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1. 发明申请

US20090017493A1 Gene SMS 02 审中-公开
标题翻译：基因短信02
公开(公告)号：US20090017493A1
公开(公告)日：2009-01-15
申请号：US11883780
申请日：2006-02-10
申请人： Bastien Chevreux , Anne Mayer , Anja Meury , Nigel Mouncey , Masako Shinjoh
发明人： Bastien Chevreux , Anne Mayer , Anja Meury , Nigel Mouncey , Masako Shinjoh
IPC分类号： C12P21/02 , C07H21/04 , C12N15/63 , C12N1/21 , C12P17/04 , C12N9/04 , C12N15/74
CPC分类号： C12P17/04 , C12N9/0006
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及编码参与L-抗坏血酸合成（以下也称为维生素C）的蛋白质的新鉴定的基因。本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。本发明还涉及所述多核苷酸和多肽在从微生物生产维生素C中作为生物技术工具的用途，其中所述多核苷酸和/或编码多肽的修饰对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

2. 发明申请

US20080160589A1 Gene Rcs 24 审中-公开
标题翻译：基因Rcs 24
公开(公告)号：US20080160589A1
公开(公告)日：2008-07-03
申请号：US11883843
申请日：2006-02-10
申请人： Bastien Chevreux , Anne F. Mayer , Anja Meury , Nigel J. Mouncey , Masako Shinjoh
发明人： Bastien Chevreux , Anne F. Mayer , Anja Meury , Nigel J. Mouncey , Masako Shinjoh
IPC分类号： C12P17/04 , C12N15/11 , C12N15/00 , C12N1/20 , C07K14/00 , C12N15/74
CPC分类号： C12P7/60 , C12N9/0006 , C12P17/04
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及编码参与L-抗坏血酸合成（以下也称为维生素C）的蛋白质的新鉴定的基因。本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。本发明还涉及所述多核苷酸和多肽在从微生物生产维生素C中作为生物技术工具的用途，其中所述多核苷酸和/或编码多肽的修饰对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

3. 发明申请

US20080176297A1 Gene Rcs 21 审中-公开
标题翻译：基因Rcs 21
公开(公告)号：US20080176297A1
公开(公告)日：2008-07-24
申请号：US11883723
申请日：2006-02-10
申请人： Bastien Chevreux , Anne F. Mayer , Anja Meury , Nigel J. Mouncey , Masako Shinjoh
发明人： Bastien Chevreux , Anne F. Mayer , Anja Meury , Nigel J. Mouncey , Masako Shinjoh
IPC分类号： C12P17/04 , C12N15/31 , C12N15/63 , C12N1/21 , C07K14/195 , C12N15/74
CPC分类号： C12P17/04 , C07K14/195
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及编码参与L-抗坏血酸合成（以下也称为维生素C）的蛋白质的新鉴定的基因。本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。本发明还涉及所述多核苷酸和多肽在从微生物生产维生素C中作为生物技术工具的用途，其中所述多核苷酸和/或编码多肽的修饰对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

4. 发明申请

US20090023191A1 Gene RCS 23 审中-公开
标题翻译：基因RCS 23
公开(公告)号：US20090023191A1
公开(公告)日：2009-01-22
申请号：US11883825
申请日：2006-02-10
申请人： Bastien Chevreux , Anne F. Mayer , Anja Meury , Nigel J. Mouncey , Masako Shinjoh
发明人： Bastien Chevreux , Anne F. Mayer , Anja Meury , Nigel J. Mouncey , Masako Shinjoh
IPC分类号： C12P17/04 , C07H21/00 , C12N1/21 , C12N15/11 , C12N15/31 , C12P7/60 , C12N15/74
CPC分类号： C12P17/04 , C07K14/195
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及编码参与L-抗坏血酸合成（以下也称为维生素C）的蛋白质的新鉴定的基因。本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。本发明还涉及所述多核苷酸和多肽在从微生物生产维生素C中作为生物技术工具的用途，其中所述多核苷酸和/或编码多肽的修饰对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

5. 发明授权

US09090920B2 Gene SMS 27 有权
标题翻译：基因短信27
公开(公告)号：US09090920B2
公开(公告)日：2015-07-28
申请号：US11991422
申请日：2006-09-07
申请人： Bastien Chevreux , Nigel J. Mouncey , Masako Shinjoh
发明人： Bastien Chevreux , Nigel J. Mouncey , Masako Shinjoh
IPC分类号： C12N1/21 , C12P17/04 , C12N9/02
CPC分类号： C12P17/04 , C12N9/0004
摘要： Microorganism selected from Gluconobacter, Gluconacetobacter, Acetobacter or Ketogulonicigenium, wherein a gene encoding a polypeptide with the activity of a repressor of L-sorbosone dehydrogenase (SNDH) and L-sorbose dehydrogenase (SDH) is disrupted. The gene has a polynucleotide selected from polynucleotides encoding a polypeptide comprising the amino acid sequence of which is represented by SEQ ID NO:2, polynucleotide comprising the nucleotide sequence according to SEQ ID NO:1, polynucleotides the complementary strand of which hybridizes under stringent conditions to a polynucleotide as defined above and which encodes a polypeptide with the activity of a repressor of SNDH and SDH. The microorganism produces at least 10% more Vitamin C and/or 2-KGA from L-sorbose compared to a microorganism wherein the repressor is intact.
摘要翻译：选自葡糖杆菌，葡糖酸杆菌属，醋杆菌属或酮多糖属的微生物，其中编码具有L-山梨糖酮脱氢酶（SNDH）和L-山梨糖脱氢酶（SDH）的阻遏物的活性的多肽的基因被破坏。该基因具有选自编码包含SEQ ID NO：2所示的氨基酸序列的多肽的多核苷酸的多核苷酸，包含根据SEQ ID NO：1的核苷酸序列的多核苷酸，其互补链在严格条件下杂交的多核苷酸涉及如上定义的多核苷酸，其编码具有SNDH和SDH阻遏物活性的多肽。与其中阻遏物是完整的微生物相比，微生物从L-山梨糖产生至少10％的维生素C和/或2-KGA。

6. 发明申请

US20080305532A1 Gene For Coenzyme Pqq Synthesis Protein B From Gluconobacter Oxydans 审中-公开
标题翻译：用于辅酶Pqq的基因从氧化葡糖杆菌合成蛋白B
公开(公告)号：US20080305532A1
公开(公告)日：2008-12-11
申请号：US11883781
申请日：2006-02-10
申请人： Bastien Chevreux , Anne F. Mayer , Nigel J. Mouncey , Masako Shinjoh
发明人： Bastien Chevreux , Anne F. Mayer , Nigel J. Mouncey , Masako Shinjoh
IPC分类号： C12P7/48 , C12N15/11 , C12N15/00 , C12N1/20 , C07K14/00
CPC分类号： C12P7/60 , C07K14/195 , C12P17/04
摘要： The present invention relates to a newly identified gene that encodes a protein that is involved in the synthesis of L-ascorbic acid (hereinafter also referred to a Vitamin C). The protein is coenzyme PQQ synthesis protein B. The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及新鉴定的参与L-抗坏血酸合成的蛋白质的基因（以下也称为维生素C）。蛋白质是辅酶PQQ合成蛋白B.本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。本发明还涉及所述多核苷酸和多肽在从微生物生产维生素C中作为生物技术工具的用途，其中所述多核苷酸和/或编码多肽的修饰对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

7. 发明授权

US09079951B2 Method for production of vitamin C 有权
标题翻译：生产维生素C的方法
公开(公告)号：US09079951B2
公开(公告)日：2015-07-14
申请号：US12905282
申请日：2010-10-15
申请人： Bastien Chevreux , Corina Hauk , Andrea Muffler , Nigel J. Mouncey , Masako Shinjoh
发明人： Bastien Chevreux , Corina Hauk , Andrea Muffler , Nigel J. Mouncey , Masako Shinjoh
IPC分类号： C12P17/04 , C12N1/21 , C12N15/63 , C12N15/74 , C07K14/195
CPC分类号： C07K14/195 , C12P17/04
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of the polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of the polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in the microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及编码参与L-抗坏血酸合成（以下也称为维生素C）的蛋白质的新鉴定的基因。本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。本发明还涉及多核苷酸和多肽在从微生物生产维生素C中作为生物技术工具的用途，其中多核苷酸和/或编码多肽的修饰对产量，产量和/或微生物发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

8. 发明申请

US20080274520A1 Novel Gene Sms 37 审中-公开
标题翻译：新基因短信37
公开(公告)号：US20080274520A1
公开(公告)日：2008-11-06
申请号：US11991399
申请日：2006-09-07
申请人： Bastien Chevreux , Corina Hauk , Andrea Muffler , Nigel J. Mouncey , Masako Shinjoh
发明人： Bastien Chevreux , Corina Hauk , Andrea Muffler , Nigel J. Mouncey , Masako Shinjoh
IPC分类号： C12P17/04 , C07H21/00 , C12N15/63 , C12N1/00 , C12N1/21 , C07K2/00 , C12N15/74
CPC分类号： C07K14/195 , C12P17/04
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及编码参与L-抗坏血酸合成（以下也称为维生素C）的蛋白质的新鉴定的基因。本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。本发明还涉及所述多核苷酸和多肽在从微生物生产维生素C中作为生物技术工具的用途，其中所述多核苷酸和/或编码多肽的修饰对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

9. 发明申请

US20090148909A1 GENE SMS 27 有权
标题翻译：基因SMS 27
公开(公告)号：US20090148909A1
公开(公告)日：2009-06-11
申请号：US11991422
申请日：2006-09-07
申请人： Bastien Chevreux , Nigel J. Mouncey , Masako Shinjoh
发明人： Bastien Chevreux , Nigel J. Mouncey , Masako Shinjoh
IPC分类号： C12P19/34 , C07H21/04 , C12N15/63 , C12N1/00 , C12P17/04 , C07K2/00 , C12N15/74 , C12N1/21
CPC分类号： C12P17/04 , C12N9/0004
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及编码参与L-抗坏血酸合成（以下也称为维生素C）的蛋白质的新鉴定的基因。本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。本发明还涉及所述多核苷酸和多肽在从微生物生产维生素C中作为生物技术工具的用途，其中所述多核苷酸和/或编码多肽的修饰对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

10. 发明授权

US08685683B2 Method for production of vitamin C and or 2-Keto-L gulonic acid 失效
标题翻译：生产维生素C和/或2-酮-L-古洛糖酸的方法
公开(公告)号：US08685683B2
公开(公告)日：2014-04-01
申请号：US12811958
申请日：2009-01-09
申请人： Bastien Chevreux , Nigel John Mouncey
发明人： Bastien Chevreux , Nigel John Mouncey
IPC分类号： C12P7/60 , C12P17/04 , C12N15/00 , C12N1/21 , C12N9/12
CPC分类号： C12P17/04 , C12N9/1223
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C) and/or 2-keto-L-gulonic acid (hereinafter also referred to as 2-KGA). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechno logical tools in the production of Vitamin C and/or 2-KGA from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C and/or 2-KGA.
摘要翻译：本发明涉及编码参与L-抗坏血酸（以下也称为维生素C）和/或2-酮-L-古洛糖酸合成的蛋白质的新鉴定的基因（以下也称为2- KGA）。本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。本发明还涉及所述多核苷酸和多肽作为生物技术工具在从微生物生产维生素C和/或2-KGA中的用途，其中所述多核苷酸和/或编码多肽的修饰具有直接或间接的影响在所述微生物中产生，生产和/或发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。本发明还涉及基因工程微生物及其用于直接生产维生素C和/或2-KGA的用途。

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