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1. 发明申请

WO2010121045A3 FIXTURING MEMBER AND DEVICE FOR PERMITTING MIXING IN A PEN INJECTOR 审中-公开
公开(公告)号：WO2010121045A3
公开(公告)日：2010-10-21
申请号：PCT/US2010/031264
申请日：2010-04-15
申请人： BECTON, DICKINSON AND COMPANY , CRONENBERG, Richard , VEDRINE, Lionel
发明人： CRONENBERG, Richard , VEDRINE, Lionel
IPC分类号： A61M5/14 , A61J1/14
摘要： In one aspect, a fixturing member for fixing a source of flowable material relative to a pen injector so as to permit introduction of the flowable material into the pen injector is provided herein. The fixturing member includes a body having a web with opposing proximal and distal faces. A distal wall extends distally from the distal face of the web, with the distal wall at least partially encompassing a distal chamber. Features are formed on the body for removable mounting onto a pen injector. Also, features are formed on the body for mounting onto a source of flowable material, A cannula extends through the web the cannula having proximal and distal ends with a lumen extending therebetween. The distal end of the cannula is located in the distal chamber and positioned such that, with the member being mounted to a pen injector, the distal end is located to be in the pen injector. The proximal end of the cannula is located proximally of the proximally face of the web such that, with the member being mounted to a source of flowable material, the proximal end of the cannula is located to be in communication with the flowable material. Advantageously, with the subject invention, a fixturing member is provided which facilitates mixing of substances in a pen injector in preparing a pen injector for injection.

2. 发明申请

WO2015081337A2 MEDICAMENT DEVICE 审中-公开
标题翻译：药物装置
公开(公告)号：WO2015081337A2
公开(公告)日：2015-06-04
申请号：PCT/US2014/067925
申请日：2014-12-01
申请人： BECTON, DICKINSON AND COMPANY
发明人： CRONENBERG, Richard , RAJ, Abhijitsing , CHARVIN, Matthieu , BOOTH, David
IPC分类号： A61M25/18
CPC分类号： A61M5/20 , A61M5/142 , A61M5/1454 , A61M5/162 , A61M5/2455 , A61M5/2459 , A61M5/2466 , A61M5/31568 , A61M2005/206 , A61M2005/2414 , A61M2005/247
摘要： A method for creating a sterile connection with a fluid in a container. The container has a sealing member sealing a first end of the container, and a barrier sealing a chamber in fluid communication with the sealing member. The method includes providing a valve sleeve assembly that includes a flexible sleeve having a barrier portion at an end of the flexible sleeve, a hollow first penetrator disposed within the flexible sleeve, and a hollow second penetrator at least partially disposed within the first penetrator. An interior of the flexible sleeve is sterile. The method also includes piercing the barrier portion and the barrier with the first penetrator, and displacing the second penetrator relative to the first penetrator and the sealing member to pierce the sealing member and establish the sterile connection with an interior of the container.
摘要翻译：用于在容器中形成与流体的无菌连接的方法。容器具有密封容器的第一端的密封构件以及密封与密封构件流体连通的腔室的屏障。该方法包括提供包括柔性套筒的阀套组件，该柔性套筒在柔性套筒的端部处具有阻挡部分，布置在柔性套筒内的中空第一穿透器以及至少部分布置在第一穿透器内的中空第二穿透器。柔性套管的内部是无菌的。该方法还包括用第一穿透器刺穿屏障部分和屏障，以及相对于第一穿透器和密封构件移动第二穿透器以刺穿密封构件并建立与容器内部的无菌连接。

3. 发明申请

WO2013155426A1 INFUSION DEVICE WITH SAFETY FEATURE FOR PREVENTING INADVERTENT ACTIVATION 审中-公开
标题翻译：具有安全功能的输液装置，用于防止不能激活
公开(公告)号：WO2013155426A1
公开(公告)日：2013-10-17
申请号：PCT/US2013/036391
申请日：2013-04-12
申请人： BECTON, DICKINSON AND COMPANY
发明人： SCHNEIDER, Jared , GUARRAIA, Mark , BOYAVAL, Margaux , SHAFER, Ryan , CRONENBERG, Richard
IPC分类号： A61M5/32 , A61M5/00
CPC分类号： A61M5/16831 , A61M5/14248 , A61M2005/14252 , A61M2005/2073 , A61M2205/276 , A61M2205/582 , A61M2205/583 , A61M2205/584 , A61M2205/586
摘要： A safety device for a wearable infusion device is disclosed. The safety device is configured to prevent accidental activation of the infusion device by protecting the activation button of the infusion device prior to and after the actuation of the activation button. The safety device includes a wall section that protrudes from the main body of the infusion device in the vicinity of the activation button. A cover device covers the activation button prior to the actuation of the activation button. The cover device slides on the main body of the infusion device. When the cover covers the activation button, movement of the cover is restricted by the protruding wall section adjacent to the activation button, to hold the cover in position over the activation button.
摘要翻译：公开了一种用于可穿戴式输注装置的安全装置。安全装置被配置为通过在致动按钮的启动之前和之后保护输注装置的启动按钮来防止意外激活输注装置。安全装置包括从激活按钮附近的输液装置的主体突出的壁部。在启动激活按钮之前，盖装置覆盖激活按钮。盖装置在输液装置的主体上滑动。当盖子覆盖激活按钮时，盖子的移动受到与激活按钮相邻的突出壁部分的限制，以将盖子保持在激活按钮上的适当位置。

4. 发明申请

WO2013134246A1 TRANSFER SET WITH FLOATING NEEDLE FOR DRUG RECONSTITUTION 审中-公开
标题翻译：带有用于药物重新配置的浮动针的转移装置
公开(公告)号：WO2013134246A1
公开(公告)日：2013-09-12
申请号：PCT/US2013/029088
申请日：2013-03-05
申请人： BECTON, DICKINSON AND COMPANY
发明人： WU, Haiming , CRONENBERG, Richard
IPC分类号： A61J1/20 , A61J1/06 , A61J1/14
CPC分类号： A61J1/2089 , A61J1/062 , A61J1/1406 , A61J1/1481 , A61J1/201 , A61J1/2013 , B65B3/003
摘要： An adapter assembly for establishing bidirectional fluid connection between a cartridge and a vial includes a housing having an open first end adapted to engage the cartridge and a second open end adapted to engage the vial. The adapter includes a needle assembly having a first tip and a second tip, with the needle assembly disposed within the housing and at least partially supported by a needle holder. The needle assembly is movable relative to the housing from an initial position in which the first and second tip are isolated from the cartridge and vial, to an end of use position, in which first tip is engaged with the vial and the second tip is engaged with the cartridge, establishing fluid communication therebetween. The needle assembly is maintained in the initial position by a locking structure which is released by rotationally advancing the needle holder relative to the housing.
摘要翻译：用于在盒和小瓶之间建立双向流体连接的适配器组件包括壳体，该壳体具有适于接合盒的敞开的第一端和适于接合小瓶的第二开口端。适配器包括具有第一尖端和第二末端的针组件，其中针组件设置在壳体内并且至少部分地由针保持器支撑。针组件可以从第一和第二尖端与药筒和小瓶隔离的初始位置相对于壳体移动到使用位置的终点，其中第一尖端与小瓶接合，并且第二末端接合与墨盒之间建立流体连通。针组件通过锁定结构保持在初始位置，锁定结构通过使针保持器相对于壳体旋转地前进而释放。

5. 发明申请

WO2012158137A1 INJECTION DEVICE WITH AUTOMATED SUBSTANCE COMBINING FEATURE 审中-公开
标题翻译：具有自动化物质组合特征的注射装置
公开(公告)号：WO2012158137A1
公开(公告)日：2012-11-22
申请号：PCT/US2011/000897
申请日：2011-05-19
申请人： BECTON, DICKINSON AND COMPANY , CRONENBERG, Richard
发明人： CRONENBERG, Richard
IPC分类号： A61M5/20
CPC分类号： A61M5/2066 , A61M5/2033 , A61M5/2448 , A61M5/347 , Y10T29/49826
摘要： An injection device for automatically combining two substances, including a body and a cartridge displaceably disposed within the body having a first chamber for containing a first substance, a second chamber for containing a second substance, a first stopper displaceably disposed within the cartridge separating the first and second chambers, a second stopper displaceably disposed within the cartridge defining an end of the second chamber. The device also includes a needle hub displaceably disposed within the body having threads thereon for connecting a pen needle to the injection device. The device additionally includes a plunger displaceably disposed within the body, a biasing member, a sleeve, biased by the biasing member and communicating the bias to the plunger, and an activation button radially displaceable with respect to the body to selectively release the sleeve to drive the plunger and automatically mix the first and second substances.
摘要翻译：一种用于自动组合两种物质的注射装置，包括主体和可移动地设置在主体内的盒，其具有用于容纳第一物质的第一室，用于容纳第二物质的第二室，可移动地设置在盒中的第一塞子，和第二腔室，可移动地设置在所述筒体内的限定所述第二腔室的端部的第二塞子。该装置还包括可移动地设置在主体内的针座，其上具有用于将笔针连接到注射装置的线。该装置还包括可移动地设置在主体内的柱塞，偏置构件，由偏压构件偏置并将偏压连通到柱塞的套筒，以及可相对于主体径向移位的启动按钮，以选择性地释放套筒以驱动柱塞并自动混合第一和第二物质。

6. 发明申请

WO2011068544A1 CARTRIDGE FOR CONTAINING AND DISPENSING A MEDICAMENT 审中-公开
标题翻译：用于包含和分配药物的药盒
公开(公告)号：WO2011068544A1
公开(公告)日：2011-06-09
申请号：PCT/US2010/003087
申请日：2010-12-03
申请人： BECTON, DICKINSON AND COMPANY , CRONENBERG, Richard , VEDRINE, Lionel , BEGLEY, Patrick
发明人： CRONENBERG, Richard , VEDRINE, Lionel , BEGLEY, Patrick
IPC分类号： A61M5/00
CPC分类号： A61M5/24 , A61J1/062 , A61M5/2448 , A61M5/2466 , A61M5/28 , A61M5/284 , A61M5/3134 , A61M5/3135 , A61M5/31525 , A61M5/31533 , A61M5/347 , A61M2005/2488 , A61M2005/2492 , A61M2005/3123 , A61M2005/3126 , A61M2005/3132 , A61M2005/31516 , A61M2207/00 , B65B3/003 , B65B3/022 , B65B7/2821 , B65B63/08 , Y10T29/494
摘要： A cartridge (100) for containing and dispensing a medicament, the cartridge (100) including a cartridge body (104) having an interior cavity (10B) therein, a stopper (112) movably disposed within the interior cavity (108), and a septum (116, 148) disposed at an opposite end of the interior cavity (108) from the stopper (112), for containing the medicament within the Interior cavity (108). The cartridge (100) also Includes a connection thread (120) integrally formed as a unitary construction of the cartridge body (104), the thread (120) being disposed at a first end of the cartridge body (104) for connecting a pen needle directly to the cartridge body (104) to pierce the septum (116, 148) and provide communication between the medicament and a patient end of the pen needle.
摘要翻译：一种用于容纳和分配药物的药筒（100），所述药筒（100）包括其中具有内腔（10B）的药筒本体（104），可移动地设置在所述内腔（108）内的止动件（112）所述隔膜（116,148）设置在所述内部空腔（108）的与所述止动件（112）的相对的端部处，用于将所述药物容纳在所述内腔（108）内。盒（100）还包括整体形成为盒体（104）的整体结构的连接线（120），线（120）设置在盒体（104）的第一端，用于连接笔针直接到药筒体（104）刺穿隔膜（116,148），并提供药物与笔针的患者端之间的连通。

7. 发明申请

WO2021195483A2 IMPROVED SYSTEMS, COMPONENTS, AND COMBINATIONS THEREOF FOR PEN-TYPE INJECTION DEVICES 审中-公开
公开(公告)号：WO2021195483A2
公开(公告)日：2021-09-30
申请号：PCT/US2021/024337
申请日：2021-03-26
申请人： BECTON, DICKINSON AND COMPANY
发明人： QUINN, Michael , CRONENBERG, Richard , BOYER, Robert , GORSHKOV, Alexander
IPC分类号： A61M5/00 , A61M5/20 , A61M5/315 , A61M5/2033 , A61M5/2422 , A61M5/31541 , A61M5/31551 , A61M5/31563 , A61M5/31585
摘要： The disclosure provides driver components, systems and drive methods that facilitate improved dose setting, correcting, and/or dispensing in a multiple use pen-type injection device. In particular, various novel braking systems are disclosed that can be implemented within pen-type injection devices to achieve such improvements.

8. 发明申请

WO2013155153A1 MICROINFUSER WITH AUTOMATIC NEEDLE RETRACTION 审中-公开
标题翻译：具有自动针头回缩的微型收缩机
公开(公告)号：WO2013155153A1
公开(公告)日：2013-10-17
申请号：PCT/US2013/035925
申请日：2013-04-10
申请人： BECTON, DICKINSON AND COMPANY
发明人： CRONENBERG, Richard
IPC分类号： A61M5/145
CPC分类号： A61M5/14248 , A61M5/1454 , A61M5/20 , A61M5/2033 , A61M2005/14252 , A61M2005/14256 , A61M2005/206 , A61M2205/582 , A61M2205/584 , A61M2205/585
摘要： A device (10) for delivering a fluid includes a housing (12) defining an interior space (22) and having a bottom surface (18) configured for contacting a patient. The bottom surface (18) defines a needle opening (56). The device (10)also includes a reservoir (26) disposed within the interior space (22) of the housing (12) for containing a fluid therein, a needle carrier (30) disposed within the housing (12), and an injection needle (28) supported by the needle carrier (30) and defining a lumen. The lumen of the injection needle (28) is configured to be placed in fluid communication with the reservoir (26). The injection needle (28) is transitionable from an initial position in which the injection needle is disposed within the housing (12), to a use position in which the injection needle extends through the needle opening (56), and a substantially shielded position in which the injection needle (28) is disposed within the housing (12) and the lumen of the needle (28) is blocked by a portion of the housing (12).
摘要翻译：用于输送流体的装置（10）包括限定内部空间（22）的壳体（12），并且具有构造成用于接触患者的底部表面（18）。底表面（18）限定针孔（56）。所述装置（10）还包括设置在所述壳体（12）的内部空间（22）内用于容纳流体的储存器（26），设置在所述壳体（12）内的针架（30），以及注射针（28），其由所述针架（30）支撑并限定管腔。注射针（28）的管腔构造成与贮液器（26）流体连通。注射针（28）可从其中注射针设置在壳体（12）内的初始位置转移到注射针穿过针孔（56）延伸的使用位置，并且基本上屏蔽位置其中注射针（28）设置在壳体（12）内并且针（28）的内腔被壳体（12）的一部分阻挡。

9. 发明申请

WO2013134614A2 DRUG RECONSTITUTION SYSTEM 审中-公开
标题翻译：药物重组系统
公开(公告)号：WO2013134614A2
公开(公告)日：2013-09-12
申请号：PCT/US2013/029807
申请日：2013-03-08
申请人： BECTON, DICKINSON AND COMPANY
发明人： CRONENBERG, Richard , WU, Haiming
IPC分类号： A61M5/19
CPC分类号： A61M5/31505 , A61J1/2048 , A61M5/19 , A61M5/24 , A61M5/2448 , A61M5/31596 , A61M2005/31508 , A61M2202/064
摘要： A system including an adapter for sequential engagement with a cartridge containing a first substance and a vial containing a second substance is disclosed. The adapter is configured to first engage with the vial and subsequently engage with the cartridge such that the cartridge is in fluid communication with the vial via the adapter. The system includes a latch member engageable with a portion of the cartridge. A plunger rod includes a protrusion and is adapted to communicate with the latch member, the plunger rod being transitionable from a disengaged position, in which the protrusion of the plunger rod is disengaged from the latch member and the latch member is locked to the cartridge, to an engaged position, in which the protrusion is engaged with the latch member and the latch member is unlocked from the cartridge and locked to the plunger rod.
摘要翻译：公开了包括用于与包含第一物质的药筒顺序接合的适配器和包含第二物质的小瓶的系统。适配器被配置为首先与小瓶接合并随后与盒接合，使得盒经由适配器与小瓶流体连通。该系统包括可与盒的一部分接合的闩锁构件。柱塞杆包括突起并且适于与闩锁构件连通，柱塞杆可从分离位置转换，其中柱塞杆的突起与闩锁构件脱离，并且闩锁构件锁定到盒，到接合位置，其中突起与闩锁构件接合，并且闩锁构件从盒中解锁并锁定到柱塞杆。

10. 发明申请

WO2011068543A1 PEN NEEDLE REMOVAL DEVICE FOR A DRUG DELIVERY DEVICE 审中-公开
标题翻译：用于药物递送装置的笔针去除装置
公开(公告)号：WO2011068543A1
公开(公告)日：2011-06-09
申请号：PCT/US2010/003086
申请日：2010-12-03
申请人： BECTON, DICKINSON AND COMPANY , CRONENBERG, Richard
发明人： CRONENBERG, Richard
IPC分类号： A61M5/178
CPC分类号： A61M5/3213 , A61M5/24 , A61M5/31525 , A61M5/31533 , A61M5/3202 , A61M5/3276 , A61M2005/2407 , A61M2005/3206 , A61M2005/3208 , A61M2207/10 , Y10T29/49822 , Y10T29/53
摘要： A removal device (121, 221) for removing and disposing of a pen needle (113, 213) connectable to a drug delivery device (111, 211) includes a body (123, 223) having a cavity (141, 241) for receiving the pen needle of the drug delivery device such that a patient end (116, 216) of a needle (115, 215) of the pen needle is covered by the body. An ejector (151, 251) is movably connected to the body (123, 223) for engaging the received pen needle (113, 213) and selectively ejecting the engaged pen needle from the body. The pen needle (113, 213) is securely retained within the removal device (121, 221) without exposing the needle (115, 215) of the pen needle until the pen needle (113, 213) can be properly disposed of, such as in a sharps container, thereby substantially preventing an accidental needle stick.
摘要翻译：用于去除和布置可连接到药物输送装置（111,211）的笔针（113,213）的去除装置（121,221）包括具有空腔（141,241）的主体（123,223），用于接收药物输送装置的笔针，使得笔针的针（115,215）的患者端（116,216）被身体覆盖。喷射器（151,251）可移动地连接到主体（123,223），用于接合所接收的笔式针头（113,213）并且选择性地将接合的笔针从主体上弹出。笔针113,113被牢固地保持在移除装置121,221内，不会露出笔针的针头115,215，直到笔针113,213能被适当地处理，例如在锐利的容器中，从而基本上防止了意外的针刺。

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