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1. 发明申请

US20120322083A1 ANTIBODY BINDING TO ABCA1 POLYPEPTIDE 审中-公开
标题翻译：抗体与ABCA1多肽结合
公开(公告)号：US20120322083A1
公开(公告)日：2012-12-20
申请号：US13517863
申请日：2012-06-14
申请人： Barbara Ecabert , Hugues Matile , Everson Nogoceke , Bernhard Reis , Haiyan Wang
发明人： Barbara Ecabert , Hugues Matile , Everson Nogoceke , Bernhard Reis , Haiyan Wang
IPC分类号： C07K16/18 , C12P21/00 , C12N15/63 , C12N15/13 , C12N1/21 , C12N5/18 , G01N33/566
CPC分类号： C07K16/18
摘要： The invention relates to an isolated antibody that binds to native ABCA1 polypeptide and its uses for the detection of ABCA1 polypeptides in tissue samples.
摘要翻译：本发明涉及结合天然ABCA1多肽的分离抗体及其在组织样品中检测ABCA1多肽的用途。

2. 发明授权

US08512704B2 Tmem27 antibody 失效
标题翻译： Tmem27抗体
公开(公告)号：US08512704B2
公开(公告)日：2013-08-20
申请号：US13388974
申请日：2010-07-30
申请人： Kerstin Jahn-Hofmann , Sannah Zoffmann Jensen , Hugues Matile , Cristiano Migliorini , Haiyan Wang
发明人： Kerstin Jahn-Hofmann , Sannah Zoffmann Jensen , Hugues Matile , Cristiano Migliorini , Haiyan Wang
IPC分类号： A61K39/395 , C12N5/12 , C07K16/28
CPC分类号： C07K16/18
摘要： The present invention relates to an antibody directed to a beta cell marker protein, in particular to an antibody directed to the protein TMEM27.
摘要翻译：本发明涉及针对β细胞标记蛋白的抗体，特别涉及针对蛋白TMEM27的抗体。

3. 发明申请

US20120276561A1 MARKER PROTEIN FOR TYPE-2 DIABETES 审中-公开
标题翻译： 2型糖尿病标记蛋白
公开(公告)号：US20120276561A1
公开(公告)日：2012-11-01
申请号：US13512102
申请日：2010-11-23
申请人： Laura Badi , Martin Ebeling , Hugues Matile , Cristiano Migliorini , Jacob Sabates Bellver , Thomas Schindler , Elena Sebokova , Haiyan Wang
发明人： Laura Badi , Martin Ebeling , Hugues Matile , Cristiano Migliorini , Jacob Sabates Bellver , Thomas Schindler , Elena Sebokova , Haiyan Wang
IPC分类号： G01N33/577 , C07K16/18
CPC分类号： C07K16/18 , G01N2500/00 , G01N2800/042
摘要： The present invention provides a marker protein for the early detection of type II diabetes, antibodies directed to the marker protein and their use in a diagnostic method for type II diabetes and in drug development.
摘要翻译：本发明提供了用于早期检测II型糖尿病的标记蛋白，针对标记蛋白的抗体及其在II型糖尿病的诊断方法中的用途以及药物开发中的用途。

4. 发明申请

US20120134927A1 BETA CELL MARKER ANTIBODY 失效
标题翻译： BETA细胞标记抗体
公开(公告)号：US20120134927A1
公开(公告)日：2012-05-31
申请号：US13388974
申请日：2010-07-30
申请人： Kerstin Jahn-Hofmann , Sannah Zoffmann Jensen , Hugues Matile , Christiano Migliorini , Haiyan Wang
发明人： Kerstin Jahn-Hofmann , Sannah Zoffmann Jensen , Hugues Matile , Christiano Migliorini , Haiyan Wang
IPC分类号： A61K49/00 , C12N5/16 , C07H21/04 , C12N15/63 , C07K16/18 , A61K39/395 , C12N5/10
CPC分类号： C07K16/18
摘要： The present invention relates to an antibody directed to a beta cell marker protein, in particular to an antibody directed to the protein TMEM27.
摘要翻译：本发明涉及针对β细胞标记蛋白的抗体，特别涉及针对蛋白TMEM27的抗体。

5. 发明申请

US20110229922A1 SCREENING ASSAYS FOR THE IDENTIFICATION OF BACE2 INHIBITORS 审中-公开
标题翻译：用于鉴定BACE2抑制剂的筛选测定
公开(公告)号：US20110229922A1
公开(公告)日：2011-09-22
申请号：US13131331
申请日：2009-11-26
申请人： Jeremy Beauchamp , Heinz Doebeli , Hugues Matile , Cristiano Migliorini , Michael Prummer , Paolo Salvioni , Haiyan Wang
发明人： Jeremy Beauchamp , Heinz Doebeli , Hugues Matile , Cristiano Migliorini , Michael Prummer , Paolo Salvioni , Haiyan Wang
IPC分类号： C12Q1/37
CPC分类号： G01N33/5008 , C12Q1/37 , G01N2333/8107
摘要： The present invention relates to screening assays for the identification of BACE2 inhibitors.
摘要翻译：本发明涉及用于鉴定BACE2抑制剂的筛选试验。

6. 发明授权

US10023977B2 Method for producing high stacking fault energy (SFE) metal films, foils, and coatings with high-density nanoscale twin boundaries 有权
公开(公告)号：US10023977B2
公开(公告)日：2018-07-17
申请号：US14428538
申请日：2013-09-17
申请人： Xinghang Zhang , Daniel Bufford , Haiyan Wang , Yue Liu
发明人： Xinghang Zhang , Daniel Bufford , Haiyan Wang , Yue Liu
IPC分类号： C30B29/68 , C30B29/02
摘要： Materials, including metals such as bulk metals, specialty alloys, metallic films and coatings, are made up of many tiny single crystals, which may also be referred to as grains. The boundaries between crystals are called grain boundaries and govern properties such as mechanical strength, deformation, and electrical resistivity. These properties are affected by not only the number of grain boundaries formed, but also the density and orientation of those grain boundaries. Twin boundaries are a special type of grain boundary which have symmetrical “mirror image” structures and preserve favorable qualities of grain boundaries while suppressing unfavorable properties such as the initiation of cracks, inclusions, and other unwanted flaws. Some metals and alloys form twins more easily than others during processing. Metals with low stacking fault energy (SFE) such as austenitic stainless steel, copper (Cu), and silver (Ag) form twin boundaries more easily than metals with high SFE such as Magnesium (Mg) and Aluminum (Al).

7. 发明授权

US08912221B2 Biaryl amide derivatives 有权
标题翻译：二芳基酰胺衍生物
公开(公告)号：US08912221B2
公开(公告)日：2014-12-16
申请号：US13329349
申请日：2011-12-19
申请人： Johannes Aebi , Alfred Binggeli , Cornelia Hertel , Anish Ashok Konkar , Holger Kuehne , Bernd Kuhn , Hans P. Maerki , Haiyan Wang
发明人： Johannes Aebi , Alfred Binggeli , Cornelia Hertel , Anish Ashok Konkar , Holger Kuehne , Bernd Kuhn , Hans P. Maerki , Haiyan Wang
IPC分类号： A61K31/443 , C07D413/14 , C07D405/14 , C07D413/12 , C07D405/12 , C07D305/08 , C07D417/14
CPC分类号： C07D305/08 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/14
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and A are as described herein, compositions including the compounds and methods of using the compounds.
摘要翻译：本发明提供具有通式（I）的新化合物，其中R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，R11，R12和A如本文所述，包括该化合物和使用化合物。

8. 发明申请

US20130307417A1 HIGH POWER DIRECT DRIVE CIRCUIT 有权
标题翻译：高功率直流驱动电路
公开(公告)号：US20130307417A1
公开(公告)日：2013-11-21
申请号：US13473559
申请日：2012-05-16
申请人： Timothy Chen , Haiyan Wang
发明人： Timothy Chen , Haiyan Wang
IPC分类号： H05B37/02
CPC分类号： H05B33/0809
摘要： A driver circuit for driving an LED includes a rectifier circuit to receive AC voltage and to convert the AC voltage to DC voltage. The driver circuit further includes a filter circuit for filtering the DC voltage. The driver circuit further includes a detection circuit for determining a change in the filtered DC voltage over a predetermined time interval. The driver circuit further includes a dampening circuit for dampening the filtered DC voltage responsive to the detection circuit determining that the change in filtered DC voltage over the predetermined time interval exceeds a predetermined threshold.
摘要翻译：用于驱动LED的驱动器电路包括用于接收AC电压并将AC电压转换为DC电压的整流器电路。驱动器电路还包括用于对直流电压进行滤波的滤波电路。驱动器电路还包括用于在预定时间间隔内确定经滤波的DC电压的变化的检测电路。驱动器电路还包括用于衰减滤波后的DC电压的阻尼电路，该阻尼电路响应于检测电路确定在预定时间间隔内滤波的直流电压的变化超过预定阈值。

9. 发明授权

US08574427B2 Process for removing refractory nitrogen compounds from vacuum gas oil 有权
$Process for removing refractory nitrogen compounds from vacuum gas oil$
标题翻译：从真空瓦斯油中除去难溶氮化合物的方法
公开(公告)号：US08574427B2
公开(公告)日：2013-11-05
申请号：US13555769
申请日：2012-07-23
申请人： Beckay J. Mezza , Haiyan Wang , Alakananda Bhattacharyya , Christopher P. Nicholas
发明人： Beckay J. Mezza , Haiyan Wang , Alakananda Bhattacharyya , Christopher P. Nicholas
IPC分类号： C10G21/24 , C10G21/12 , C10G21/06 , C07C7/10
CPC分类号： C10G69/04 , C10G55/06 , C10G67/04 , C10G2300/1074
摘要： A process for removing a refractory nitrogen compound from a hydroprocessed vacuum gas oil feed includes contacting the hydroprocessed vacuum gas oil feed comprising the nitrogen compound with a VGO-immiscible phosphonium ionic liquid to produce a hydroprocessed vacuum gas oil and VGO-immiscible phosphonium ionic liquid mixture, and separating the mixture to produce a hydroprocessed vacuum gas oil effluent having a reduced refractory nitrogen compound content relative to the vacuum gas oil feed.
摘要翻译：从加氢真空瓦斯油原料中除去难熔氮化合物的方法包括使包含氮化合物的加氢真空瓦斯油进料与VGO不混溶的鏻离子液体接触以产生加氢处理的真空瓦斯油和VGO不混溶的鏻离子液体混合物并分离混合物以产生相对于减压瓦斯油进料具有降低的耐难氮氮化合物含量的加氢处理的减压瓦斯油流出物。

10. 发明申请

US20120165338A1 NEW BIARYL AMIDE DERIVATIVES 有权
标题翻译：新的二元胺衍生物
公开(公告)号：US20120165338A1
公开(公告)日：2012-06-28
申请号：US13329349
申请日：2011-12-19
申请人： Johannes Aebi , Alfred Binggeli , Cornelia Hertel , Anish Ashok Konkar , Holger Kuehne , Bernd Kuhn , Hans P. Maerki , Haiyan Wang
发明人： Johannes Aebi , Alfred Binggeli , Cornelia Hertel , Anish Ashok Konkar , Holger Kuehne , Bernd Kuhn , Hans P. Maerki , Haiyan Wang
IPC分类号： A61K31/501 , A61K31/4439 , A61K31/506 , C07D305/08 , A61K31/337 , A61P13/12 , C07D413/12 , A61K31/422 , A61K31/41 , A61K31/4245 , A61K31/444 , A61P29/00 , C07D413/14 , C07D405/12
CPC分类号： C07D305/08 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/14
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and A are as described herein, compositions including the compounds and methods of using the compounds.
摘要翻译：本发明提供具有通式（I）的新化合物，其中R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，R11，R12和A如本文所述，包括该化合物和使用化合物。

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