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    • 6. 发明申请
    • Method for Producing and Monitoring Oral Active Ingredient Films
    • 口服活性成分薄膜的生产和监测方法
    • US20140272099A1
    • 2014-09-18
    • US14238619
    • 2012-07-09
    • Sebastian BraunArmin BreitenbachRalf Schliephacke
    • Sebastian BraunArmin BreitenbachRalf Schliephacke
    • A61K9/00A61K9/70
    • A61K9/0056A61K9/006A61K9/2095A61K9/7007A61K47/38
    • Method for producing and monitoring oral active ingredient films with a base to which a solution containing at least one active ingredient is applied, the method comprising the steps: • metering and mixing the base formulation, • coating the base formulation onto a substrate, so that a strip results • if necessary, drying the base formulation strip coated on the substrate • printing a colorant solution containing at least one active ingredient onto the upper side of the base formulation strip according to the flexographic printing method, • drying the base formulation strip coated on the substrate together with the printed active ingredient solution, • penetrating the base formulation strip coated on the substrate together with the printed active ingredient solution from the upper and/or lower side by means of radiation from a radiation source, • measuring the transmission of the penetrating radiation by means of at least one reception unit on the opposite side of the base formulation strip coated on the substrate together with the printed active ingredient solution.
    • 用于制备和监测含有至少一种活性成分的溶液的基质的口服活性成分膜的方法,所述方法包括以下步骤:·计量和混合所述基础制剂,·将所述基础制剂涂布在基材上,使得 条带结果•如果需要,干燥涂覆在基材上的基础制剂条带•根据柔性版印刷方法将含有至少一种活性成分的着色剂溶液印刷到基底制剂条的上侧上;•将涂布的基础制剂条 与印刷的活性成分溶液一起在基底上;·通过来自辐射源的辐射,从上和/或下侧将印刷的活性成分溶液与印刷的活性成分溶液一起穿透基底制剂条;·测量 穿透辐射借助于在该相对侧的至少一个接收单元 e制剂条带与印刷的活性成分溶液一起涂覆在基材上。
    • 7. 发明授权
    • Method for producing and monitoring oral active ingredient films
    • 口服活性成分膜的生产和监测方法
    • US09539206B2
    • 2017-01-10
    • US14238619
    • 2012-07-09
    • Sebastian BraunArmin BreitenbachRalf Schliephacke
    • Sebastian BraunArmin BreitenbachRalf Schliephacke
    • A61K9/00A61K9/20A61K9/70A61K47/38
    • A61K9/0056A61K9/006A61K9/2095A61K9/7007A61K47/38
    • Method for producing and monitoring oral active ingredient films with a base to which a solution containing at least one active ingredient is applied, the method comprising the steps: • metering and mixing the base formulation, • coating the base formulation onto a substrate, so that a strip results • if necessary, drying the base formulation strip coated on the substrate • printing a colorant solution containing at least one active ingredient onto the upper side of the base formulation strip according to the flexographic printing method, • drying the base formulation strip coated on the substrate together with the printed active ingredient solution, • penetrating the base formulation strip coated on the substrate together with the printed active ingredient solution from the upper and/or lower side by means of radiation from a radiation source, • measuring the transmission of the penetrating radiation by means of at least one reception unit on the opposite side of the base formulation strip coated on the substrate together with the printed active ingredient solution.
    • 用于制备和监测含有至少一种活性成分的溶液的基质的口服活性成分膜的方法,所述方法包括以下步骤:·计量和混合所述基础制剂,·将所述基础制剂涂布在基材上,使得 条带结果•如果需要,干燥涂覆在基材上的基础制剂条带•根据柔性版印刷方法将含有至少一种活性成分的着色剂溶液印刷到基底制剂条的上侧上;•将涂布的基础制剂条 与印刷的活性成分溶液一起在基底上;·通过来自辐射源的辐射,从上和/或下侧将印刷的活性成分溶液与印刷的活性成分溶液一起穿透基底制剂条;·测量 穿透辐射借助于在该相对侧的至少一个接收单元 e制剂条带与印刷的活性成分溶液一起涂覆在基材上。