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1. 发明授权

US07368469B2 Use of inhibitors of the renin-angiotensin system in the prevention of cardiovascular events 有权
标题翻译：使用肾素 - 血管紧张素系统抑制剂预防心血管事件
公开(公告)号：US07368469B2
公开(公告)日：2008-05-06
申请号：US11490061
申请日：2006-07-21
申请人： Bernward Schölkens , Norbert Bender , Badrudin Rangoonwala , Gilles Dagenais , Hertzel Gerstein , Salim Yusuf
发明人： Bernward Schölkens , Norbert Bender , Badrudin Rangoonwala , Gilles Dagenais , Hertzel Gerstein , Salim Yusuf
IPC分类号： A61K31/40 , A61K31/60 , A61K31/35
CPC分类号： A61K45/06 , A61K31/00 , A61K31/355 , A61K31/403 , A61K31/616 , A61K2300/00
摘要： Use of an inhibitor of the renin-angiotensin system or a pharmaceutically acceptable derivative thereof, optionally together with another antihypertensive, a cholesterol lowering agent, a diuretic or aspirin, in the manufacture of a medicament for the prevention of cardiovascular events; a method of preventing cardiovascular events comprising administering to a patient in need of such prevention an effective amount of an inhibitor of the renin angiotensin system or a pharmaceutically acceptable derivative thereof, optionally together with another antihypertensive, a cholesterol lowering agent, a diuretic or aspirin; and a combination product containing an an inhibitor of the renin-angiotensin system or a pharmaceutically acceptable derivative thereof and a cholesterol lowering agent.
摘要翻译：在制备用于预防心血管事件的药物中使用肾素 - 血管紧张素系统抑制剂或其药学上可接受的衍生物，任选地与另一种抗高血压剂，降胆固醇剂，利尿剂或阿司匹林一起使用; 一种预防心血管事件的方法，包括对需要这种预防的患者施用有效量的肾素 - 血管紧张素系统的抑制剂或其药学上可接受的衍生物，任选与另一种降压药，降胆固醇，利尿剂或阿司匹林 ; 以及含有肾素 - 血管紧张素系统抑制剂或其药学上可接受的衍生物和降胆固醇剂的组合产品。

2. 发明申请

US20110263619A1 PHARMACEUTICAL FORMULATIONS AND USE THEREOF IN THE PREVENTION OF STROKE, DIABETES AND/OR CONGESTIVE HEART FAILURE 审中-公开
标题翻译：药物制剂及其用于预防冲击，糖尿病和/或焦虑性心脏衰竭的药物制剂及其用途
公开(公告)号：US20110263619A1
公开(公告)日：2011-10-27
申请号：US12957777
申请日：2010-12-01
申请人： Bernward Schölkens , Norbert Bender , Badrudin Rangoonwala , Gilles Dagenais , Hertzel Gerstein , Anders Ljunggren , Salim Yusuf
发明人： Bernward Schölkens , Norbert Bender , Badrudin Rangoonwala , Gilles Dagenais , Hertzel Gerstein , Anders Ljunggren , Salim Yusuf
IPC分类号： A61K31/519 , A61K31/41 , A61P3/10 , A61P9/12 , A61P9/00 , A61K31/4178 , A61K31/4184
CPC分类号： A61K31/519 , A61K31/403 , A61K31/41 , A61K31/4178 , A61K31/4184
摘要： The present invention relates to use of an inhibitor of the renin-angiotensin system (RAS) or a pharmaceutically acceptable derivative thereof, such as ramipril or ramiprilat, in the prevention of stroke, diabetes and/or congestive heart failure (CHF).
摘要翻译：本发明涉及肾素 - 血管紧张素系统抑制剂（RAS）或其药学上可接受的衍生物如雷米普利或雷米普利在预防中风，糖尿病和/或充血性心力衰竭（CHF）中的用途。

3. 发明申请

US20080125472A1 PHARMACEUTICAL FORMULATIONS AND USE THEREOF IN THE PREVENTION OF STROKE, DIABETES AND/OR CONGESTIVE HEART FAILURE 审中-公开
标题翻译：药物制剂及其用于预防冲击，糖尿病和/或焦虑性心脏衰竭的药物制剂及其用途
公开(公告)号：US20080125472A1
公开(公告)日：2008-05-29
申请号：US12027938
申请日：2008-02-07
申请人： Bernward Scholkens , Norbert Bender , Badrudin Rangoonwala , Gilles Dagenais , Hertzel Gerstein , Anders Ljunggren , Salim Yusuf
发明人： Bernward Scholkens , Norbert Bender , Badrudin Rangoonwala , Gilles Dagenais , Hertzel Gerstein , Anders Ljunggren , Salim Yusuf
IPC分类号： A61K31/41 , A61P9/00
CPC分类号： A61K31/519 , A61K31/403 , A61K31/41 , A61K31/4178 , A61K31/4184
摘要： The present invention relates to use of an inhibitor of the renin-angiotensin system (RAS) or a pharmaceutically acceptable derivative thereof, such as ramipril or ramiprilat, in the prevention of stroke, diabetes and/or congestive heart failure (CHF).
摘要翻译：本发明涉及肾素 - 血管紧张素系统抑制剂（RAS）或其药学上可接受的衍生物如雷米普利或雷米普利在预防中风，糖尿病和/或充血性心力衰竭（CHF）中的用途。

4. 发明申请

US20090258919A1 Pharmaceutical formulations and use thereof in the prevention of stroke, diabetes and / or congestive heart failure 审中-公开
标题翻译：药物制剂及其在预防中风，糖尿病和/或充血性心力衰竭中的用途
公开(公告)号：US20090258919A1
公开(公告)日：2009-10-15
申请号：US12457589
申请日：2009-06-16
申请人： Bernward Scholkens , Norbert Bender , Badrudin Rangoonwala , Gilles Dagenais , Hertzel Gerstein , Anders Ljunggren , Salim Yusuf
发明人： Bernward Scholkens , Norbert Bender , Badrudin Rangoonwala , Gilles Dagenais , Hertzel Gerstein , Anders Ljunggren , Salim Yusuf
IPC分类号： A61K31/4184 , A61K31/403 , A61P3/10 , A61P9/00
CPC分类号： A61K31/519 , A61K31/403 , A61K31/41 , A61K31/4178 , A61K31/4184
摘要： The present invention relates to use of an inhibitor of the renin-angiotensin system (RAS) or a pharmaceutically acceptable derivative thereof, such as ramipril or ramiprilat, in the prevention of stroke, diabetes and/or congestive heart failure (CHF).
摘要翻译：本发明涉及肾素 - 血管紧张素系统抑制剂（RAS）或其药学上可接受的衍生物如雷米普利或雷米普利在预防中风，糖尿病和/或充血性心力衰竭（CHF）中的用途。

5. 发明申请

US20080287403A1 USE OF INHIBITORS OF THE RENIN-ANGIOTENSIN SYSTEM IN THE PREVENTION OF CARDIOVASCULAR EVENTS 审中-公开
标题翻译：使用瑞恩 - 血管紧张素系统抑制剂预防心血管事件
公开(公告)号：US20080287403A1
公开(公告)日：2008-11-20
申请号：US12125313
申请日：2008-05-22
申请人： Bernward Scholkens , Norbert Bender , Badrudin Rangoonwala , Gilles Dagenais , Hertzel Gerstein , Salim Yusuf
发明人： Bernward Scholkens , Norbert Bender , Badrudin Rangoonwala , Gilles Dagenais , Hertzel Gerstein , Salim Yusuf
IPC分类号： A61K31/403 , A61K31/616 , A61P9/00
CPC分类号： A61K45/06 , A61K31/00 , A61K31/355 , A61K31/403 , A61K31/616 , A61K2300/00
摘要： Use of an inhibitor of the renin-angiotensin system or a pharmaceutically acceptable derivative thereof, optionally together with an other antihypertensive, a cholesterol lowering agent, a diuretic or aspirin, in the manufacture of a medicament for the prevention of cardiovascular events; a method of preventing cardiovascular events comprising administering to a patient in need of such prevention an effective amount of an inhibitor of the renin angiotensin system or a pharmaceutically acceptable derivative thereof, optionally together with an other antihypertensive, a cholesterol lowering agent, a diuretic or aspirin; and a combination product containing an an inhibitor of the renin-angiotensin system or a pharmaceutically acceptable derivative thereof and a cholesterol lowering agent.
摘要翻译：在制备用于预防心血管事件的药物中使用肾素 - 血管紧张素系统的抑制剂或其药学上可接受的衍生物，任选与其它抗高血压剂，降胆固醇剂，利尿剂或阿司匹林一起使用; 一种预防心血管事件的方法，包括对需要这种预防的患者施用有效量的肾素血管紧张素系统抑制剂或其药学上可接受的衍生物，任选与其它降压药，降胆固醇剂，利尿剂或阿司匹林 ; 以及含有肾素 - 血管紧张素系统抑制剂或其药学上可接受的衍生物和降胆固醇剂的组合产品。

6. 发明申请

US20060194868A1 Pharmaceutical formulations and use thereof in the prevention of stroke, diabetes and /or congestive heart failure 审中-公开
标题翻译：药物制剂及其在预防中风，糖尿病和/或充血性心力衰竭中的用途
公开(公告)号：US20060194868A1
公开(公告)日：2006-08-31
申请号：US11415137
申请日：2006-05-02
申请人： Bernward Scholkens , Norbert Bender , Badrudin Rangoonwala , Gilles Dagenais , Hertzel Gerstein , Anders Ljunggren , Salim Yusuf
发明人： Bernward Scholkens , Norbert Bender , Badrudin Rangoonwala , Gilles Dagenais , Hertzel Gerstein , Anders Ljunggren , Salim Yusuf
IPC分类号： A61K31/401
CPC分类号： A61K31/519 , A61K31/403 , A61K31/41 , A61K31/4178 , A61K31/4184
摘要： The present invention relates to use of an inhibitor of the renin-angiotensin system (RAS) or a pharmaceutically acceptable derivative thereof, such as ramipril or ramiprilat, in the prevention of stroke, diabetes and/or congestive heart failure (CHF).
摘要翻译：本发明涉及肾素 - 血管紧张素系统抑制剂（RAS）或其药学上可接受的衍生物如雷米普利或雷米普利在预防中风，糖尿病和/或充血性心力衰竭（CHF）中的用途。

7. 发明申请

US20070021491A1 Use of inhibitors of the renin-angiotensin system in the prevention of cardiovascular events 有权
标题翻译：使用肾素 - 血管紧张素系统抑制剂预防心血管事件
公开(公告)号：US20070021491A1
公开(公告)日：2007-01-25
申请号：US11490061
申请日：2006-07-21
申请人： Bernward Scholkens , Norbert Bender , Badrudin Rangoonwala , Gilles Dagenais , Hertzel Gerstein , Salim Yusuf
发明人： Bernward Scholkens , Norbert Bender , Badrudin Rangoonwala , Gilles Dagenais , Hertzel Gerstein , Salim Yusuf
IPC分类号： A61K31/401 , A61K31/366 , A61K31/22 , A61K31/138
CPC分类号： A61K45/06 , A61K31/00 , A61K31/355 , A61K31/403 , A61K31/616 , A61K2300/00
摘要： Use of an inhibitor of the renin-angiotensin system or a pharmaceutically acceptable derivative thereof, optionally together with another antihypertensive, a cholesterol lowering agent, a diuretic or aspirin, in the manufacture of a medicament for the prevention of cardiovascular events; a method of preventing cardiovascular events comprising administering to a patient in need of such prevention an effective amount of an inhibitor of the renin angiotensin system or a pharmaceutically acceptable derivative thereof, optionally together with another antihypertensive, a cholesterol lowering agent, a diuretic or aspirin; and a combination product containing an an inhibitor of the renin-angiotensin system or a pharmaceutically acceptable derivative thereof and a cholesterol lowering agent.
摘要翻译：在制备用于预防心血管事件的药物中使用肾素 - 血管紧张素系统抑制剂或其药学上可接受的衍生物，任选地与另一种抗高血压剂，降胆固醇剂，利尿剂或阿司匹林一起使用; 一种预防心血管事件的方法，包括向需要这种预防的患者施用有效量的肾素血管紧张素系统抑制剂或其药学上可接受的衍生物，任选与另一种降压药，降胆固醇剂，利尿剂或阿斯匹林一起使用; 以及含有肾素 - 血管紧张素系统抑制剂或其药学上可接受的衍生物和降胆固醇剂的组合产品。

8. 发明申请

US20050101658A1 Use of inhibitors of the renin-angiotensin system in the prevention of cardiovascular events 审中-公开
标题翻译：使用肾素 - 血管紧张素系统抑制剂预防心血管事件
公开(公告)号：US20050101658A1
公开(公告)日：2005-05-12
申请号：US11001028
申请日：2004-12-02
申请人： Bernward Scholkens , Norbert Bender , Badrudin Rangoonwala , Gilles Dagenais , Hertzel Gerstein , Salim Yusuf
发明人： Bernward Scholkens , Norbert Bender , Badrudin Rangoonwala , Gilles Dagenais , Hertzel Gerstein , Salim Yusuf
IPC分类号： A61K45/00 , A61K31/00 , A61K31/216 , A61K31/355 , A61K31/401 , A61K31/403 , A61K31/404 , A61K31/41 , A61K31/4166 , A61K31/4174 , A61K31/4178 , A61K31/4184 , A61K31/472 , A61K31/519 , A61K31/55 , A61K31/551 , A61K31/554 , A61K31/612 , A61K31/616 , A61K31/675 , A61K45/06 , A61P3/10 , A61P9/04 , A61P9/08 , A61P9/10
CPC分类号： A61K45/06 , A61K31/00 , A61K31/355 , A61K31/403 , A61K31/616 , A61K2300/00
摘要： Use of an inhibitor of the renin-angiotensin system or a pharmaceutically acceptable derivative thereof, optionally together with an other antihypertensive, a cholesterol lowering agent, a diuretic or aspirin, in the manufacture of a medicament for the prevention of cardiovascular events; a method of preventing cardiovascular events comprising administering to a patient in need of such prevention an effective amount of an inhibitor of the renin angiotensin system or a pharmaceutically acceptable derivative thereof, optionally together with an other antihypertensive, a cholesterol lowering agent, a diuretic or aspirin; and a combination product containing an an inhibitor of the renin-angiotensin system or a pharmaceutically acceptable derivative thereof and a cholesterol lowering agent.
摘要翻译：在制备用于预防心血管事件的药物中使用肾素 - 血管紧张素系统的抑制剂或其药学上可接受的衍生物，任选与其它抗高血压剂，降胆固醇剂，利尿剂或阿司匹林一起使用; 一种预防心血管事件的方法，包括对需要这种预防的患者施用有效量的肾素血管紧张素系统抑制剂或其药学上可接受的衍生物，任选与其它降压药，降胆固醇剂，利尿剂或阿司匹林 ; 以及含有肾素 - 血管紧张素系统抑制剂或其药学上可接受的衍生物和降胆固醇剂的组合产品。

9. 发明授权

US4155264A Method of determining internal stresses in structural members 失效
标题翻译：确定结构构件内应力的方法
公开(公告)号：US4155264A
公开(公告)日：1979-05-22
申请号：US906633
申请日：1978-05-16
申请人： Norbert Bender , Gerhard Hofer , Olaf Lenz , Erwin Stucker
发明人： Norbert Bender , Gerhard Hofer , Olaf Lenz , Erwin Stucker
IPC分类号： G01L1/00 , G01L5/00 , G01N1/04
CPC分类号： G01L5/0047
摘要： Method for determining internal stresses in structural members in machine or apparatus manufacturing by machining, around a measuring location provided with strain gages, a circular slot into the surface of the structural member that is to be measured, measuring changes in strain of the core of the measuring location left standing, and calculating the internal stresses from the measured strains and a depth-dependent decay function determined on a calibrating material sample, the improvement therein affording the determination of internal stresses in the structural members at depths greater than about 5 mm, includes the steps of mechanically removing the measuring-location core down to a new surface at the base of the circular slot, securing a strain gage to a new measuring location at the new surface, machining another circular slot around the new measuring location, measuring changes in strain of the core of the new measuring location left standing while measuring changes in strain thereof and repeating the foregoing steps for respective slot depths until a given depth at which internal stresses in the structural members are to be determined is reached, a separate depth-dependent decay function being determined on a calibrating material sample for each new measuring location core.
摘要翻译：用于确定机器或设备制造中的结构构件中的内应力的方法，通过机械加工，围绕具有应变计的测量位置，待测量的结构构件的表面中的圆形槽，测量芯的应变变化测量位置保持不变，并计算来自测量应变的内部应力和在校准材料样品上确定的深度依赖衰减函数，其中提供在大于约5mm深度的结构构件中的内部应力的确定包括将测量位置的核心机械地移除到圆形槽底部的新表面的步骤，将应变计固定在新表面的新测量位置，在新的测量位置周围加工另一个圆形槽，测量变化新测量位置的核心应变在测量应变的变化时保持静止并且对于相应的槽深度重复上述步骤，直到达到要确定结构构件中的内部应力的给定深度，在每个新的测量位置芯的校准材料样品上确定单独的深度依赖衰减函数。

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