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1. 发明授权

US08298154B2 Techniques for accurately deriving physiologic parameters of a subject from photoplethysmographic measurements 有权
标题翻译：用于从光体积描记测量精确地得出受试者生理参数的技术
公开(公告)号：US08298154B2
公开(公告)日：2012-10-30
申请号：US11972431
申请日：2008-01-10
申请人： Bernard F. Hete , Eric J Ayers
发明人： Bernard F. Hete , Eric J Ayers
IPC分类号： A61B5/0205
CPC分类号： A61B5/02416 , A61B5/02405 , A61B5/0816 , A61B5/0823 , A61B5/1455 , A61B5/7207 , A61B5/7253 , A61B5/7257
摘要： Several techniques are disclosed for isolating either heart or breath rate data from a photoplethysmograph, which is a time domain signal such as from a pulse oximeter. The techniques involve the use of filtering in the frequency domain, after a Fast Fourier Transform (FFT) has been conducted on a given photoplethysmograph also references as a given set of discrete time-domain data. The filtering may be applied to an identified fundamental frequency and one or more harmonics for heart related parameters. The filter may be truncated to the frequency data set and further applied multiple times to improve roll off. After filtering, an Inverse FFT (IFFT) is used to reconstruct the time-domain signal, except with undesirable frequency content eliminated or reduced. Calculation or measurement of parameters is then conducted on this reconstructed time-domain signal.
摘要翻译：公开了几种用于从例如来自脉搏血氧计的时间域信号的光电体积描记器中分离心脏或呼吸速率数据的技术。在对给定的光电体积描记仪进行快速傅里叶变换（FFT）之后，技术还涉及在频域中使用滤波，也可以将参考作为一组给定的离散时域数据。滤波可以应用于所识别的基频和用于心脏相关参数的一个或多个谐波。滤波器可以被截断为频率数据集，并进一步应用多次以改善滚降。滤波后，使用逆FFT（IFFT）重建时域信号，除了消除或减少不期望的频率内容。然后对该重构的时域信号进行参数的计算或测量。

2. 发明申请

US20120143071A1 ALGORITHMS FOR CALCULATION OF PHYSIOLOGIC PARAMETERS FROM NONINVASIVE PHOTOPLETHYSMOGRAPHIC SENSOR MEASUREMENTS OF AWAKE ANIMALS 审中-公开
标题翻译：用于计算动物动物非活动光电子传感器测量的生理参数的算法
公开(公告)号：US20120143071A1
公开(公告)日：2012-06-07
申请号：US13156489
申请日：2011-06-09
申请人： Bernard F. Hete , Eric J. Ayers , Eric W. Starr
发明人： Bernard F. Hete , Eric J. Ayers , Eric W. Starr
IPC分类号： A61B5/02
CPC分类号： A61B5/02416 , A61B5/7257 , A61B2503/40
摘要： A noninvasive photoplethysmographic sensor system for mobile animals such as small rodents, namely rats and mice is useful such as in a laboratory research environment. The noninvasive photoplethysmographic sensor for mobile animals such as small rodents utilizes multiple FFT's in the processing of the phtotoplethysmograophic signal, where each FFT has a different time record of the signals such as a number of points, or a zero padded FFTs. The noninvasive photoplethysmographic sensor for mobile animals provides actigraphy measurements for the animal.
摘要翻译：用于诸如小鼠和小鼠之类的移动动物的无创光电体积描记传感器系统是有用的，例如在实验室研究环境中。用于诸如小型啮齿动物的移动动物的非侵入性光电容积描记传感器在处理噬菌体同位素信号时利用多个FFT，其中每个FFT具有诸如点数或零填充FFT之类的信号的不同时间记录。用于移动动物的无创光电体积描记传感器为动物提供了动态测量。

3. 发明授权

US07857768B2 Integrated tail mounted blood pressure monitor and pulse oximeter system for animal research 有权
标题翻译：综合尾装血压计和脉搏血氧仪系统进行动物研究
公开(公告)号：US07857768B2
公开(公告)日：2010-12-28
申请号：US12249044
申请日：2008-10-10
申请人： Eric W Starr , Bernard F. Hete , Eric J Ayers
发明人： Eric W Starr , Bernard F. Hete , Eric J Ayers
IPC分类号： A61B5/0205 , A61B5/1455 , A61B5/022
CPC分类号： A61B5/02255 , A61B5/14552 , A61B2503/40
摘要： An integrated tail mounted blood pressure monitor and pulse oximeter system includes a tail blood flow occlusion member configured to selectively occlude blood flow through the tail; a sensor coupled to the tail blood flow occlusion member detecting a degree of operation thereof; Light sources coupled to the tail closer to the distal end of the tail than the tail blood flow occlusion member, and selectively directing light of two different wavelengths into the tail; a light receiver coupled to the tail and selectively receiving a signal associated with light directed into the tail from the light sources; and a controller configured to selectively determine blood pressure parameters from the data and pulse oximeter parameters from the data.
摘要翻译：综合的尾部安装的血压监测器和脉搏血氧计系统包括构造成选择性地阻塞穿过尾部的血流的尾部血流阻塞构件; 耦合到所述尾部血流阻塞构件的传感器，其检测其操作程度; 耦合到尾部的光源比尾部血流阻塞构件更靠近尾部的远端，并且选择性地将两种不同波长的光引导到尾部中; 耦合到尾部的光接收器并且选择性地接收与从光源引导到尾部中的光相关联的信号; 以及控制器，被配置为从数据中选择性地从数据和脉搏血氧计参数确定血压参数。

4. 发明申请

US20100145170A1 Small Animal Pulse Oximeter User Interface 审中-公开
标题翻译：小型动物脉搏血氧仪用户界面
公开(公告)号：US20100145170A1
公开(公告)日：2010-06-10
申请号：US12473244
申请日：2009-05-27
申请人： Eric J. Ayers , Bernard F. Hete , Patrick W. Truitt
发明人： Eric J. Ayers , Bernard F. Hete , Patrick W. Truitt
IPC分类号： A61B5/1455
CPC分类号： A61B5/02416 , A61B5/02405 , A61B5/0816 , A61B5/1455 , A61B5/7203 , G16H15/00 , G16H40/63
摘要： A user interface for a pulse oximetry device that calculates physiologic parameters of a subject including at least a subject's heart rate and SpO2, is disclosed wherein the interface comprises a graphical display of at least one raw data signal of the pulse oximetry device that maintains heart and breath rate components and a display of the calculated heart rate and SpO2 of the subject. The interface may further include a user selectable data averaging function in which the interface is configured to selectively obtain and display averages of at least some of the calculated physiologic parameters over a defined period. The interface may further include a user selectable noise suppression function for the displayed data.
摘要翻译：公开了一种用于计算包括至少受试者的心率和SpO2的对象的生理参数的脉搏血氧饱和度测量装置的用户界面，其中所述界面包括维持心脏的脉搏血氧仪装置的至少一个原始数据信号的图形显示，呼吸速率组分和显示计算的心率和受试者的SpO2。接口还可以包括用户可选择的数据平均功能，其中接口被配置为在规定的周期内选择性地获得和显示所计算的生理参数中的至少一些的平均值。接口还可以包括用于所显示的数据的用户可选噪声抑制功能。

5. 发明申请

US20130085354A1 TECHNIQUES FOR ACCURATELY DERIVING PHYSIOLOGIC PARAMETERS OF A SUBJECT FROM PHOTOPLETHYSMOGRAPHIC MEASUREMENTS 审中-公开
标题翻译：从光电子能谱测量中精确获取物理生物学参数的技术
公开(公告)号：US20130085354A1
公开(公告)日：2013-04-04
申请号：US13626083
申请日：2012-09-25
申请人： Bernard F. Hete , Eric J. Ayers
发明人： Bernard F. Hete , Eric J. Ayers
IPC分类号： A61B5/1455 , A61B5/0205
CPC分类号： A61B5/14551 , A61B5/0205 , A61B5/02405 , A61B5/02416 , A61B5/0816 , A61B5/7207 , A61B5/7253 , A61B5/7257 , A61B5/7278
摘要： Several techniques are disclosed for isolating either heart or breath rate data from a photoplethysmograph, which is a time domain signal such as from a pulse oximeter. The techniques involve the use of filtering in the frequency domain, after a Fast Fourier Transform (FFT) has been conducted on a given photoplethysmograph also references as a given set of discrete time-domain data. The filtering may be applied to an identified fundamental frequency and one or more harmonics for heart related parameters. The filter may be truncated to the frequency data set and further applied multiple times to improve roll off. After filtering, an Inverse FFT (IFFT) is used to reconstruct the time-domain signal, except with undesirable frequency content eliminated or reduced. Calculation or measurement of parameters is then conducted on this reconstructed time-domain signal.
摘要翻译：公开了几种用于从例如来自脉搏血氧计的时间域信号的光电体积描记器中分离心脏或呼吸速率数据的技术。在对给定的光电体积描记仪进行快速傅里叶变换（FFT）之后，技术还涉及在频域中使用滤波，也可以将参考作为一组给定的离散时域数据。滤波可以应用于所识别的基频和用于心脏相关参数的一个或多个谐波。滤波器可以被截断为频率数据集，并进一步应用多次以改善滚降。滤波后，使用逆FFT（IFFT）重建时域信号，除了消除或减少不期望的频率内容。然后对该重构的时域信号进行参数的计算或测量。

6. 发明授权

US08359079B2 Pulse oximetry system and techniques for deriving cardiac and breathing parameters from extra-thoracic blood flow measurements 有权
标题翻译：脉搏血氧饱和度测定系统和技术，用于从胸外血流测量中得出心脏和呼吸参数
公开(公告)号：US08359079B2
公开(公告)日：2013-01-22
申请号：US11858879
申请日：2007-09-20
申请人： Bernard F. Hete , Eric W Starr , Eric J Ayers
发明人： Bernard F. Hete , Eric W Starr , Eric J Ayers
IPC分类号： A61B5/1455
CPC分类号： A61B5/14551 , A61B5/02416 , A61B5/0816 , A61B5/7257 , A61B5/7278 , A61B2503/40
摘要： Medical devices and techniques derive breath rate, breath distention, and pulse distention measurements of a subject from a pulse oximeter system coupled to a subject. These parameters, together with the conventional physiologic parameters obtained from a pulse oximeter system, can be used to assist in controlling the ventilation levels and the anesthesia levels of the subject. The development has human applications and particular applications for animal research.
摘要翻译：医疗装置和技术从耦合到受试者的脉搏血氧计系统获得受试者的呼吸速率，呼吸膨胀和脉搏扩张测量。这些参数以及从脉搏血氧计系统获得的常规生理参数可用于帮助控制受试者的通气水平和麻醉水平。该发展具有人类应用和动物研究的特殊应用。

7. 发明授权

US07922666B2 Pulse oximeter based techniques for controlling anesthesia levels and ventilation levels in subjects 失效
标题翻译：基于脉搏血氧仪的技术，用于控制受试者的麻醉水平和通气水平
公开(公告)号：US07922666B2
公开(公告)日：2011-04-12
申请号：US11858881
申请日：2007-09-20
申请人： Eric W Starr , Eric J Ayers , Bernard F. Hete
发明人： Eric W Starr , Eric J Ayers , Bernard F. Hete
IPC分类号： A61B5/0205 , A61B5/1455 , A61B5/024
CPC分类号： A61B5/02007 , A61B5/0205 , A61B5/0816 , A61B5/14551 , A61B5/14552 , A61B5/4821 , A61B5/7257 , A61B5/746 , A61B2503/40 , A61M16/0051 , A61M16/01 , A61M16/024
摘要： Medical devices and techniques derive breath rate, breath distention, and pulse distention measurements of a subject from a pulse oximeter system coupled to the subject. These parameters together with the conventional physiologic parameters obtained from a pulse oximeter system can be used to assist in controlling the ventilation levels and the anesthesia levels of the subject. The development has human applications and particular application for animal research.
摘要翻译：医疗装置和技术从耦合到受试者的脉搏血氧计系统获得受试者的呼吸速率，呼吸膨胀和脉搏扩张测量。这些参数与从脉搏血氧计系统获得的常规生理参数一起可用于帮助控制受试者的通气水平和麻醉水平。该发展具有人类应用和动物研究的特殊应用。

8. 发明申请

US20100160751A1 PHOTOPLETHYSMOGRAPHIC SENSOR BASED BLOOD GAS MONITOR DEVICE FOR ANALYSIS, RESEARCH AND CALIBRATION IN AN EXTRACORPOREAL CIRCUIT OR EXTRACORPOREAL PULSE SIMULATION SYSTEM 审中-公开
标题翻译：基于光电传感器的血液气体监测装置，用于在外部电路或外部脉冲模拟系统中进行分析，研究和校准
公开(公告)号：US20100160751A1
公开(公告)日：2010-06-24
申请号：US12704024
申请日：2010-02-11
申请人： Bernard F. Hete , Eric W. Starr , Eric J. Ayers
发明人： Bernard F. Hete , Eric W. Starr , Eric J. Ayers
IPC分类号： A61B5/1455
CPC分类号： G01N33/4925 , A61B5/14557
摘要： A blood oxygenation monitoring device may comprise an extracorporeal pulse simulation system including one at least partially transparent blood holding element with a photoplethysmographic sensor coupled to the element and adapted to measure particular gas content of the blood. The system includes a pulse simulation mechanism configured to simulate pulsatile behavior of the blood within the element relative to the photoplethysmographic sensors. The blood holding element may be a reservoir, wherein the pulse simulation mechanism includes a magnetic stirrer and stir bar within the reservoir. The blood holding member may be flexible tubing having blood flow there through, wherein the pulse simulation mechanism is a peristaltic pump coupled to the tubing. The monitoring device can rapidly and accurately form oxygen dissociation curves. The monitoring device can be utilized in conjunction with a heart lung bypass machine or other extra corporeal circuit devices or can be a calibration tool for sensors.
摘要翻译：血氧监测装置可以包括体外脉冲模拟系统，其包括一个至少部分透明的血液保持元件，其具有耦合到该元件的光电容积传感器传感器，并且适于测量血液的特定气体含量。该系统包括脉冲模拟机构，其被配置为模拟元件内相对于光电容积传感器的血液的脉动行为。血液保持元件可以是储存器，其中脉冲模拟机构包括储存器内的磁力搅拌器和搅拌棒。血液保持构件可以是具有血液流过的柔性管，其中脉冲模拟机构是联接到管道的蠕动泵。监测装置可以快速准确地形成氧解离曲线。监测装置可以与心脏肺旁路机或其他额外的物理电路装置结合使用，或者可以是用于传感器的校准工具。

9. 发明申请

US20090099425A1 INTEGRATED TAIL MOUNTED BLOOD PRESSURE MONITOR AND PULSE OXIMETER SYSTEM FOR ANIMAL RESEARCH 有权
标题翻译：用于动物研究的综合尾栓血压监测器和脉冲OMS系统
公开(公告)号：US20090099425A1
公开(公告)日：2009-04-16
申请号：US12249044
申请日：2008-10-10
申请人： Eric W. Starr , Bernard F. Hete , Eric J. Ayers
发明人： Eric W. Starr , Bernard F. Hete , Eric J. Ayers
IPC分类号： A61B5/1455 , A61B5/0205 , A61B5/022
CPC分类号： A61B5/02255 , A61B5/14552 , A61B2503/40
摘要： An integrated tail mounted blood pressure monitor and pulse oximeter system includes a tail blood flow occlusion member configured to selectively occlude blood flow through the tail; a sensor coupled to the tail blood flow occlusion member detecting a degree of operation thereof; Light sources coupled to the tail closer to the distal end of the tail than the tail blood flow occlusion member, and selectively directing light of two different wavelengths into the tail; a light receiver coupled to the tail and selectively receiving a signal associated with light directed into the tail from the light sources; and a controller configured to selectively determine blood pressure parameters from the data and pulse oximeter parameters from the data.
摘要翻译：综合的尾部安装的血压监测器和脉搏血氧计系统包括构造成选择性地阻塞穿过尾部的血流的尾部血流阻塞构件; 耦合到所述尾部血流阻塞构件的传感器，其检测其操作程度; 耦合到尾部的光源比尾部血流阻塞构件更靠近尾部的远端，并且选择性地将两种不同波长的光引导到尾部中; 耦合到尾部的光接收器并且选择性地接收与从光源引导到尾部中的光相关联的信号; 以及控制器，被配置为从数据中选择性地从数据和脉搏血氧计参数确定血压参数。

10. 发明申请

US20080262326A1 Signal Processing Method and Apparatus for Processing a Physiologic Signal such as a Photoplethysmography Signal 审中-公开
标题翻译：用于处理诸如光电体积描记信号的生理信号的信号处理方法和装置
公开(公告)号：US20080262326A1
公开(公告)日：2008-10-23
申请号：US12106781
申请日：2008-04-21
申请人： Bernard F. Hete , Eric J. Ayers
发明人： Bernard F. Hete , Eric J. Ayers
IPC分类号： A61B5/1455
CPC分类号： A61B5/14551 , A61B5/02416 , A61B5/0816
摘要： A signal processing method of processing a physiologic signal, such as a Photoplethysmography Signal having at least some cardiac components and/or respirator components in the physiologic signal, the processing including the steps of: Identifying a potential cardiac and or respiratory components of a physiologic signal wherein the potential cardiac and or respiratory components have a series of peaks and valleys; Calculating a comparison of the durations of a peak to valley sub-component and a valley to peak sub component of the potential cardiac and or respiratory components; and Utilizing the calculated comparison to evaluate the potential cardiac and or respiratory components.
摘要翻译：一种处理生理信号的信号处理方法，例如在生理信号中具有至少一些心脏成分和/或呼吸器成分的光电体积描记信号，所述处理包括以下步骤：识别生理信号的潜在心脏和/或呼吸成分其中所述潜在心脏和/或呼吸成分具有一系列峰和谷; 计算潜在的心脏和/或呼吸成分的峰谷亚组分的持续时间和谷到峰次分量的比较; 并利用计算的比较来评估潜在的心脏和/或呼吸成分。

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