardiac pumping for supplementing the circulation of blood, including the cardiac output, in a patient without any component thereof being connected to the patient's heart, and methods of using same. One embodiment provides a vascular graft that has a first end that is sized and configured to couple to a non-primary blood vessel and a second end that is fluidly coupled to a pump to conduct blood between the pump and the non-primary blood vessel. An outflow conduit is also provided that has a first end sized and configured to be positioned within the same or different blood vessel, whether primary or non-primary, through the vascular graft. The outflow conduit is fluidly coupled to the pump to conduct blood between the pump and the patient. The vascular graft may be connected to the blood vessel subcutaneously to permit application of the extracardiac pumping system in a minimally-invasive procedure.

7. 发明申请

US20050131385A1 Cannulae for selectively enhancing blood flow 审中-公开
标题翻译：插管用于选择性增强血流量
公开(公告)号：US20050131385A1
公开(公告)日：2005-06-16
申请号：US10735413
申请日：2003-12-12
申请人： Steven Bolling , Anthony Viole , Shawn O'Leary , Robert Pecor
发明人： Steven Bolling , Anthony Viole , Shawn O'Leary , Robert Pecor
IPC分类号： A61M25/00 , A61M29/00
CPC分类号： A61M27/008 , A61M25/003 , A61M25/0068 , A61M25/007 , A61M2025/0031 , A61M2025/0037 , A61M2025/0073
摘要： A perfusion cannula system for directing blood through the vasculature of a patient comprises a cannula body having a proximal end, a distal end, and at least one lumen extending therebetween. The perfusion cannula system enhances blood flow past the cannula when the cannula body resides within the patient. A first balloon can be located on an exterior surface of the cannula body and the balloon can be deployed within the vasculature whereby space may be provided between a vessel wall and the cannula body. A cannula body can have an aperture formed therein in fluid communication with a lumen. A sleeve can be carried by the cannula and can be configured to be moveable relative to the aperture to selectively cover and uncover the aperture as desired.
摘要翻译：用于引导血液通过患者的脉管系统的灌注插管系统包括具有近端，远端以及在其间延伸的至少一个内腔的插管主体。当套管主体位于患者体内时，灌注插管系统增强穿过套管的血液流动。第一气球可以位于套管主体的外表面上，并且球囊可以部署在脉管系统内，从而可以在血管壁和套管本体之间提供空间。套管主体可以具有形成在其中的与内腔流体连通的孔。套管可以由套管承载，并且可以被配置为相对于孔可移动，以根据需要选择性地覆盖和露出孔。

8. 发明授权

US07458929B2 Implantable heart assist system and method of applying same 有权
标题翻译：植入式心脏辅助系统及其应用方法
公开(公告)号：US07458929B2
公开(公告)日：2008-12-02
申请号：US11121352
申请日：2005-05-03
申请人： Steven F. Bolling , Anthony Viole , Shawn O'Leary
发明人： Steven F. Bolling , Anthony Viole , Shawn O'Leary
IPC分类号： A61M1/12
CPC分类号： A61M1/101 , A61M1/10 , A61M1/1005 , A61M1/1008 , A61M1/1034 , A61M1/107 , A61M1/1086 , A61M1/12 , A61M1/122 , A61M1/125 , A61M1/3621 , A61M1/3653 , A61M1/3655 , A61M1/3659 , A61M25/0026 , A61M25/003 , A61M25/007 , A61M2230/04
摘要： An extracardiac pumping for supplementing the circulation of blood, including the cardiac output, in a patient without any component thereof being connected to the patient's heart, and methods of using same. One embodiment provides a vascular graft that has a first end that is sized and configured to couple to a non-primary blood vessel and a second end that is fluidly coupled to a pump to conduct blood between the pump and the non-primary blood vessel. An outflow conduit is also provided that has a first end sized and configured to be positioned within the same or different blood vessel, whether primary or non-primary, through the vascular graft. The outflow conduit is fluidly coupled to the pump to conduct blood between the pump and the patient. The vascular graft may be connected to the blood vessel subcutaneously to permit application of the extracardiac pumping system in a minimally-invasive procedure.
摘要翻译：用于补充患者的血液循环（包括心输出量）的心外泵送，而不将其任何组分连接到患者的心脏，以及使用它们的方法。一个实施例提供一种血管移植物，其具有第一端的尺寸和构造以耦合到非原发性血管和流体耦合到泵的第二端，以在泵和非原发性血管之间引导血液。还提供了流出管道，其具有第一端的尺寸和构造以通过血管移植物定位在相同或不同的血管内，无论是初级的还是非原发的。流出管道流体耦合到泵以在泵和患者之间进行血液。血管移植物可以皮下连接到血管，以允许将心脏内泵送系统应用于微创手术。

9. 发明申请

US20060270965A1 Multilumen catheter for minimizing limb ischemia 审中-公开
公开(公告)号：US20060270965A1
公开(公告)日：2006-11-30
申请号：US11417918
申请日：2006-05-03
申请人： Anthony Viole , Laksen Sirimanne , Steven Bolling , Shawn O'Leary , Robert Pecor , Ryan Kelly , Wolfgang Werner , Masoud Beizai
发明人： Anthony Viole , Laksen Sirimanne , Steven Bolling , Shawn O'Leary , Robert Pecor , Ryan Kelly , Wolfgang Werner , Masoud Beizai
IPC分类号： A61M5/00
CPC分类号： A61M25/003 , A61M1/10 , A61M1/122 , A61M1/3613 , A61M1/3653 , A61M1/3659 , A61M25/00 , A61M25/0068 , A61M25/007 , A61M25/0071 , A61M2025/0025 , A61M2025/0031 , A61M2025/0037 , A61M2025/0039 , A61M2025/0073 , A61M2025/1095
摘要： A multilumen catheter that maximizes the blood flow into and out of the patient's vasculature while also providing for passive and/or active perfusion of tissue downstream of where the catheter resides in the vasculature. The inventive catheter comprises a proximal end, a first distal and a second distal end with first and second lumens extending from the proximal end to each of these distal ends to provide for blood circulation within one blood vessel or between two different blood vessels. The second lumen, and any additional lumens so desired, may be positioned coaxially with or radially around the first lumen. Redirecting means is provided at a distal end of at least one of said lumens for directing blood in a direction generally opposite of the direction of flow through said lumen.

10. 发明申请

US20060270895A1 Multilumen catheter for minimizing limb ischemia 审中-公开
公开(公告)号：US20060270895A1
公开(公告)日：2006-11-30
申请号：US11418499
申请日：2006-05-03
申请人： Anthony Viole , Laksen Sirimanne , Steven Bolling , Shawn O'Leary , Wolfgang Werner
发明人： Anthony Viole , Laksen Sirimanne , Steven Bolling , Shawn O'Leary , Wolfgang Werner
IPC分类号： A61N1/362
CPC分类号： A61M1/3653 , A61M1/10 , A61M1/122 , A61M1/3613 , A61M1/3659 , A61M2025/0031 , A61M2025/0037
摘要： A multilumen catheter that maximizes the blood flow into and out of the patient's vasculature while also providing for passive and/or active perfusion of tissue downstream of where the catheter resides in the vasculature. The inventive catheter comprises a proximal end, a first distal and a second distal end. Lumens extending from the proximal end to each of these distal ends provide for blood circulation within one or between two blood vessels. At least one aperture in one of the lumens positioned near the proximal end provides for active perfusion of blood to the patient's vasculature downstream of where the aperture resides in the vasculature when the catheter is inserted into the patient for treatment. The inventive catheter may comprise a third lumen positioned entirely within the patient's vasculature, providing passive perfusion of blood to the patient's vasculature downstream of where the third lumen resides in the vasculature when the catheter is inserted into the patient for treatment.

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