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1. 发明专利

JP2005187427A Immunoenhancing composition containing poly-gamma-glutamic acid 有权
标题翻译：包含多糖 - 谷氨酸的免疫组合物
公开(公告)号：JP2005187427A
公开(公告)日：2005-07-14
申请号：JP2003433754
申请日：2003-12-26
申请人： Bioleaders Corp , Korea Research Inst Of Bioscience & Biotechnology , コリアリサーチインスティチュートオブバイオサイエンスアンドバイオテクノロジー , バイオリーダース・コーポレイションBioLeaders Corp.
发明人： SUNG MOON-HEE , JUNG CHANG MIN , PARK CHUNG , HONG SEUNG-PYO , LEE JONG SU , CHOI YOON HO , KIM JOONG-JAE , KIM SU-MI , KIM CHUL JOONG , POO HA RYOUNG , LEE TEYON , KURODA SHUNICHI , SEWAKI TOMOMITSU
IPC分类号： A23K1/16 , A23L1/305 , A61K31/785 , A61K39/39 , A61P31/04 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/04
摘要： PROBLEM TO BE SOLVED: To provide a use of a poly-γ-glutamic acid exhibiting immunoenhancing and modulating effects. SOLUTION: The subject immunoenhancing composition containing the poly-γ-glutamic acid has little toxicity and side action and, accordingly, is safely usable for a long period for prevention, usable for the prevention and treatment of infective diseases and usable as medicines and health foods for imparting the enhancement and regulation of immunity to a patient having lowered or suppressed immunizing power. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供显示免疫增强和调节作用的聚-γ-谷氨酸的用途。解决方案：含有聚-γ-谷氨酸的受试者免疫增强组合物具有很小的毒性和副作用，因此可长期安全使用，可用于预防和治疗感染性疾病并可用作药物以及用于赋予具有降低或抑制的免疫功率的患者的增强和调节免疫力的健康食品。版权所有（C）2005，JPO＆NCIPI

2. 发明专利

JP2008202043A Poly-gamma-glutamic acid having super-high molecular weight and use thereof 审中-公开
标题翻译：具有超高分子量的聚氨基葡萄糖酸及其用途
公开(公告)号：JP2008202043A
公开(公告)日：2008-09-04
申请号：JP2008024118
申请日：2008-02-04
申请人： Bioleaders Corp , Korea Research Inst Of Bioscience & Biotechnology , コリアリサーチインスティテュートオブバイオサイエンスアンドバイオテクノロジー , バイオリーダーズコーポレイション
发明人： SUNG MOON HEE , PARK CHUNG , HONG SEUNG-PYO , KIM KWANG SEOK , SONG JAE JUN , RHA EU GENE , KIM KWANG , SODA KENJI , ASHIUCHI MAKOTO , POO HA RYOUNG , LEE SEUNG GOO
IPC分类号： A23K1/175 , C08G69/10 , A23K1/16 , A23L1/03 , A23L1/30 , A23L1/304 , A61K8/64 , A61K8/72 , A61K8/81 , A61K8/88 , A61K9/00 , A61K47/42 , A61Q19/00 , C07K14/32 , C08G69/02 , C08H1/00 , C12P21/02
CPC分类号： A61K9/0014 , A61K8/88 , A61K9/0095 , A61K47/42 , A61Q19/00 , C08H1/00 , C12P21/02
摘要： PROBLEM TO BE SOLVED: To provide a poly-γ-glutamic acid having a super-high molecular weight produced by a halotolerant strain, Bacillus subtills var. chungk, and food products, cosmetics, animal feeds and mineral absorption-promoting composition each including the glutamic acid. SOLUTION: This is a super-high molecular weight poly-γ-glutamic acid (PGA) having a molecular weight of more than 5,000 kDa which is produced by a halotolerant strain, in which more than 95% of the molecules have a molecular weight in the range of 3,000 to 15,000 kDa, and can be produced through the culture of Bacillus subtills var. chungk. The PGA shows excellent hygroscopicity, moisture retaining property, sustained release property, mineral-solubility and water absorptivity. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：为了提供由耐火菌株产生的具有超高分子量的聚-γ-谷氨酸，枯草芽孢杆菌变种。香草，以及各自包含谷氨酸的食品，化妆品，动物饲料和矿物质吸收促进组合物。解决方案：这是一种分子量大于5,000kDa的超高分子量聚-γ-谷氨酸（PGA），其由耐热菌株产生，其中超过95％的分子具有分子量在3000〜15000kDa范围内，可以通过芽孢杆菌变种培养产生。 chungk。 PGA显示出优异的吸湿性，保湿性，持续释放性，矿物溶解性和吸水性。版权所有（C）2008，JPO＆INPIT

3. 发明公开

EP1291432A4 NOVEL PROMOTERS AND GENE EXPRESSION METHOD BY USING THE PROMOTERS 审中-公开
标题翻译：新启动子与基因表达中的方法使用SAME
公开(公告)号：EP1291432A4
公开(公告)日：2004-07-14
申请号：EP01925940
申请日：2001-04-26
申请人： BIOLEADERS CORP , TAKARA BIO INC
发明人： SUNG MOON-HEE , LEE SEUNG-GOO , HONG SEUNG-PYO , SEO HWA-JUNG
IPC分类号： C07K14/32 , C12N1/21 , C12N15/70 , C12N15/75 , C12P21/02
CPC分类号： C07K14/32 , C12N15/70 , C12N15/75
摘要： Promoters capable of expressing a gene at a high level without inducing the gene expression; recombinant DNAs; vectors for gene expression; expression vectors; transformed cells; a process for producing a protein which can be conveniently performed at a low cost; and a kit therefor. Namely, an isolated DNA having a base sequence represented by SEQ ID NO:1 or 2 in Sequence Listing or its fragment showing a constitutive promoter activity in Escherichia coli or bacteria belonging to the genus Bacillus ; an isolated DNA hybridizable with the above DNA and showing a constitutive promoter activity in Escherichia coli or bacteria belonging to the genus Bacillus ; a recombinant DNA wherein the above DNA and a foreign gene are provided in such a state as enabling the expression of the foreign gene; a vector for gene expression which contains at least the above DNA; an expression vector containing the above recombinant DNA; a transformed cells carrying the above recombinant DNA or the above expression vector; a process for producing a protein which comprises culturing the above transformed cell and collecting the protein from the culture medium thus obtained; and a kit for producing a protein which contains at least the above DNA or the above vector for gene expression.

4. 发明公开

EP1421195A4 SURFACE EXPRESSION VECTORS HAVING pgsBCA, THE GENE CODING POLY-GAMMA-GLUTAMATE SYNTHETASE, AND A METHOD FOR EXPRESSION OF TARGET PROTEIN AT THE SURFACE OF MICROORGANISM USING THE VECTOR 有权
标题翻译： WITH pgsBCA，THE FOR聚-γ-谷氨酸合成酶编码基因AND METHOD FOR表达靶蛋白的关于使用矢量微生物表面表面EXPRESSION VECTORS
公开(公告)号：EP1421195A4
公开(公告)日：2005-04-27
申请号：EP02755966
申请日：2002-08-09
申请人： BIOLEADERS CORP , M D LAB CO LTD
发明人： SUNG MOON-HEE , HONG SEUNG-PYO , LEE JONG-SU , JUNG CHANG-MIN , KIM CHUL-JOONG , SODA KENJI , ASHIUCHI MAKOTO
IPC分类号： C12N15/09 , C12N1/20 , C12N1/21 , C12N9/00 , C12N9/10 , C12N9/12 , C12N9/20 , C12N9/78 , C12N15/02 , C12N15/63 , C12N15/75 , C12P21/02 , C12R1/01 , C12N15/52
CPC分类号： C12N9/1051 , C07K2319/02 , C12N9/1288 , C12Y204/01133 , C12Y207/08005

5. 发明专利

DE60215521D1 未知
公开(公告)号：DE60215521D1
公开(公告)日：2006-11-30
申请号：DE60215521
申请日：2002-08-09
申请人： BIOLEADERS CORP , M D LAB CO LTD
发明人： SUNG MOON-HEE , HONG SEUNG-PYO , LEE JONG-SU , JUNG CHANG-MIN , KIM CHUL-JOONG , SODA KENJI , ASHIUCHI MAKOTO
IPC分类号： C12N15/09 , C12N15/63 , C12N1/20 , C12N1/21 , C12N9/00 , C12N9/10 , C12N9/12 , C12N9/20 , C12N9/78 , C12N15/02 , C12N15/52 , C12N15/75 , C12P21/02 , C12R1/01
摘要： The present invention relates to a surface expression vector having pgsBCA, a gene coding poly-gamma-glutamate synthetase and a method for expression of target protein at the surface of microorganism using the vector. The vector, in which foreign genes are inserted, transforms microorganisms and makes foreign proteins expressed stably on the surface of microorganisms.

6. 发明公开

EP1519979A4 POLY-GAMMA-GLUTAMATE HAVING ULTRA HIGH MOLECULAR WEIGHT AND METHOD FOR USING THE SAME 审中-公开
标题翻译： POLY-GAMMA-GLUTAMAT MIT HOHEM MOLEKULARGEWICHT UND VERWENDUNGSVERFAHRENDAFÜR
公开(公告)号：EP1519979A4
公开(公告)日：2005-08-17
申请号：EP03764235
申请日：2003-07-10
申请人： BIOLEADERS CORP , KOREA RES INST OF BIOSCIENCE
发明人： SUNG MOON-HEE , PARK CHUNG , HONG SEUNG-PYO , KIM KWANG SEOK , SONG JAE JUN , RHA EU GENE , KIM KWANG , SODA KENJI , ASHIUCHI MAKOTO , POO HA RYOUNG , LEE SEUNG GOO
IPC分类号： A23K1/175 , A23L1/30 , A23L1/304 , A61K8/64 , A61K8/72 , A61K8/88 , A61K9/00 , A61K47/42 , A61Q19/00 , C07K14/32 , C08G69/02 , C08H1/00 , C12P21/02
CPC分类号： A61K9/0014 , A61K8/88 , A61K9/0095 , A61K47/42 , A61Q19/00 , C08H1/00 , C12P21/02
摘要： The present invention relates to a poly-gamma-glutamate (PGA) having an ultra-high molecular weight greater than 5,000 kDa. The ultra-high molecular weight PGA according to the present invention has a mean molecular weight greater than 13,000 kDa, and more than 95% of its molecules have a molecular weight ranging from 3,000 to 15,000 kDa. Also, it can be produced by the culturing of Bacillus subtilis var. chungkookjang. The ultra-high molecular weight PGA according to the present invention shows very excellent moisture-absorbing, moisture-retaining, sustained release, mineral solubility, and water-absorbing properties, and thus, can be used as a new and high value-added material in various applications.
摘要翻译：本发明涉及具有超过5,000kDa的超高分子量的聚γ-谷氨酸（PGA）。根据本发明的超高分子量PGA具有大于13,000kDa的平均分子量，并且其超过95％的分子具有3,000至15,000kDa的分子量。此外，它可以通过培养枯草芽孢杆菌变种产生。 chungkookjang。根据本发明的超高分子量PGA显示非常优异的吸湿性，保湿性，持续释放性，矿物质溶解性和吸水性，因此可以用作新的和高附加值材料在各种应用中。

7. 发明专利

AU5259101A Novel promoters and gene expression method by using the promoters 未知
公开(公告)号：AU5259101A
公开(公告)日：2001-11-12
申请号：AU5259101
申请日：2001-04-26
申请人： BIOLEADERS CORP , TAKARA SHUZO CO
发明人： SUNG MOON-HEE , LEE SEUNG-GOO , HONG SEUNG-PYO , SEO HWA-JUNG
IPC分类号： C07K14/32 , C12N1/21 , C12N15/70 , C12N15/75 , C12P21/02
摘要： To provide a promoter, a recombinant DNA, a gene expression vector, an expression vector, and a transformant, which are capable of expressing a gene without inducing gene expression with an inducer; and a method for producing a protein and a kit therefor, which can be operated easily and performed inexpensively by convenient and inexpensive steps. An isolated DNA having the nucleotide sequence of SEQ ID NO: 1 or 2 of Sequence Listing or a fragment thereof, wherein the isolated DNA exhibits a constitutive promoter activity in Escherichia coli or a bacterium belonging to the genus Bacillus; an isolated DNA having a nucleotide sequence of a nucleic acid capable of hybridizing to the above DNA, wherein the isolated DNA exhibits a constitutive promoter activity in Escherichia coli or a bacterium belonging to the genus Bacillus; a recombinant DNA comprising the above DNA and a foreign gene, wherein the foreign gene is operably located; a gene expression vector, at least comprising the above DNA; an expression vector comprising the recombinant DNA; a transformant having the above recombinant DNA, or the above expression vector; a method for producing a protein, characterized by culturing the above transformant, and collecting a protein from the resulting culture; and a kit for producing a protein, at least comprising the above DNA, or the above gene expression vector.

8. 发明专利

GB2460800A Novel constitutive strong promoter and use thereof 未知
公开(公告)号：GB2460800A
公开(公告)日：2009-12-16
申请号：GB0918277
申请日：2008-03-21
申请人： BIOLEADERS CORP , KOREA RES INST OF BIOSCIENCE
发明人： SUNG MOON-HEE , KIM CHUL JOONG , HONG SEUNG-PYO , POO HARYOUNG , LEE IL HAN , KIM JI YEON , KIM KWANG
IPC分类号： C12N15/74 , C12N9/88
摘要： Disclosed herein are an aldolase gene promoter and the use thereof, more particularly, disclosed are a promoter of aldolase gene derived from Lactobacillus casei, having a base sequence of SEQ ID NO: 15 an expression vector containing said promoter, and a recombinant microorganism transformed with said expression vector. The recombinant microorganism transformed with the expression vector containing the disclosed promoter can effectively express a target protein on the surface thereof, and thus will be useful as vaccine vehicles and the like.

10. 发明专利

AU2003271215A1 VECTOR FOR ANTI-HPV VACCINE AND TRANSFORMED MICROORGANISM BY THE VECTOR 未知
公开(公告)号：AU2003271215A1
公开(公告)日：2004-05-04
申请号：AU2003271215
申请日：2003-10-17
申请人： BIOLEADERS CORP
发明人： KIM CHUL-JOONG , PARK SUE-NIE , PYO HYUN-MI , SUNG MOON-HEE , POO HA-RYOUNG , LEE JONG-SOO , JUNG CHANG-MIN , HONG SEUNG-PYO
IPC分类号： C12N15/86 , A61K31/00 , A61K39/00 , A61K39/02 , A61K39/12 , C07K14/02 , C07K14/025 , C12N1/21 , C12N15/63 , C12N15/74
摘要： Expression vectors that can efficiently produce virion capsid protein, tumor-associated protein of human papillomavirus on a microbial surface. Bacterial strains harboring such surface display vectors, and the use of the bacterial strains or their extracts or purified products as complex vaccines, are also described. The surface display vectors contain one or more than two genes selected from among pgsB, pgsC and pgsA, encoding a poly-χ-glutamic acid synthetase complex (pgsBCA) of a Bacillus sp. strain, and genes that encode virion capsid proteins, tumor-associated proteins of human papillomavirus. Methods for preparing the foregoing vectors, vaccines and transformed microorganisms are also described.

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