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1. 发明授权

US08039594B2 Human synthetic single-chain antibodies directed against the common epitope of mutant P53 and their uses 失效
标题翻译：针对突变P53的常见表位的人合成单链抗体及其用途
公开(公告)号：US08039594B2
公开(公告)日：2011-10-18
申请号：US11887123
申请日：2006-03-23
申请人： Beka Solomon , Sara Orgad , Itai Benhar , Ronit Rosenfeld
发明人： Beka Solomon , Sara Orgad , Itai Benhar , Ronit Rosenfeld
IPC分类号： C12P21/08
CPC分类号： C07K16/32 , A61K2039/505 , C07K2317/622 , C07K2317/92
摘要： Isolated polypeptides, isolated polynucleotides or expression vectors encoding same, viral display vehicles which can be specifically bind an exposed epitope shared by mutant, but not wild type, p53 protein are provided. Also provided are methods of inducing apoptosis and treating cancer as well as diagnosing a p53-related cancer using the isolated polypeptides uncovered by the present invention.
摘要翻译：提供了分离的多肽，分离的多核苷酸或编码它们的表达载体，可以特异性结合由突变体而不是野生型p53蛋白共有的暴露表位的病毒显示载体。还提供了诱导凋亡和治疗癌症以及使用本发明未覆盖的分离的多肽诊断p53相关癌症的方法。

2. 发明授权

US07854931B2 Immunizing compostion and method for inducing an immune response against the beta-secretase cleavage site of amyloid precursor protein 有权
标题翻译：免疫组合和诱导针对淀粉样蛋白前体蛋白的β-分泌酶切割位点的免疫应答的方法
公开(公告)号：US07854931B2
公开(公告)日：2010-12-21
申请号：US11695948
申请日：2007-04-03
申请人： Beka Solomon
发明人： Beka Solomon
IPC分类号： A61K39/395 , C12P21/08
CPC分类号： C07K16/18 , A61K39/0007 , A61K2039/645 , C07K2317/77
摘要： The present invention is directed to an immunizing composition containing an antigenic product such as a multiple antigen peptide system (MAPS) or a filamentous bacteriophage displaying an AβPP epitope spanning the β-secretase cleavage site of AβPP and a method for inducing an immune response against the β-secretase cleavage site of AβPP using this immunizing composition. The present invention is also directed to antibodies against the β-secretase cleavage site of AβPP and their use in a method for inhibiting the formation of amyloid β.
摘要翻译：本发明涉及含有抗原产物的免疫组合物，所述抗原产物如多抗原肽系统（MAPS）或丝状噬菌体，其显示跨越A＆bgr。PP的分泌酶切割位点的A表位和PP表位，以及诱导方法使用该免疫组合物对A＆bgr; PP的分泌酶切割位点的免疫应答。本发明还涉及针对A＆Bgr; PP的分泌酶切割位点的抗体及其在抑制淀粉样蛋白形成的方法中的用途。

3. 发明申请

US20100074908A1 Human synthetic single-chain antibodies directed against the common epitope of mutant P53 and their uses 失效
标题翻译：针对突变P53的常见表位的人合成单链抗体及其用途
公开(公告)号：US20100074908A1
公开(公告)日：2010-03-25
申请号：US11887123
申请日：2006-03-23
申请人： Beka Solomon , Sara Orgad , Itai Benhar , Ronit Rosenfeld
发明人： Beka Solomon , Sara Orgad , Itai Benhar , Ronit Rosenfeld
IPC分类号： A61K39/395 , C07H21/04 , A61K31/7088 , C07K16/00 , A61K35/76 , G01N33/53 , A61P35/00
CPC分类号： C07K16/32 , A61K2039/505 , C07K2317/622 , C07K2317/92
摘要： Isolated polypeptides, isolated polynucleotides or expression vectors encoding same, viral display vehicles which can be specifically bind an exposed epitope shared by mutant, but not wild type, p53 protein are provided. Also provided are methods of inducing apoptosis and treating cancer as well as diagnosing a p53-related cancer using the isolated polypeptides uncovered by the present invention.
摘要翻译：提供了分离的多肽，分离的多核苷酸或编码它们的表达载体，可以特异性结合由突变体而不是野生型p53蛋白共有的暴露表位的病毒显示载体。还提供了诱导凋亡和治疗癌症以及使用本发明未覆盖的分离的多肽诊断p53相关癌症的方法。

4. 发明授权

US06919075B1 Bacteriophage displaying aβ epitopes and method of use 失效
标题翻译：噬菌体展示abeta表位和使用方法
公开(公告)号：US06919075B1
公开(公告)日：2005-07-19
申请号：US09830954
申请日：2000-08-31
申请人： Beka Solomon , Dan Frenkel , Eilat Hanan
发明人： Beka Solomon , Dan Frenkel , Eilat Hanan
IPC分类号： G01N33/53 , A61K35/74 , A61K35/76 , A61K38/00 , A61K38/17 , A61K39/00 , A61K39/395 , A61K49/00 , A61P19/08 , A61P25/28 , A61P35/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N7/01 , C12N15/02 , A01N61/00 , C12N15/00 , C12N15/86
CPC分类号： A61K39/0007 , A61K38/1709 , A61K49/0004 , A61K2039/6075 , C07K14/47 , C07K14/4711 , C07K16/18 , C07K2317/622 , C07K2317/74 , C07K2319/00
摘要： A method of immunizing against plaque forming diseases using display technology is provided. The method utilize novel agents, or pharmaceutical compositions for vaccination against plaque forming diseases which rely upon presentation of an antigen or epitope on a display vehicle. The method further includes agents, or pharmaceutical compositions for vaccination against plaque forming diseases, which rely upon presentation of an antibody, or an active portion thereof, on a display vehicle. Whether antigens or antibodies are employed, disaggregation of plaques results from the immunization.
摘要翻译：提供了使用显示技术免疫斑块形成疾病的方法。该方法利用依赖于在显示载体上呈递抗原或表位的新型药剂或药物组合物用于接种针对斑块形成疾病的疫苗。该方法还包括依赖于在显示载体上呈递抗体或其活性部分的针对斑块形成疾病接种的药剂或药物组合物。无论是使用抗原还是抗体，均免疫后产生斑块分解。

5. 发明申请

US20050152878A1 Agents and compositions and methods utilizing same useful in diagnosing and/or treating or preventing plaque forming diseases 审中-公开
标题翻译：用于诊断和/或治疗或预防斑块形成疾病的药物和组合物和方法
公开(公告)号：US20050152878A1
公开(公告)日：2005-07-14
申请号：US11073526
申请日：2005-03-08
申请人： Beka Solomon , Dan Frenkel , Eilat Hanan
发明人： Beka Solomon , Dan Frenkel , Eilat Hanan
IPC分类号： G01N33/53 , A61K35/74 , A61K35/76 , A61K38/00 , A61K38/17 , A61K39/00 , A61K39/395 , A61K49/00 , A61P19/08 , A61P25/28 , A61P35/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N7/01 , C12N15/02 , A61K48/00 , C12N15/86
CPC分类号： A61K39/0007 , A61K38/1709 , A61K49/0004 , A61K2039/6075 , C07K14/47 , C07K14/4711 , C07K16/18 , C07K2317/622 , C07K2317/74 , C07K2319/00
摘要： A method of immunizing against plaque forming diseases using display technology is provided. The method utilizes novel agents, or pharmaceutical compositions for vaccination against plaque forming diseases that rely upon presentation of an antigen or epitope on a display vehicle. The method further includes agents, or pharmaceutical compositions for vaccination against plaque forming diseases, which rely upon presentation of an antibody, or an active portion thereof, on a display vehicle. Whether antigens or antibodies are employed, disaggregation of plaques results from the immunization.
摘要翻译：提供了使用显示技术免疫斑块形成疾病的方法。该方法利用新型药剂或药物组合物用于接种抗依赖于在显示载体上呈递抗原或表位的斑块形成疾病。该方法还包括依赖于在显示载体上呈递抗体或其活性部分的针对斑块形成疾病接种的药剂或药物组合物。无论是使用抗原还是抗体，均免疫后产生斑块分解。

6. 发明申请

US20050089510A1 Agents and compositions and methods utilizing same useful in diagnosing and/or treating or preventing plaque forming diseases 审中-公开
标题翻译：用于诊断和/或治疗或预防斑块形成疾病的药物和组合物和方法
公开(公告)号：US20050089510A1
公开(公告)日：2005-04-28
申请号：US10749522
申请日：2004-01-02
申请人： Beka Solomon , Eilat Hanan , Dan Frenkel
发明人： Beka Solomon , Eilat Hanan , Dan Frenkel
IPC分类号： G01N33/53 , A61K35/74 , A61K35/76 , A61K38/00 , A61K38/17 , A61K39/00 , A61K39/395 , A61K49/00 , A61P19/08 , A61P25/28 , A61P35/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N7/01 , C12N15/02 , A61K48/00
CPC分类号： A61K39/0007 , A61K38/1709 , A61K49/0004 , A61K2039/6075 , C07K14/47 , C07K14/4711 , C07K16/18 , C07K2317/622 , C07K2317/74 , C07K2319/00
摘要： A method of immunizing against plaque forming diseases using display technology is provided. The method utilize novel agents, or pharmaceutical compositions for vaccination against plaque forming diseases which rely upon presentation of an antigen or epitope on a display vehicle. The method further includes agents, or pharmaceutical compositions for vaccination against plaque forming diseases, which rely upon presentation of an antibody, or an active portion thereof, on a display vehicle. Whether antigens or antibodies are employed, disaggregation of plaques results from the immunization.
摘要翻译：提供了使用显示技术免疫斑块形成疾病的方法。该方法利用依赖于在显示载体上呈递抗原或表位的新型药剂或药物组合物用于接种针对斑块形成疾病的疫苗。该方法还包括依赖于在显示载体上呈递抗体或其活性部分的针对斑块形成疾病接种的药剂或药物组合物。无论是使用抗原还是抗体，均免疫后产生斑块分解。

7. 发明申请

US20140086880A1 METHOD FOR TREATING NEURODEGENERATIVE TAUOPATHY 有权
标题翻译：治疗神经损伤性脑病的方法
公开(公告)号：US20140086880A1
公开(公告)日：2014-03-27
申请号：US14004615
申请日：2012-03-12
申请人： Beka Solomon
发明人： Beka Solomon
IPC分类号： A61K35/76
CPC分类号： A61K35/76 , C12N2795/14132 , C12N2795/14171
摘要： The present invention is directed to a filamentous bacteriophage for use in treating a neurodegenerative tauopathy or susceptibility to a neurodegenerative tauopathy and a method of using the bacteriophage for reducing the formation of fibrils of tau protein or for disaggregating pre-formed fibrils of tau protein, such as in a patient suffering from neurodegenerative tauopathy. The filamentous bacteriophage used in the present invention does not display (i) a mammalian cell internalization signal (ii) a β-amyloid antigen or an antibody to β-amyloid, or (iii) a tau protein antigen or an antibody to tau protein.
摘要翻译：本发明涉及用于治疗神经退行性tau蛋白病或对神经退行性tau蛋白病的易感性的丝状噬菌体，以及使用该噬菌体减少tau蛋白原纤维形成或分解tau蛋白的预先形成的原纤维的方法，如在患有神经变性tau病的患者中。本发明中使用的丝状噬菌体不显示（i）哺乳动物细胞内化信号（ii）和淀粉样蛋白抗原或抗 - 淀粉样蛋白抗体，或（iii）tau蛋白抗原或抗tau抗体蛋白。

8. 发明申请

US20110286970A1 METHOD FOR TREATING PARKINSON'S DISEASE 审中-公开
标题翻译：治疗帕金森病的方法
公开(公告)号：US20110286970A1
公开(公告)日：2011-11-24
申请号：US13130894
申请日：2009-11-24
申请人： Beka Solomon , Haim M. Dimant
发明人： Beka Solomon , Haim M. Dimant
IPC分类号： A61K35/76 , A61P25/16
CPC分类号： A61K35/76 , A61K9/0043 , A61K2039/5256 , C12N2795/14132 , C12N2795/14171 , C12N2810/859 , A61K2300/00
摘要： The present invention relates to the use of a filamentous bacteriophage, which displays an antibody that specifically binds to a pro-inflammatory cytokine, either alone or in combination with a filamentous bacteriophage that does not display a mammalian cell internalization signal, to treat Parkinson's disease.
摘要翻译：本发明涉及丝状噬菌体的使用，其显示单独或与不显示哺乳动物细胞内化信号的丝状噬菌体特异性结合促炎细胞因子的抗体来治疗帕金森病。

9. 发明申请

US20090304726A1 VIRAL DISPLAY VEHICLES FOR TREATING MULTIPLE SCLEROSIS 审中-公开
标题翻译：用于治疗多发性硬化症的病毒显示车辆
公开(公告)号：US20090304726A1
公开(公告)日：2009-12-10
申请号：US12279694
申请日：2007-02-15
申请人： Beka Solomon , Natalla Zabavnik , Rela Koppel , Idan Rakover
发明人： Beka Solomon , Natalla Zabavnik , Rela Koppel , Idan Rakover
IPC分类号： A61K39/00
CPC分类号： A61K39/0008
摘要： Provided are viral display vehicles which display multiple sclerosis associated antigens on the surface thereof for induction of immune tolerance to autoantigens such as MOG. Also provided are methods and pharmaceutical compositions for treating multiple sclerosis using the viral display vehicles of the present invention.
摘要翻译：提供了在其表面上显示多发性硬化相关抗原的病毒显示载体，用于诱导对自身抗原如MOG的免疫耐受性。还提供了使用本发明的病毒显示载体治疗多发性硬化的方法和药物组合物。

10. 发明申请

US20050053575A1 Antigenic product displaying multiple copies of an epitope of a deposit-forming polypeptide involved in plaque-forming diseases and methods of using same 审中-公开
标题翻译：涉及斑块形成疾病的沉积形成多肽的表位的多个拷贝的抗原产物及其使用方法
公开(公告)号：US20050053575A1
公开(公告)日：2005-03-10
申请号：US10481642
申请日：2002-06-20
申请人： Beka Solomon
发明人： Beka Solomon
IPC分类号： A61K38/00 , A61P43/00 , C07K14/36 , C07K14/465 , C07K14/47 , C12N15/62 , A61K39/00 , C08G63/48 , C08G63/91
CPC分类号： C12N15/62 , A61K38/00 , A61K2039/55516 , A61K2039/55555 , A61K2039/645 , C07K14/36 , C07K14/465 , C07K14/47 , C07K14/4711
摘要： The present invention relates to an antigenic product for inducing an immune response to a deposit-forming polypeptide, such as amyloid ss, which antigenic product is a multiple antigenic peptide (MAP) that contains multiple copies of an epitope of a deposit-forming polypeptide involved in a plaque-forming disease. This antigenic product can be formulated into an immunizing composition and used to elicit an immune response against a deposit-forming polypeptide involved in a plaque-forming disease or disorder.
摘要翻译：本发明涉及用于诱导对沉积形成多肽例如淀粉样蛋白ss的免疫应答的抗原产物，该抗原产物是多重抗原肽（MAP），其含有涉及沉积形成多肽的表位的多个拷贝在斑块形成疾病。该抗原产物可以配制成免疫组合物，并用于引发针对形成斑块的疾病或病症的沉积形成多肽的免疫应答。

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