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1. 发明授权

US08226953B2 Group B Streptococcus antigens 有权
标题翻译： B组链球菌抗原
公开(公告)号：US08226953B2
公开(公告)日：2012-07-24
申请号：US12980172
申请日：2010-12-28
申请人： Bernard R. Brodeur , Clement Rioux , Martine Boyer , Isabelle Charlebois , Josée Hamel , Denis Martin
发明人： Bernard R. Brodeur , Clement Rioux , Martine Boyer , Isabelle Charlebois , Josée Hamel , Denis Martin
IPC分类号： A61K39/09
CPC分类号： C07K14/315 , A61K39/00
摘要： Group B streptococcus (GBS) proteins and polynucleotides encoding them are disclosed. Said proteins are antigenic and therefore useful vaccine components for the prophylaxis or therapy of streptococcus infection in animals. Also disclosed are recombinant methods of producing the protein antigens as well as diagnostic assays for detecting streptococcus bacterial infection.
摘要翻译： B组链球菌（GBS）蛋白和编码它们的多核苷酸被公开。所述蛋白质是抗原性的，因此用于预防或治疗动物中链球菌感染的有用的疫苗组分。还公开了产生蛋白质抗原的重组方法以及用于检测链球菌细菌感染的诊断测定法。

2. 发明授权

US08211437B2 Streptococcus antigens 有权
标题翻译：链球菌抗原
公开(公告)号：US08211437B2
公开(公告)日：2012-07-03
申请号：US12634464
申请日：2009-12-09
申请人： Josée Hamel , Bernard R. Brodeur , Isabelle Pineau , Denis Martin , Clement Rioux , Nathalie Charland
发明人： Josée Hamel , Bernard R. Brodeur , Isabelle Pineau , Denis Martin , Clement Rioux , Nathalie Charland
IPC分类号： A61K39/02
CPC分类号： C07K14/3156 , A61K39/00
摘要： Streptococcus proteins and polynucleotides encoding them are disclosed. Said proteins are antigenic and therefore useful vaccine components for the prophylaxis or therapy of streptococcus infection in animals. Also disclosed are recombinant methods of producing the protein antigens as well as diagnostic assays for detecting streptococcus bacterial infection.
摘要翻译：公开了链球菌蛋白质和编码它们的多核苷酸。所述蛋白质是抗原性的，因此用于预防或治疗动物中链球菌感染的有用的疫苗组分。还公开了产生蛋白质抗原的重组方法以及用于检测链球菌细菌感染的诊断测定法。

3. 发明授权

US07786286B2 Proteinase K resistant surface protein of Neisseria meningitidis 失效
公开(公告)号：US07786286B2
公开(公告)日：2010-08-31
申请号：US11582527
申请日：2006-10-16
申请人： Bernard R. Brodeur , Denis Martin , Josée Hamel , Clement Rioux
发明人： Bernard R. Brodeur , Denis Martin , Josée Hamel , Clement Rioux
IPC分类号： C07H21/04 , C12N1/20 , C12N15/00 , C12P21/06
CPC分类号： A61K39/095 , A61K38/00 , A61K39/00 , A61K2039/522 , C07K14/22
摘要： The identification of a highly conserved, immunologically accessible antigen at the surface of Neisseria facilitates treatment, prophylaxis, and diagnosis of Neisseria diseases. This antigen is highly resistant to Proteinase K and has an apparent molecular weight of 22 kDa on SDS-PAGE. Specific polynucleotides encoding proteins of this class have been isolated from three Neisseria meningitidis strains and from one Neisseria gonorrhoeae strain. These polynucleotides have been sequenced, and the corresponding full-length amino acid sequences of the encoded polypeptides have been deduced. Recombinant DNA methods for the production of the Neisseria surface protein, and antibodies that bind to this protein are also disclosed.

4. 发明授权

US07410648B2 Polypeptides of Moraxella (Branhamella) catarrhalis 失效
标题翻译：莫拉氏杆菌（Branhamella）卡他氏菌多肽
公开(公告)号：US07410648B2
公开(公告)日：2008-08-12
申请号：US10495643
申请日：2002-11-15
申请人： Denis Martin , Josée Hamel , Bernard R. Brodeur , Stéphane Rioux , Julie Couture
发明人： Denis Martin , Josée Hamel , Bernard R. Brodeur , Stéphane Rioux , Julie Couture
IPC分类号： A61K39/02 , A61K39/00 , C07H21/04 , C07K14/00 , C12P21/04
CPC分类号： C07K14/212 , A61K38/00 , A61K39/1045 , C07K9/00 , C07K16/1214 , C07K19/00 , C07K2319/00 , C07K2319/21 , C12N5/10 , G01N33/53 , G01N33/569 , G01N33/56911
摘要： The present invention relates to polypeptides, more particularly polypeptides of Moraxella (Branhamella) catarrhalis which may be used to prevent, diagnose and/or treat Moraxella (Branhamella) catarrhalis infection.
摘要翻译：本发明涉及可用于预防，诊断和/或治疗莫拉氏菌（布拉汉氏菌）卡他莫氏菌感染的莫拉氏菌（布拉汉氏菌）卡他氏菌多肽。

5. 发明授权

US07329500B2 Moraxella (Branhamella) catarrhalis polypeptides and corresponding DNA fragments 失效
标题翻译：莫拉氏菌（Branhamella）卡他氏菌多肽和相应的DNA片段
公开(公告)号：US07329500B2
公开(公告)日：2008-02-12
申请号：US10487783
申请日：2002-08-27
申请人： Denis Martin , Josée Hamel , Bernard R. Brodeur , Stéphane Rioux , Julie Couture
发明人： Denis Martin , Josée Hamel , Bernard R. Brodeur , Stéphane Rioux , Julie Couture
IPC分类号： G01N33/53
CPC分类号： C07K14/212 , A61K39/00 , Y10S435/975
摘要： The present invention relates to polypeptides of Moraxella (Branhamela) catarrhalis which may be used for prophy-laxis, diagnostic and/or therapy purposes.
摘要翻译：本发明涉及可用于放射性泻药，诊断和/或治疗目的的莫拉氏菌（Branhamela）卡他氏菌多肽。

6. 发明申请

US20110182923A1 NOVEL GROUP B STREPTOCOCCUS ANTIGENS 有权
标题翻译：新组B STREPTOCOCCUS抗原
公开(公告)号：US20110182923A1
公开(公告)日：2011-07-28
申请号：US12980172
申请日：2010-12-28
申请人： Bernard R. Brodeur , Clément Rioux , Martine Boyer , Isabelle Charlebois , Josée Hamel , Denis Martin
发明人： Bernard R. Brodeur , Clément Rioux , Martine Boyer , Isabelle Charlebois , Josée Hamel , Denis Martin
IPC分类号： A61K39/09 , C12N15/63 , C12N1/00 , C12N5/10 , C12P21/00 , C07H21/00 , G01N33/566 , C07K14/315 , C07K16/12 , A61P37/04 , A61P31/04 , G01N33/569
CPC分类号： C07K14/315 , A61K39/00
摘要： Group B streptococcus (GBS) proteins and polynucleotides encoding them are disclosed. Said proteins are antigenic and therefore useful vaccine components for the prophylaxis or therapy of streptococcus infection in animals. Also disclosed are recombinant methods of producing the protein antigens as well as diagnostic assays for detecting streptococcus bacterial infection.
摘要翻译： B组链球菌（GBS）蛋白和编码它们的多核苷酸被公开。所述蛋白质是抗原性的，因此用于预防或治疗动物中链球菌感染的有用的疫苗组分。还公开了产生蛋白质抗原的重组方法以及用于检测链球菌细菌感染的诊断测定法。

7. 发明授权

US07914794B2 Group B streptococcus antigens 有权
标题翻译： B组链球菌抗原
公开(公告)号：US07914794B2
公开(公告)日：2011-03-29
申请号：US10340792
申请日：2003-01-13
申请人： Bernard R. Brodeur , Clément Rioux , Martine Boyer , Isabelle Charlebois , Josée Hamel , Denis Martin
发明人： Bernard R. Brodeur , Clément Rioux , Martine Boyer , Isabelle Charlebois , Josée Hamel , Denis Martin
IPC分类号： A61K39/09
CPC分类号： C07K14/315 , A61K39/00
摘要： Group B streptococcus (GBS) proteins and polynucleotides encoding them are disclosed. Said proteins are antigenic and therefore useful vaccine components for the prophylaxis or therapy of streptococcus infection in animals. Also disclosed are recombinant methods of producing the protein antigens as well as diagnostic assays for detecting streptococcus bacterial infection.
摘要翻译： B组链球菌（GBS）蛋白和编码它们的多核苷酸被公开。所述蛋白质是抗原性的，因此用于预防或治疗动物中链球菌感染的有用的疫苗组分。还公开了产生蛋白质抗原的重组方法以及用于检测链球菌细菌感染的诊断测定法。

8. 发明授权

US08580262B2 Group B Streptococcus antigens 有权
标题翻译： B组链球菌抗原
公开(公告)号：US08580262B2
公开(公告)日：2013-11-12
申请号：US13550363
申请日：2012-07-16
申请人： Bernard R. Brodeur , Clément Rioux , Martine Boyer , Isabelle Charlebois , Josée Hamel , Denis Martin
发明人： Bernard R. Brodeur , Clément Rioux , Martine Boyer , Isabelle Charlebois , Josée Hamel , Denis Martin
IPC分类号： A61K39/09
CPC分类号： C07K14/315 , A61K39/00
摘要： Group B streptococcus (GBS) proteins and polynucleotides encoding them are disclosed. Said proteins are antigenic and therefore useful vaccine components for the prophylaxis or therapy of streptococcus infection in animals. Also disclosed are recombinant methods of producing the protein antigens as well as diagnostic assays for detecting streptococcus bacterial infection.
摘要翻译： B组链球菌（GBS）蛋白和编码它们的多核苷酸被公开。所述蛋白质是抗原性的，因此用于预防或治疗动物中链球菌感染的有用的疫苗组分。还公开了产生蛋白质抗原的重组方法以及用于检测链球菌细菌感染的诊断测定法。

9. 发明申请

US20130095498A1 NOVEL GROUP B STREPTOCOCCUS ANTIGENS 有权
公开(公告)号：US20130095498A1
公开(公告)日：2013-04-18
申请号：US13550363
申请日：2012-07-16
申请人： Bernard R. Brodeur , Clément Rioux , Martine Boyer , Isabelle Charlebois , Josée Hamel , Denis Martin
发明人： Bernard R. Brodeur , Clément Rioux , Martine Boyer , Isabelle Charlebois , Josée Hamel , Denis Martin
IPC分类号： C07K14/315
CPC分类号： C07K14/315 , A61K39/00
摘要： Group B streptococcus (GBS) proteins and polynucleotides encoding them are disclosed. Said proteins are antigenic and therefore useful vaccine components for the prophylaxis or therapy of streptococcus infection in animals. Also disclosed are recombinant methods of producing the protein antigens as well as diagnostic assays for detecting streptococcus bacterial infection.

10. 发明授权

US07410645B2 Moraxella (Branhamella) catarrhalis antigens 失效
公开(公告)号：US07410645B2
公开(公告)日：2008-08-12
申请号：US10477592
申请日：2002-05-15
申请人： Denis Martin , Josée Hamel , Bernard R. Brodeur , Stéphane Rioux , Julie Couture
发明人： Denis Martin , Josée Hamel , Bernard R. Brodeur , Stéphane Rioux , Julie Couture
IPC分类号： A61K39/02 , A61K39/00 , A61K38/00 , C07H21/04 , C07K14/00 , C12P21/04
CPC分类号： C07K14/212 , A61K39/00 , C07K2319/00
摘要： The present invention relates to polypeptides of Moraxella(Branhamella) catarrhalis which may be useful for prophylaxis, diagnosis and/or therapy purposes. 1ATGGACACTG ACATGAAACA TTTAACAAAA CATCGCCTAT CAGCTGCCAT 51CATTGGCGTT TTATTATTCA TTAGCCCATC AGTGCAAGCA AATACGACAC 101ACCATCACAC GCTAACCAGT AGCGAGCTTA AACTTGCTGA TGATAGTATT 151ATTGATAGTA TCAATCAATT GGGTGAGCTG ACCGTCAATA TTCCAAATAC 201ACAATATTTT CAAACCAACA ACGGTGTGAG CGTTGCTTTT ACGCCATTAC 251ATGAGCTGCC TATTGTCGAT ATCAGCTTGT ATTTTAATGC AGGGTCAGCG 301TATCACCATC AGGTTGGCAA ATCAGGCACG GCTAACATGG TTGCAACCAT 351GCTCACCCAA GGAACTGACA GCCTTTCTGA AGATGAGTTT GTTGCTGCCA 401AAGAGCGTCT TCGCATTCAT TTTACCAGTA CAGCAAATAA GGATAACTTA 451ACTTTATCAT TAAGAAGCTT GTCTGATCAA TCATTATTAA ATCAAGCCGC 501CGATTTAATG GTCGATGCTG TCACTCAACC TGCTTTTGAT GATAAGACTC 551TACAACGCAA CAAAAATCAG CTCATCACCA GTTTAAAACA AAAAAAGCAA 601AACCCTTATC ATGTAGCTTC TGTTGCTTAT CATCAAGCCG TATATGAAAA 651TCATCCTTAT GCACACGCAA CCACAGGCGA TGAAGATAGT ATTGCCAAAA 701TTGATCGTGA TGAGCTGCTT AATTTTTGGC ATACTTTTAT TAATGCAAAT 751AATGCGACAC TGCTGATTAC AGGTGATATG ACCGCCGAGC AAGCCAAATC 801ACTTGCCAAC CATCTGACCG CCAAATTACC CACAGGCAAG TCGTATAAAA 851ATACGCTGGA TTTGACAAAA CCAGTTAAGG CTCGTCATAT CCATATTCCT 901CACAACAGTA GTCAAACCCA AATCATCATC GGTCATCCCA CCAGTAAAGT 951ACGCACGGAC AAAGCAGGTC GTCAAGAGTT CAGCGATTTT TCATTAGCTA 1001ATGAAATTTT GGCAGGTGGT GATTTTAATG CCAGATTGAT GAAAACCATT 1051CGAGAGCAAA AAGGCTACAC TTATGGCATT TATGGCGGTA TGGAACGCCT 1101CAGAGCAGGT GGTAATTATG TGGTTGAATT TTCAACCGAT GGCGATAAAG 1151CAGCCGATGC CATTTTAGAG ACGCTACACA TCATTAATCA GTCGCTGAAT 1201GAAGGCATAA CCCAAGAAGA GCTTGAGTTG GTGCGTTTGG GCAATAAAAA 1251TGGTTTTGCC AATATTTTTT CAAGCAATGC CAGTATTCAT CGTGTCATTC 1301GTGCTTTATT TGTTGCCGAT TATCCAAAAG ATCATCTTAA CCATACGCTC 1351AATCGCTTGG ATAATGCCAC GATAAATAGT GTTAATACCG CACTGAACTT 1401GCGTATCAAG CCTGATGAAT TTATCATCAT CACCGTGGGT AAAACTAAGC 1451CAAATTTGGA CAAATAA

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