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1. 发明申请

US20100280390A1 CATHETER FOR THREE-DIMENSIONAL INTRACARDIAC ECHOCARDIOGRAPHY AND SYSTEM INCLUDING THE SAME 有权
标题翻译：三维入侵物理学及其系统的导管
公开(公告)号：US20100280390A1
公开(公告)日：2010-11-04
申请号：US12522037
申请日：2008-01-10
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper , Jan Frederik Suijver , Ronald Tabaksblat , Nijs Cornelis Van Der Vaart , Christopher Stephen Hall , Anna Teresa Fernandez
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper , Jan Frederik Suijver , Ronald Tabaksblat , Nijs Cornelis Van Der Vaart , Christopher Stephen Hall , Anna Teresa Fernandez
IPC分类号： A61B8/14
CPC分类号： A61B8/12 , A61B8/0883 , A61B8/445 , A61B8/483 , G10K11/30
摘要： A catheter apparatus (100, 2000, 3000, 4000, 540) includes an elongated body (110) having proximal (112) and distal (114) ends, an acoustic transducer (130, 2300, 5 3300, 4300, 544), disposed proximate the distal end (114) of the elongated body (110), and a variably-refracting acoustic lens (140, 2200, 3200, 4200, 542) adapted to dynamically adjust a direction associated with an acoustic wave coupled to the acoustic transducer in response to one or more control signals provided thereto.
摘要翻译：导管装置（100,2000,3000,4000,540）包括具有近端（112）和远端端（114）的细长体（110），设置有声变换器（130,2300,5300,4300,544）靠近所述细长体（110）的远端（114），以及可变折射声透镜（140,2200,3200,4200,542），其适于动态地调节与耦合到所述声换能器的声波相关联的方向响应于提供给其的一个或多个控制信号。

2. 发明授权

US08702612B2 Catheter for three-dimensional intracardiac echocardiography and system including the same 有权
标题翻译：导管用于三维心内超声心动图和系统包括相同
公开(公告)号：US08702612B2
公开(公告)日：2014-04-22
申请号：US12522037
申请日：2008-01-10
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper , Jan Frederik Suijver , Ronald Tabaksblat , Nijs Cornelis Van Der Vaart , Christopher Stephen Hall , Anna Teresa Fernandez
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper , Jan Frederik Suijver , Ronald Tabaksblat , Nijs Cornelis Van Der Vaart , Christopher Stephen Hall , Anna Teresa Fernandez
IPC分类号： A61B8/12 , A61B8/14
CPC分类号： A61B8/12 , A61B8/0883 , A61B8/445 , A61B8/483 , G10K11/30
摘要： A catheter apparatus includes an elongated body having proximal and distal ends, and an acoustic transducer disposed proximate the distal end of the elongated body. A variably-refracting acoustic lens is provided to dynamically adjust a direction associated with an acoustic wave coupled to the acoustic transducer in response to one or more control signals provided thereto.
摘要翻译：导管装置包括具有近端和远端的细长主体和靠近细长主体的远端设置的声换能器。提供可变折射声透镜以响应于提供给其的一个或多个控制信号而动态地调整与耦合到声换能器的声波相关联的方向。

3. 发明授权

US08764665B2 Methods and apparatuses of microbeamforming with adjustable fluid lenses 失效
标题翻译：具有可调节流体透镜的微波成像的方法和装置
公开(公告)号：US08764665B2
公开(公告)日：2014-07-01
申请号：US12596841
申请日：2008-04-30
申请人： Christopher Stephen Hall , Chien Ting Chin , Jan Frederik Suijver , Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper
发明人： Christopher Stephen Hall , Chien Ting Chin , Jan Frederik Suijver , Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper
IPC分类号： A61B8/00
CPC分类号： G10K11/30
摘要： An acoustic probe (100, 300) includes an acoustic transducer (15, 444), and a plurality of variably-refracting acoustic lens elements (10, 210a, 210b, 442) coupled to the acoustic transducer. Each variably-refracting acoustic lens element has at least a pair of electrodes (150, 160) adapted to adjust at least one characteristic of the variably-refracting acoustic lens element in response to a selected voltage applied across the electrodes. In one embodiment, each variably-refracting acoustic lens element includes a cavity, first and second fluid media (141, 142) disposed within the cavity, and the pair of electrodes. The speed of sound of an acoustic wave in the first fluid medium is different than the speed of sound of the acoustic wave in the second fluid medium. The first and second fluid media are immiscible with respect to each other, and the first fluid medium has a substantially different electrical conductivity than the second fluid medium.
摘要翻译：声探针（100,300）包括声换能器（15,444）和耦合到声换能器的多个可变折射声透镜元件（10,210a，210b，442）。每个可变折射声透镜元件具有至少一对电极（150,160），其适于响应于跨过电极施加的选定电压来调节可变折射声透镜元件的至少一个特性。在一个实施例中，每个可变折射声透镜元件包括空腔，设置在空腔内的第一和第二流体介质（141,142）和一对电极。第一流体介质中声波的声速不同于第二流体介质中声波的声速。第一和第二流体介质相对于彼此是不混溶的，并且第一流体介质具有与第二流体介质基本上不同的导电性。

4. 发明申请

US20100087735A1 METHODS AND APPARATUSES OF MICROBEAMFORMING WITH ADJUSTABLE FLUID LENSES 失效
标题翻译：具有可调节流体镜片的微球的方法和装置
公开(公告)号：US20100087735A1
公开(公告)日：2010-04-08
申请号：US12596841
申请日：2008-04-30
申请人： Christopher Stephen Hall , Chien Ting Chin , Jan Frederik Suijver , Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper
发明人： Christopher Stephen Hall , Chien Ting Chin , Jan Frederik Suijver , Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper
IPC分类号： A61B8/00 , G03B42/06
CPC分类号： G10K11/30
摘要： An acoustic probe (100, 300) includes an acoustic transducer (15, 444), and a plurality of variably-refracting acoustic lens elements (10, 210a, 210b, 442) coupled to the acoustic transducer. Each variably-refracting acoustic lens element has at least a pair of electrodes (150, 160) adapted to adjust at least one characteristic of the variably-refracting acoustic lens element in response to a selected voltage applied across the electrodes. In one embodiment, each variably-refracting acoustic lens element includes a cavity, first and second fluid media (141, 142) disposed within the cavity, and the pair of electrodes. The speed of sound of an acoustic wave in the first fluid medium is different than the speed of sound of the acoustic wave in the second fluid medium. The first and second fluid media are immiscible with respect to each other, and the first fluid medium has a substantially different electrical conductivity than the second fluid medium.
摘要翻译：声探针（100,300）包括声换能器（15,444）和耦合到声换能器的多个可变折射声透镜元件（10,210a，210b，442）。每个可变折射声透镜元件具有至少一对电极（150,160），其适于响应于跨过电极施加的选定电压来调节可变折射声透镜元件的至少一个特性。在一个实施例中，每个可变折射声透镜元件包括空腔，设置在空腔内的第一和第二流体介质（141,142）和一对电极。第一流体介质中声波的声速不同于第二流体介质中声波的声速。第一和第二流体介质相对于彼此是不混溶的，并且第一流体介质具有与第二流体介质基本上不同的导电性。

5. 发明申请

US20100259832A1 ADJUSTABLE LENS SYSTEM FOR REAL-TIME APPLICATIONS 失效
标题翻译：可调镜头系统实时应用
公开(公告)号：US20100259832A1
公开(公告)日：2010-10-14
申请号：US12742658
申请日：2008-12-10
申请人： Jan Frederik Suijver , Christopher Stephen Hall , Anna Teresa Fernandez , Stein Kuiper , Yan Shi
发明人： Jan Frederik Suijver , Christopher Stephen Hall , Anna Teresa Fernandez , Stein Kuiper , Yan Shi
IPC分类号： G02B3/14
CPC分类号： G02B3/14
摘要： An adjustable fluid type lens system is provided that allows e.g. ultrasound imaging through the lens during adjustment of the lens. The lens includes a container enclosing two immiscible fluids, e.g. water and oil, being in contact with each other at an interface. Incoming waves are then refracted at this interface. The shape of the interface, and thereby the refraction property, is adjustable by adjusting a voltage applied to the lens. The two fluids are selected such that they together exhibit a mechanical damping which is critical or near critical. A control circuit generates the electric voltage for adjusting the refraction from one value to another, the control circuit being arranged to change the electric voltage such that a rate of voltage change is limited to avoid oscillation of the interface, thereby adjusting refraction of incoming waves at the interface in a continuous manner. This makes it possible to use the lens while it is during adjustment from one refraction value to another, since the interface shape will at all time during the adjustment have a controlled shape. The voltage can be either a continuous voltage or a discrete stepwise (digital) voltage which is just controlled with respect to step size and temporal extension of the steps. The lens system has a number of applications e.g. within the medical field, e.g. for ‘on the fly’ high speed ultrasound imaging, or for ultrasound ablation applications where ablation can be performed during adjustment of the lens to follow a pre-defined trajectory.
摘要翻译：提供了一种可调节流体型透镜系统，超声波成像通过透镜在调整镜片期间。透镜包括容纳两个不混溶流体的容器，例如水和油在界面处彼此接触。然后在这个界面折射出来的波。通过调节施加到透镜上的电压来调节界面的形状以及由此的折射特性。选择两种流体使得它们一起显示出关键或近临界的机械阻尼。控制电路产生用于将折射率从一个值调整到另一个值的电压，控制电路被布置成改变电压，使得电压变化率被限制以避免界面的振荡，由此调节入射波的折射界面以连续的方式。这使得可以在从一个折射值到另一个折射值的调整期间使用透镜，因为在调节期间的所有时间的界面形状都具有受控的形状。电压可以是连续电压或离散的逐步（数字）电压，其仅仅相对于步长的步长和时间延长而被控制。透镜系统具有许多应用，例如，在医疗领域内。用于“飞行”高速超声成像，或用于超声消融应用，其中可以在镜片调节期间遵循预定义的轨迹进行消融。

6. 发明授权

US08233221B2 Adjustable lens system for real-time applications 失效
标题翻译：可调透镜系统，用于实时应用
公开(公告)号：US08233221B2
公开(公告)日：2012-07-31
申请号：US12742658
申请日：2008-12-10
申请人： Jan Frederik Suijver , Christopher Stephen Hall , Anna Teresa Fernandez , Stein Kuiper , Yan Shi
发明人： Jan Frederik Suijver , Christopher Stephen Hall , Anna Teresa Fernandez , Stein Kuiper , Yan Shi
IPC分类号： G02B1/06 , G02B3/12
CPC分类号： G02B3/14
摘要： An adjustable fluid type lens system is provided that allows e.g. ultrasound imaging through the lens during adjustment of the lens. The lens includes a container enclosing two immiscible fluids, e.g. water and oil, being in contact with each other at an interface. Incoming waves are then refracted at this interface. The shape of the interface, and thereby the refraction property, is adjustable by adjusting a voltage applied to the lens. The two fluids are selected such that they together exhibit a mechanical damping which is critical or near critical. A control circuit generates the electric voltage for adjusting the refraction from one value to another, the control circuit being arranged to change the electric voltage such that a rate of voltage change is limited to avoid oscillation of the interface, thereby adjusting refraction of incoming waves at the interface in a continuous manner. This makes it possible to use the lens while it is during adjustment from one refraction value to another, since the interface shape will at all time during the adjustment have a controlled shape. The voltage can be either a continuous voltage or a discrete stepwise (digital) voltage which is just controlled with respect to step size and temporal extension of the steps. The lens system has a number of applications e.g. within the medical field, e.g. for ‘on the fly’ high speed ultrasound imaging, or for ultrasound ablation applications where ablation can be performed during adjustment of the lens to follow a pre-defined trajectory.
摘要翻译：提供了一种可调节流体型透镜系统，超声波成像通过透镜在调整镜片期间。透镜包括容纳两个不混溶流体的容器，例如水和油在界面处彼此接触。然后在这个界面折射出来的波。通过调节施加到透镜上的电压来调节界面的形状以及由此的折射特性。选择两种流体使得它们一起显示出关键或近临界的机械阻尼。控制电路产生用于将折射率从一个值调整到另一个值的电压，控制电路被布置成改变电压，使得电压变化率被限制以避免界面的振荡，由此调节入射波的折射界面以连续的方式。这使得可以在从一个折射值到另一个折射值的调整期间使用透镜，因为在调节期间的所有时间的界面形状都具有受控的形状。电压可以是连续电压或离散的逐步（数字）电压，其仅仅相对于步长的步长和时间延长而被控制。透镜系统具有许多应用，例如，在医疗领域内。用于“飞行”高速超声成像，或用于超声消融应用，其中可以在镜片调节期间遵循预定义的轨迹进行消融。

7. 发明申请

US20100228082A1 DEVICE, SYSTEM AND METHOD FOR INTERACTING WITH A CELL OR TISSUE IN A BODY 审中-公开
标题翻译：用于与身体中的细胞或组织相互作用的装置，系统和方法
公开(公告)号：US20100228082A1
公开(公告)日：2010-09-09
申请号：US12376460
申请日：2007-04-12
申请人： Hans Zou , Stein Kuiper , Bernardus Hendrikus Wilhelmus Hendriks , Jan Frederik Suijver , Anke Pierik , Judith Margreet Rensen , Johan Frederik Dijksman , Jeff Shimizu , Jacob Marinus Jan Den Toonder
发明人： Hans Zou , Stein Kuiper , Bernardus Hendrikus Wilhelmus Hendriks , Jan Frederik Suijver , Anke Pierik , Judith Margreet Rensen , Johan Frederik Dijksman , Jeff Shimizu , Jacob Marinus Jan Den Toonder
IPC分类号： A61B1/00
CPC分类号： A61B5/6882 , A61B1/041 , A61B5/0031 , A61B5/073 , A61B5/4839
摘要： A device or support, system and method are provided for precisely targeted and/or highly controlled interaction with a targeted cell or tissue in a body, with the support providing an ergonomic connecting interface for selectively connecting the support to a cell or tissue with at least minimal adverse affect to such cell or tissue, the system providing a remote facility that may be operatively associated with the support, and the method providing steps for employing the support and/or system so as to, inter alia, improve treatment, diagnostic and/or monitoring techniques and increase sensitivity and specificity with respect to interacting with, for example, diseased or abnormal cells or tissue without adversely effecting surrounding healthy cells or tissue, and/or the body in general.
摘要翻译：提供了一种装置或支撑件，系统和方法，用于与身体中的靶细胞或组织精确地靶向和/或高度受控的相互作用，其中所述支持物提供符合人体工程学的连接界面，用于至少选择性地将支持体连接到细胞或组织对这种细胞或组织的最小的不利影响，该系统提供可能与支持物可操作地相关联的远程设施，以及提供使用支持和/或系统的方法，以便除其他外改善治疗，诊断和/ 或监测技术，并提高与例如患病或异常细胞或组织的相互作用的灵敏度和特异性，而不会不利地影响周围的健康细胞或组织和/或身体。

8. 发明授权

US08422338B2 System for variably refracting ultrasound and/or light 失效
$System for variably refracting ultrasound and/or light$
标题翻译：用于可变地折射超声和/或光的系统
公开(公告)号：US08422338B2
公开(公告)日：2013-04-16
申请号：US12376307
申请日：2007-04-12
申请人： Stein Kuiper , Bernardus Hendrikus Wilhelmus Hendriks , Jan Frederik Suijver
发明人： Stein Kuiper , Bernardus Hendrikus Wilhelmus Hendriks , Jan Frederik Suijver
IPC分类号： G10K11/30
CPC分类号： G10K11/30
摘要： The disclosure is directed to a system for variably refracting, and is transparent for, ultrasound as well as for light. By choosing liquids with the right optical and acoustical properties, it is possible to variably refract (including focusing and deflecting or steering) ultrasound while not affecting the refraction of light, or vice versa. Two lenses in series, or preferably one lens, allow for variably refracting ultrasound and light.
摘要翻译：本公开涉及用于可变折射并且对于超声波以及用于光的透明系统。通过选择具有正确光学和声学特性的液体，可以可变地折射（包括聚焦和偏转或转向）超声波，同时不影响光的折射，反之亦然。串联的两个镜片，或者优选地，一个透镜允许可变地折射超声波和光。

9. 发明授权

US07957219B2 Method and apparatus for elevation focus control of acoustic waves 有权
标题翻译：用于声波高程聚焦控制的方法和装置
公开(公告)号：US07957219B2
公开(公告)日：2011-06-07
申请号：US12297902
申请日：2007-04-27
申请人： Christopher S. Hall , Chien Ting Chin , Jan Frederik Suijver , Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper
发明人： Christopher S. Hall , Chien Ting Chin , Jan Frederik Suijver , Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper
IPC分类号： G03B42/06
CPC分类号： G10K11/30
摘要： An acoustic probe includes an acoustic transducer having acoustic transducer elements arranged in a one-dimensional array; and a variably-refracting acoustic lens coupled to the acoustic transducer. The variably-refracting acoustic lens has a pair of electrodes configured to adjust the focus of the variably-refracting acoustic lens in response to a selected voltage applied across the electrodes. In one embodiment, the variably-refracting acoustic lens includes a cavity, first and second fluid media disposed within the cavity, and the pair of electrodes. The speed of sound of an acoustic wave in the first fluid medium is different than the speed of sound of the acoustic wave in the second fluid medium. The first and second fluid media are immiscible with respect to each other, and the first fluid medium has a substantially different electrical conductivity than the second fluid medium.
摘要翻译：声探头包括具有以一维阵列布置的声换能器元件的声换能器; 以及耦合到声换能器的可变折射声透镜。可变折射声透镜具有一对电极，其被配置为响应于跨过电极施加的选定电压来调节可变折射声透镜的焦点。在一个实施例中，可变折射声透镜包括空腔，设置在空腔内的第一和第二流体介质和一对电极。第一流体介质中声波的声速不同于第二流体介质中声波的声速。第一和第二流体介质相对于彼此是不混溶的，并且第一流体介质具有与第二流体介质基本上不同的导电性。

10. 发明申请

US20100277809A1 FLUID LENS WITH PRESSURE RELEASE SYSTEM 有权
标题翻译：带压力释放系统的流体镜
公开(公告)号：US20100277809A1
公开(公告)日：2010-11-04
申请号：US12811831
申请日：2009-01-12
申请人： Jan Frederik Suijver , Stein Kuiper , Bernardus Hendrikus Wilhelmus Hendriks , Szabolcs Deladi , Antonius Johannes Josephus Rademakers , Cornelius Antonius Micolaas Maria Van Der Vleuten , Johannes Wilhelmus Weekamp , Waltherus Cornelis Jozef Bierhoff
发明人： Jan Frederik Suijver , Stein Kuiper , Bernardus Hendrikus Wilhelmus Hendriks , Szabolcs Deladi , Antonius Johannes Josephus Rademakers , Cornelius Antonius Micolaas Maria Van Der Vleuten , Johannes Wilhelmus Weekamp , Waltherus Cornelis Jozef Bierhoff
IPC分类号： G02B3/14 , A61B1/06
CPC分类号： G02B7/008 , A61B1/0019 , G02B3/14 , G02B23/2407
摘要： Fluid lens system, e.g. for medical imaging or medical treatment, with a container enclosing a fluid arranged to refract incoming waves. A pressure release mechanism is in contact with the fluid so as to compensate changes in its volume due to thermal variations, e.g. during high temperature medical cleaning. This pressure release mechanism is positioned within a pathway of incoming waves. In preferred embodiments a fluid container connected via a tube to the fluid as a reservoir, is arranged within or outside the container, e.g. beyond an image sensor. Alternatively, an easily compressible body, e.g. a small closed metal bellows enclosing a gas, is positioned inside the fluid to absorb volume changes by compression. In both embodiments, the pressure release elements are preferably positioned in a peripheral part of the pathway of incoming waves to not affect performance of the lens. In another aspect, a fluid lens includes a container with an inner container part that fits inside an outer container part, wherein the inner container part is in rigid connection to at least a one boundary arranged for penetration of incoming waves. The pressure release mechanism is positioned within the outer container part, and it is in contact with the fluid so as to compensate changes in volume of the fluid due to thermal variations. In one embodiment the inner and outer container parts are arranged for relative one-dimensional movement and fluid tight interconnected. In another embodiment, a fluid filled cavity is formed between the inner and outer container parts, and this cavity houses a compressible body. The lens systems are suited for applications such as medical endoscopes, catheters and needles, optically as well as acoustically based.
摘要翻译：流体透镜系统，例如用于医疗成像或医疗处理，容器包围布置成折射入射波的流体。压力释放机构与流体接触，以便补偿由于热变化引起的体积变化，例如，在高温医疗清洗过程中。该压力释放机构位于入射波的通路内。在优选实施例中，经由管连接到作为储存器的流体的流体容器设置在容器内或外部，例如，超越图像传感器。或者，容易压缩的主体，例如，围绕气体的小封闭金属波纹管位于流体内部以通过压缩吸收体积变化。在两个实施例中，压力释放元件优选地定位在入射波通路的周边部分中，从而不影响透镜的性能。在另一方面，一种流体透镜包括具有内部容器部分的容器，该内部容器部分装配在外部容器部分内部，其中内部容器部分刚好连接至布置成用于穿透入射波的至少一个边界。压力释放机构定位在外部容器部分内，并且与流体接触，以补偿由于热变化引起的流体体积的变化。在一个实施例中，内部和外部容器部件布置用于相对一维运动并且流体密封互连。在另一个实施例中，在内部和外部容器部分之间形成流体填充空腔，并且该空腔容纳可压缩体。透镜系统适用于诸如医用内窥镜，导管和针的应用，光学和声学基础。

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