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1. 发明授权

US5324351A Aqueous dispersions of zein and preparation thereof 失效
标题翻译：玉米蛋白的水分散体及其制备
公开(公告)号：US5324351A
公开(公告)日：1994-06-28
申请号：US930107
申请日：1992-08-13
申请人： Benjamin Oshlack , Mark Chasin , James McGinity , Roland Bodmeier
发明人： Benjamin Oshlack , Mark Chasin , James McGinity , Roland Bodmeier
IPC分类号： A23G4/00 , A23J3/18 , A23L1/00 , A23P1/08 , A61K9/28 , A61K9/50 , A61K9/64 , A61K47/42 , C07K14/415 , C08J3/07 , C08L89/00 , C09D189/00
CPC分类号： C08J3/07 , A23J3/18 , A23P20/10 , A61K9/2873 , A61K9/5052 , A61K9/5078 , C08L89/00 , C09D189/00 , C08J2389/00
摘要： Aqueous dispersions of zein which may be used in the coating of pharmaceutical, animal, health, or food products in an inorganic solvent-free environment are disclosed, as well as methods for preparing the same.
摘要翻译：公开了可用于无机溶剂环境中的药物，动物，健康或食品涂料中的玉米醇溶蛋白的水分散体及其制备方法。

2. 发明授权

US5356467A Controlled release coatings derived from aqueous dispersions of zein 失效
标题翻译：衍生自玉米醇溶蛋白水分散体的控制释放涂层
公开(公告)号：US5356467A
公开(公告)日：1994-10-18
申请号：US103887
申请日：1993-08-06
申请人： Benjamin Oshlack , James McGinity , Mark Chasin , Roland Bodmeier
发明人： Benjamin Oshlack , James McGinity , Mark Chasin , Roland Bodmeier
IPC分类号： A23G4/00 , A23J3/18 , A23L1/00 , A23P1/08 , A61K9/28 , A61K9/50 , A61K9/64 , A61K47/42 , C07K14/415 , C08J3/07 , C08L89/00 , C09D189/00
CPC分类号： C08J3/07 , A23J3/18 , A23P20/10 , A61K9/2873 , A61K9/5052 , A61K9/5078 , C08L89/00 , C09D189/00 , C08J2389/00
摘要： Stable aqueous dispersions of zein which may be used as controlled release coatings of pharmaceutical, animal, health, or food products in an inorganic solvent-free environment are disclosed, as well as methods for preparing the same.
摘要翻译：公开了稳定的玉米醇溶蛋白水分散体，其可用作无机溶剂环境中药物，动物，健康或食品的控制释放包衣，以及其制备方法。

3. 发明授权

US07303756B1 Multiphase system 失效
标题翻译：多相系统
公开(公告)号：US07303756B1
公开(公告)日：2007-12-04
申请号：US09445311
申请日：1998-06-05
申请人： Roland Bodmeier
发明人： Roland Bodmeier
IPC分类号： A61F13/00 , A61K9/14 , A61K9/16
CPC分类号： A61K9/0024 , A61K9/10 , A61K9/107
摘要： The invention relates to a preparation comprising a carrier phase and at least one further phase which cannot be mixed with the carrier phase or only partially mixed therewith, wherein the change in ambient conditions alters the viscosity of the carrier phase. The invention also relates to a method for the production thereof and to particles and implants containing said preparations. The inventive preparations can contain various active substances with a delayed release action.
摘要翻译：本发明涉及包含载体相和不能与载体相混合或仅与其部分混合的至少一个其它相的制剂，其中环境条件的变化改变了载体相的粘度。本发明还涉及其制备方法和含有所述制剂的颗粒和植入物。本发明的制剂可以含有具有延迟释放作用的各种活性物质。

4. 发明授权

US09668998B2 Solid molecular dispersion of fesoterodine hydrogen fumarate and polymeric binder 有权
公开(公告)号：US09668998B2
公开(公告)日：2017-06-06
申请号：US13978887
申请日：2012-01-17
申请人： Roland Bodmeier , Alan Francis Carmody , Mesut Ciper , Anne Therese Gustaaf De Paepe , John Mark Heimlich , Martin Korber , Mathias Walther , Neil Feeder
发明人： Roland Bodmeier , Alan Francis Carmody , Mesut Ciper , Anne Therese Gustaaf De Paepe , John Mark Heimlich , Martin Korber , Mathias Walther , Neil Feeder
IPC分类号： A61K31/222 , A61K31/22 , A61K47/38 , A61K9/10 , A61K9/14 , A61K9/16 , A61K9/20 , A61K9/50 , A61K9/08
CPC分类号： A61K31/222 , A61K9/08 , A61K9/10 , A61K9/146 , A61K9/1652 , A61K9/1676 , A61K9/1694 , A61K9/2054 , A61K9/5078 , A61K31/22 , A61K47/38
摘要： The present invention relates to a solid molecular dispersion of from 3:97 to 12:88 weight % ratio of fesoterodine hydrogen fumarate and a polymeric binder selected from the group consisting of an alkyl hydroxyalkylcellulose ether, a hydroxyalkylcellulose ether, an ester of either thereof, and a mixture of any two or more thereof.

5. 发明授权

US07820202B2 Extended release particle dispersion 有权
标题翻译：延长释放颗粒分散体
公开(公告)号：US07820202B2
公开(公告)日：2010-10-26
申请号：US10378733
申请日：2003-03-04
申请人： Roland Bodmeier
发明人： Roland Bodmeier
IPC分类号： A61K9/14 , A61K9/16 , A61K9/50
CPC分类号： A61K9/1694 , A61K9/1647
摘要： The invention relates to extended release compositions that can be advantageously used as drug products, plant protection agents, in foods or other products. The invention especially relates to liquid compositions in which extended release particles are dispersed. The compositions according to this invention are available in the form of single-dose or multi-dose compositions and as such are produced from liquid preproducts. The invention further relates to kits and methods for producing the compositions and to the preproducts thereof.
摘要翻译：本发明涉及可有利地用作药物产品，植物保护剂，食品或其他产品的延长释放组合物。本发明特别涉及其中分散有延长释放颗粒的液体组合物。根据本发明的组合物可以单剂量或多剂量组合物的形式获得，因此由液体前产物制备。本发明还涉及用于制备组合物及其前产物的试剂盒和方法。

6. 发明授权

US06169130A Method for improving the dispersion of redispersible polymer powders 失效
标题翻译：改善可再分散聚合物粉末分散性的方法
公开(公告)号：US06169130A
公开(公告)日：2001-01-02
申请号：US09316815
申请日：1999-05-21
申请人： Roland Bodmeier , James W. McGinity
发明人： Roland Bodmeier , James W. McGinity
IPC分类号： C08K716
CPC分类号： A61K9/5161 , A61K9/2866 , A61K9/2893 , C08J3/05 , C08J2301/08
摘要： The method according to the present invention includes the step of adding sufficient amounts of an alkalinizing agent to an aqueous solution into which a redispersible polymer powder will be dispersed or to an aqueous dispersion which will be dried to form a redispersible polymer powder. The method of the invention is particularly well suited for nonionic polymers. A surfactant, plasticizer and/or preservative can also be used in addition to the alkalinizing agent. Redispersible polymer powders processed according to the invention form acceptable tablet coatings which are comparable in quality to those coatings formed from aqueous polymer dispersions that have not been dried into redispersible polymer powders.
摘要翻译：根据本发明的方法包括向待分散的可再分散聚合物粉末的水溶液中加入足量的碱化剂或将其干燥以形成可再分散聚合物粉末的水分散体的步骤。本发明的方法特别适用于非离子聚合物。除了碱化剂之外，还可以使用表面活性剂，增塑剂和/或防腐剂。根据本发明加工的可再分散聚合物粉末形成可接受的片剂涂层，其质量与由尚未干燥成可再分散聚合物粉末的水性聚合物分散体形成的涂层相当。

7. 发明申请

US20130287847A1 Solid Molecular Dispersion 审中-公开
标题翻译：固体分子分散体
公开(公告)号：US20130287847A1
公开(公告)日：2013-10-31
申请号：US13978887
申请日：2012-01-17
申请人： Roland Bodmeier , Alan Francis Carmody , Mesut Ciper , Anne Therese Gustaaf De Paepe , John Mark Heimlich , Martin Korber , Mathias Walther , Neil Feeder
发明人： Roland Bodmeier , Alan Francis Carmody , Mesut Ciper , Anne Therese Gustaaf De Paepe , John Mark Heimlich , Martin Korber , Mathias Walther , Neil Feeder
IPC分类号： A61K47/38 , A61K9/20 , A61K9/14 , A61K31/222
CPC分类号： A61K31/222 , A61K9/08 , A61K9/10 , A61K9/146 , A61K9/1652 , A61K9/1676 , A61K9/1694 , A61K9/2054 , A61K9/5078 , A61K31/22 , A61K47/38
摘要： The present invention relates to a solid molecular dispersion of fesoterodine hydrogen fumarate and a polymeric binder. The invention also relates to an inert core bead or particle which is coated with said solid molecular dispersion and to pharmaceutical formulations comprising such coated beads or particles.
摘要翻译：本发明涉及非索罗定氢富马酸盐和聚合物粘合剂的固体分子分散体。本发明还涉及涂覆有所述固体分子分散体的惰性芯珠或颗粒以及包含这种包衣珠粒或颗粒的药物制剂。

8. 发明申请

US20050106252A1 Combination of polyvinyl acetate with water-insoluble, acid-insoluble, or alkali-insoluble polymers used for the production of film coatings with highly controlled release and high stability 有权
标题翻译：聚乙酸乙烯酯与水不溶性，酸不溶性或碱不溶性聚合物的组合，用于生产具有高度控制释放和高稳定性的薄膜涂料
公开(公告)号：US20050106252A1
公开(公告)日：2005-05-19
申请号：US10507607
申请日：2003-03-11
申请人： Karl Kolter , Roland Bodmeier , Andriy Dashevskiy
发明人： Karl Kolter , Roland Bodmeier , Andriy Dashevskiy
IPC分类号： A61K9/22 , A61K9/32 , A61K9/50 , A61K9/26
CPC分类号： A61K9/5026 , A61K9/5047 , A61K9/5073 , A61K9/5078
摘要： The invention relates to the combination of polyvinyl acetate and water-insoluble, acid-insoluble, or alkali-insoluble polymers used for producing film coatings for forms of administration in which agents are released in a controlled manner, and methods for the production thereof. The controlled-release properties can be specifically adjusted by means of said combinations, resulting in films having excellent mechanical stability and storage stability. In particular, agents are released independent of the pH by means of the inventive forms of administration.
摘要翻译：本发明涉及聚乙酸乙烯酯和水不溶性，酸不溶性或碱不溶性聚合物的组合，其用于生产用于以受控方式释放试剂的给药形式的膜包衣及其生产方法。可以通过所述组合特异性地调节控释特性，从而得到具有优异的机械稳定性和储存稳定性的膜。特别地，通过本发明的给药形式，释放与pH无关的药剂。

9. 发明授权

US5622993A Stick formulations for topical drug delivery of therapeutic agents and uses thereof 失效
公开(公告)号：US5622993A
公开(公告)日：1997-04-22
申请号：US523084
申请日：1995-09-01
申请人： James W. McGinity , Thomas G. Gerding , Roland Bodmeier
发明人： James W. McGinity , Thomas G. Gerding , Roland Bodmeier
IPC分类号： A61K8/63 , A61K9/02 , A61K9/06 , A61K31/135 , A61K31/138 , A61K31/16 , A61K31/167 , A61K31/57 , A61Q15/00 , A61Q19/00
CPC分类号： A61K31/135 , A61K31/138 , A61K31/167 , A61K31/573 , A61K8/0229 , A61K8/63 , A61K9/06 , A61Q15/00 , A61Q17/00 , A61Q19/00 , A61K2800/75 , Y10S514/817
摘要： Stick formulations for topical delivery of water soluble and/or water insoluble agents are disclosed. The stick formulations may contain steroids, antibiotics, antifungals, antihistamines anti inflammatories or local anesthetics. The vehicles comprise a combination of waxes and oils and a surfactant in embodiments involving water soluble agents. Methods for preparing the various stick formulations are also disclosed.

10. 发明授权

US07927618B2 Implants, particles 有权
标题翻译：植入物，颗粒
公开(公告)号：US07927618B2
公开(公告)日：2011-04-19
申请号：US10192575
申请日：2002-07-10
申请人： Roland Bodmeier
发明人： Roland Bodmeier
IPC分类号： A61F2/00 , A61M37/00 , C08J3/02
CPC分类号： A61K9/0024 , A61K9/0019 , A61K9/1274 , A61K9/204 , A61K47/14 , A61K47/34 , A61K47/36 , A61K47/44 , A61L27/18 , A61L27/26 , A61L27/54 , A61L2300/602 , A61L2300/802 , C08L67/04
摘要： This invention relates to kits for the preparation of a composition, which comprises a carrier phase that forms an implant or particles in the body, on the body or under physiological conditions. The carrier phase comprises at least one solid carrier material and a solvent, wherein the carrier material and the solvent are stored separately in the kit. The kit can also include an additional liquid phase to aid in forming the particles. An active compound included in the carrier phase is generally released in an extended manner. This invention also relates to compositions prepared from this kit and to methods for the preparation of the kits and the composition.
摘要翻译：本发明涉及用于制备组合物的试剂盒，其包含在体内，身体或生理条件下形成植入物或颗粒的载体相。载体相包含至少一种固体载体材料和溶剂，其中载体材料和溶剂分别存储在试剂盒中。试剂盒还可以包括另外的液相以帮助形成颗粒。包含在载体相中的活性化合物通常以延长的方式释放。本发明还涉及由该试剂盒制备的组合物以及制备试剂盒和组合物的方法。

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