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1. 发明申请

US20050085413A1 Dimeric pharmaceutical compounds and their use 审中-公开
标题翻译：二聚药物化合物及其用途
公开(公告)号：US20050085413A1
公开(公告)日：2005-04-21
申请号：US10494942
申请日：2002-11-08
申请人： Betty Jin , John Lambert , Roland Nearn , Van Nguyen , Simon Tucker , Wen-Yang Wu
发明人： Betty Jin , John Lambert , Roland Nearn , Van Nguyen , Simon Tucker , Wen-Yang Wu
IPC分类号： A61K47/48 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/16 , C07D215/56 , C07D309/28 , C07H15/232 , C07H15/234 , C07H15/236 , C07H17/08 , A61K31/704 , A61K38/14 , C07H15/22 , C07K9/00
CPC分类号： C07H15/232 , A61K47/54 , A61K47/55 , C07D215/56 , C07D309/28 , C07H15/234
摘要： The invention relates to a compound of general formula (I): X-L-Y (I) in which X and Y are pharmaceutically active moieties which may be the same or different; and L is a linker which is an optionally substituted saturated or unsaturated straight chain, branched and/or cyclic hydrocarbon radical having a backbone of at least 11 atoms, or a pharmaceutically acceptable derivative or salt thereof, methods for their preparation, pharmaceutical formulations containing them or their use in the prevention or treatment of a microbial infection.
摘要翻译：本发明涉及通式（I）的化合物：<？in-line-formula description =“In-line formula”end =“lead”？> XLY（I）<？in-line-formula description =“In 其中X和Y是可以相同或不同的药学活性部分; 并且L是具有至少11个原子骨架的任选取代的饱和或不饱和的直链，支链和/或环状烃基或其药学上可接受的衍生物或盐的接头，其制备方法，含有它们的药物制剂或其用于预防或治疗微生物感染的用途。

2. 发明申请

US20070225358A1 DIMERIC COMPOUNDS AND THIER USE AS ANTI-VIRAL AGENTS 失效
标题翻译：二元化合物，并被用作反病毒剂
公开(公告)号：US20070225358A1
公开(公告)日：2007-09-27
申请号：US11734394
申请日：2007-04-12
申请人： Betty JIN , Simon MacDonald , Darryl McConnell , Van Nguyen , Stephen Shanahan , Wen-Yang Wu
发明人： Betty JIN , Simon MacDonald , Darryl McConnell , Van Nguyen , Stephen Shanahan , Wen-Yang Wu
IPC分类号： A61K31/35
CPC分类号： A61K31/351 , A61K31/13 , A61K31/7056 , A61K38/00 , A61K45/06 , A61K47/54 , A61K47/55 , C07D309/28 , C07K5/06104 , A61K2300/00
摘要： The invention relates to compounds of general formula (I); in which R is an amino or guanidino group; R2 is acetyl or trifluoroacetyl; X is CONH, NHCO or O; n is an integer from 2 to 6; and Y is C2-C9 alkyl C3-8 cycloalkyl, C1-C4 alkoxyalkyl, an amino acid or dipeptide, or a pharmaceutically acceptable derivative thereof, methods for their preparation, pharmaceutical formulations containing them or their use in the prevention or treatment of a viral infection.
摘要翻译：本发明涉及通式（I）的化合物; 其中R是氨基或胍基; R 2是乙酰基或三氟乙酰基; X是CONH，NHCO或O; n为2-6的整数; 且Y为C 2 -C 9烷基C 3-8环烷基，C 1 -C 3烷基， 4烷氧基烷基，氨基酸或二肽或其药学上可接受的衍生物，其制备方法，含有它们的药物制剂或其在预防或治疗病毒感染中的用途。

3. 发明申请

US20050038108A1 Dimeric compounds and their use as anti-viral agents 有权
标题翻译：二聚体化合物及其作为抗病毒剂的用途
公开(公告)号：US20050038108A1
公开(公告)日：2005-02-17
申请号：US10494243
申请日：2002-11-08
申请人： Michael Dowle , Betty Jin , Simon Macdonald , Andrew McM Mason , Darryl Mcconnell , Van Nguyen , Stepehn Shanahan , Wen-Yang Wu
发明人： Michael Dowle , Betty Jin , Simon Macdonald , Andrew McM Mason , Darryl Mcconnell , Van Nguyen , Stepehn Shanahan , Wen-Yang Wu
IPC分类号： A61K9/12 , A61K9/14 , A61K31/13 , A61K31/351 , A61K31/7052 , A61K45/00 , A61P31/04 , A61P31/12 , A61P31/16 , A61P43/00 , C07D309/28 , A61K31/34 , C07D45/02
CPC分类号： C07D309/28
摘要： The invention relates to compounds of general formula (I); in which R is an amino or guanidino group; R2 is acetyl or trifluoroacetyl; X is CONH, SO2NH, NHCO or NHCONH; m is either 0 or 1; n is an integer from 2 to 6; q is an integer from 0 to 3; and Y is hydrogen or an aromatic substituent, or a pharmaceutically acceptable derivative thereof; methods for their preparation, pharmaceutical formulations containing them or their use in the prevention or treatment of a viral infection.
摘要翻译：本发明涉及通式（I）的化合物; 其中R是氨基或胍基; R 2是乙酰基或三氟乙酰基; X是CONH，SO2NH，NHCO或NHCONH; m为0或1; n为2-6的整数; q是0至3的整数; Y为氢或芳香族取代基，或其药学上可接受的衍生物; 其制备方法，含有它们的药物制剂或其在预防或治疗病毒感染中的用途。

4. 发明申请

US20070293564A1 Dimeric compounds and their use as anti-viral agents 审中-公开
标题翻译：二聚体化合物及其作为抗病毒剂的用途
公开(公告)号：US20070293564A1
公开(公告)日：2007-12-20
申请号：US11607872
申请日：2006-12-04
申请人： Michael Dowle , Betty Jin , Simon MacDonald , Andrew Mason , Darryl McConnell , Van Nguyen , Stephen Shanahan , Wen-Yang Wu
发明人： Michael Dowle , Betty Jin , Simon MacDonald , Andrew Mason , Darryl McConnell , Van Nguyen , Stephen Shanahan , Wen-Yang Wu
IPC分类号： A61K31/35
CPC分类号： C07D309/28
摘要： A method for the prevention of an orthomyxovirus or paramyxovirus infection comprising the step of administration to a subject in need thereof of an effective amount of a compound of formula (I)
摘要翻译：一种用于预防正粘病毒或副粘病毒感染的方法，包括向有需要的受试者施用有效量的式（I）化合物的步骤，

5. 发明申请

US20050054719A1 Dimeric compounds and their use as anti-viral agents 失效
标题翻译：二聚体化合物及其作为抗病毒剂的用途
公开(公告)号：US20050054719A1
公开(公告)日：2005-03-10
申请号：US10494260
申请日：2002-11-08
申请人： Betty Jin , Simon MacDonald , Darryl McConnell , Van Nguyen , Stephen Shanahan , Wen-Yang Wu
发明人： Betty Jin , Simon MacDonald , Darryl McConnell , Van Nguyen , Stephen Shanahan , Wen-Yang Wu
IPC分类号： A61K31/13 , A61K31/351 , A61K31/7052 , A61K31/7056 , A61K38/00 , A61K45/06 , A61K47/48 , A61P11/00 , A61P31/04 , A61P31/12 , A61P31/16 , C07D309/28 , C07K5/072 , C07D45/02 , A61K31/35
CPC分类号： A61K31/351 , A61K31/13 , A61K31/7056 , A61K38/00 , A61K45/06 , A61K47/54 , A61K47/55 , C07D309/28 , C07K5/06104 , A61K2300/00
摘要： The invention relates to compounds of general formula (1); in which R is an amino or guanidino group; R2 is acetyl or trifluoroacetyl; X is CONH, NHCO or O; n is an integer from 2 to 6; and Y is C2-C8 alkyl C3-8 cycloalkyl, C1-C4 alkoxyalkyl, an amino acid or dipeptide, or a pharmaceutically acceptable derivative thereof, methods for their preparation, pharmaceutical formulations containing them or their use in the prevention or treatment of a viral infection.
摘要翻译：本发明涉及通式（1）的化合物; 其中R是氨基或胍基; R 2是乙酰基或三氟乙酰基; X为CONH，NHCO或O; n为2-6的整数; 并且Y是C 2 -C 8烷基C 3-8环烷基，C 1 -C 4烷氧基烷基，氨基酸或二肽或其药学上可接受的衍生物，其制备方法，含有它们的药物制剂或其用于预防或治疗病毒感染。

6. 发明授权

US08927565B2 Compositions for veterinary and medical applications 有权
标题翻译：兽医和医疗应用的组成
公开(公告)号：US08927565B2
公开(公告)日：2015-01-06
申请号：US10570509
申请日：2004-08-26
申请人： Betty Jin , Wen-Yang Wu
发明人： Betty Jin , Wen-Yang Wu
IPC分类号： A61K31/4745 , A61K31/717 , A23K1/16 , A23K1/17 , A23K1/18 , A23L1/30 , A61K31/47 , A61K31/718 , A61K31/78
CPC分类号： A61K31/717 , A23K20/132 , A23K20/195 , A23K50/30 , A23K50/75 , A23L33/105 , A61K31/47 , A61K31/718 , A61K31/78 , A61K2300/00
摘要： Compositions including polymeric dialdehydes and compounds of where R1, R2, R7, R8, R9, and R10 may be the same or different and are selected from H, CH3, OH, OCH3, C2H5, OC2H5OCH2Ph, OCH2PhNO2, F or Cl; R3, R4, R5, R6 may be the same or different and are selected from H, CH3, OCH3, C2H5, OC2H5OCH2Ph, OCH2PhNO2, F or Cl, or R5 and R6 are the same or different and are selected from H, CH3, OCH3, C2H5, OC2H5OCH2Ph, OCH2PhNO2, F or Cl and R3 and R4 together are ═O, or R4 and R6 are the same or different and are selected from H, CH3, OCH3, C2H5, OC2H5OCH2Ph, OCH2PhNO2, F or Cl and R3 and R5 together form a double bond or are ═O, or R3 and R4, are the same or different and are selected from H, CH3, OCH3, C2H5, OC2H5OCH2Ph, OCH2PhNO2, F or Cl and R5 and R6 together are ═O; R11 and R12 together form ═CH2, or R11 and R12 may be the same or different and are independently selected from the group consisting of H, CH3, CH2CH3 and CH2CH2CH3; and X is selected from the group consisting of Cl, Br, SO4, I and R13COO, where R13 is CH3 or poly acids, for the treatment of gastrointestinal functional disorders or related conditions as well as for the promotion of general health and weight gain in animals including humans.
摘要翻译：包括聚合二醛和其中R 1，R 2，R 7，R 8，R 9和R 10可以相同或不同并且选自H，CH 3，OH，OCH 3，C 2 H 5，OC 2 H 5 OCH 2 Ph，OCH 2 PhNO 2，F或Cl的化合物的组合物; R 3，R 4，R 5，R 6可以相同或不同，选自H，CH 3，OCH 3，C 2 H 5，OC 2 H 5 OCH 2 Ph，OCH 2 PhNO 2，F或Cl，或R 5和R 6相同或不同，选自H， OCH 3，C 2 H 5，OC 2 H 5 OCH 2 Ph，OCH 2 PhNO 2，F或Cl和R 3和R 4一起为=或者R 4和R 6相同或不同，并且选自H，CH 3，OCH 3，C 2 H 5，OC 2 H 5 OCH 2 Ph，OCH 2 PhNO 2，F或Cl和R 3 并且R 5和R 5一起形成双键，或者是=或者R 3和R 4相同或不同，并且选自H，CH 3，OCH 3，C 2 H 5，OC 2 H 5 OCH 2 Ph，OCH 2 PhNO 2，F或Cl和R 5和R 6一起是= R 11和R 12一起形成= CH 2，或者R 11和R 12可以相同或不同，并且独立地选自H，CH 3，CH 2 CH 3和CH 2 CH 2 CH 3; X选自Cl，Br，SO 4，I和R 13 COO，其中R 13为CH 3或多酸，用于治疗胃肠功能障碍或相关病症，以及促进一般健康和体重增加动物包括人类。

7. 发明授权

US5639786A Antiviral 4-substituted-2-deoxy-2,3-didehydro-derivatives of .alpha.-D-neuraninic acid 失效
标题翻译： α-D-神经氨酸的抗病毒4-取代-2-脱氧-2,3-二脱氢衍生物
公开(公告)号：US5639786A
公开(公告)日：1997-06-17
申请号：US267309
申请日：1994-06-29
申请人： Laurence Mark Von Itzstein , Wen-Yang Wu , Tho Van Phan , Basil Danylec , Betty Jin
发明人： Laurence Mark Von Itzstein , Wen-Yang Wu , Tho Van Phan , Basil Danylec , Betty Jin
IPC分类号： C07D309/28 , A61K31/35
CPC分类号： C07D309/28
摘要： N-Acetylneuraminic and derivatives of formula (I) ##STR1## pharmaceutical formulations thereof, their use in medicine, in particular as antiviral agents and methods for their preparation are described.
摘要翻译：描述了N-乙酰神经氨酸和式（I）的衍生物，其描述了它们在药物中的用途，特别是抗病毒剂及其制备方法。

8. 发明授权

US07468388B2 Dimeric compounds and their use as anti-viral agents 失效
标题翻译：二聚体化合物及其作为抗病毒剂的用途
公开(公告)号：US07468388B2
公开(公告)日：2008-12-23
申请号：US11734394
申请日：2007-04-12
申请人： Betty Jin , Simon J. F. MacDonald , Darryl McConnell , Van T. T. Nguyen , Stephen E. Shanahan , Wen-Yang Wu
发明人： Betty Jin , Simon J. F. MacDonald , Darryl McConnell , Van T. T. Nguyen , Stephen E. Shanahan , Wen-Yang Wu
IPC分类号： A61K31/351
CPC分类号： A61K31/351 , A61K31/13 , A61K31/7056 , A61K38/00 , A61K45/06 , A61K47/54 , A61K47/55 , C07D309/28 , C07K5/06104 , A61K2300/00
摘要： The invention relates to compounds of general formula (I); in which R is an amino or guanidino group; R2 is acetyl or trifluoroacetyl; X is CONH, NHCO or O; n is an integer from 2 to 6; and Y is C2-C9 alkyl C3-8 cycloalkyl, C1-C4 alkoxyalkyl, an amino acid or dipeptide, or a pharmaceutically acceptable derivative thereof, methods for their preparation, pharmaceutical formulations containing them or their use in the prevention or treatment of a viral infection.
摘要翻译：本发明涉及通式（I）的化合物; 其中R是氨基或胍基; R2是乙酰基或三氟乙酰基; X是CONH，NHCO或O; n为2-6的整数; 并且Y是C 2 -C 9烷基C 3-8环烷基，C 1 -C 4烷氧基烷基，氨基酸或二肽或其药学上可接受的衍生物，其制备方法，含有它们的药物制剂或其用于预防或治疗病毒感染。

9. 发明申请

US20070027176A1 Compositions for veterinary and medical applications 有权
公开(公告)号：US20070027176A1
公开(公告)日：2007-02-01
申请号：US10570509
申请日：2004-08-26
申请人： Betty Jin , Wen-Yang Wu
发明人： Betty Jin , Wen-Yang Wu
IPC分类号： A61K31/4745
CPC分类号： A61K31/717 , A23K20/132 , A23K20/195 , A23K50/30 , A23K50/75 , A23L33/105 , A61K31/47 , A61K31/718 , A61K31/78 , A61K2300/00
摘要： This invention is related to compositions including compounds of where R1, R2, R7, R8, R9, and R10 may be the same or different and are selected from H, CH3, OH, OCH3, C2H5, OC2H5OCH2Ph, OCH2PhNO2, F or Cl; R3, R4, R5, R6 may be the same or different and are selected from H, CH3, OCH3, C2H5, OC2H5OCH2Ph, OCH2PhNO2, F or Cl, or R5 and R6 are the same or different and are selected from H, CH3, OCH3, C2H5, OC2H5OCH2Ph, OCH2PhNO2, F or Cl and R3 and R4 together are ═O, or R4 and R6 are the same or different and are selected from H, CH3, OCH3, C2H5, OC2H5OCH2Ph, OCH2PhNO2, F or Cl and R3 and R5 together form a double bond or are ═O, or R3 and R4, are the same or different and are selected from H, CH3, OCH3, C2H5, OC2H5OCH2Ph, OCH2PhNO2, F or Cl and R5 and R6 together are ═O; R11 and R12 together form ═CH2, or R11 and R12 may be the same or different and are independently selected from the group consisting of H, CH3, CH2CH3 and CH2CH2CH3; and X is selected from the group consisting of Cl, Br, SO4, I and R13COO, where R13 is CH3 or poly acids, and/or compounds of Formula (2) wherein each of the monomers Rp and Rr, are independently selected from the group consisting of: and each monomer Rq is independently selected from the group consisting of: wherein each R14 may be the same or different and is independently selected from the group consisting of CH2OH, COOH, CH2OCH2COOH and CH2OR15, where R15 is selected from the group consisting of CH2C6H4COOH, C6H4COOH and CH2(CH2)yCOOH where y=1 to 20; wherein p1 - - - pn may be the same or different and are each independently selected from the range 0 to n; q1 - - - qn may be the same or different and are each independently selected from the range 1 to m; r1 - - - rn may be the same or different and are each independently selected from the range of 0 to n, n is an integer greater than 0 and m is an integer greater than 1; and wherein ⁢ q 1 + ⋯ + q n p 1 + ⋯ + p n + q 1 + ⋯ + q n + r 1 + ⋯ + r n ⨯ 100 ⁢ % ≥ 30 ⁢ % for the treatment of gastrointestinal functional disorders or related conditions; as well as for the promotion of general health and weight gain in animals including humans.

10. 发明授权

US06548476B1 Dimeric inhibitors of influenza neuraminidase 有权
标题翻译：流感神经氨酸酶二聚体抑制剂
公开(公告)号：US06548476B1
公开(公告)日：2003-04-15
申请号：US09658445
申请日：2000-09-08
申请人： Wen-Yang Wu , Betty Jin
发明人： Wen-Yang Wu , Betty Jin
IPC分类号： A61K3116
CPC分类号： C07D309/28 , A61K31/00 , A61K31/351 , A61K47/54 , A61K47/55 , A61K47/59 , A61K47/595 , A61K47/60
摘要： This invention relates to novel dimeric compounds, methods for their preparation, pharmaceutical formulations thereof, and their use as antiviral agents. The compounds are particularly useful against influenza virus. In particular the invention provides a dimeric compound which comprises two neuraminidase binding groups attached to a spacer or linking group. Preferably the dimeric molecule comprises two neuraminidase-binding neuraminic acid (sialic acid) or cyclopentyl or cyclohexenyl carboxylic acid derivatives covalently attached to a common spacer group. Pharmaceutical compositions and methods of treatment, prophylaxis and diagnosis are disclosed and claimed.
摘要翻译：本发明涉及新的二聚化合物，其制备方法，其药物制剂及其作为抗病毒剂的用途。该化合物特别适用于流感病毒。特别地，本发明提供了一种二聚化合物，其包含连接到间隔基或连接基团的两个神经氨酸酶结合基团。优选地，二聚体分子包含共价连接到共同间隔基团上的两种神经氨酸酶结合神经氨酸（唾液酸）或环戊基或环己烯基羧酸衍生物。公开和要求保护药物组合物和治疗，预防和诊断方法。

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