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1. 发明授权

US08114888B2 Isothiazoloquinolones and related compounds as anti-infective agents 失效
标题翻译：异噻唑并喹啉酮和相关化合物作为抗感染剂
公开(公告)号：US08114888B2
公开(公告)日：2012-02-14
申请号：US11354521
申请日：2006-02-15
申请人： Barton James Bradbury , Godwin Pais , Qiuping Wang , Milind Deshpande , Michael Pucci , Yongsheng Song , Edlaine Lucien , Jason Allan Wiles , Akihiro Hashimoto
发明人： Barton James Bradbury , Godwin Pais , Qiuping Wang , Milind Deshpande , Michael Pucci , Yongsheng Song , Edlaine Lucien , Jason Allan Wiles , Akihiro Hashimoto
IPC分类号： A61K31/4365 , A61K31/4375 , C07D491/14
CPC分类号： C07D513/04 , C07D513/14
摘要： The invention provides certain compounds and salts of Formula I and Formula II: which possess antimicrobial activity. The invention also provides novel synthetic intermediates useful in making compounds of Formula I and Formula II. The variables A1, R2, R3, R5, R6, R7, A8 and R9 are defined herein.
摘要翻译：本发明提供某些具有抗微生物活性的式I和式II化合物和盐。本发明还提供了可用于制备式I和式II化合物的新型合成中间体。变量A1，R2，R3，R5，R6，R7，A8和R9在本文中定义。

2. 发明申请

US20120114601A1 NEW ISOTHIAZOLOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS 审中-公开
标题翻译：新的异黄酮和相关化合物作为抗感染剂
公开(公告)号：US20120114601A1
公开(公告)日：2012-05-10
申请号：US13348703
申请日：2012-01-12
申请人： Barton James Bradbury , Godwin Pais , Quiping Wang , Milind Deshpande , Michael Pucci , Yongsheng Song , Edlaine Lucien , Jason Allan Wiles , Akihiro Hashimoto
发明人： Barton James Bradbury , Godwin Pais , Quiping Wang , Milind Deshpande , Michael Pucci , Yongsheng Song , Edlaine Lucien , Jason Allan Wiles , Akihiro Hashimoto
IPC分类号： A61K31/4745 , A61K31/4375 , A61K38/21 , A61P31/12 , A61P31/04 , A61P33/02 , A61P31/10 , A61P17/00 , A61P13/02 , A61P11/00 , A61P19/08 , A61P19/02 , A61P1/12 , C07D513/14 , C07D513/04
CPC分类号： C07D513/04 , C07D513/14
摘要： The invention provides certain compounds and salts of Formula I and Formula II: which possess antimicrobial activity. The invention also provides novel synthetic intermediates useful in making compounds of Formula I and Formula II. The variables A1, R2, R3, R5, R6, R7, A8 and R9 are defined herein.Certain compounds of Formula I and Formula II disclosed herein are potent and selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula I or Formula II and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula I or Formula II as the only active agent or may contain a combination of a compound of Formula I or Formula II and one or more other active agents. The invention also provides methods for treating microbial infections in animals.
摘要翻译：本发明提供某些具有抗微生物活性的式I和式II化合物和盐。本发明还提供了可用于制备式I和式II化合物的新型合成中间体。变量A1，R2，R3，R5，R6，R7，A8和R9在本文中定义。本文公开的某些式I和式II化合物是细菌DNA合成和细菌复制的有效和选择性抑制剂。本发明还提供包含一种或多种式I或式II化合物和一种或多种载体，赋形剂或稀释剂的抗微生物组合物，包括药物组合物。这样的组合物可以含有式I或式II的化合物作为唯一的活性剂或可以含有式I或式II的化合物与一种或多种其它活性剂的组合。本发明还提供了治疗动物微生物感染的方法。

3. 发明申请

US20060235041A1 New isothiazoloquinolones and related compounds as anti-infective agents 失效
标题翻译：新异噻唑并喹啉酮和相关化合物作为抗感染剂
公开(公告)号：US20060235041A1
公开(公告)日：2006-10-19
申请号：US11354521
申请日：2006-02-15
申请人： Barton Bradbury , Godwin Pais , Qiuping Wang , Milind Deshpande , Michael Pucci , Yongsheng Song , Edlaine Lucien , Jason Wiles , Akihiro Hashimoto
发明人： Barton Bradbury , Godwin Pais , Qiuping Wang , Milind Deshpande , Michael Pucci , Yongsheng Song , Edlaine Lucien , Jason Wiles , Akihiro Hashimoto
IPC分类号： C07D498/02 , A61K31/4745
CPC分类号： C07D513/04 , C07D513/14
摘要： The invention provides certain compounds and salts of Formula I and Formula II: which possess antimicrobial activity. The invention also provides novel synthetic intermediates useful in making compounds of Formula I and Formula II. The variables A1, R2, R3, R5, R6, R7, A8 and R9 are defined herein. Certain compounds of Formula I and Formula II disclosed herein are potent and selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula I or Formula II and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula I or Formula II as the only active agent or may contain a combination of a compound of Formula I or Formula II and one or more other active agents. The invention also provides methods for treating microbial infections in animals.
摘要翻译：本发明提供某些具有抗微生物活性的式I和式II化合物和盐。本发明还提供了可用于制备式I和式II化合物的新型合成中间体。变量A 1，R 2，R 3，R 5，R 6，/或 >，R 7，A 8和R 9在本文中定义。本文公开的某些式I和式II化合物是细菌DNA合成和细菌复制的有效和选择性抑制剂。本发明还提供包含一种或多种式I或式II化合物和一种或多种载体，赋形剂或稀释剂的抗微生物组合物，包括药物组合物。这样的组合物可以含有式I或式II的化合物作为唯一的活性剂或可以含有式I或式II的化合物与一种或多种其它活性剂的组合。本发明还提供了治疗动物微生物感染的方法。

4. 发明申请

US20060100215A1 8A,9-dihydro-4aH-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents 审中-公开
标题翻译： 8A，9-二氢-4a-异噻唑并[5,4-b]喹啉-3,4-二酮和相关化合物作为抗感染剂
公开(公告)号：US20060100215A1
公开(公告)日：2006-05-11
申请号：US11271556
申请日：2005-11-10
申请人： Barton Bradbury , Milind Deshpande , Michael Pucci , Qiuping Wang , Jason Wiles , Yongsheng Song , Akihiro Hashimoto , Edlaine Lucien
发明人： Barton Bradbury , Milind Deshpande , Michael Pucci , Qiuping Wang , Jason Wiles , Yongsheng Song , Akihiro Hashimoto , Edlaine Lucien
IPC分类号： A61K31/496 , A61K31/4745 , C07D498/02
CPC分类号： C07D513/04 , C07D513/14
摘要： The invention provides compounds and salts of Formula I and Formula II: which possess antimicrobial activity. The invention also provides novel synthetic intermediates useful in making compounds of Formula I and Formula II. The variables n, m, p, RA, RB, A1, R2, R3, R5, R6, R7, A8 and R9 are defined herein. Certain compounds of Formula I and Formula II disclosed herein are potent and/or selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula I or Formula II and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula I or Formula II as the only active agent or may contain a combination of a compound of Formula I or Formula II and one or more other active agents. The invention also provides methods for treating microbial infections in eukaryotes.
摘要翻译：本发明提供具有抗微生物活性的式I和式II化合物和盐。本发明还提供了可用于制备式I和式II化合物的新型合成中间体。变量n，m，p，R a，R B，A 1，R 2，R 2， R 3，R 5，R 6，R 7，A 8和R 8，本文定义了SUB> 9 。本文公开的某些式I和式II化合物是细菌DNA合成和细菌复制的有效和/或选择性抑制剂。本发明还提供包含一种或多种式I或式II化合物和一种或多种载体，赋形剂或稀释剂的抗微生物组合物，包括药物组合物。这样的组合物可以含有式I或式II的化合物作为唯一的活性剂或可以含有式I或式II的化合物与一种或多种其它活性剂的组合。本发明还提供了用于治疗真核生物中的微生物感染的方法。

5. 发明申请

US20120250222A1 ANTI-REDUCTIVE HIGH-FREQUENCY CERAMIC DIELECTRIC MATERIAL SINTERED AT LOW TEMPERATURE AND MATCHED WITH COPPER INTERNAL ELECTRODE 有权
标题翻译：抗低温高频陶瓷电介质材料在低温烧结并与铜内电极匹配
公开(公告)号：US20120250222A1
公开(公告)日：2012-10-04
申请号：US13377499
申请日：2010-12-20
申请人： Beibei Song , Yongsheng Song , Fangce Mo , Juan Li , Xiaoguo Wang , Jinghua Guo
发明人： Beibei Song , Yongsheng Song , Fangce Mo , Juan Li , Xiaoguo Wang , Jinghua Guo
IPC分类号： B32B15/04 , H01G4/10
CPC分类号： C04B35/20 , C04B35/62685 , C04B2235/3201 , C04B2235/3203 , C04B2235/3208 , C04B2235/3215 , C04B2235/3232 , C04B2235/3244 , C04B2235/3267 , C04B2235/3281 , C04B2235/3284 , C04B2235/3298 , C04B2235/3409 , C04B2235/3418 , C04B2235/3445 , C04B2235/652
摘要： Provided is an anti-reductive high-frequency ceramic dielectric material sintered at low temperature and matched with copper internal electrode, which can be used for producing multi-layer ceramic capacitor with a copper internal electrode. The ceramic dielectric material consists of main crystalline phase, modifying additive and sintering flux. The formula of the main crystalline phase is MgxBa(1−x)ZrySi(1−y)O3, wherein 0.8≦0.95, 0.05≦y≦0.2. The modifying additive is one or more of MnO2, CaO, Li2O, Bi2O3 and TiO2, and the sintering flux is one or more of B2O3, SiO2, ZnO, CuO, K2O and BaO. The ceramic dielectric material meets the requirements of COG characteristics by EIA standard, has such characteristics as uniform particle size distribution, high dispersiveness, optimized molding process, eco-friendliness and excellent dielectric properties.
摘要翻译：提供了一种低温烧结并与铜内电极匹配的抗还原高频陶瓷介电材料，可用于生产具有铜内电极的多层陶瓷电容器。陶瓷介电材料由主结晶相，改性添加剂和烧结助焊剂组成。主结晶相的配方是MgxBa（1-x）ZrySi（1-y）O3，其中0.8＆lt; ll; 0.95,0.05＆nlE; y＆nlE; 0.2。改性添加剂是MnO 2，CaO，Li 2 O，Bi 2 O 3和TiO 2中的一种或多种，烧结助熔剂是B 2 O 3，SiO 2，ZnO，CuO，K 2 O和BaO中的一种或多种。陶瓷介电材料通过EIA标准符合COG特性要求，具有粒度分布均匀，分散性高，成型工艺优化，环保性和介电性能好等特点。

6. 发明授权

US09039898B2 Method for separating components in natural oil 有权
标题翻译：分离天然油成分的方法
公开(公告)号：US09039898B2
公开(公告)日：2015-05-26
申请号：US13297115
申请日：2011-11-15
申请人： Yongsheng Song
发明人： Yongsheng Song
IPC分类号： B01D11/04 , B01D17/02 , B01D9/02 , C11B3/02 , C11B3/12 , C11B3/16 , A23D9/02 , B01D11/02 , C11B1/10 , B01D36/00 , C11B3/00
CPC分类号： C11B3/00 , A23D9/02 , A61K47/06 , A61K47/08 , A61K47/10 , A61K47/12 , A61K47/22 , A61K47/28 , A61K47/44 , B01D9/02 , B01D11/0284 , B01D11/04 , B01D11/0492 , B01D17/0217 , B01D36/003 , C11B1/10 , C11B3/001 , C11B3/12 , C11B3/16 , C11D7/241 , C11D7/245 , C11D7/261 , C11D7/264 , C11D7/265 , C11D7/267 , C11D7/44
摘要： Different components of natural oils are separated by forming solid complexes of components of the natural oil with a solvent, and then separating the solid complexes from the remaining liquids. The natural oil is cooled in the presence of a solvent, and at least one component of the oil forms the solid complex with the solvent. This solid complex is separated from the remaining liquid portion of the oil solution, which also contains the solvent. Additional options concentration steps can further concentrate the components left in the liquid phase.
摘要翻译：通过用溶剂形成天然油组分的固体络合物，然后将固体复合物与剩余的液体分离，分离天然油的不同组分。天然油在溶剂存在下冷却，至少一种油组分与溶剂形成固体络合物。该固体复合物与还含有溶剂的油溶液的剩余液体部分分离。附加选项浓缩步骤可以进一步集中留在液相中的组分。

7. 发明申请

US20070082920A1 NAD+-dependent DNA ligase inhibitors 审中-公开
标题翻译： NAD +依赖性DNA连接酶抑制剂
公开(公告)号：US20070082920A1
公开(公告)日：2007-04-12
申请号：US11244614
申请日：2005-10-06
申请人： Yongsheng Song , Yongchun Hou , Sandeep Gupta , Aimee Reed , Debasis Ghosh
发明人： Yongsheng Song , Yongchun Hou , Sandeep Gupta , Aimee Reed , Debasis Ghosh
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D487/02
摘要： Disclosed herein are pyrido[2,3-d]pyrimidines having the structure wherein R1, and R2 are independently selected from nitro and amino; wherein R3 is selected from alkyl (C1-C10) and cycloalkyl (C3-C8); wherein R4 is selected from hydrogen, benzyl, alkyl (C1-C10), cycloalkyl (C3-C8), arylalkyl (C4-C8), and aryl (C3-C8); wherein R5 and R6 are independently selected from hydrogen, benzyl, alkyl (C1-C10), cycloalkyl (C3-C8), arylalkyl (C4-C14), and aryl (C3-C8); wherein R3 and R4 may form a ring; wherein R5 and R6 may form a ring or a heterocyclic structure; and wherein R5 and R6 are independently unsubstituted or substituted, wherein each substituent is independently selected from halogen, amino, alkyl (C1-C6), haloalkyl (C1-C6), alkoxy(C1-C6), alkylenedioxy, aryl, heteroaryl, and cycloalkyl (C3-C8). Also disclosed are methods for the preparation of compounds of Formula I and various intermediates. These compounds are useful as NAD+-dependent DNA ligase inhibitors.
摘要翻译：本文公开了具有其中R 1，R 2和R 2独立地选自硝基和氨基的结构的吡啶并[2,3-d]嘧啶; 其中R 3选自烷基（C 1 -C 10）和环烷基（C 3 -C 8）; 其中R 4选自氢，苄基，烷基（C1-C10），环烷基（C3-C8），芳基烷基（C4-C8）和芳基（C3-C8）; 其中R 5和R 6独立地选自氢，苄基，烷基（C1-C10），环烷基（C3-C8），芳基烷基（C4-C14）和芳基（C3-C8）; 其中R 3和R 4可以形成环; 其中R 5和R 6可以形成环或杂环结构; 并且其中R 5和R 6独立地是未取代的或取代的，其中每个取代基独立地选自卤素，氨基，烷基（C 1 -C 6），卤代烷基（C 1 -C 6 ），烷氧基（C1-C6），亚烷基二氧基，芳基，杂芳基和环烷基（C3-C8）。还公开了制备式I化合物和各种中间体的方法。这些化合物可用作NAD +依赖性DNA连接酶抑制剂。

8. 发明授权

US08753995B2 Ceramic dielectric material matched with nickel internal electrode and method for producing capacitor using same 有权
标题翻译：与镍内部电极匹配的陶瓷电介质材料及使用其制造电容器的方法
公开(公告)号：US08753995B2
公开(公告)日：2014-06-17
申请号：US13377515
申请日：2010-12-20
申请人： Beibei Song , Yongsheng Song , Fangce Mo , Juan Li , Xiaoguo Wang , Jinghua Guo
发明人： Beibei Song , Yongsheng Song , Fangce Mo , Juan Li , Xiaoguo Wang , Jinghua Guo
IPC分类号： C04B35/00 , H01L27/108 , H01L29/94
CPC分类号： H01G4/1245 , C04B35/20 , C04B2235/3201 , C04B2235/3203 , C04B2235/3208 , C04B2235/3215 , C04B2235/3217 , C04B2235/3232 , C04B2235/3244 , C04B2235/3267 , C04B2235/3284 , C04B2235/3298 , C04B2235/3409 , C04B2235/3418 , C04B2235/36 , C04B2235/365 , H01G4/0085 , H01G4/30
摘要： A high-frequency and low-dielectric-constant ceramic dielectric material matched with nickel internal electrode and a method for producing capacitor using same. The ceramic dielectric material consists of main crystalline phase, modifying additive and sintering flux. The main crystalline phase is MgZrxSi(1−x)O3, wherein 0.05≦x≦0.15. The modifying additive is one or more of MnO2, Al2O3, CaO, Bi2O3 and TiO2, and the sintering flux is one or more of B2O3, SiO2, ZnO, Li2O, K2O and BaO. The ceramic dielectric material has good uniformity, and excellent dielectric properties, meets the requirements of COG characteristics in EIA standard, and meets the environmental requirements. The ceramic dielectric material can be sintered under the reducing atmosphere and can be matched with nickel electrodes. The chip multilayer ceramic capacitor made of the ceramic dielectric material and nickel internal electrodes has stable performance.
摘要翻译：与镍内部电极匹配的高频低介电常数陶瓷电介质材料和使用其的电容器的制造方法。陶瓷介电材料由主结晶相，改性添加剂和烧结助焊剂组成。主要结晶相为MgZrxSi（1-x）O3，其中0.05＆nlE; x＆nlE; 0.15。改性添加剂是MnO 2，Al 2 O 3，CaO，Bi 2 O 3和TiO 2中的一种或多种，烧结助熔剂是B2O3，SiO2，ZnO，Li2O，K2O和BaO中的一种或多种。陶瓷介电材料均匀性好，介电性能优良，符合EIA标准中COG特性要求，符合环保要求。陶瓷介电材料可以在还原气氛下烧结，并可与镍电极相匹配。由陶瓷电介质材料和镍内电极制成的芯片多层陶瓷电容器性能稳定。

9. 发明申请

US20120268862A1 CERAMIC DIELECTRIC MATERIAL MATCHED WITH NICKEL INTERNAL ELECTRODE AND METHOD FOR PRODUCING CAPACITOR USING SAME 有权
标题翻译：用镍内电极匹配的陶瓷电介质材料及使用该电极生产电容器的方法
公开(公告)号：US20120268862A1
公开(公告)日：2012-10-25
申请号：US13377515
申请日：2010-12-20
申请人： Beibei Song , Yongsheng Song , Fangce Mo , Juan Li , Xiaoguo Wang , Jinghua Guo
发明人： Beibei Song , Yongsheng Song , Fangce Mo , Juan Li , Xiaoguo Wang , Jinghua Guo
IPC分类号： H01G4/12
CPC分类号： H01G4/1245 , C04B35/20 , C04B2235/3201 , C04B2235/3203 , C04B2235/3208 , C04B2235/3215 , C04B2235/3217 , C04B2235/3232 , C04B2235/3244 , C04B2235/3267 , C04B2235/3284 , C04B2235/3298 , C04B2235/3409 , C04B2235/3418 , C04B2235/36 , C04B2235/365 , H01G4/0085 , H01G4/30
摘要： A high-frequency and low-dielectric-constant ceramic dielectric material matched with nicket internal electrode and a method for producing capacitor using same. The ceramic dielectric material consists of main crystalline phase, modifying additive and sintering flux. The main crystalline phase is MgZrxSi(1−x)O3, wherein 0.05≦x≦0.15. The modifying additive is one or more of MnO2, Al2O3, CaO, Bi2O3 and TiO2, and the sintering flux is one or more of B2O3, SiO2, ZnO, Li2O, K2O and BaO. The ceramic dielectric material has good uniformity, and excellent dielectric properties, meets the requirements of COG characteristics in EIA standard, and meets the environmental requirements. The ceramic dielectric material can be sintered under the reducing atmosphere and can be matched with nickel electrodes. The chip multilayer ceramic capacitor made of the ceramic dielectric material and nickel internal electrodes has stable performance.
摘要翻译：与镍内电极匹配的高频低介电常数陶瓷介电材料和使用该电极制造电容器的方法。陶瓷介电材料由主结晶相，改性添加剂和烧结助焊剂组成。主要结晶相为MgZrxSi（1-x）O3，其中0.05＆nlE; x＆nlE; 0.15。改性添加剂是MnO 2，Al 2 O 3，CaO，Bi 2 O 3和TiO 2中的一种或多种，烧结助熔剂是B2O3，SiO2，ZnO，Li2O，K2O和BaO中的一种或多种。陶瓷介电材料均匀性好，介电性能优良，符合EIA标准中COG特性要求，符合环保要求。陶瓷介电材料可以在还原气氛下烧结，并可与镍电极相匹配。由陶瓷电介质材料和镍内电极制成的芯片多层陶瓷电容器性能稳定。

10. 发明授权

US06706729B1 Thiolesters and uses thereof 失效
标题翻译：巯基酯及其用途
公开(公告)号：US06706729B1
公开(公告)日：2004-03-16
申请号：US09701451
申请日：2001-05-16
申请人： James A. Turpin , Yongsheng Song , Ettore Appella , John K. Inman , David G. Covell , William G. Rice , Anders Wallqvist , Andrew Maynard , Mingjun Huang
发明人： James A. Turpin , Yongsheng Song , Ettore Appella , John K. Inman , David G. Covell , William G. Rice , Anders Wallqvist , Andrew Maynard , Mingjun Huang
IPC分类号： A61K3144
CPC分类号： C07D213/76 , C07D213/04 , C07D231/42 , C07D237/20 , C07D239/42 , C07D239/47 , C07D239/545 , C07D241/44 , C07D261/16 , C07D263/50 , C07D275/04 , C07D277/52 , C07D285/135 , C07D417/12
摘要： This invention pertains to the discovery of a novel family of thiolesters and uses thereof. Also provided for are viricidal compounds and pharmaceutical formulations comprising these novel thiolesters. The invention also provides thiolester-inactivated viruses and thiolester-complexed viral proteins.
摘要翻译：本发明涉及一种新型巯基酯类的研究及其应用。还提供了含有这些新型巯基化物的杀生物化合物和药物制剂。本发明还提供硫醇酯灭活的病毒和硫醇酯复合的病毒蛋白。

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