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1. 发明申请

WO2004020034A2 MICROABRADER WITH CONTROLLED ABRASION FEATURES 审中-公开
标题翻译：具有可控磨损特性的微型控制器
公开(公告)号：WO2004020034A2
公开(公告)日：2004-03-11
申请号：PCT/US2003/026811
申请日：2003-08-27
申请人： BECTON DICKINSON AND COMPANY , LASTOVICH, Alexander, G. , MARTIN, Frank, E. , HAIDER, Ishaq, M. , CLARKE, Richard, P. , ALARCON, Jason, B.
发明人： LASTOVICH, Alexander, G. , MARTIN, Frank, E. , HAIDER, Ishaq, M. , CLARKE, Richard, P. , ALARCON, Jason, B.
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61B17/205 , A61B2017/320004 , A61M31/002 , A61M37/00 , A61M2037/0007 , A61M2037/0023 , A61M2037/0038 , A61M2037/0046 , A61M2037/0053
摘要： An abrader device for delivering a substance into skin via an abrasion process includes a housing adapted to be pressed against the skin at a desired delivery site, an applicator head disposed, in an upper opening of the housing and movable across a lower opening of the housing to abrade the delivery site in at least one furrow, and an abrader surface attached to the applicator head whereby the housing remains firm and stationary at the delivery site and structure of the housing and the applicator head controls parameters of the abrasion process. In particular, the amount of force or pressure applied to the abrader surface, the speed at which the abrader surface moves across the skin and the number of lateral passes of the abrader surface across the skin are controlled so that the abrader device provides a furrow with a length of substantially the same depth thereby providing reproducible results, even though different technicians are applying the abrader device against a patient's skin.
摘要翻译：用于通过研磨过程将物质递送到皮肤中的研磨装置包括适于在期望的递送部位压靠皮肤的壳体，布置在壳体的上部开口中的施用器头和可移动穿过壳体的下开口以在至少一个沟槽中研磨递送位置，并且研磨表面附接至施加器头部，由此壳体在壳体的递送部位和结构处保持牢固且静止，并且施加器头部控制参数的磨损过程。具体而言，控制施加到研磨表面的力或压力的量，研磨表面在皮肤上移动的速度和研磨表面跨过皮肤的横向通过的次数，使得研磨装置提供犁沟长度基本上相同的深度，从而提供可重复的结果，即使不同的技术人员将研磨装置应用于患者的皮肤。

2. 发明申请

WO2016200800A1 FILTRATION CELL AND METHOD FOR FILTERING A BIOLOGICAL SAMPLE 审中-公开
标题翻译：过滤细胞和过滤生物样品的方法
公开(公告)号：WO2016200800A1
公开(公告)日：2016-12-15
申请号：PCT/US2016/036200
申请日：2016-06-07
申请人： BECTON, DICKINSON AND COMPANY
发明人： XU, Qihua , LASTOVICH, Alexander, G.
IPC分类号： B01D61/14 , A61M1/34 , B01D61/18 , B01D63/08
CPC分类号： B01D67/0032 , A61M1/1621 , A61M1/1631 , A61M1/3496 , A61M1/3643 , A61M1/3644 , A61M1/365 , A61M2202/0415 , B01D61/147 , B01D61/18 , B01D63/087 , B01D71/50 , B01D2321/2066 , B01D2321/2083 , B01D2323/04 , B01D2325/38
摘要： A filtration cell (10) for a biological sample including an upper chamber for receiving the biological sample to be filtered, a lower chamber in fluid communication with the upper chamber, and a filtration membrane (14) positioned between the upper chamber and the lower chamber is disclosed. A surface of the filtration membrane has a contact angle > 90°. The flow of the biological sample through the upper chamber may be tangential to the filtration membrane and a filtrate passing through the filtration membrane may be collected in the lower chamber. Also, a method of filtering a biological sample including passing the biological sample through an upper chamber of a filtration cell as described above and collecting a filtrate in the lower chamber is disclosed.
摘要翻译：一种用于生物样品的过滤池（10），包括用于接收要过滤的生物样品的上室，与上室流体连通的下室，以及位于上室和下室之间的过滤膜被披露。过滤膜的表面的接触角> 90°。生物样品通过上室的流动可以与过滤膜相切，并且通过过滤膜的滤液可以被收集在下室中。此外，公开了一种过滤生物样品的方法，包括使生物样品通过如上所述的过滤室的上室并在下室中收集滤液。

3. 发明申请

WO2004020015A2 MICROPROTRUSION ARRAYS AND METHODS FOR USING SAME TO DELIVER SUBSTANCES INTO TISSUE 审中-公开
标题翻译：微膨胀阵列和使用它们将物质输送到组织中的方法
公开(公告)号：WO2004020015A2
公开(公告)日：2004-03-11
申请号：PCT/US2003/026812
申请日：2003-08-27
申请人： BECTON DICKINSON AND COMPANY , LASTOVICH, Alexander, G. , ALARCON, Jason, B. , DEKKER, John, P., III , HAIDER, M., Ishaq , MIKSZTA, John, A. , MARTIN, Frank, E. , O'CONNOR, Scott, A.
发明人： LASTOVICH, Alexander, G. , ALARCON, Jason, B. , DEKKER, John, P., III , HAIDER, M., Ishaq , MIKSZTA, John, A. , MARTIN, Frank, E. , O'CONNOR, Scott, A.
IPC分类号： A61M
CPC分类号： A61M37/0015 , A61B17/205 , A61B2017/320004 , A61M31/002 , A61M37/00 , A61M2037/0007 , A61M2037/0023 , A61M2037/0038 , A61M2037/0046 , A61M2037/0053
摘要： Improved microprotrusion abrasion devices having fluid retaining or directing patterns, and specific design parameters and method for delivery of substances into the skin. Various configurations of such devices are disclosed, including domed, channeled, patterned and stepped.
摘要翻译：改进的具有流体保持或定向图案的微凸起磨损装置，以及用于将物质输送到皮肤中的具体设计参数和方法。公开了这种装置的各种配置，包括圆顶，通道，图案化和阶梯式。

4. 发明申请

WO2004008248A3 A METHOD OF FORMING A MOLD AND MOLDING A MICRO-DEVICE 审中-公开
公开(公告)号：WO2004008248A3
公开(公告)日：2004-01-22
申请号：PCT/US2003/021970
申请日：2003-07-11
申请人： BECTON DICKINSON AND COMPANY , LASTOVICH, Alexander, G.
发明人： LASTOVICH, Alexander, G.
IPC分类号： B29C33/38
摘要： A method of forming a device including a plurality of micron or sub-micron sized features is provided. A master having a surface contour defining a plurality of features is provided. The surface contour of the master is coated with at least one layer of material to form a shell. The master is removed from the shell to form a negative image of the surface contour in the shell. The negative image in the shell is filled with material, for example, polycarbonate, polyacrylic, or polystyrene, to form a device having features substantially the same as the master. The negative image may be filled using injection molding, compression molding, embossing or any other compatible technique.

5. 发明申请

WO2020154484A1 METHODS AND APPARATUS TO SELECTIVELY EXTRACT CONSTITUENTS FROM BIOLOGICAL SAMPLES 审中-公开
公开(公告)号：WO2020154484A1
公开(公告)日：2020-07-30
申请号：PCT/US2020/014758
申请日：2020-01-23
申请人： BECTON, DICKINSON AND COMPANY
发明人： XU, Qihua , WEIDEMAIER, Kristin , SALOMON, John, E. , LASTOVICH, Alexander, G. , FALLOWS, Eric, A. , CONNELL, Sean , HERR, Joshua , WOLFGANG, Meghan , BRASCH, Michael, A. , MOORE, Richard, L. , SEBBA, David, S. , CLAVIJO, Cristian , NG, Shirley , ABBOT, Richard , PAPP, Alexander, Adam , FU, Henry, Li-wei , AUSTIN, Caitlin, Marie , DOWLING, Sean, Patrick , JOYCE, Owen, Lewis , KIPLINGER, Michael, L. , CARPENTER, William, Kevin
IPC分类号： B01L3/00 , G01N1/40 , A61M5/165 , B01D61/18 , C12M1/00 , A61M2005/1657 , B01D2311/25 , B01D2315/10 , B01D61/142 , B01D63/087 , B01D67/0032 , B01L2200/0652 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2400/0478 , B01L2400/049 , B01L3/502753 , B01L3/502761 , C12M33/14 , C12M47/04 , G01N1/4005 , G01N1/4077 , G01N2001/4088
摘要： Methods and apparatus provide filtration for concentrating analytes, such as bacteria or exosomes, of a biological sample, such as blood or urine. The technology may employ membrane devices that implement one or more tangential flow filtration processes such as in stages. An example membrane device may typically include a membrane having sides and ends. The membrane may selectively permit constituent(s) of the sample to pass through while retaining other constituents at one side. An input chamber of the device may include an inlet near one end and an outlet near the other end, and that may permit a tangential flow of the sample along the first side surface, and a trans-membrane passing of constituent(s). An output chamber of the device may be configured at the second side surface to receive the passing constituents. Such devices may be provided in a kit to facilitate targeting of a desired biological analyte concentration.

6. 发明申请

WO2008103972A1 OPTICAL FIBER CONNECTOR 审中-公开
标题翻译：光纤连接器
公开(公告)号：WO2008103972A1
公开(公告)日：2008-08-28
申请号：PCT/US2008/054834
申请日：2008-02-25
申请人： BECTON, DICKINSON AND COMPANY , JACOBSON, Ross, W. , LASTOVICH, Alexander, G. , MONAHAN, Lawrence, A. , BROWKA, Edward, P.
发明人： JACOBSON, Ross, W. , LASTOVICH, Alexander, G. , MONAHAN, Lawrence, A. , BROWKA, Edward, P.
IPC分类号： G02B6/38 , A61B5/00
CPC分类号： A61B5/14546 , A61B5/0084 , A61B5/150022 , A61B5/150389 , A61B5/150435 , A61B5/150519 , A61B5/150809 , A61B5/150816 , A61B5/150969 , A61B5/15105 , A61B5/15142 , A61B5/155 , A61B5/6848 , G02B6/3624
摘要： An optical connector device is disclosed for optically connecting a biosensor wearable on the body of a patient to a reader outside of the body of the patient. The device comprises a base disk to be worn on the body of a patient. The base disk has a needle attached thereto and the needle houses a first fiber defining a first optical conduit. The distal end of the needle is insertable into the body of the patient, and a portion of the proximal end of the needle remains outside of the body of the patient when the device is worn. The device also comprises a connector housing a second fiber defining a second optical conduit.
摘要翻译：公开了一种光学连接器装置，用于将可佩戴在患者身体上的生物传感器光学连接到患者体外的读取器。该装置包括要戴在患者身上的基盘。基盘具有附接到其上的针，并且针容纳限定第一光导管的第一光纤。针的远端可插入患者的身体，并且当穿戴该装置时，针的近端的一部分保持在患者体内的外部。该装置还包括容纳限定第二光导管的第二光纤的连接器。

7. 发明申请

WO2004019777A2 SUBSTANCE DELIVERY VIA ROTATING MOCROABRADING SURFACE 审中-公开
标题翻译：通过旋转的表面进行物质输送
公开(公告)号：WO2004019777A2
公开(公告)日：2004-03-11
申请号：PCT/US2003/026813
申请日：2003-08-27
申请人： BECTON DICKINSON AND COMPANY , HAIDER, M., Ishaq , LASTOVICH, Alexander, G. , ERSKINE, Timothy, J. , MIKSZTA, John, A. , MARTIN, Frank, E. , O'CONNOR, Scott, A. , ALARCON, Jason, B. , DEKKER, John, P., III
发明人： HAIDER, M., Ishaq , LASTOVICH, Alexander, G. , ERSKINE, Timothy, J. , MIKSZTA, John, A. , MARTIN, Frank, E. , O'CONNOR, Scott, A. , ALARCON, Jason, B. , DEKKER, John, P., III
IPC分类号： A61B5/00
CPC分类号： A61M37/0015 , A61B17/205 , A61B2017/320004 , A61M31/002 , A61M37/00 , A61M2037/0007 , A61M2037/0023 , A61M2037/0038 , A61M2037/0046 , A61M2037/0053
摘要： A method and device for the delivery of a substance into skin via the rotational movement of a microabrader device reduces the effects of operator variability. The method includes applying a substance to an area of a patient's skin through the rotational movement of microprotrusions. The movement of the microprotrusions can be imparted by a spring device or the like present in the microabrader device or the motion of the operator through the handle of the microabrader device. The rotational motion localizes the administration of the drug or vaccine dosage in the abraded skin area. The device can include means for monitoring pressure of the device against the skin and thereby promote consistency between applications and control of penetration depth. The substance, drug or vaccine may be placed on the microprotrusions and a reconstituting liquid included in the microabrader device.
摘要翻译：用于通过微型研磨机装置的旋转运动将物质递送到皮肤中的方法和装置减少了操作者变化的影响。该方法包括通过微凸头的旋转运动将物质施加到患者皮肤的区域。微凸头的运动可以通过存在于微研磨装置中的弹簧装置等或者通过微研磨装置的手柄的操作者的运动来实现。旋转运动局限了药物或疫苗剂量在磨损皮肤区域的施用。该装置可以包括用于监测装置抵靠皮肤的压力的装置，从而促进应用之间的一致性和对刺入深度的控制。物质，药物或疫苗可以放置在微突出物和包含在微型研磨装置中的重构液体上。

8. 发明申请

WO2003066126A2 DEVICE AND METHOD FOR DELIVERING OR WITHDRAWING A SUBSTANCE THROUGH THE SKIN 审中-公开
标题翻译：通过皮肤递送或减少物质的装置和方法
公开(公告)号：WO2003066126A2
公开(公告)日：2003-08-14
申请号：PCT/US2003/003424
申请日：2003-02-04
申请人： BECTON, DICKINSON AND COMPANY , LASTOVICH, Alexander, G. , FENTRESS, Jim, K. , GRIGGS, Julia, E. , PETTIS, Ronald, J. , SUTTER, Diane, E. , MARTIN, Frank, E. , HAIDER, M., Ishaq , LOCKHART, Artis, R. , POWELL, Kenneth, G.
发明人： LASTOVICH, Alexander, G. , FENTRESS, Jim, K. , GRIGGS, Julia, E. , PETTIS, Ronald, J. , SUTTER, Diane, E. , MARTIN, Frank, E. , HAIDER, M., Ishaq , LOCKHART, Artis, R. , POWELL, Kenneth, G.
IPC分类号： A61M
CPC分类号： A61M5/425 , A61M5/14244 , A61M5/3007 , A61M5/46 , A61M37/0015
摘要： An apparatus for delivering or withdrawing a fluid through at least one layer of the skin is provided. A device includes a body having a top face, a bottom face, a side edge and at least one channel. The bottom face includes a first surface area and a second surface area adjacent to and recessed at a first distance from the first surface area. The bottom face further includes at least one raised protrusion disposed on the second surface area. The protrusion has a height from the first surface greater than the first distance. At least one dermal-access member is provided in the protrusion and is in fluid communication with the channel to deliver or withdraw the fluid. The dermal-access member extends at least 1 mm from the protrusion. A mechanism drives the device against the skin at a calculated speed of about 6 m/s to about 18 m/s.
摘要翻译：提供了一种用于通过至少一层皮肤递送或取出流体的装置。一种装置包括具有顶面，底面，侧缘和至少一个通道的主体。底面包括与第一表面区域相邻并且与第一表面区域第一距离凹陷的第一表面区域和第二表面区域。底面还包括设置在第二表面区域上的至少一个凸起突起。突起具有从第一表面的高度大于第一距离。在突起中提供至少一个真皮进入构件，并且与通道流体连通以输送或抽出流体。真皮进入构件从突起延伸至少1mm。机构以约6m / s至约18m / s的计算速度驱动装置抵靠皮肤。

9. 发明申请

WO2021252336A1 BIOLOGICAL FLUID SEPARATION DEVICE 审中-公开
公开(公告)号：WO2021252336A1
公开(公告)日：2021-12-16
申请号：PCT/US2021/036131
申请日：2021-06-07
申请人： BECTON, DICKINSON AND COMPANY
发明人： WEIDEMAIER, Kristin , LASTOVICH, Alexander, G. , XU, Qihua , ABBOTT, Richard
IPC分类号： B01L3/00 , A61B5/15003 , A61B5/150213 , A61B5/150351 , A61B5/150755 , A61B5/154 , B01L2200/0684 , B01L2300/0681 , B01L2300/0825 , B01L2300/0864 , B01L2300/087 , B01L2400/0481 , B01L2400/0605 , B01L3/50273 , B01L3/502738 , B01L3/502753 , G01N33/491
摘要： A blood separation device that allows high quality plasma to be generated using a single power source. The device includes a housing with an inlet port adapted to receive the blood sample, a first chamber having a first chamber flow channel in fluid communication with the inlet port, a second chamber having a second chamber flow channel, a separation member disposed between the first chamber and the second chamber. In some embodiments, the blood separation device detects or tests for the presence of a substance, such as an antigen or an antibody.

10. 发明申请

WO2016200806A1 PLASMA EXTRACTOR 审中-公开
标题翻译：等离子提取机
公开(公告)号：WO2016200806A1
公开(公告)日：2016-12-15
申请号：PCT/US2016/036209
申请日：2016-06-07
申请人： BECTON, DICKINSON AND COMPANY
发明人： XU, Qihua , LASTOVICH, Alexander, G.
IPC分类号： B01D61/14 , A61M1/34 , B01D61/18 , B01D63/06 , B01D63/16
CPC分类号： B01D63/16 , A61M1/262 , A61M1/3496 , B01D61/147 , B01D61/18 , B01D63/062 , B01D69/02 , B01D71/50 , B01D2313/04 , B01D2315/02 , B01D2315/04 , B01D2325/04 , B01D2325/06
摘要： A filtration cell (10) for a biological sample having an outer housing (12) defining a first chamber and an inner housing (14) defining a second chamber is disclosed. The inner housing is disposed within the first chamber and rotatable with respect to the outer housing and at least a portion of the inner housing includes a filtration membrane (52). Upon rotation of the inner housing, a first portion of the biological sample passes from the first chamber into the second chamber and a second portion of the biological sample is restrained in the first chamber. Alternatively, the filtration cell may also include a rotation element disposed in the inner housing. Upon rotation of the rotation element with respect to the inner housing, a first portion of the biological sample to passes from the second chamber into the first chamber and a second portion of the biological sample is restrained in the second chamber.
摘要翻译：公开了一种用于生物样品的过滤池（10），其具有限定第一室的外壳体（12）和限定第二腔室的内壳体（14）。所述内壳体设置在所述第一腔室内并相对于所述外壳体可旋转，并且所述内壳体的至少一部分包括过滤隔膜（52）。在内壳旋转时，生物样品的第一部分从第一室进入第二室，生物样品的第二部分被约束在第一室中。或者，过滤单元还可以包括设置在内壳体中的旋转元件。当旋转元件相对于内壳旋转时，生物样品的第一部分从第二腔室进入第一腔室，生物样品的第二部分被限制在第二腔室中。

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