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1. 发明申请

WO2013163630A1 MODIFIED ANTIBODY REGIONS AND USES THEREOF 审中-公开
标题翻译：改良抗体区及其用途
公开(公告)号：WO2013163630A1
公开(公告)日：2013-10-31
申请号：PCT/US2013/038538
申请日：2013-04-26
申请人： BIOATLA LLC. , FREY, Gerhard , SHORT, Jay, M. , CHANG, Hwai, Wen
发明人： FREY, Gerhard , SHORT, Jay, M. , CHANG, Hwai, Wen
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K16/00 , A61K2039/505 , C07K2317/52 , C07K2317/94
摘要： The present invention relates to modified Fc regions of antibodies, and uses thereof, such as in antibodies that contain an Fc region of the present invention.
摘要翻译：本发明涉及抗体的修饰的Fc区及其用途，例如含有本发明的Fc区的抗体。

2. 发明申请

WO2010104821A1 MIRAC PROTEINS 审中-公开
标题翻译： MIRAC蛋白
公开(公告)号：WO2010104821A1
公开(公告)日：2010-09-16
申请号：PCT/US2010/026611
申请日：2010-03-09
申请人： BIOATLA, LLC , SHORT, Jay, M. , CHANG, Hwai, Wen , FREY, Gerhard
发明人： SHORT, Jay, M. , CHANG, Hwai, Wen , FREY, Gerhard
IPC分类号： C12Q1/68 , C12P21/00 , C07K14/00 , A61K38/17
CPC分类号： C12N15/102 , A61K38/00 , C07K7/06 , C07K14/3153 , C07K14/47 , C07K14/575 , C07K14/57545 , C07K14/57563 , C12N9/16 , C12N9/50 , C12N9/6435 , C12N9/6459 , C12N9/6462 , C12N15/1058 , C12Y302/01035 , C12Y304/21007 , C12Y304/21069 , C12Y304/21073 , C12Y304/23015 , C12Y304/24029 , G01N33/54306 , G01N33/573 , G01N33/6845 , G01N33/6854 , Y02A50/473
摘要： This disclosure relates to a method of generating conditionally active biologic proteins from wild type proteins, in particular therapeutic proteins, which are reversibly or irreversibly inactivated at the wild type normal physiological conditions. For example, evolved proteins are virtually inactive at body temperature, but are active at lower temperatures.
摘要翻译：本公开涉及从野生型正常生理条件下可逆地或不可逆地灭活的野生型蛋白质，特别是治疗性蛋白质产生条件活性生物蛋白质的方法。例如，进化蛋白质在体温实际上是无活性的，但在较低温度下是活性的。

3. 发明申请

WO2019241216A1 MULTI-SPECIFIC ANTIBODY CONSTRUCTS 审中-公开
公开(公告)号：WO2019241216A1
公开(公告)日：2019-12-19
申请号：PCT/US2019/036503
申请日：2019-06-11
申请人： BIOATLA, LLC
发明人： SHORT, Jay, M. , FREY, Gerhard , CHANG, Hwai, Wen
IPC分类号： C07K16/28 , C07K16/30 , C07K16/32 , C07K16/46 , A61P35/00
摘要： A multi-specific antibody contains at least one binding site for a cell specific antigen and at least one binding site for a tumor-reactive lymphocyte antigen and a multi-specific antibody including an IgG antibody or fragment thereof that binds to a first antigen; and at least one scFv antibody that binds to a second antigen that is different from the first antigen and is linked to a C terminus of at least one light chain or heavy chain of said IgG antibody or fragment. The multi-specific antibody reversibly binds to at least one of the cell specific antigen and tumor-reactive lymphocyte antigen or the first antigen and the second antigen with a greater affinity at an aberrant condition than at a normal physiological condition. Conjugates of the multi-specific antibodies and methods for generating the multi-specific antibody are also provided.

4. 发明申请

WO2011109726A3 HOMOLOGOUS MULTI-SPECIFIC ANTIBODIES 审中-公开
公开(公告)号：WO2011109726A3
公开(公告)日：2011-09-09
申请号：PCT/US2011/027222
申请日：2011-03-04
申请人： BIOATLA LLC , SHORT, Jay, M. , CHANG, Hwai, Wen , FREY, Gerhard
发明人： SHORT, Jay, M. , CHANG, Hwai, Wen , FREY, Gerhard
IPC分类号： G01N33/53 , C07K16/18 , C40B40/10 , C40B30/04
摘要： The present invention is relevant to the generation and optimization of homologous multi-specific antibodies, antibodies that are distinguished by their ability to bind to multiple antigens with high specificity and with high affinity. The invention is also relevant to other multi-specific proteins that bind more than one target.

5. 发明申请

WO2017197234A1 ANTI-ROR2 ANTIBODIES, ANTIBODY FRAGMENTS, THEIR IMMUNOCONJUGATES AND USES THEREOF 审中-公开
标题翻译：抗ROR2抗体，抗体片段，免疫复合物及其用途
公开(公告)号：WO2017197234A1
公开(公告)日：2017-11-16
申请号：PCT/US2017/032357
申请日：2017-05-12
申请人： BIOATLA, LLC
发明人： SHORT, Jay, M. , CHANG, Hwai, Wen , FREY, Gerhard
IPC分类号： C07K16/28 , A61K47/50 , G01N33/574
摘要： A polypeptide having a heavy chain variable region and/or light chain variable region that specifically binds to Ror2 protein as well as antibodies and antibody fragments containing the heavy chain variable region and/or the light chain variable region that bind to Ror2 protein. Pharmaceutical compositions and kits comprising the polypeptide or antibodies and antibody fragments containing the polypeptide are also provided
摘要翻译：具有特异性结合Ror2蛋白的重链可变区和/或轻链可变区的多肽以及含有重链可变区和/或轻链可变区的抗体和抗体片段与Ror2蛋白结合。还提供了包含所述多肽或包含所述多肽的抗体和抗体片段的药物组合物和试剂盒

6. 发明申请

WO2017100670A1 HUMANIZED ANTI-CD73 ANTIBODIES 审中-公开
标题翻译：人源化抗CD73抗体
公开(公告)号：WO2017100670A1
公开(公告)日：2017-06-15
申请号：PCT/US2016/065968
申请日：2016-12-09
申请人： CORVUS PHARMACEUTICALS, INC. , BIOATLA, LLC
发明人： GRIFFIN, Emily, Piccione , MILLER, Richard, A. , FREY, Gerhard, Johann , CHANG, Hwai, Wen
IPC分类号： G01N33/574 , C07K16/28 , C07K16/40
CPC分类号： G01N33/84 , C07K16/2896 , C07K2317/24 , C07K2317/52 , C07K2317/71 , C07K2317/76 , C07K2317/92 , G01N33/573 , G01N2333/916
摘要： Provided herein are, inter alia , humanized 1E9 antibodies capable of binding CD73. The humanized antibodies are useful for the treatment of cancer. Further provided are nucleic acids encoding humanized 1E9 antibodies and methods of inhibiting cell proliferation using the humanized antibodies provided herein.
摘要翻译：本文提供了能够结合CD73的人源化1E9抗体，尤其是其中的。人源化抗体可用于治疗癌症。还提供了编码人源化1E9抗体的核酸和使用本文提供的人源化抗体抑制细胞增殖的方法。

7. 发明申请

WO2018044619A1 CONDITIONALLY ACTIVE POLYPEPTIDES AND METHODS OF GENERATING THEM 审中-公开
标题翻译：有活性的多肽及其产生方法
公开(公告)号：WO2018044619A1
公开(公告)日：2018-03-08
申请号：PCT/US2017/047950
申请日：2017-08-22
申请人： BIOATLA, LLC
发明人： SHORT, Jay, M. , CHANG, Hwai, Wen , FREY, Gerhard
IPC分类号： C07K16/18 , C07K16/28 , G01N33/574 , A61K39/00
摘要： A method of preparing a conditionally active polypeptide from a parent polypeptide, comprising steps of evolving a DNA encoding the parent polypeptide by increasing a net charge of the parent polypeptide using one or more techniques selected from increasing a total number of codons of charged amino acid residues in the DNA and decreasing a total number of codons of uncharged amino acid residues in the DNA to create mutant DNAs; expressing the mutant DNAs to obtain mutant polypeptides; and selecting the conditionally active polypeptide from the mutant polypeptides which exhibits a decrease in activity in a first assay at a first value of a condition compared to the same activity in a second assay at a second value of the same condition. The conditionally active polypeptide, pharmaceutical compositions containing same, nanoparticle and drug conjugates thereof and uses thereof are also provided.
摘要翻译：从亲本多肽制备条件活性多肽的方法，包括以下步骤：通过使用选自以下的一种或多种技术增加亲本多肽的净电荷来演化编码亲本多肽的DNA：增加总数 DNA中带电荷氨基酸残基密码子的数目并减少DNA中不带电荷氨基酸残基的密码子总数以产生突变DNA; 表达突变DNA以获得突变多肽; 并从突变多肽中选择条件性活性多肽，所述多肽在第一测定中在第一测定值条件下表现出活性降低，与第二测定中相同条件下第二测定值下的相同活性相比。还提供了有条件活性的多肽，含有其的药物组合物，纳米颗粒和其药物缀合物及其用途。

8. 发明申请

WO2013170168A1 MULTI-SPECIFIC MONOCLONAL ANTIBODIES 审中-公开
标题翻译：多特异性单克隆抗体
公开(公告)号：WO2013170168A1
公开(公告)日：2013-11-14
申请号：PCT/US2013/040575
申请日：2013-05-10
申请人： BIOATLA LLC , FREY, Gernard , CHANG, Hwai, Wen , SHORT, Jay, M.
发明人： FREY, Gernard , CHANG, Hwai, Wen , SHORT, Jay, M.
IPC分类号： C07K16/46 , C07K16/18 , G01N33/53 , C12N15/13
CPC分类号： C07K16/468 , A01K2267/03 , C07K16/005 , C07K2317/14 , C07K2317/21 , C07K2317/31 , C07K2317/92 , C07K2317/94 , C12N15/1034 , G01N33/6854
摘要： The present invention is relevant to the generation of multi-specific antibodies, antibodies that are distinguished by their ability to bind to multiple antigens with specificity and with affinity. In particular, the present invention is related to bi-specific antibodies.
摘要翻译：本发明与多特异性抗体的产生相关，抗体的特异性是通过其特异性和亲和性与多种抗原结合的能力来区分。特别地，本发明涉及双特异性抗体。

9. 发明公开

EP3455261A1 ANTI-ROR2 ANTIBODIES, ANTIBODY FRAGMENTS, THEIR IMMUNOCONJUGATES AND USES THEREOF 有权转让
公开(公告)号：EP3455261A1
公开(公告)日：2019-03-20
申请号：EP17796915.1
申请日：2017-05-12
申请人： Bioatla, LLC
发明人： SHORT, Jay, M. , CHANG, Hwai, Wen , FREY, Gerhard
IPC分类号： C07K16/28 , A61K47/50 , G01N33/574

10. 发明公开

EP2841458A1 MODIFIED ANTIBODY REGIONS AND USES THEREOF 审中-公开
标题翻译：修饰抗体区及其用途
公开(公告)号：EP2841458A1
公开(公告)日：2015-03-04
申请号：EP13781110.5
申请日：2013-04-26
申请人： BioAtla LLC
发明人： FREY, Gerhard , SHORT, Jay, M. , CHANG, Hwai, Wen
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K16/00 , A61K2039/505 , C07K2317/52 , C07K2317/94
摘要： The present invention relates to modified Fc regions of antibodies, and uses thereof, such as in antibodies that contain an Fc region of the present invention.

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