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1. 发明申请

WO2023057336A1 THERMISCH LEITENDEN MIKROPLATTEN 审中-公开
公开(公告)号：WO2023057336A1
公开(公告)日：2023-04-13
申请号：PCT/EP2022/077311
申请日：2022-09-30
申请人： BAYER AKTIENGESELLSCHAFT , GREINER BIO-ONE GMBH
发明人： SUMMER, Holger , NOLL, Ralph , GOLZ, Stefan , KALTHOF, Bernd , HÜSER, Jörg , SCHADE, Andreas , KÜSTER, Mike , FELLER, Torsten , NICOL, Andreas , KUTTIG, Jochen , KNEBEL, Günther , KROHM, Philipp , HELLER, Rainer
IPC分类号： B01L3/00 , B29C45/26 , B29C45/57 , B29C45/56 , B01L2200/12 , B01L2300/0829 , B01L2300/0851 , B01L3/50851 , B29C45/2624 , B29C45/561
摘要： Eine thermisch leitende Mikroplatte aus thermoplastischem Kunststoff, umfassend einen Mikroplattenkörper (150) mit mindestens 96 in dem Mikroplattenkörper (150) angeordneten Näpfchen (151), wobei der Mikroplattenkörper (150) einen ebenen Mikroplattenboden (154) aufweist und jedes Näpfchen (151) mindestens eine Näpfchenwand (152) und einen planen, auf einer allen Näpfchenböden (153) gemeinsamen Näpfchenbodenebene (200) ausgerichteten Näpfchenboden (153) mit einer Bodendicke von höchstens 1000 µm aufweist sowie ein Verfahren zur Herstellung der thermisch leitende Mikroplatten. Der Mikroplattenkörper (150) ist bevorzugt in einem Rahmenträger (300) angeordnet, insbesondere mit diesem verschweißt, verklebt oder vernietet. Hochformatige thermisch leitende Mikroplatten sind für das automatisierte Prozessieren mit hoher thermischer Leitfähigkeit für den Einsatz in temperatursensitive und auf Temperaturwechsel basierende Analyse- und Synthesemethoden optimiert.

3. 发明申请

WO2003080100A2 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH HOMO SAPIENS G - PROTEIN - COUPLED RECEPTOR 63 (GPR63) 审中-公开
标题翻译：与HOMO SAPIENS相关的疾病的诊断和治疗G-蛋白质 - 偶联受体63（GPR63）
公开(公告)号：WO2003080100A2
公开(公告)日：2003-10-02
申请号：PCT/EP2003/002686
申请日：2003-03-14
申请人： BAYER AKTIENGESELLSCHAFT , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
IPC分类号： A61K38/00
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/566 , G01N33/74 , G01N2333/726 , G01N2500/00
摘要： The invention provides a human GPR63 receptor which is associated with hematological diseases, disorders of the peripheral and central nervous system, COPD, asthma, genito-urological disorders, gastro-intestinal diseases, inflammation diseases and cancer. The invention also provides assays for the identification of compounds useful in the treatment or prevention of hematological diseases, disorders of the peripheral and central nervous system, COPD, asthma, genito-urological disorders, gastro-intestinal diseases, inflammation diseases and cancer. The invention also features compounds which bind to and/or activate or inhibit the activity of GPR63 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与血液疾病，外周和中枢神经系统疾病，COPD，哮喘，泌尿系统疾病，胃肠疾病，炎症疾病和癌症有关的人类GPR63受体。本发明还提供了用于鉴定可用于治疗或预防血液疾病，外周和中枢神经系统疾病，COPD，哮喘，泌尿系统疾病，胃肠疾病，炎症疾病和癌症的化合物的测定。本发明还涉及结合和/或活化或抑制GPR63活性的化合物以及包含这些化合物的药物组合物。

4. 发明申请

WO2003080097A2 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH HOMO SAPIENS G - PROTEIN - COUPLED RECEPTOR 7 (GPR7) 审中-公开
标题翻译：与HOMO SAPIENS相关的疾病诊断和治疗G - 蛋白 - 偶联受体7（GPR7）
公开(公告)号：WO2003080097A2
公开(公告)日：2003-10-02
申请号：PCT/EP2003/002404
申请日：2003-03-10
申请人： BAYER AKTIENGESELLSCHAFT , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
IPC分类号： A61K38/00
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/566 , G01N33/74 , G01N2333/726 , G01N2500/00
摘要： The invention provides a human GPR7 which is associated with the cardiovascular, hematological, peripheral and central nervous system diseases, COPD, asthma, inflammation, gastro-intestinal diseases and cancer. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular, hematological, peripheral and central nervous system diseases, COPD, asthma, inflammation, gastro-intestinal diseases and cancer. The invention also features compounds which bind to and/or activate or inhibit the activity of GPR7 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管，血液学，外周和中枢神经系统疾病，COPD，哮喘，炎症，胃肠道疾病和癌症相关的人类GPR7。本发明还提供了用于鉴定可用于治疗或预防心血管，血液，外周和中枢神经系统疾病，COPD，哮喘，炎症，胃肠道疾病和癌症的化合物的测定。本发明还涉及结合和/或活化或抑制GPR7活性的化合物以及包含这些化合物的药物组合物。

5. 发明申请

WO2003046179A2 NEW G-PROTEIN COUPLED RECEPTOR LUSTR2 AND USES THEREOF 审中-公开
标题翻译：新型G蛋白偶联受体LUSTR2及其用途
公开(公告)号：WO2003046179A2
公开(公告)日：2003-06-05
申请号：PCT/EP2002/012820
申请日：2002-11-15
申请人： BAYER AKTIENGESELLSCHAFT , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
IPC分类号： C12N15/12
CPC分类号： C07K14/705
摘要： Polynucleotide sequence for novel G-protein coupled receptor LUSTR2 and uses thereof. The present invention is directed to a polynucleotide sequence of a novel G-Protein Coupled Receptor LUSTR2. More particularly, the present invention provides a polynucleotide sequence comprising the nucleic acid sequence SEQ ID NO: 1 or nucleic acid sequences that hybridize to SEQ ID NO: 1 or its complimentary strand having at least 40% sequence identity. Preferably, the hybridizing nucleic acid sequence should hybridize under stringent conditions and in particular have 85% sequence identity, more preferably 90% sequence identity, and most preferably 95% sequence identity. The invention also provides the human LUSTR2 associated with the haemaotological, peripheral and central nervous system, COPD, asthma, genito-urological, metabolic diseases and pancreas and heart disorders as a result of relative quantification of the mRNA distribution in different human tissues by expression profiling. The invention also provides assays for the identification of compounds useful for the modulation of hematological, peripheral and central nervous system, COPD, asthma, genito-urological, metabolic diseases and pancreas and heart disorders for treating or preventing hematological, peripheral and central nervous system, COPD, asthma, genito-urological, metabolic diseases and pancreas and heart disorders associated with expression of the LUSTR2. The methods of the invention involve cell-free and cell-based assays that identify compounds which bind to and/or activate or inhibit the activity of LUSTR2, a G protein coupled receptor, followed by an in vivo assay of the effect of the compound on hematological, peripheral and central nervous system, COPD, asthma, genito-urological, metabolic diseases and pancreas and heart disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of LUSTR2 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：新型G蛋白偶联受体LUSTR2的多核苷酸序列及其用途。本发明涉及新型G-蛋白偶联受体LUSTR2的多核苷酸序列。更具体地，本发明提供了包含核酸序列SEQ ID NO：1或与SEQ ID NO：1杂交的核酸序列或其具有至少40％序列同一性的互补链的多核苷酸序列。优选地，杂交核酸序列应在严格条件下杂交，特别是具有85％序列同一性，更优选90％序列同一性，最优选95％序列同一性。本发明还提供了与通过表达谱分析在不同人体组织中mRNA分布的相对定量相结合的血液学，外周和中枢神经系统COPD，哮喘，生殖泌尿，代谢疾病和胰腺和心脏病的人LUSTR2 。本发明还提供了用于鉴定可用于调节血液系统，外周和中枢神经系统，COPD，哮喘，泌尿系统，代谢疾病和胰腺以及用于治疗或预防血液学，外周和中枢神经系统的心脏病的化合物的测定， COPD，哮喘，生殖泌尿，代谢疾病，与LUSTR2表达相关的胰腺和心脏病。本发明的方法包括无细胞和基于细胞的测定，其鉴定结合和/或激活或抑制LUSTR2，G蛋白偶联受体的活性的化合物，随后在体内测定化合物对血液学，外周和中枢神经系统，COPD，哮喘，泌尿系统，代谢疾病和胰腺和心脏病。本发明还涉及结合和/或活化或抑制LUSTR2的活性的化合物以及包含这些化合物的药物组合物。

6. 发明申请

WO2021204701A1 RAPID DETECTION OF VIRAL INFECTION USING RT-PCR 审中-公开
公开(公告)号：WO2021204701A1
公开(公告)日：2021-10-14
申请号：PCT/EP2021/058720
申请日：2021-04-01
申请人： BAYER AKTIENGESELLSCHAFT
发明人： GOLZ, Stefan , SUMMER, Holger , AIGNER, Silke , ELLINGER-ZIEGELBAUER, Heidrun , LEINEWEBER, Kirsten , MÜLLER, Thomas
IPC分类号： C12Q1/6844 , C12Q1/70
摘要： A lysis buffer comprising one non-ionic surfactant is provided which can be used as a one-step reagent of the preparation, storage, amplification, and/or detection of nucleic acids. Various embodiments of the lysis buffer of the invention comprise other substances that are compatible or useful in lysing cells, storing nucleic acids, amplifying nucleic acids, purifying nucleic acids, detecting nucleic acids, and/or other procedures for analysis of nucleic acids. Methods and kits based on the lysis buffer are also provided, including those for rapid lysis of cells and direct use of the resulting cell lysates in RT-PCR.

7. 发明申请

WO2004003567A1 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH THE G2A-RECEPTOR (G2A) 审中-公开
标题翻译：与G2A受体（G2A）相关疾病的诊断和治疗方法
公开(公告)号：WO2004003567A1
公开(公告)日：2004-01-08
申请号：PCT/EP2003/006612
申请日：2003-06-24
申请人： BAYER AKTIENGESELLSCHAFT , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
IPC分类号： G01N33/74
CPC分类号： G01N33/74 , A61K38/00 , C07K14/723 , G01N2333/726 , G01N2500/00
摘要： The invention provides a human G2A which is associated with the hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, gastro-intestinal diseases and inflammation. The invention also provides assays for the identification of compounds useful in the treatment or prevention of hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, gastro-intestinal diseases and inflammation. The invention also features compounds which bind to and/or activate or inhibit the activity of G2A as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与血液疾病，心血管疾病，外周和中枢神经系统紊乱，胃肠道疾病和炎症相关的人类G2A。本发明还提供了用于鉴定可用于治疗或预防血液疾病，心血管疾病，外周和中枢神经系统疾病，胃肠道疾病和炎症的化合物的测定。本发明还涉及结合和/或活化或抑制G2A活性的化合物以及包含这些化合物的药物组合物。

8. 发明申请

WO2003100435A2 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH NEUROMEDIN U2 RECEPTOR (NMU2) 审中-公开
标题翻译：与NEUROMEDIN U2受体（NMU2）相关的疾病的诊断和治疗
公开(公告)号：WO2003100435A2
公开(公告)日：2003-12-04
申请号：PCT/EP2003/005043
申请日：2003-05-14
申请人： BAYER AKTIENGESELLSCHAFT , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , A61K38/11 , G01N33/566 , G01N2500/04
摘要： The invention provides a human NMU2 which is associated with the hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, cancer, genitourinary diseases and respiratory diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, cancer, genitourinary diseases and respiratory diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of NMU2 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与血液疾病，心血管疾病，外周和中枢神经系统疾病，癌症，泌尿生殖系疾病和呼吸系统疾病相关的人NMU2。本发明还提供了用于鉴定可用于治疗或预防血液疾病，心血管疾病，外周和中枢神经系统疾病，癌症，泌尿生殖疾病和呼吸系统疾病的化合物的测定。本发明还涉及结合和/或活化或抑制NMU2的活性的化合物以及包含这些化合物的药物组合物。

9. 发明申请

WO2003099867A1 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH ARGININE VASOPRESSIN RECEPTOR 1 (AVPR1) 审中-公开
标题翻译：与ARGININE VASOPRESSIN受体1（AVPR1）相关的疾病的诊断和治疗
公开(公告)号：WO2003099867A1
公开(公告)日：2003-12-04
申请号：PCT/EP2003/005042
申请日：2003-05-14
申请人： BAYER AKTIENGESELLSCHAFT , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , THIELE, Ralf
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas , THIELE, Ralf
IPC分类号： C07K14/72
CPC分类号： C07K14/705
摘要： The invention provides a human AVPR1 which is associated with the hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, inflammation diseases and genitourinary diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, inflammation diseases and genitourinary diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of AVPR1 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与血液疾病，心血管疾病，外周和中枢神经系统紊乱，炎症疾病和泌尿生殖疾病有关的人AVPR1。本发明还提供了用于鉴定可用于治疗或预防血液疾病，心血管疾病，外周和中枢神经系统疾病，炎症疾病和泌尿生殖疾病的化合物的测定。本发明还涉及结合和/或活化或抑制AVPR1的活性的化合物以及包含这些化合物的药物组合物。

10. 发明申请

WO2003096020A2 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH CHEMOKINE RECEPTOR 8 (CCR8) 审中-公开
标题翻译：与化疗受体8（CCR8）相关疾病的诊断和治疗
公开(公告)号：WO2003096020A2
公开(公告)日：2003-11-20
申请号：PCT/EP2003/004496
申请日：2003-04-30
申请人： BAYER AKTIENGESELLSCHAFT , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
IPC分类号： G01N33/68
CPC分类号： G01N33/6863 , A61K38/1793
摘要： The invention provides a human CCR8 which is associated with the disorders of the peripheral and central nervous system, cardio-vascular diseases, gastro-intestinal diseases, cancer and hematological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of disorders of the peripheral and central nervous system, cardio-vascular diseases, gastro-intestinal diseases, cancer and hematological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of CCR8 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与外周和中枢神经系统疾病，心血管疾病，胃肠道疾病，癌症和血液疾病相关的人类CCR8。本发明还提供了用于鉴定可用于治疗或预防外周和中枢神经系统疾病，心血管疾病，胃肠道疾病，癌症和血液疾病的化合物的测定。本发明还涉及结合和/或活化或抑制CCR8活性的化合物以及包含这些化合物的药物组合物。

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