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1. 发明授权

US06927286B1 Bleomycin gene cluster components and their uses 有权
标题翻译：博来霉素基因簇组成及其用途
公开(公告)号：US06927286B1
公开(公告)日：2005-08-09
申请号：US09477962
申请日：2000-01-05
申请人： Ben Shen , Liangcheng Du , Cesar Sanchez , Mei Chen , Daniel J. Edwards
发明人： Ben Shen , Liangcheng Du , Cesar Sanchez , Mei Chen , Daniel J. Edwards
IPC分类号： C12N15/52 , C12P13/04 , C12P17/14 , C12P19/26 , C12P19/44 , C12P19/58 , C07H12/04
CPC分类号： C12P19/26 , C12N15/52 , C12P13/04 , C12P17/14 , C12P19/44 , C12P19/58
摘要： This invention provides detailed sequence analysis and characterization of the gene cluster responsible for the synthesis of bleomycin in Streptomyces verticillus. The bleomycin gene cluster provides the first hybrid polyketide synthase/nonribosomal peptide synthetase pathway and elucidation of the various modules and enzymatic domains characterizing the pathway provides convenient synthetic routes for bleomycins, bleomycin analogs, and various other polyketides.
摘要翻译：本发明提供了负责在链霉链霉菌中合成博来霉素的基因簇的详细序列分析和表征。博来霉素基因簇提供了第一个混合聚酮化合物合酶/非核糖体多肽合成酶途径，并阐明了该途径的各种模块和酶域，为博莱霉素，博来霉素类似物和各种其他聚酮化合物提供了方便的合成途径。

2. 发明公开

US20240317854A1 METHODS FOR TREATING CANCER WITH ANTI-ILT3 ANTIBODIES 审中-公开
公开(公告)号：US20240317854A1
公开(公告)日：2024-09-26
申请号：US18550537
申请日：2022-03-17
申请人： Philip E. Brandish , Mei Chen , Andrey Loboda , Michael Nebozhyn, III , Cai Wu , Daping Zhang , Jie Zhang-Hoover
发明人： Philip E. Brandish , Mei Chen , Andrey Loboda , Michael Nebozhyn, III , Cai Wu , Daping Zhang , Jie Zhang-Hoover
IPC分类号： C07K16/28 , A61K31/337 , A61K31/7068 , A61K39/00 , A61K39/395 , A61P35/00
CPC分类号： C07K16/2803 , A61K31/337 , A61K31/7068 , A61K39/3955 , A61P35/00 , C07K16/2818 , A61K2039/505 , A61K2039/507 , A61K2039/545
摘要： This disclosure relates to methods for treating solid tumors in a patient identified as having metastatic triple negative breast cancer, glioblastoma, metastatic pancreatic ductal adenocarcinoma, metastatic soft tissue sarcoma, or metastatic non-squamous non-small cell lung carcinoma, comprising administering an anti-ILT3 antigen binding protein, or antigen binding fragment, and an anti-PD1 antigen binding protein, or antigen binding fragment, to the patient every three weeks (Q3W).

3. 发明授权

US10711052B2 Method for promoting wound healing 有权
公开(公告)号：US10711052B2
公开(公告)日：2020-07-14
申请号：US13657594
申请日：2012-10-22
申请人： Mei Chen , David Woodley
发明人： Mei Chen , David Woodley
IPC分类号： A61K38/39 , C07K14/78 , A61K31/70
摘要： The present invention discloses a method for treating wounds and for accelerating the healing of wounds by administering an effective amount of a pharmaceutical composition containing type VII collagen protein, mini-C7 protein, variants thereof or any combinations thereof. The pharmaceutical composition may be administered through a variety of routes including intravenous injection, topical application, or oral ingestion. The method may further include administering a genetically modified fibroblast capable of expressing type VII collagen protein, mini-C7 protein, variants thereof or small growth factors to achieve synergistic healing effect.

4. 发明授权

US08712505B2 Automated macular pathology diagnosis in three-dimensional (3D) spectral domain optical coherence tomography (SD-OCT) images 失效
标题翻译：自动黄斑病理诊断三维（3D）光谱相干层析成像（SD-OCT）图像
公开(公告)号：US08712505B2
公开(公告)日：2014-04-29
申请号：US13294601
申请日：2011-11-11
申请人： Hiroshi Ishikawa , Gadi Wollstein , Joel S. Schuman , Yu-Ying Liu , James M. Rehg , Mei Chen
发明人： Hiroshi Ishikawa , Gadi Wollstein , Joel S. Schuman , Yu-Ying Liu , James M. Rehg , Mei Chen
IPC分类号： A61B8/00 , A61B6/00 , A61B3/14 , A61B3/00
CPC分类号： A61B3/102 , G06K9/4642 , G06K2009/4666
摘要： Systems and methods of analyzing an optical coherence tomography image of a retina are discussed. A 2-dimensional slice of the image can be aligned to produce an approximately horizontal image of the retina and an edge map based at least in part on the aligned slice. Also, at least one global representation can be determined based on a (multi-scale) spatial division, such as multi-scale spatial pyramid, on the slice and/or edge map. Creating the local features is based on the specified cell structure of the global representation. The local features can be constructed based on local binary pattern (LBP)-based features. Additionally, a slice can be categorized into one or more categories via one or more classifiers (e.g., support vector machines). Each category can be associated with at least one ocular pathology, and classifying can be based on the constructed global descriptors, which can include the LBP-based local descriptors.
摘要翻译：讨论了分析视网膜的光学相干断层图像的系统和方法。图像的二维切片可以被对准以至少部分地基于对齐的切片来产生视网膜的近似水平的图像和边缘图。此外，可以基于切片和/或边缘图上的（多尺度）空间划分（例如多尺度空间金字塔）来确定至少一个全局表示。创建局部特征是基于全局表示的指定单元格结构。可以基于局部二进制模式（LBP）的特征构建局部特征。此外，切片可以经由一个或多个分类器（例如，支持向量机）被分类为一个或多个类别。每个类别可以与至少一个眼部病理学相关联，并且分类可以基于构建的全局描述符，其可以包括基于LBP的局部描述符。

5. 发明授权

US08644183B2 Systems and methods for memory-efficient storage and extraction of maximum power reduction (MPR) values in two-carrier wireless data systems 有权
标题翻译：用于存储高效存储和提取双载波无线数据系统中最大功率降低（MPR）值的系统和方法
公开(公告)号：US08644183B2
公开(公告)日：2014-02-04
申请号：US13533585
申请日：2012-06-26
申请人： Jinhua Jiang , Zae Yong Choi , Mei Chen
发明人： Jinhua Jiang , Zae Yong Choi , Mei Chen
IPC分类号： H04J1/16
CPC分类号： H04W52/367 , H04W52/34
摘要： Systems and methods for memory-efficient storage and extraction of maximum power reduction (MPR) values in two-carrier wireless data systems are presented. A wireless broadband device can operate under the HSUPA Category 9 standard, in which two carriers can be employed for data uplinks. Due to power saturation, interference, and other factors, transmission output power is limited to various levels depending on channel configuration. Under previous standards using one carrier, the maximum power reduction (MPR) needed to address those issues could be stored on the device, since the total number of MPR values was limited. With the introduction of dual carriers in HSUPA-9, storing all possible MPR values is no longer feasible. Platforms and techniques are disclosed which allow accurate generation of MPR values in a two-carrier system, utilizing the 2nd, 4th, and 6th moments of the complex signals to derive MPR values without attempting to store all possible carrier combinations.
摘要翻译：介绍了在双载波无线数据系统中高效存储和提取最大功率降低（MPR）值的系统和方法。无线宽带设备可以在HSUPA类别9标准下工作，其中两个载波可用于数据上行链路。由于功率饱和，干扰和其他因素，传输输出功率受限于根据信道配置的各种级别。在使用一个载波的以前的标准下，解决这些问题所需的最大功率降低（MPR）可以存储在设备上，因为MPR值的总数是有限的。随着在HSUPA-9中引入双载波，存储所有可能的MPR值不再可行。公开了平台和技术，其允许在双载波系统中精确地生成MPR值，利用复信号的第2，第4和第6时刻导出MPR值而不尝试存储所有可能的载波组合。

6. 发明申请

US20130243822A1 Composition and Method for Healing of Skin Wounds 审中-公开
标题翻译：治疗皮肤伤口的组合和方法
公开(公告)号：US20130243822A1
公开(公告)日：2013-09-19
申请号：US13610581
申请日：2012-09-11
申请人： Mei Chen , David Woodley
发明人： Mei Chen , David Woodley
IPC分类号： A61K9/00 , A61K38/18 , A61K38/39
CPC分类号： A61K9/0014 , A61K38/1858 , A61K38/39
摘要： This invention provides compositions and methods for topically treating skin wounds. The composition comprises C7, C7M, a variant thereof, or a combination thereof in a pharmaceutically acceptable carrier. The method comprises the steps of topically applying compositions of this invention to the skin wound.
摘要翻译：本发明提供了用于局部治疗皮肤伤口的组合物和方法。组合物包含C7，C7M，其变体，或其药学上可接受的载体中的组合。该方法包括将本发明的组合物局部施用于皮肤伤口的步骤。

7. 发明授权

US08207118B2 Skin wound healing compositions and methods of use thereof 有权
标题翻译：皮肤伤口愈合组合物及其使用方法
公开(公告)号：US08207118B2
公开(公告)日：2012-06-26
申请号：US12505361
申请日：2009-07-17
申请人： Wei Li , Mei Chen , David T. Woodley , Chieh-Fang Cheng
发明人： Wei Li , Mei Chen , David T. Woodley , Chieh-Fang Cheng
IPC分类号： A61K38/00 , A61K45/00
CPC分类号： C07K14/47 , A61K38/00
摘要： A wound healing composition comprising a class of polypeptide compounds having a polypeptide chain with 5 to 120 amino acid units per chain. The composition includes a pharmaceutical medium to carry the polypeptide compound, such as an aqueous solution, suspension, dispersion, salve, ointment, gel, cream, lotion, spray or paste. Additionally, a method of applying a wound healing composition comprising a class of polypeptide compounds having a polypeptide chain with 5 to 120 amino acid units per chain in a concentration of from about 1 μg/ml to about 100 μg/ml for a time sufficient to heal the wound is disclosed.
摘要翻译：一种伤口愈合组合物，其包含一类多肽化合物，所述多肽化合物具有每链5至120个氨基酸单元的多肽链。组合物包括携带多肽化合物的药物介质，例如水溶液，悬浮液，分散体，药膏，软膏，凝胶，霜剂，洗剂，喷雾剂或糊剂。另外，一种施用伤口愈合组合物的方法，其包含一类具有多肽链的多肽化合物，所述多肽化合物具有约1μg/ ml至约100μg/ ml浓度的每链5至120个氨基酸单元，时间足以治愈伤口披露。

8. 发明授权

US08036494B2 Enhancing image resolution 有权
标题翻译：增强图像分辨率
公开(公告)号：US08036494B2
公开(公告)日：2011-10-11
申请号：US10824692
申请日：2004-04-15
申请人： Mei Chen
发明人： Mei Chen
IPC分类号： G06K9/32
CPC分类号： G06T3/4053 , G06T7/215 , G06T2207/20016
摘要： Methods, machines, and machine-readable media for enhancing image resolution are described. In one aspect, a respective motion map is computed for each pairing of a reference image and a respective image neighboring the reference image in a sequence of base images. Each motion map includes a set of motion vectors mapping reference image pixels to respective neighboring image pixels. Respective regions of a target image are assigned to motion classes based on the computed motion maps. The target image has a target resolution level and the base images have a base resolution level equal to or lower than the target resolution level. Pixel values for the target image are computed based on corresponding pixel value contributions from the motion-compensated neighboring base images selected in accordance with the motion classes assigned to the target image regions.
摘要翻译：描述了用于增强图像分辨率的方法，机器和机器可读介质。在一个方面，针对参考图像和基准图像序列中与参考图像相邻的各个图像的每个配对来计算相应的运动图。每个运动图包括将参考图像像素映射到各个相邻图像像素的一组运动矢量。基于所计算的运动图，将目标图像的各个区域分配给运动类别。目标图像具有目标分辨率级别，并且基本图像具有等于或低于目标分辨率级别的基本分辨率级别。基于根据分配给目标图像区域的运动类别选择的运动补偿相邻基本图像的相应像素值贡献来计算目标图像的像素值。

9. 发明授权

US07660383B2 Three dimensional image processing apparatus and X-ray diagnosis apparatus 有权
标题翻译：三维图像处理装置和X射线诊断装置
公开(公告)号：US07660383B2
公开(公告)日：2010-02-09
申请号：US11844048
申请日：2007-08-23
申请人： Takuya Sakaguchi , Michael D. Silver , Jingwu Yao , Mei Chen , Stefan Bozhilov , Satoru Ohishi
发明人： Takuya Sakaguchi , Michael D. Silver , Jingwu Yao , Mei Chen , Stefan Bozhilov , Satoru Ohishi
IPC分类号： A61B6/00
CPC分类号： G01N23/046 , G01N2223/419
摘要： A three dimensional image processing apparatus includes a storage unit storing data of images in different radiographing directions together with information concerning cardiac phases, a key image selection unit selecting key images from the images, a feature point designation unit designatting feature points on the selected key images in accordance with operation by an operator, and an image reconstruction unit reconstructing a three dimensional image from the images on the basis of positions of the designated feature points, wherein the key image selection unit selects, as the key images, a pair of images which are located at the same cardiac phase and whose radiographing directions are different by a substantially predetermined angle and images spaced apart from each other by an angle obtained by substantially equally dividing an interval between the pair of images by a predetermined number.
摘要翻译：三维图像处理装置包括存储单元，其存储与不同的放射线方向的图像的数据以及关于心脏相位的信息，按键图像选择单元从图像中选择关键图像，特征点指定单元指定所选择的关键图像上的特征点根据操作者的操作，以及图像重建单元，其基于所指定的特征点的位置，根据所述图像重建三维图像，其中，所述键图像选择单元选择一对图像，所述一对图像位于相同的心脏相位，并且其放射照相方向以基本上预定的角度不同，并且将图像彼此间隔开通过基本上将该对图像之间的间隔除以预定数目而获得的角度。

10. 发明申请

US20090052613A1 THREE DIMENSIONAL IMAGE PROCESSING APPARATUS AND X-RAY DIAGNOSIS APPARATUS 有权
标题翻译：三维图像处理装置和X射线诊断装置
公开(公告)号：US20090052613A1
公开(公告)日：2009-02-26
申请号：US11844048
申请日：2007-08-23
申请人： Takuya Sakaguchi , Michael D. Silver , Jingwu Yao , Mei Chen , Stefan Bozhilov , Satoru Ohishi
发明人： Takuya Sakaguchi , Michael D. Silver , Jingwu Yao , Mei Chen , Stefan Bozhilov , Satoru Ohishi
IPC分类号： G01N23/00
CPC分类号： G01N23/046 , G01N2223/419
摘要： A three dimensional image processing apparatus includes a storage unit storing data of images in different radiographing directions together with information concerning cardiac phases, a key image selection unit selecting key images from the images, a feature point designation unit designatting feature points on the selected key images in accordance with operation by an operator, and an image reconstruction unit reconstructing a three dimensional image from the images on the basis of positions of the designated feature points, wherein the key image selection unit selects, as the key images, a pair of images which are located at the same cardiac phase and whose radiographing directions are different by a substantially predetermined angle and images spaced apart from each other by an angle obtained by substantially equally dividing an interval between the pair of images by a predetermined number.
摘要翻译：三维图像处理装置包括存储单元，其存储与不同的放射线方向的图像的数据以及关于心脏相位的信息，按键图像选择单元从图像中选择关键图像，特征点指定单元指定所选择的关键图像上的特征点根据操作者的操作，以及图像重建单元，其基于所指定的特征点的位置，根据所述图像重建三维图像，其中，所述键图像选择单元选择一对图像，所述一对图像位于相同的心脏相位，并且其放射照相方向以基本上预定的角度不同，并且将图像彼此间隔开通过基本上将该对图像之间的间隔除以预定数目而获得的角度。

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