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    • 4. 发明授权
    • Process of preparing N-substituted aldobionamides
    • 制备N-取代的醛二酰胺的方法
    • US5336765A
    • 1994-08-09
    • US23529
    • 1993-02-26
    • Van AuBijan Harirchian
    • Van AuBijan Harirchian
    • C07C235/06C07H15/04C07H15/00
    • C07H15/04C07C235/06Y02P20/582
    • A process of preparing aldobionamides and N-substituted aldobionamides which includes the steps of recovering a by-product of the process (an ammonium salt of an aldobionic acid) and converting it into at least one starting material. Aldobiono-1,5-lactone is reacted with a primary or secondary amine and the resulting solution containing the by-product of the reaction is passed through an anionic exchange column to obtain the eluate containing the starting amine and some aldobionamide. The eluate may be recycled as part of the starting material mixture. Alternatively, the amine and the aldobionamide may be recovered from the eluate, and the amine alone may be recycled. Aldobionate anion is retained on the column and may be converted into the salt of an aldobionic acid and then into the aldobionic acid.
    • 制备醛二酰胺和N-取代的醛二酰胺的方法,其包括回收方法的副产物(醛糖酸的铵盐)并将其转化为至少一种起始原料的步骤。 将醛缩二酮-1,5-内酯与伯胺或仲胺反应,并将所得含有反应副产物的溶液通过阴离子交换柱,得到含有起始胺和一些醛二酰胺的洗脱液。 洗脱液可作为原料混合物的一部分再循环。 或者,胺和醛二酰胺可以从洗脱液中回收,单独的胺可以被再循环。 醛缩醇阴离子保留在柱上,可以转化成醛糖酸的盐,然后转化成醛糖酸。
    • 6. 发明授权
    • Process of preparing N-substituted aldonamides
    • 制备N-取代的异黄酮类药物的方法
    • US5296588A
    • 1994-03-22
    • US958402
    • 1992-10-08
    • Van AuBijan Harirchian
    • Van AuBijan Harirchian
    • C07C235/06C07H15/04C07G3/00
    • C07H15/04C07C235/06Y02P20/582
    • A process of preparing aldonamides and N-substituted aldonamides which includes the steps of recovering a by-product of the process (an ammonium salt of an aldonic acid) and converting it into at least one starting material. Aldonolactone is reacted with a primary or secondary amine and the resulting solution containing the by-product of the reaction is treated with a solid base to obtain a solid aldonate salt and a second solution containing the starting amine and some aldonamide. The second solution may be recycled as part of the starting material mixture. Alternatively, the amine and the aldonamide may be recovered from the second solution, and the amine alone may be recycled. The solid salt of aldonic acid may be converted into aldonic acid, which in turn may be converted into aldonolactone. The obtained aldono-1,5-lactone may also be utilized as a starting ingredient in the synthesis according to the present invention.
    • 一种制备异黄酮类和N-取代的异黄酮酰胺的方法,包括回收方法的副产物(醛糖酸的铵盐)并将其转化成至少一种起始原料的步骤。 将醛缩酮与伯胺或仲胺反应,并将所得含有反应副产物的溶液用固体碱处理,得到固体醛糖醛酸盐和含有起始胺和一些醛固酮的第二溶液。 第二溶液可以作为原料混合物的一部分再循环。 或者,可以从第二溶液中回收胺和异黄酮酰胺,并且单独的胺可以被再循环。 醛糖酸的固体盐可以转化成醛糖酸,其又可以转化成醛糖内酯。 所得醛醛-1,5-内酯也可用作本发明合成中的起始成分。