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1. 发明申请

US20080176870A1 Heterobicyclic metalloprotease inhibitors 审中-公开
标题翻译：异双环金属蛋白酶抑制剂
公开(公告)号：US20080176870A1
公开(公告)日：2008-07-24
申请号：US11986622
申请日：2007-11-20
申请人： Bert Nolte , Irving Sucholeiki , Tim Feuerstein , Brian M. Gallagher , Xinyuan Wu , Christoph Steeneck , Christian Gege , Hongbo Deng , Joshua Van Veldhuizen , Arthur Taveras
发明人： Bert Nolte , Irving Sucholeiki , Tim Feuerstein , Brian M. Gallagher , Xinyuan Wu , Christoph Steeneck , Christian Gege , Hongbo Deng , Joshua Van Veldhuizen , Arthur Taveras
IPC分类号： A61K31/495 , C07D487/04 , A61P19/02 , A61P29/00 , A61P9/10
CPC分类号： C07D487/04
摘要： The present invention relates generally to heterobicyclic containing pharmaceutical agents, and in particular, to heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic metalloprotease inhibiting compounds that exhibit an increased potency in relation to currently known metalloprotease inhibitors.
摘要翻译：本发明一般涉及含杂环的药物，特别是涉及杂双环金属蛋白酶抑制剂化合物。更具体地，本发明提供了一类新型的杂双环金属蛋白酶抑制化合物，其与当前已知的金属蛋白酶抑制剂相比表现出增加的效力。

2. 发明申请

US20080261968A1 Heterobicyclic metalloprotease inhibitors 失效
标题翻译：异双环金属蛋白酶抑制剂
公开(公告)号：US20080261968A1
公开(公告)日：2008-10-23
申请号：US11986626
申请日：2007-11-20
申请人： Christian Gege , Matthias Schneider , Carine Chevrier , Hongbo Deng , Irving Sucholeiki , Brian M. Gallagher , Michael Bosies , Christoph Steeneck , Xinyuan Wu , Matthias Hochgurtel , Bert Nolte , Arthur Taveras
发明人： Christian Gege , Matthias Schneider , Carine Chevrier , Hongbo Deng , Irving Sucholeiki , Brian M. Gallagher , Michael Bosies , Christoph Steeneck , Xinyuan Wu , Matthias Hochgurtel , Bert Nolte , Arthur Taveras
IPC分类号： A61K31/5375 , C07D239/72 , A61K31/517 , A61K31/52 , C07D413/02 , A61P19/02 , A61K31/519 , C07D473/00 , C07D495/04
CPC分类号： C07D495/04 , C07D239/88 , C07D401/12 , C07D413/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/14 , C07D495/22 , C07D498/04 , C07D513/04
摘要： The present invention relates generally to azabicyclic containing pharmaceutical agents, and in particular, to azabicyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of azabicyclic MMP-3, MMP-8 and/or MMP-13 inhibiting compounds, which exhibit an increased potency and selectivity in relation to currently known MMP-13, MMP-8 and MMP-3 inhibitors.
摘要翻译：本发明一般涉及含有氮杂双环的药物，特别涉及氮杂双环金属蛋白酶抑制化合物。更具体地说，本发明提供了一类新的氮杂双环MMP-3，MMP-8和/或MMP-13抑制化合物，其相对于目前已知的MMP-13，MMP-8和MMP- 3抑制剂。

3. 发明申请

US20080207607A1 Heterotricyclic metalloprotease inhibitors 失效
标题翻译：异环金属蛋白酶抑制剂
公开(公告)号：US20080207607A1
公开(公告)日：2008-08-28
申请号：US11986603
申请日：2007-11-20
申请人： Christian Gege , Carine Chevrier , Matthias Schneider , Harald Bluhm , Matthias Hochgurtel , Hongbo Deng , Brian M. Gallagher , Irving Sucholeiki , Arthur Taveras
发明人： Christian Gege , Carine Chevrier , Matthias Schneider , Harald Bluhm , Matthias Hochgurtel , Hongbo Deng , Brian M. Gallagher , Irving Sucholeiki , Arthur Taveras
IPC分类号： A61K31/538 , C07D265/36 , C07D217/00 , A61K31/4725 , A61K31/541 , A61P29/00 , A61K31/519 , C07D239/00 , C07D417/14
CPC分类号： C07D495/04 , C07D239/88 , C07D401/12 , C07D413/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/14 , C07D495/22 , C07D498/04 , C07D513/04
摘要： The present invention relates generally to azatriocyclic containing pharmaceutical agents, and in particular, to azatricyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of azatricyclic MMP-3, MMP-8 and/or MMP-13 inhibiting compounds, that exhibit an increased potency and selectivity in relation to currently known MMP-13, MMP-8 and MMP-3 inhibitors.
摘要翻译：本发明一般涉及含有三氮杂环的药物，尤其涉及氮杂三环金属蛋白酶抑制化合物。更具体地说，本发明提供了一类新型的azatricyclic MMP-3，MMP-8和/或MMP-13抑制化合物，其与当前已知的MMP-13，MMP-8和MMP- 3抑制剂。

4. 发明申请

US20080221128A1 Metalloprotease inhibitors containing a squaramide moiety 审中-公开
标题翻译：含有方酰胺部分的金属蛋白酶抑制剂
公开(公告)号：US20080221128A1
公开(公告)日：2008-09-11
申请号：US12074925
申请日：2008-03-07
申请人： Christian Gege , Carine Chevrier , Brian M. Gallagher , Arthur Taveras
发明人： Christian Gege , Carine Chevrier , Brian M. Gallagher , Arthur Taveras
IPC分类号： A61K31/517 , C07D401/12 , A61P19/00 , A61P19/02 , A61K31/513
CPC分类号： C07D498/02 , C07D487/02 , C07D519/00
摘要： The present invention relates generally to pharmaceutical agents containing a heterocyclic moiety, and in particular, to heterocyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of heterocyclic MMP-3, MMP-8 and/or MMP-13 inhibiting compounds with a squaramide or benzoxazinone moiety, that exhibit an increased potency and selectivity in relation to currently known MMP-13, MMP-8 and MMP-3 inhibitors.
摘要翻译：本发明一般涉及含有杂环部分的药剂，尤其涉及杂环金属蛋白酶抑制化合物。更具体地说，本发明提供了一种新型杂环基MMP-3，MMP-8和/或MMP-13抑制化合物与方酸酰胺或苯并恶嗪酮部分，其显示出与当前已知的MMP-13相关的增加的效力和选择性， MMP-8和MMP-3抑制剂。

5. 发明申请

US20080221095A1 Metalloprotease inhibitors containing a heterocyclic moiety 审中-公开
标题翻译：含有杂环部分的金属蛋白酶抑制剂
公开(公告)号：US20080221095A1
公开(公告)日：2008-09-11
申请号：US12075070
申请日：2008-03-07
申请人： Christian Gege , Carine Chevrier , Brian M. Gallagher , Arthur Taveras
发明人： Christian Gege , Carine Chevrier , Brian M. Gallagher , Arthur Taveras
IPC分类号： A61K31/538 , C07D239/36 , A61K31/513 , A61P19/02 , C07D413/12
CPC分类号： C07D498/02 , C07D487/02 , C07D519/00
摘要： The present invention relates generally to pharmaceutical agents containing a heterocyclic moiety, and in particular, to heterocyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of heterocyclic MMP-3, MMP-8 and/or MMP-13 inhibiting compounds with a squaramide or benzoxazinone moiety, that exhibit an increased potency and selectivity in relation to currently known MMP-13, MMP-8 and MMP-3 inhibitors.
摘要翻译：本发明一般涉及含有杂环部分的药剂，尤其涉及杂环金属蛋白酶抑制化合物。更具体地说，本发明提供了一种新型杂环基MMP-3，MMP-8和/或MMP-13抑制化合物与方酸酰胺或苯并恶嗪酮部分，其显示出与当前已知的MMP-13相关的增加的效力和选择性， MMP-8和MMP-3抑制剂。

6. 发明授权

US08572975B2 Systems relating to turbine engine control and operation 有权
标题翻译：与涡轮发动机控制和运行相关的系统
公开(公告)号：US08572975B2
公开(公告)日：2013-11-05
申请号：US12480239
申请日：2009-06-08
申请人： Timothy R. Bilton , Dean M. Erickson , Brian M. Gallagher , Korey F. Rendo , John V. Hains
发明人： Timothy R. Bilton , Dean M. Erickson , Brian M. Gallagher , Korey F. Rendo , John V. Hains
IPC分类号： F02C7/08 , F02C7/22 , F02C7/224
CPC分类号： F02C7/224
摘要： A combustion turbine engine that includes: a compressor; a combustor that receives fuel from a fuel line; a turbine; a heat exchange portion comprising a portion of the fuel line in heat transfer relationship with a heat source for heating the fuel; a rapid heating value meter disposed to test the heating value of the fuel that is configured to provide heating value test results within approximately 1 minute; a cold leg bypass comprising a fuel line that bypasses the heat exchange portion, the cold leg bypass being connected to the fuel line at an upstream fork and at a fuel mixing junction; and valves for controlling the fuel being directed through the heat exchange portion and the fuel being direct through the cold leg bypass; wherein the length of fuel line between the fuel mixing junction and the combustor is less than 20 meters.
摘要翻译：一种燃气轮机，包括：压缩机; 从燃料管线接收燃料的燃烧器; 涡轮机热交换部分，其包括与用于加热燃料的热源的传热关系的燃料管线的一部分; 设置用于测试在大约1分钟内配置为提供热值测试结果的燃料的热值的快速发热值计; 冷腿旁路，其包括旁路热交换部的燃料管路，冷腿旁路在上游叉和燃料混合连接处连接到燃料管路; 以及用于控制燃料的阀通过热交换部分引导并且燃料直接通过冷腿旁路; 其中燃料混合连接点和燃烧器之间的燃料管线的长度小于20米。

7. 发明申请

US20100307158A1 SYSTEMS RELATING TO TURBINE ENGINE CONTROL AND OPERATION 有权
标题翻译：关于涡轮发动机控制和运行的系统
公开(公告)号：US20100307158A1
公开(公告)日：2010-12-09
申请号：US12480239
申请日：2009-06-08
申请人： Timothy R. Bilton , Dean M. Erickson , Brian M. Gallagher , Korey F. Rendo , John V. Hains
发明人： Timothy R. Bilton , Dean M. Erickson , Brian M. Gallagher , Korey F. Rendo , John V. Hains
IPC分类号： F02C7/08 , F02C9/00
CPC分类号： F02C7/224
摘要： A combustion turbine engine that includes: a compressor; a combustor that receives fuel from a fuel line; a turbine; a heat exchange portion comprising a portion of the fuel line in heat transfer relationship with a heat source for heating the fuel; a rapid heating value meter disposed to test the heating value of the fuel that is configured to provide heating value test results within approximately 1 minute; a cold leg bypass comprising a fuel line that bypasses the heat exchange portion, the cold leg bypass being connected to the fuel line at an upstream fork and at a fuel mixing junction; and valves for controlling the fuel being directed through the heat exchange portion and the fuel being direct through the cold leg bypass; wherein the length of fuel line between the fuel mixing junction and the combustor is less than 20 meters.
摘要翻译：一种燃气轮机，包括：压缩机; 从燃料管线接收燃料的燃烧器; 涡轮机热交换部分，其包括与用于加热燃料的热源的传热关系的燃料管线的一部分; 设置用于测试在大约1分钟内配置为提供热值测试结果的燃料的热值的快速发热值计; 冷腿旁路，其包括旁路热交换部的燃料管路，冷腿旁路在上游叉和燃料混合连接处连接到燃料管路; 以及用于控制燃料的阀通过热交换部分引导并且燃料直接通过冷腿旁路; 其中燃料混合连接点和燃烧器之间的燃料管线的长度小于20米。

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