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1. 发明授权

US08618158B2 Therapeutic agents 有权
标题翻译：治疗剂
公开(公告)号：US08618158B2
公开(公告)日：2013-12-31
申请号：US13001372
申请日：2009-06-25
申请人： Bernard Thomas Golding , Christiane Riedinger , Roger John Griffin , Ian Robert Hardcastle , Eric Valeur , Anna Frances Watson , Martin Noble
发明人： Bernard Thomas Golding , Christiane Riedinger , Roger John Griffin , Ian Robert Hardcastle , Eric Valeur , Anna Frances Watson , Martin Noble
IPC分类号： A61K31/4035 , C07D207/46
CPC分类号： C07D209/49 , A61K31/4035 , A61K31/4402 , A61K45/06 , C07D209/48 , C07D401/06 , C07D403/06
摘要： A compound of formula (I) or a compound of formula (II) or pharmaceutically acceptable salts thereof, wherein R1-R7 and X are as defined in the description, and the use of these compounds in therapy, in particular in treating cancer or as an inhibitor of the interaction of the MDM2 protein with p53.
摘要翻译：式（I）化合物或式（II）化合物或其药学上可接受的盐，其中R 1 -R 7和X如说明书中所定义，以及这些化合物在治疗中的用途，特别是在治疗癌症或作为 MDM2蛋白与p53相互作用的抑制剂。

2. 发明申请

US20110224274A1 New Therapeutic Agents 有权
标题翻译：新型治疗剂
公开(公告)号：US20110224274A1
公开(公告)日：2011-09-15
申请号：US13001372
申请日：2009-06-25
申请人： Bernard Thomas Golding , Christiane Riedinger , Roger John Griffin , Ian Robert Hardcasctle , Eric Valeur , Anna Frances Watson , Martin Noble
发明人： Bernard Thomas Golding , Christiane Riedinger , Roger John Griffin , Ian Robert Hardcasctle , Eric Valeur , Anna Frances Watson , Martin Noble
IPC分类号： A61K31/4035 , C07D209/48 , A61P35/00 , A61K31/403
CPC分类号： C07D209/49 , A61K31/4035 , A61K31/4402 , A61K45/06 , C07D209/48 , C07D401/06 , C07D403/06
摘要： A compound of formula (I) or a compound of formula (II) or pharmaceutically acceptable salts thereof, wherein R1-R7 and X are as defined in the description, and the use of these compounds in therapy, in particular in treating cancer or as an inhibitor of the interaction of the MDM2 protein with p53.
摘要翻译：式（I）化合物或式（II）化合物或其药学上可接受的盐，其中R 1 -R 7和X如说明书中所定义，以及这些化合物在治疗中的用途，特别是在治疗癌症或作为 MDM2蛋白与p53相互作用的抑制剂。

3. 发明申请

US20080097080A1 Protein structure 审中-公开
标题翻译：蛋白质结构
公开(公告)号：US20080097080A1
公开(公告)日：2008-04-24
申请号：US11807922
申请日：2007-05-30
申请人： John Sinclair , Martin Noble
发明人： John Sinclair , Martin Noble
IPC分类号： C07K14/00 , C12N1/00 , C12N15/62 , C12N15/63 , G06F19/00
CPC分类号： C07K14/001 , C07K14/24 , C07K14/47 , C07K19/00 , C07K2319/00 , H01J37/20 , H01J37/295 , H01J2237/201
摘要： Protein structures 1 repeating regularly in one, two or three dimensions comprise protein protomers 2 which each comprise at least two monomers 5, 6 genetically fused together. The monomers 5, 6 are monomers of respective oligomer assemblies 3, 4 into which the monomers are assembled to assembly of the protein structure. The first oligomer assembly 3 has rotational symmetry axes including a set of rotational symmetry axes of order N, where N equals 2, 3, 4 or 6. The second oligomer assembly 4 has a rotational symmetry axis of the same order N as said set of rotational symmetry axes of said first oligomer assembly 3. Due to the symmetry of the oligomer assemblies 3, 4, the rotational symmetry axis axes of each second oligomer assembly 4 is aligned with one of said set of rotational symmetry axes of a first oligomer assembly 3 with N protomers being arranged symmetrically therearound. Thus, an N-fold fusion between the oligomer assemblies 3, 4 is produced and the arrangements of the rotational symmetry axes of the oligomer assemblies 3, 4 cause the protein structure to repeat regularly. The protein structure has many uses, for example to support molecular entities for x-ray crystallography or electron microscopy.
摘要翻译：在一个，两个或三个维度上规则重复的蛋白质结构1包含蛋白质反转录剂2，其每个包含至少两个遗传融合在一起的单体5,6。单体5,6是相应低聚物组件3,4的单体，其中单体被组装成蛋白质结构的组装。第一低聚物组件3具有旋转对称轴，其包括一组N级的旋转对称轴，其中N等于2,3,4或6.第二低聚物组件4具有与所述一组所述第一低聚物组件3的旋转对称轴。由于低聚物组件3,4的对称性，每个第二低聚物组件4的旋转对称轴线与第一低聚物组件3的所述一组旋转对称轴线中的一个对准，其中N个探测器对称地布置。因此，产生低聚物组件3,4之间的N折融合，并且低聚物组件3,4的旋转对称轴的布置导致蛋白质结构定期重复。蛋白质结构具有许多用途，例如用于支持X射线晶体学或电子显微镜的分子实体。

4. 发明申请

US20060173166A1 Protein lattice 有权
标题翻译：蛋白质晶格
公开(公告)号：US20060173166A1
公开(公告)日：2006-08-03
申请号：US10530795
申请日：2003-10-08
申请人： John Sinclair , Martin Noble
发明人： John Sinclair , Martin Noble
IPC分类号： C07K14/47 , G06F19/00
CPC分类号： C07K19/00 , C07K14/001 , C07K14/24 , C07K14/47 , C07K2319/00
摘要： Protein lattice (1) having a regular structure with a repeating unit repeating in three dimensions may have many uses, for example to support an array of macromolecular entities for x-ray crystallography. The repeating unit comprises protein protomers (2) which each comprise at least two monomers (5, 6) fused together. The monomers (5, 6) are each monomers of a respective oligomer assembly (3, 4) into which the monomers are assembled for assembly of the protomers into the lattice. The first oligomer assembly (3) has a set of rotational symmetry axes extending in three dimensions. In said protomers (2), further monomers (6) fused to said first monomers (5) are monomers of respective further oligomer assemblies (4) which have a rotational symmetry axis of the same order as a respective one of said set of rotational symmetry axes of said first oligomer assembly (3). Thus, the repeating unit includes protomers (2) with the first monomers (5) of the protomers (2) being assembled into said first oligomer assembly (3) and, in respect of respective ones of said set of rotational symmetry axes, with further monomers (6) of the protomers (2) fused to respective first monomers (3) being assembled into respective further oligomer assemblies (4). As a result of the symmetry of the oligomer assemblies (3, 4) said rotational symmetry axis of said respective further oligomer assemblies (4) is aligned with the respective rotational symmetry axis of said first oligomer assembly (3). Thus, an N-fold fusion between the oligomer assemblies (3, 4) is produced and the rotational symmetry axes of the oligomer assemblies (3, 4) define the symmetry of the lattice.
摘要翻译：具有在三维重复的重复单元的规则结构的蛋白质晶格（1）可以具有许多用途，例如用于支持用于x射线晶体学的大分子实体的阵列。重复单元包括蛋白质反转录剂（2），每种蛋白质包含至少两种融合在一起的单体（5,6）。单体（5,6）各自是各自的低聚物组件（3,4）的单体，其中组装单体以将反型体组装成晶格。第一低聚物组件（3）具有一组三维延伸的旋转对称轴。在所述检测器（2）中，与所述第一单体（5）熔合的另外的单体（6）是各自另外的低聚物组件（4）的单体，其具有与所述一组旋转对称中的相应一个相同顺序的旋转对称轴所述第一低聚物组件（3）的轴线。因此，重复单元包括反转剂（2），其中反萃剂（2）的第一单体（5）被组装到所述第一低聚物组合物（3）中，并且相对于所述一组旋转对称轴中的相应组与各自的第一单体（3）熔合的反射体（2）的单体（6）被组装成各自的另外的低聚物组件（4）。由于低聚物组件（3,4）的对称性，所述各个另外的低聚物组件（4）的所述旋转对称轴线与所述第一低聚物组件（3）的相应旋转对称轴线对齐。因此，产生低聚物组件（3,4）之间的N折融合，并且低聚物组件（3,4）的旋转对称轴限定了晶格的对称性。

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