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1. 发明申请

US20110224170A1 Pyranopyranone derivatives as antimicrobial agents 审中-公开
公开(公告)号：US20110224170A1
公开(公告)日：2011-09-15
申请号：US13028576
申请日：2011-02-16
申请人： Barbara Wagner , Janina Purschwitz , Karin Bieler
发明人： Barbara Wagner , Janina Purschwitz , Karin Bieler
IPC分类号： A61K31/366 , A61K31/695 , A01N43/90 , A01N55/10 , C07D493/04 , A61P31/00 , A01P1/00
CPC分类号： A61K31/366 , A01N43/90 , A01N55/00 , C07D493/04 , C07D493/08 , C07D493/10 , C07D493/20 , C07F7/0812 , A01N2300/00
摘要： Disclosed is the use of pyranopyranone derivatives of formula wherein R1, R2, R3, R4 and R5 independently of one another are hydrogen; C1-C30alkyl, C2-C30alkenyl, or C3-C12cycloalkyl, which may be substituted by one or more E and/or interrupted by one or more D; C6-C20aryl, which may be substituted by one or more G; C4-C20heteroaryl, which may be substituted by one or more G, C2-C18alkenyl, C2-C18alkynyl, C7-C25aralkyl, or —CO—R6; —SiR8R9R10; or R4 and R5 together form a five or six membered ring; or R3 and R4 together form a five or six membered ring; D is —CO—; —COO—; —S—; —SO—; —SO2—; —O—; —NR7—; —SiR8R9—; —POR10—; —CR12═CR13—; or —C≡C—; and E is —OR6; —SR6; —NR14R15; —NR14COR15; —COR6; —COOR6; —CONR14R15; —CN; halogen; or OSO3R11; SO3R11; SO2R11; PO3(R11)2; OPO3(R11)2; G is E; C1-C18alkyl, which is optionally interrupted by D; C1-C18 perfluoroalkyl; C1-C18alkoxy, which is optionally substituted by E and/or interrupted by D; wherein R6 is H; C6-C18aryl which is optionally substituted by OH, C1-C30alkyl or C1-C30alkoxy; or C1-C30alkyl which is optionally interrupted by —O—; R7 is H; C6-C18aryl which is optionally substituted by OH, C1-C30alkyl or C1-C30alkoxy; or C1-C30alkyl which is optionally interrupted by —O—; R8, R9 and R10 independently of each other are hydrogen; C1-C30alkyl; C6-C18aryl which is optionally substituted by C1-C30alkyl; and R11 is hydrogen; C6-C18aryl, which is optionally substituted by OH, C1-C30alkyl or C1-C30alkoxy; or C1-C30alkyl, which is optionally interrupted by —O—; R12, R13, R14 and R15 independently of each other are hydrogen; C6-C18aryl which is optionally substituted by OH, C1-C30alkyl or C1-C30alkoxy; C1-C30alkyl, which is optionally interrupted by —O—; or R14 and R15 together form a five or six membered ring; as antimicrobial and/or preserving agents.

2. 发明申请

US20120189568A1 ANTIMICROBIAL AMINO-SALICYLIC ACID DERIVATIVES 有权
标题翻译：抗微生物氨基磺酸衍生物
公开(公告)号：US20120189568A1
公开(公告)日：2012-07-26
申请号：US13391671
申请日：2010-08-13
申请人： Werner Hölzl , Janina Purschwitz
发明人： Werner Hölzl , Janina Purschwitz
IPC分类号： A01N37/46 , A61P31/04 , A61K8/42 , A01P1/00 , A01P3/00 , A61L9/01 , A61K31/606 , A61P31/10
CPC分类号： C11D3/48 , A61K8/42 , A61Q5/02 , A61Q11/02 , A61Q15/00 , A61Q17/005 , C11D3/32
摘要： Disclosed is a novel method for achieving an antimicrobial, preservative and/or microorganism adhesion inhibiting effect, for the protection within an article and/or material or on the surface of an article and/or material. The novel method comprises application of a salicylic compound of the formula (I) wherein one of A and A is a residue of the formula (I′): —NH—CO—R1 while the other is hydrogen; R1 is C1-C22alkyl, C3-C12cycloalkyl, C3-C12cycloalkyl interrupted by O and/or NR5, C4-C12aryl, C5-C18arylalkyl; R2 is OR3 or NHR4; R3 and R4 are selected from H, C1-C22alkyl, C3-C12cycloalkyl, C3-C12cycloalkyl interrupted by O and/or NR5, C4-C12aryl, C5-C18arylalkyl; R5 is H or C1-C8alkyl; wherein each aryl moiety is unsubstituted or substituted by C1-C4alkyl, C1-C4alkoxy, C1-C4acyl, C1-C4acyloxy, C1-C4acylamino, CF3, OH, amino, halogen; or an adduct or salt thereof; to said article and/or material.
摘要翻译：公开了一种用于在制品和/或材料内或制品和/或材料的表面上实现抗微生物，防腐和/或微生物粘附抑制作用的新颖方法。该新方法包括施用式（I）的水杨酸化合物，其中A和A之一是式（I'）的残基：-NH-CO-R 1，而另一个是氢; R1是C1-C22烷基，C3-C12环烷基，被O和/或NR5，C4-C12芳基，C5-C18芳烷基中断的C3-C12环烷基; R2是OR3或NHR4; R 3和R 4选自H，C 1 -C 22烷基，C 3 -C 12环烷基，被O和/或NR 5，C 4 -C 12芳基，C 5 -C 18芳烷基间隔的C 3 -C 12环烷基; R5是H或C1-C8烷基; 其中每个芳基部分是未取代的或被C 1 -C 4烷基，C 1 -C 4烷氧基，C 1 -C 4酰基，C 1 -C 4酰氧基，C 1 -C 4酰氨基，CF 3，OH，氨基，卤素取代。或其加合物或其盐; 对所述物品和/或材料。

3. 发明授权

US09644175B2 Antimicrobial amino-salicylic acid derivatives 有权
公开(公告)号：US09644175B2
公开(公告)日：2017-05-09
申请号：US13391671
申请日：2010-08-13
申请人： Werner Hölzl , Janina Purschwitz
发明人： Werner Hölzl , Janina Purschwitz
IPC分类号： C11D3/48 , A61K8/42 , A61Q17/00 , C11D3/32 , A61Q5/02 , A61Q11/02 , A61Q15/00
CPC分类号： C11D3/48 , A61K8/42 , A61Q5/02 , A61Q11/02 , A61Q15/00 , A61Q17/005 , C11D3/32
摘要： Disclosed is a novel method for achieving an antimicrobial, preservative and/or microorganism adhesion inhibiting effect, for the protection within an article and/or material or on the surface of an article and/or material. The novel method comprises application of a salicylic compound of the formula (I) wherein one of A and A is a residue of the formula (I′): —NH—CO—R1 while the other is hydrogen; R1 is C1-C22alkyl, C3-C12cycloalkyl, C3-C12cycloalkyl interrupted by O and/or NR5, C4-C12aryl, C5-C18arylalkyl; R2 is OR3 or NHR4; R3 and R4 are selected from H, C1-C22alkyl, C3-C12cycloalkyl, C3-C12cycloalkyl interrupted by O and/or NR5, C4-C12aryl, C5-C18arylalkyl; R5 is H or C1-C8alkyl; wherein each aryl moiety is unsubstituted or substituted by C1-C4alkyl, C1-C4alkoxy, C1-C4acyl, C1-C4acyloxy, C1-C4acylamino, CF3, OH, amino, halogen; or an adduct or salt thereof; to said article and/or material.

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