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1. 发明申请

US20110085950A1 CENTRIFUGAL FORCE BASED MICROFLUIDIC SYSTEM AND BIO CARTRIDGE FOR THE MICROFLUIDIC SYSTEM 审中-公开
标题翻译：基于离散力的微流体系统和微生物系统的生物盒
公开(公告)号：US20110085950A1
公开(公告)日：2011-04-14
申请号：US12575635
申请日：2009-10-08
申请人： Beom Seok LEE , Jeong Gun LEE , Yoon Kyoung CHO , Ki Eun KIM , Jung Nam LEE
发明人： Beom Seok LEE , Jeong Gun LEE , Yoon Kyoung CHO , Ki Eun KIM , Jung Nam LEE
IPC分类号： G01N33/50 , B01L3/00 , G01N1/38 , G01N21/77
CPC分类号： G01N35/00029 , B01L3/50273 , B01L2200/027 , B01L2200/04 , B01L2200/12 , B01L2300/0806 , B01L2300/087 , B01L2400/0409 , B01L2400/0677 , G01N21/07 , G01N2035/00495
摘要： A microfluidic system based on centrifugal force and a bio cartridge for the microfluidic system are provided. The system includes a spindle motor, a rotatable frame detachably mounted on the motor and having a plurality of cells separated by partition walls, and the bio cartridge detachably accommodated in one of the plurality of cells. The bio cartridge includes a chamber for storing a fluid, a channel for transporting the fluid, and a valve for controlling the flow of the fluid. The valve may include a phase transition material, and exothermic minute particles dispersed in the material and generating heat when energy is applied thereto.
摘要翻译：提供了基于离心力的微流体系统和用于微流体系统的生物药筒。该系统包括主轴电动机，可拆卸地安装在电动机上的可旋转框架，并且具有由分隔壁隔开的多个单元，以及可拆卸地容纳在多个单元之一中的生物盒。生物药筒包括用于存储流体的腔室，用于输送流体的通道和用于控制流体流动的阀。阀可以包括相变材料，并且散热的微小颗粒在能量被施加到材料中时产生热量。

2. 发明申请

US20110201101A1 CENTRIFUGAL FORCE-BASED MICROFLUIDIC DEVICE FOR PROTEIN DETECTION AND MICROFLUIDIC SYSTEM INCLUDING THE SAME 审中-公开
标题翻译：用于蛋白质检测的基于离心力的微流体装置和包括其的微流感系统
公开(公告)号：US20110201101A1
公开(公告)日：2011-08-18
申请号：US13035654
申请日：2011-02-25
申请人： Beom Seok LEE , Yoon Kyoung CHO , Jeong Gun LEE , Jong Myeon PARK
发明人： Beom Seok LEE , Yoon Kyoung CHO , Jeong Gun LEE , Jong Myeon PARK
IPC分类号： C12M1/34 , G01N9/30
CPC分类号： B01L3/502738 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2300/0806 , B01L2300/0867 , B01L2300/1861 , B01L2400/0409 , B01L2400/0442 , B01L2400/0633 , B01L2400/0677 , B01L2400/0688 , G01N33/54326 , G01N33/54366 , Y10T436/25375
摘要： Disclosed is a microfluidic structure and a microfluidic device comprising the microfluidic device, which is suitable for detecting a target material. The microfluidic structure mixes the beads, biological samples, and the detection probe to react and washes and separates the beads after the reaction.
摘要翻译：公开了一种微流体结构和包含微流体装置的微流体装置，其适合于检测目标材料。微流体结构混合珠，生物样品和检测探针，以在反应后反应并洗涤和分离珠粒。

3. 发明申请

US20110020194A1 CENTRIFUGAL FORCE-BASED MICROFLUIDIC DEVICE FOR PROTEIN DETECTION AND MICROFLUIDIC SYSTEM INCLUDING THE SAME 有权
标题翻译：用于蛋白质检测的基于离心力的微流体装置和包括其的微流感系统
公开(公告)号：US20110020194A1
公开(公告)日：2011-01-27
申请号：US12851819
申请日：2010-08-06
申请人： Beom Seok LEE , Yoon Kyoung CHO , Jeong Gun LEE , Jong-myeon PARK
发明人： Beom Seok LEE , Yoon Kyoung CHO , Jeong Gun LEE , Jong-myeon PARK
IPC分类号： G01N33/53 , G01N21/75
CPC分类号： B01L3/502738 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2300/0806 , B01L2300/0867 , B01L2300/1861 , B01L2400/0409 , B01L2400/0442 , B01L2400/0633 , B01L2400/0677 , B01L2400/0688 , G01N33/54326 , G01N33/54366 , Y10T436/25375
摘要： A centrifugal force-based microfluidic device for the detection of a target biomolecule and a microfluidic system including the same are provided. The device includes a body of revolution; a microfluidic structure disposed in the body of revolution including chambers, channels connecting the chambers, and valves disposed in the channels to control fluid flow, the microfluidic structures transmitting fluid using centrifugal force due to rotation of the body of revolution; and beads disposed in the microfluidic structures, the beads having capture probes on the surfaces thereof which are selectively bonded with target protein; and a detection probe disposed in the microfluidic structures and selectively bonded to the target protein, and which includes a material required to express an optical signal, wherein the microfluidic structure mixes the beads, biological samples, and the detection probe to react and washes and separates the beads after the reaction.
摘要翻译：提供了用于检测靶生物分子的离心力微流体装置和包括其的微流体系统。该装置包括一个革命体; 设置在旋转体中的微流体结构，包括腔室，连接腔室的通道，以及设置在通道中的阀，以控制流体流动，微流体结构由于旋转体旋转而使用离心力传送流体; 和珠子，其设置在微流体结构中，珠粒在其表面上具有与靶蛋白质选择性结合的捕获探针; 以及设置在微流体结构中并选择性地结合到靶蛋白上并且包括表达光信号所需的材料的检测探针，其中微流体结构混合珠，生物样品和检测探针以反应和洗涤和分离反应后的珠子。

4. 发明申请

US20100081213A1 CENTRIFUGAL-BASED MICROFLUIDIC APPARATUS, METHOD OF FABRICATING THE SAME, AND METHOD OF TESTING SAMPLES USING THE MICROFLUIDIC APPARATUS 有权
标题翻译：基于离心的微流体装置，其制造方法和使用微流控装置测试样品的方法
公开(公告)号：US20100081213A1
公开(公告)日：2010-04-01
申请号：US12569437
申请日：2009-09-29
申请人： Beom Seok LEE , Ji Won KIM , Jeong Gun LEE , Kui Hyun KIM
发明人： Beom Seok LEE , Ji Won KIM , Jeong Gun LEE , Kui Hyun KIM
IPC分类号： G01N33/564 , G01N1/28 , B01J8/00 , C25B9/00 , G01N21/00 , G01N21/75 , G01N21/72
CPC分类号： B01L3/50273 , B01L3/502738 , B01L3/545 , B01L2200/0621 , B01L2200/0689 , B01L2200/10 , B01L2300/021 , B01L2300/0806 , B01L2300/0816 , B01L2300/0861 , B01L2300/161 , B01L2300/1827 , B01L2400/0406 , B01L2400/0409 , B01L2400/0677 , G01N21/07 , G01N33/54386 , G01N35/00069
摘要： Provided is a microfluidic apparatus including: a microfluidic structure for providing spaces for receiving a fluid and for forming channels, through which the fluid flows; and valves for controlling the flow of fluid through the channels in the microfluidic apparatus. The microfluidic structure includes: a sample chamber; a sample separation unit receiving the sample from the sample chamber and separating a supernatant from the sample by using a centrifugal force; a testing unit receiving the supernatant from the sample separation unit for detecting a specimen from the supernatant using an antigen-antibody reaction, and a quality control chamber for identifying reliability of the test.
摘要翻译：提供了一种微流体装置，包括：微流体结构，用于提供用于接收流体的空间和用于形成流体流过的通道; 以及用于控制通过微流体装置中的通道的流体流动的阀。微流体结构包括：样品室; 样品分离单元，从样品室接收样品，并通过离心力从样品中分离上清液; 接收来自样品分离单元的上清液的测试单元，用于使用抗原 - 抗体反应从上清液检测样品;以及质量控制室，用于识别测试的可靠性。

5. 发明申请

US20100092985A1 SOLID SUPPORT WITH ENHANCED DENSITY OF SIGNAL MATERIAL, KIT CONTAINING THE SAME AND METHOD OF DETECTING TARGET MATERIAL USING THE SAME 审中-公开
标题翻译：具有增强的信号密度的固体支持，包含该材料的试剂盒及使用其检测目标材料的方法
公开(公告)号：US20100092985A1
公开(公告)日：2010-04-15
申请号：US12578628
申请日：2009-10-14
申请人： Beom Seok LEE , Jeong Gun LEE , Jeong Woo CHOI , Byung Keun OH
发明人： Beom Seok LEE , Jeong Gun LEE , Jeong Woo CHOI , Byung Keun OH
IPC分类号： C12Q1/68 , G01N33/544 , G01N33/553 , G01N33/545
CPC分类号： G01N33/54306 , B82Y15/00
摘要： A solid support on which a labeled nucleic acid including a high density of signal materials, a kit containing the same, and a method of detecting a target material are provided.
摘要翻译：提供了包含高密度信号材料的标记核酸的固体支持物，含有其的试剂盒和检测靶材料的方法。

6. 发明申请

US20100086925A1 MICROFLUIDIC STRUCTURE FOR MULTI-ASSAY AND MICROFLUIDIC DEVICE COMPRISING THE SAME 审中-公开
标题翻译：包含其的多测定和微流体装置的微流体结构
公开(公告)号：US20100086925A1
公开(公告)日：2010-04-08
申请号：US12494383
申请日：2009-06-30
申请人： Jung Nam LEE , Beom Seok LEE , Kui Hyun KIM , Ji Won KIM
发明人： Jung Nam LEE , Beom Seok LEE , Kui Hyun KIM , Ji Won KIM
IPC分类号： C12Q1/68 , C12M1/34 , G01N33/53
CPC分类号： G01N33/54366 , B01L3/5027 , B01L2200/10 , B01L2300/0806 , B01L2300/0867 , B01L2400/0409
摘要： Exemplary embodiments relate to a microfluidic structure including: a plurality of sample chambers; a reaction chamber in which at least two types of materials, which respectively specifically react with at least two types of target materials, are immobilized; a detection chamber connected to the reaction chamber; a path connecting the chambers; and a valve for opening and closing the path, and a microfluidic device including the microfluidic structure. Since at least two types of materials specifically binding to target materials are immobilized in a reaction chamber of the microfluidic structure, space may be efficiently used and the target materials may be assayed in a one-step test. An internal space of the microfluidic device using the microfluidic structure, the amount of samples, and costs for manufacturing the microfluidic device may be reduced, and internal quality control may be efficiently performed using the microfluidic structure as a control for the operations.
摘要翻译：示例性实施例涉及微流体结构，包括：多个样品室; 其中固定有分别与至少两种类型的目标材料特异性反应的至少两种类型的材料的反应室; 连接到所述反应室的检测室; 连接室的路径; 以及用于打开和关闭路径的阀以及包括微流体结构的微流体装置。由于特异性结合目标材料的至少两种类型的材料被固定在微流体结构的反应室中，所以可以有效地使用空间，并且可以在一步测试中测定目标材料。可以减少使用微流体结构的微流体装置的内部空间，样品量和制造微流体装置的成本，并且可以使用微流体结构作为操作的控制来有效地执行内部质量控制。

7. 发明申请

US20110124132A1 CENTRIFUGAL MICRO-FLUIDIC DEVICE AND METHOD FOR DETECTING TARGET IN FLUID SAMPLE 审中-公开
标题翻译：离心微流体装置和检测流体样品中的目标的方法
公开(公告)号：US20110124132A1
公开(公告)日：2011-05-26
申请号：US12894683
申请日：2010-09-30
申请人： In Wook KIM , Beom Seok LEE , Kui Hyun KIM , Ji Won KIM
发明人： In Wook KIM , Beom Seok LEE , Kui Hyun KIM , Ji Won KIM
IPC分类号： G01N33/553 , G01N30/00 , B01L3/00 , C12M1/34 , G01N27/00 , G01N21/00 , G01N21/76
CPC分类号： G01N21/07 , B01L3/50273 , B01L3/502753 , B01L2300/0806 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0409 , G01N33/54313 , G01N33/54346 , G01N35/00069
摘要： Disclosed are a centrifugal micro-fluidic device and an immunosorbent assay method using the same. In particular, a centrifugal micro-fluidic device having a plurality of micro-fluidic structures placed in a disc type platform to simultaneously conduct several immunosorbent assays, as well as an immunosorbent assay method using the same are provided.
摘要翻译：公开了一种使用其的离心微流体装置和免疫吸附测定方法。特别地，提供了具有多个微流体结构的离心微流体装置，其放置在盘型平台中以同时进行几种免疫吸附测定，以及使用其的免疫吸附测定方法。

8. 发明申请

US20110091356A1 MICRO-FLUIDIC DEVICE AND SAMPLE TESTING METHOD USING THE SAME 审中-公开
标题翻译：微流体装置和使用其的样品测试方法
公开(公告)号：US20110091356A1
公开(公告)日：2011-04-21
申请号：US12884762
申请日：2010-09-17
申请人： Kui Hyun KIM , Beom Seok LEE , In Wook KIM , Ji Won KIM , Yang Ui LEE
发明人： Kui Hyun KIM , Beom Seok LEE , In Wook KIM , Ji Won KIM , Yang Ui LEE
IPC分类号： G01N33/00
CPC分类号： F16K99/003 , B01L3/502738 , B01L2300/0803 , B01L2300/1861 , B01L2400/0409 , B01L2400/0677 , F16K99/0001 , F16K99/0032 , F16K99/004 , F16K2099/0084
摘要： A micro-fluidic device containing an anti-coagulant and a sample testing apparatus equipped with the same are provided. The micro-fluidic device includes a sample chamber which receives a sample, an anti-coagulant chamber which receives an anti-coagulant, a channel which communicably connects the sample chamber to the anti-coagulant chamber, and a valve which opens and closes the channel.
摘要翻译：提供含有抗凝剂的微流体装置和装备有该装置的样品测试装置。微流体装置包括容纳样品的样品室，接收抗凝剂的抗凝剂室，将样品室与抗凝剂室可通信地连接的通道和打开和关闭通道的阀。

9. 发明申请

US20120178182A1 MICROFLUIDIC DEVICE AND ANALYTE DETECTION METHOD USING THE SAME 审中-公开
标题翻译：微流体装置和使用其的分析物检测方法
公开(公告)号：US20120178182A1
公开(公告)日：2012-07-12
申请号：US13345134
申请日：2012-01-06
申请人： Kui Hyun KIM , Beom Seok LEE
发明人： Kui Hyun KIM , Beom Seok LEE
IPC分类号： G01N21/75 , B01L3/00
CPC分类号： B01L3/502738 , B01L2300/1838 , B01L2300/1861 , B01L2400/0677 , G01N33/54366
摘要： Provided are a micro-fluidic device having multiple reaction chambers to simultaneously detect a plurality of different analytes, and an analyte detection method using the same. The micro-fluidic device includes multiple reaction chambers containing a plurality of capture materials to be combined with different analytes, multiple channels connecting the multiple reaction chambers, and valves provided within the multiple channels to control fluid flowing through the channels.
摘要翻译：提供了具有多个反应室以同时检测多种不同分析物的微流体装置和使用其的分析物检测方法。微流体装置包括多个反应室，其包含多个捕获材料以与不同的分析物组合，连接多个反应室的多个通道以及设置在多个通道内的阀，以控制流过通道的流体。

10. 发明申请

US20110070603A1 DISC FOR TESTING BLOOD, BLOOD TESTER HAVING THE SAME, AND CONTROL METHOD THEREOF 审中-公开
标题翻译：用于测试血液的盘，具有该血液的血液检测器及其控制方法
公开(公告)号：US20110070603A1
公开(公告)日：2011-03-24
申请号：US12862138
申请日：2010-08-24
申请人： Ji Won KIM , Beom Seok LEE , In Wook KIM , Kui Hyum KIM
发明人： Ji Won KIM , Beom Seok LEE , In Wook KIM , Kui Hyum KIM
IPC分类号： C12Q1/02 , C12M1/34 , C12M1/38
CPC分类号： G01N33/487
摘要： Disclosed are a blood tester for measurement of temperature of a sample placed in a blood-testing disc using a thermochromic pigment, and a control method thereof. The disclosed blood-testing disc, the blood tester having the blood-testing disc loaded therein, and the control method of the same, are used to measure a light absorbance of the thermochromic pigment in order to determine a temperature of a sample when a biological material such as blood, blood serum, blood plasma, or sputum, is subjected to analysis, so that the test may be executed at a constant temperature. Accordingly, more reproducible and accurate results are obtainable, and temperature measurement of a sample may be simply and effectively attained by an optical analyzer built in the blood tester, without an alternative instrument or sensor for measurement thereof.
摘要翻译：公开了使用热变色颜料测量放置在血液测试盘中的样品的温度的血液测试仪及其控制方法。所公开的血液测试盘，其中装有血液测试盘的血液测试仪及其控制方法用于测量热致变色素的吸光度，以便当生物学对血液，血清，血浆，痰等材料进行分析，可以在恒温下进行试验。因此，可以获得更多的可再现和准确的结果，并且可以通过内置在血液测试仪中的光学分析器简单有效地获得样品的温度测量，而不需要用于测量的替代仪器或传感器。

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